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1. 发明申请

WO2009082218A1 REAL-TIME METHOD FOR THE DETECTION OF VIABLE MICRO-ORGANISMS 审中-公开
标题翻译：用于检测可见微量有机物的实时方法
公开(公告)号：WO2009082218A1
公开(公告)日：2009-07-02
申请号：PCT/NL2008/050828
申请日：2008-12-19
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , KORT, Remco , SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan
发明人： KORT, Remco , SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan
IPC分类号： G01N21/64 , G01N33/50
CPC分类号： C12Q1/04 , G01N21/6428 , G01N21/80
摘要： The invention relates to a method for real-time detection of viable microorganisms comprising: a. addition of a cell-permeable, phototautomeric compound to a micro-organism or other living cell; and b. measuring the fluorescent emission of said phototautomeric compound. Preferably the phototautomeric compound is salicylic acid, 2-hydroxy-l-naphtoic acid or 1- hydroxy-2-naphtoic acid. Further, the assay can be used to assess the antibiotic effect of a test compound. This test can be used as a high- throughput screening for compounds with antibiotic activity. Also part of the invention is the use of a cell permeable phototautomeric compound in a method for determining the viability of micro-organisms and for assessing the antibiotic effect of a test compound.
摘要翻译：本发明涉及一种用于实时检测活微生物的方法，包括：a。向微生物或其他活细胞中加入细胞可渗透的光敏化合物; 和b。测量所述光自由基化合物的荧光发射。优选光敏化合物是水杨酸，2-羟基-1-萘甲酸或1-羟基-2-萘甲酸。此外，该测定可用于评估测试化合物的抗生素效果。该测试可用作具有抗生素活性的化合物的高通量筛选。本发明的一部分也是在测定微生物活力的方法中以及用于评估测试化合物的抗生素效果的方法中使用细胞可渗透的光致敏化合物。

2. 发明申请

WO2008120992A1 NOVEL ANTIBIOTICS 审中-公开
标题翻译：新型抗生素
公开(公告)号：WO2008120992A1
公开(公告)日：2008-10-09
申请号：PCT/NL2008/050188
申请日：2008-04-03
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan
发明人： SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan
IPC分类号： C07D257/04 , C07D401/14 , A61K31/41 , A61P31/04
CPC分类号： C07D257/04 , C07D401/14
摘要： The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, variants of bis(l-aryl-5-tetrazolyl)methanes, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.
摘要翻译：本发明涉及医疗领域内外的抗生素组合物领域。提出了一类新的抗生素化合物，双（1-芳基-5-四唑基）甲烷的变体，其特别可用于抗革兰氏阳性菌特别是MRSA的感染。

3. 发明申请

WO2007037685A1 NOVEL ANTIBIOTICS COMPRISING BIS(1-ARYL-5-TETRAZ0LYL)METHANE DERIVATIVES 审中-公开
标题翻译：包含BIS（1-ARYL-5-TETRAZ0LYL）甲基衍生物的新型抗生素
公开(公告)号：WO2007037685A1
公开(公告)日：2007-04-05
申请号：PCT/NL2006/000489
申请日：2006-09-29
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , SCHUREN, Frank Henri Johan , THIJSSEN, Henricus Matheus Wilhelmus Maria , MONTIJN, Roy Christiaan
发明人： SCHUREN, Frank Henri Johan , THIJSSEN, Henricus Matheus Wilhelmus Maria , MONTIJN, Roy Christiaan
IPC分类号： A61K31/41 , C07D257/04 , A61P31/04
CPC分类号： C07D403/06 , A61K31/41
摘要： The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, the bis(1-aryl-5-tetrazolyl)methanes, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.
摘要翻译：本发明涉及医疗领域内外的抗生素组合物领域。提出了一类新型的抗生素化合物，即双（1-芳基-5-四唑基）甲烷，特别适用于抗革兰氏阳性菌特别是MRSA的感染。

4. 发明申请

WO2010002254A1 MARKERS FOR DETECTION OF LEGIONELLA PNEUMOPHILA STRAINS 审中-公开
标题翻译：用于检测LEGIONELLA PNEUMOPHILA菌株的标记物
公开(公告)号：WO2010002254A1
公开(公告)日：2010-01-07
申请号：PCT/NL2009/050391
申请日：2009-07-01
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , VITENS N.V. , SCHUREN, Frank Henri Johan , ATSMA, Waatze Aize
发明人： SCHUREN, Frank Henri Johan , ATSMA, Waatze Aize
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y02A50/451
摘要： The invention relates to a method of detecting Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to one or morespecific sequence markers, as identified by SEQ ID NO:1 through SEQ ID NO:10 or homologues thereof or in an immunoassay with antibodies specifically recognizing the amino acid sequence of SEQ ID NO: 11 and/or 12. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.
摘要翻译：本发明涉及通过将疑似含有军团菌的样品的基因组DNA与SEQ ID NO：1至SEQ ID NO：10所鉴定的或其同系物或免疫测定法鉴定的一种或多种特异性序列标记物进行杂交来检测嗜肺军团杆菌菌株的方法具有特异性识别SEQ ID NO：11和/或12的氨基酸序列的抗体。本发明还涉及包含用于实施本发明方法的阵列和参考材料的试剂盒。

5. 发明申请

WO2010151124A2 SELECTION OF A NUTRITIONAL COMPOSITION CAPABLE OF PROMOTING HEALTH 审中-公开
标题翻译：选择可促进健康的营养成分
公开(公告)号：WO2010151124A2
公开(公告)日：2010-12-29
申请号：PCT/NL2010/050387
申请日：2010-06-23
申请人： FRIESLAND BRANDS B.V. , TE BIESEBEKE, Rob , GLAS, Cornelis , NAUTA, Arjen , MONTIJN, Roy Christiaan , SCHUREN, Frank Henri Johan
发明人： TE BIESEBEKE, Rob , GLAS, Cornelis , NAUTA, Arjen , MONTIJN, Roy Christiaan , SCHUREN, Frank Henri Johan
IPC分类号： C12Q1/02 , C12Q1/04
CPC分类号： C12Q1/025 , C12Q1/04
摘要： The invention relates to the area of food items and the development of nutritional compositions having beneficial effects on human health, such as increasing resistance and protection against diseases. The invention provides a method based on bacterial species profiling to determine whether an (infant) nutritional composition comprising probiotic micro-organisms has a health promoting effect on the human body, in particular increasing resistance against (common) infections of the gastro-intestinal (GI) and/or respiratory tract. Also provided is a microarray device for use in such method.
摘要翻译：本发明涉及食品的面积以及对人体健康有益的营养成分的开发，例如增加抗性和防止疾病。本发明提供了一种基于细菌物种分析的方法，以确定包含益生菌微生物的（婴儿）营养组合物对人体是否具有健康促进作用，特别是增加抗胃肠道（GI）的（常见）感染）和/或呼吸道。还提供了一种用于这种方法的微阵列装置。

6. 发明申请

WO2008082290A1 METHOD OF DETECTING PATHOGENIC LEGIONELLA STRAINS 审中-公开
标题翻译：检测病原性菌株的方法
公开(公告)号：WO2008082290A1
公开(公告)日：2008-07-10
申请号：PCT/NL2007/000332
申请日：2007-12-28
申请人： NEDERLANDSE ORGANISTATE VOOR TOEGEPAST-NATUURWETENS CHAPPELIJK ONDERZOEK TNO , SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan , THIJSSEN, Henricus Matheus Wilhelmus Maria
发明人： SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan , THIJSSEN, Henricus Matheus Wilhelmus Maria
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y02A50/451
摘要： The invention relates to a method of detecting pathogenic Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to two or five specific sequence markers, as identified by MARKER NO. 1 through MARKER NO. 5 or homologues thereof.. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.
摘要翻译：本发明涉及通过将怀疑含有军团菌的样品的基因组DNA与MARKER NO鉴定的两个或五个特异性序列标记杂交来检测致病性嗜肺军团菌菌株的方法。 1通过标记号 5或其同系物。本发明还涉及包含用于实施本发明的方法的阵列和参考材料的试剂盒。

7. 发明申请

WO2017043971A1 DETECTION OF QUALITY OF SURFACE WATER 审中-公开
标题翻译：检测表面水质量
公开(公告)号：WO2017043971A1
公开(公告)日：2017-03-16
申请号：PCT/NL2016/050626
申请日：2016-09-09
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人： SCHUREN, Frank Henri Johan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895
摘要： The present invention relates to a method for developing a classifier for classifying the trophic state of surface water comprising the steps of: a. taking samples of surface water of different trophic states; b. determining the nucleotide sequence of 18S RNA of micro-organisms in said sample; c. selecting for those sequences that are unique for a specific trophic state. Further, the present invention relates to a method for classifying the trophic state of surface water comprising the steps of: a. taking a surface water sample; b. extracting the nucleotide sequence of the 18S RNA of the microorganisms in said sample; c. checking for the presence of one or more of the nucleotide sequences depicted in any of Tables 1 - 6 in the extracted nucleotide sequences of step b; d. classifying the sample on basis of the presence or absence of said sequences. Further, a kit comprising an array for hybridization forms part of the invention.
摘要翻译：本发明涉及一种开发用于分级地表水的营养状态的分级器的方法，包括以下步骤：a。取不同营养状态的地表水样品; 湾确定所述样品中微生物的18S RNA的核苷酸序列; C。选择对于特定营养状态是唯一的那些序列。此外，本发明涉及一种用于分级地表水的营养状态的方法，包括以下步骤：a。取地表水样品; 湾提取所述样品中微生物的18S RNA的核苷酸序列; C。在步骤b的提取的核苷酸序列中检查表1-6中任一个所示的一个或多个核苷酸序列的存在; 天。基于所述序列的存在或不存在对样品进行分类。此外，包含用于杂交的阵列的试剂盒形成本发明的一部分。

8. 发明申请

WO2022055345A1 CONDITIONING CHAMBER FOR DUAL-INTERFACE FLUIDIC SYSTEM 审中-公开
公开(公告)号：WO2022055345A1
公开(公告)日：2022-03-17
申请号：PCT/NL2021/050540
申请日：2021-09-07
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人： DONKERS, Joanne Mariska , ESLAMI AMIRABADI, Hossein , STREEKSTRA, Eveline Julia , BOUWHUIS, Josse Johan Bernhard , SCHUREN, Frank Henri Johan , OSSENDRIJVER, Michel , VAN DE STEEG, Evita
IPC分类号： B01L3/00 , C12M3/06 , C12M1/12 , C12M1/34 , B01L1/02
摘要： A system (100) for investigating a membrane (T) comprises with a sealing chamber (10) containing a liquid container. The liquid container (11) is configured to hold a liquid medium (M1) in open communication with a controlled atmosphere (10a) inside the sealing chamber (10). A flow cell (30) is disposed outside the sealing chamber (10) and comprises flow channels (31,32) separated by the tissue. A set of liquid ducts (L13,L31) is connected to one of the flow channels (31) and configured to carry the liquid medium (M1) from the liquid container (11), through a barrier (10b,10t) of the sealing chamber (10) to an entrance of the flow channel (31) into the flow cell (30), and carry at least part of the liquid medium (M1') exiting the flow channel (31) from the flow cell (30) back into the liquid container (11).

9. 发明申请

WO2015026235A2 PRODUCTION OF PROBIOTICS BY IN VITRO ENRICHMENT OF BENEFICIAL MICROORGANISMS FROM HUMAN OR ANIMAL MICROBIOTA 审中-公开
标题翻译：通过从人类或动物微生物中获得有益微生物的生物制造生物
公开(公告)号：WO2015026235A2
公开(公告)日：2015-02-26
申请号：PCT/NL2014/050570
申请日：2014-08-22
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人： KORT, Remco , SCHUREN, Frank Henri Johan
IPC分类号： A61K35/74
CPC分类号： A61K35/747 , A61K35/741 , A61K35/745
摘要： The present invention is directed to a method of treating a dysbiosis in a mammal, preferably a human, by taking a sample of the micro-organisms that are causative of the dysbiosis, whereafter said sample is enriched in vitro for healthy bacteria, after which the sample is replaced.
摘要翻译：本发明涉及一种通过摄取致病性生殖障碍的微生物样品来治疗哺乳动物，优选人类的生殖障碍的方法，之后所述样品在体外富含健康细菌，之后样品被替换

10. 发明申请

WO2015160251A1 NEW ANTI-CLOSTRIDIUM COMPOUNDS 审中-公开
标题翻译：新抗菌化合物
公开(公告)号：WO2015160251A1
公开(公告)日：2015-10-22
申请号：PCT/NL2015/050248
申请日：2015-04-14
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人： SCHUREN, Frank Henri Johan , MONTIJN, Roy Christiaan
IPC分类号： A61K31/122 , A61K31/4745 , A61P31/04
CPC分类号： A61K31/4745 , A61K31/122
摘要： The present invention relates to compounds having a backbone structure for use as antibiotic, more specifically use against infections with Gram positive bacteria, preferably Clostridium, more preferably C. difficile or C. perfringens. The compounds of the invention are particularly useful against spores of these bacteria.
摘要翻译：本发明涉及具有用作抗生素的骨架结构的化合物，更具体地，可用于抵抗革兰氏阳性菌，优选梭菌（Clostridium），更优选艰难梭菌（C. difficile）或产气荚膜梭菌（C.expringens）的感染。本发明的化合物特别适用于这些细菌的孢子。

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