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1. 发明申请

WO2012101136A1 ENDO Tv, A NOVEL HIGH-MANNOSE-SPECIFIC ENDO-ß-N-ACETYLGLUCOSAMINIDASE FROM TRICHODERMA VIRIDE 审中-公开
标题翻译： ENDO Tv，一种来自TRICHODERMA VIRIDE的新型高通量特异性内切-β-N-乙酰胆碱磷酸酶
公开(公告)号：WO2012101136A1
公开(公告)日：2012-08-02
申请号：PCT/EP2012/051070
申请日：2012-01-24
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY , JOSHI, Lokesh , GERLACH, Jared , KILCOYNE, Michelle , FARRELL, Mark
发明人： JOSHI, Lokesh , GERLACH, Jared , KILCOYNE, Michelle , FARRELL, Mark
IPC分类号： C07K14/37 , C12N9/24
CPC分类号： C12N9/2402 , C12N9/2442 , C12Q1/34 , C12Y302/01096 , G01N2333/942
摘要： The invention relates to an endo-β-N -acetylglucosaminidase enzyme isolatable from the fungus Trichoderma virde and to methods of producing the enzyme and uses of said enzyme.
摘要翻译：本发明涉及可从真菌木霉分离的内切-β-N-乙酰氨基葡萄糖苷酶，以及生产酶的方法和所述酶的用途。

2. 发明申请

WO2014060436A1 SIALYLTRANSFERASE ST3GAL6 AS A MARKER FOR MULTIPLE MYELOMA 审中-公开
标题翻译： SIALYLTRANSFERASE ST3GAL6作为MELTIPLE MYELOMA的标记
公开(公告)号：WO2014060436A1
公开(公告)日：2014-04-24
申请号：PCT/EP2013/071555
申请日：2013-10-15
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： GLAVEY, Siobhan , JOSHI, Lokesh , O'DWYER, Michael
IPC分类号： G01N33/574
CPC分类号： A61K31/7105 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/57407 , G01N33/57423 , G01N2333/91 , G01N2333/91148 , G01N2333/924 , G01N2400/00
摘要： The present invention relates to the sialyltransferase ST3GAL6 for use as a biomarker for multiple myeloma, and especially as a marker for myelomas with inferior survival rates. The inventors have shown that glycosylation gene expression is dysregulated in Multiple Myeloma and that overexpression of the sialyltransferase ST3GAL6 is associated with inferior survival rates in patients.
摘要翻译：本发明涉及用作多发性骨髓瘤生物标志物的唾液酸转移酶ST3GAL6，特别是作为存活率较低的骨髓瘤标志物。本发明人已经表明糖基化基因表达在多发性骨髓瘤中失调，唾液酸转移酶ST3GAL6的过度表达与患者的较差存活率相关。

3. 发明申请

WO2014057129A1 THE DETECTION OF FREE AND PROTEIN-BOUND NON-HUMAN GAL-α-(1→3)-GAL EPITOPE 审中-公开
标题翻译：免费和蛋白质结合的非人类GAL-α-（1→3）-GAL EPITOPE的检测
公开(公告)号：WO2014057129A1
公开(公告)日：2014-04-17
申请号：PCT/EP2013/071367
申请日：2013-10-11
申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY
发明人： CUNNINGHAM, Stephen , STARR, Emily , SHAW, Iain , GLAVIN, John , KANE, Marian , JOSHI, Lokesh
IPC分类号： C07K16/44 , C07K16/18 , G01N33/577
CPC分类号： G01N33/6842 , C07K16/18 , C07K16/44 , C07K2317/23 , C07K2317/33 , C07K2317/622 , C07K2317/92 , G01N2400/02 , G01N2800/245
摘要： The present invention relates to the provision of antibody fragments capable of binding selectively to the Gal-α-(1→3)-Gal epitope. The invention further relates to assay systems comprising these antibody fragments for use in testing transplantation tissue for possible rejection complications. This epitope is often found on porcine tissue destined for human transplantation. The epitope is also found on biopharmaceuticals and on some infectious agents and accordingly the invention also provides assay systems for these applications.
摘要翻译：本发明涉及提供能够选择性结合Gal-α-（1→3）-Gal表位的抗体片段。本发明还涉及包含用于测试移植组织以用于可能的排斥并发症的这些抗体片段的测定系统。这种表位经常发现在用于人类移植的猪组织上。表位也在生物药物和一些感染因子上发现，因此本发明还提供了用于这些应用的测定系统。

4. 发明申请

WO2012051370A1 SYSTEM AND METHOD FOR DISPLAYING COMPLEX SCRIPTS WITH A CLOUD COMPUTING ARCHITECTURE 审中-公开
标题翻译：使用云计算架构显示复杂脚本的系统和方法
公开(公告)号：WO2012051370A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/056061
申请日：2011-10-13
申请人： BITSTREAM, INC. , JOSHI, Lokesh , JOSHI, Himanshu
发明人： JOSHI, Lokesh , JOSHI, Himanshu
IPC分类号： G06F9/44
CPC分类号： G06T11/00 , G06F17/214 , G06F17/2223 , H04L67/02
摘要： A system and method for displaying complex scripts with a cloud computing architecture may include a client device and a cloud computing server. The client device accesses a web application via the internet and transmits a request containing complex scripts to the cloud computing server. The cloud computing server parses the text and breaks the text down to a sequence of characters of a particular script, and maps the Unicode of each character to a particular glyph to obtain a glyph ID for each character making a one to one relationship. The cloud computing server analyzes each character, assigns, and applies specific font related operations to each glyph. The cloud computing server optimizes and compresses the glyph ID and positioning data, and transmit the compressed data back to the client device to be rendered on the display of the client device.
摘要翻译：用于使用云计算架构显示复杂脚本的系统和方法可以包括客户端设备和云计算服务器。客户端设备通过互联网访问Web应用，并将包含复杂脚本的请求发送到云计算服务器。云计算服务器解析文本并将文本分解为特定脚本的一系列字符，并将每个字符的Unicode映射到特定的字形，以获得与一对一关系相关的每个字符的字形ID。云计算服务器分析每个字符，分配和应用与每个字形相关的特定字体相关操作。云计算服务器优化和压缩字形ID和定位数据，并将压缩数据发送回客户端设备，以呈现在客户端设备的显示器上。

5. 发明申请

WO2004071177A2 SIALYLATION OF GLYCOPROTEINS IN PLANTS 审中-公开
标题翻译：甘氨酸在植物中的分解
公开(公告)号：WO2004071177A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004281
申请日：2004-02-11
申请人： ARIZONA BOARD OF REGENTS, acting for and on behalf of, ARIZONA STATE UNIVERSITY , JOSHI, Lokesh , SHAH, Miti, M.
发明人： JOSHI, Lokesh , SHAH, Miti, M.
IPC分类号： A01H
CPC分类号： C12N15/8257 , C07K14/415 , C12N9/1048 , C12N15/8242 , C12N15/8245 , C12N15/8258 , C12Q1/527
摘要： The presence of sialic acids (SAs) at the non-reducing terminal of various glycoconjugates plays important roles in the function and half-life of glycoproteins in mammals and many species of microorganisms. It has been previously unknown that plant cells have the capacity to sialylate glycoproteins. The present invention discloses the presence of sialylated glycoconjugates and identifies N-acetylneuranminic acid (Neu5Ac) and N-glycolylneuraminic (Neu5Gc) on glycoproteins in suspension-cultured cells of plants, for example , Arabidopsi s thaliana (A. thaliana ), Nicotiana tabacum (tobacco), and Medicago sativa (alfalfa), extending the complexity of glycan structures known in the plant kingdom. This invention further discloses methods for engineering plants to produce recombinant glcyoproteins.
摘要翻译：在各种糖缀合物的非还原末端存在唾液酸（SA）在哺乳动物和许多种微生物中的糖蛋白的功能和半衰期中起重要作用。以前不知道植物细胞具有唾液酸化糖蛋白的能力。本发明公开了唾液酸化糖缀合物的存在，并鉴定了植物的悬浮培养细胞中的N-乙酰神经元酸（Neu5Ac）和N-羟乙酰神经氨酸（Neu5Gc）在糖蛋白上，例如拟南芥（拟南芥），烟草（烟草））和苜蓿（Medicago sativa）（苜蓿），延长了植物界知道的聚糖结构的复杂性。本发明进一步公开了用于工程植物生产重组蛋白的方法。

6. 发明申请

WO2005037236A2 NOVEL HEAT SHOCK PROTEIN 20-RELATED POLYPEPTIDES AND USES THEREFOR 审中-公开
标题翻译：新型热休克蛋白20相关多肽及其用途
公开(公告)号：WO2005037236A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/034989
申请日：2004-10-15
申请人： ARIZONA BOARD OF REGENTS , BROPHY, Colleen , FURNISH, Elizabeth , KOMALAVILAS, Padmini , DREIZA, Catherine , JOSHI, Lokesh , PANITCH, Alyssa
发明人： BROPHY, Colleen , FURNISH, Elizabeth , KOMALAVILAS, Padmini , DREIZA, Catherine , JOSHI, Lokesh , PANITCH, Alyssa
IPC分类号： A61K
CPC分类号： A61K38/1709
摘要： The present invention provides novel HSP20-based polypeptides and pharmaceutical compositions thereof, and methods for using such polypeptides and pharmaceutical compositions for various therapeutic uses.
摘要翻译：本发明提供了新型的基于HSP20的多肽及其药物组合物，以及使用这些多肽和药物组合物用于各种治疗用途的方法。

7. 发明申请

WO2005077044A2 RATIONAL DESIGN AND ENGINEERING OF PROTEINS AND PEPTIDES FOR IMMUNOMODULATION 审中-公开
标题翻译：蛋白质和肽的免疫组化设计与工程
公开(公告)号：WO2005077044A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/004043
申请日：2005-02-07
申请人： ARIZONA BOARD OF REGENTS, acting for on behalf of ARIZONA STATE UNIVERSITY , JOSHI, Lokesh , GHIRLANDA, Giovanna
发明人： JOSHI, Lokesh , GHIRLANDA, Giovanna
IPC分类号： C07K14/57
CPC分类号： C07K14/57
摘要： The present invention discloses an immunomodulatory protein or peptide mimetic and method for treatment of immunosuppressive diseases and conditions by administering an effective dose of the immunoactive form of the mimetic sufficient to activate phagocytic cells and triggering phagocytosis, thereby activating the immune system.
摘要翻译：本发明公开了一种免疫调节蛋白或肽模拟物和用于治疗免疫抑制性疾病和病症的方法，其通过施用足够的有效剂量的模拟物的免疫活性形式来激活吞噬细胞并引发吞噬作用，由此激活免疫系统。

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