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1. 发明申请

WO2004071177A3 SIALYLATION OF GLYCOPROTEINS IN PLANTS 审中-公开
标题翻译：甘氨酸在植物中的分解
公开(公告)号：WO2004071177A3
公开(公告)日：2007-01-25
申请号：PCT/US2004004281
申请日：2004-02-11
申请人： UNIV ARIZONA STATE , JOSHI LOKESH , SHAH MITI M
发明人： JOSHI LOKESH , SHAH MITI M
IPC分类号： C12N15/82 , A01H5/00 , C12Q1/527
CPC分类号： C12N15/8257 , C07K14/415 , C12N9/1048 , C12N15/8242 , C12N15/8245 , C12N15/8258 , C12Q1/527
摘要： The presence of sialic acids (SAs) at the non-reducing terminal of various glycoconjugates plays important roles in the function and half-life of glycoproteins in mammals and many species of microorganisms. It has been previously unknown that plant cells have the capacity to sialylate glycoproteins. The present invention discloses the presence of sialylated glycoconjugates and identifies N-acetylneuranminic acid (Neu5Ac) and N-glycolylneuraminic (Neu5Gc) on glycoproteins in suspension-cultured cells of plants, for example, Arabidopsis thaliana (A. thaliana), Nicotiana tabacum (tobacco), and Medicago sativa (alfalfa), extending the complexity of glycan structures known in the plant kingdom. This invention further discloses methods for engineering plants to produce recombinant glcyoproteins.
摘要翻译：在各种糖缀合物的非还原末端存在唾液酸（SA）在哺乳动物和许多种微生物中的糖蛋白的功能和半衰期中起重要作用。以前不知道植物细胞具有唾液酸化糖蛋白的能力。本发明公开了唾液酸化糖缀合物的存在，并鉴定了植物的悬浮培养细胞中的N-乙酰神经元酸（Neu5Ac）和N-羟乙酰神经氨酸（Neu5Gc）在糖蛋白上，例如拟南芥（拟南芥），烟草（烟草））和苜蓿（Medicago sativa）（苜蓿），延长了植物界知道的聚糖结构的复杂性。本发明进一步公开了用于工程植物生产重组蛋白的方法。

2. 发明申请

WO2004071177A2 SIALYLATION OF GLYCOPROTEINS IN PLANTS 审中-公开
标题翻译：甘氨酸在植物中的分解
公开(公告)号：WO2004071177A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004281
申请日：2004-02-11
申请人： ARIZONA BOARD OF REGENTS, acting for and on behalf of, ARIZONA STATE UNIVERSITY , JOSHI, Lokesh , SHAH, Miti, M.
发明人： JOSHI, Lokesh , SHAH, Miti, M.
IPC分类号： A01H
CPC分类号： C12N15/8257 , C07K14/415 , C12N9/1048 , C12N15/8242 , C12N15/8245 , C12N15/8258 , C12Q1/527
摘要： The presence of sialic acids (SAs) at the non-reducing terminal of various glycoconjugates plays important roles in the function and half-life of glycoproteins in mammals and many species of microorganisms. It has been previously unknown that plant cells have the capacity to sialylate glycoproteins. The present invention discloses the presence of sialylated glycoconjugates and identifies N-acetylneuranminic acid (Neu5Ac) and N-glycolylneuraminic (Neu5Gc) on glycoproteins in suspension-cultured cells of plants, for example , Arabidopsi s thaliana (A. thaliana ), Nicotiana tabacum (tobacco), and Medicago sativa (alfalfa), extending the complexity of glycan structures known in the plant kingdom. This invention further discloses methods for engineering plants to produce recombinant glcyoproteins.
摘要翻译：在各种糖缀合物的非还原末端存在唾液酸（SA）在哺乳动物和许多种微生物中的糖蛋白的功能和半衰期中起重要作用。以前不知道植物细胞具有唾液酸化糖蛋白的能力。本发明公开了唾液酸化糖缀合物的存在，并鉴定了植物的悬浮培养细胞中的N-乙酰神经元酸（Neu5Ac）和N-羟乙酰神经氨酸（Neu5Gc）在糖蛋白上，例如拟南芥（拟南芥），烟草（烟草））和苜蓿（Medicago sativa）（苜蓿），延长了植物界知道的聚糖结构的复杂性。本发明进一步公开了用于工程植物生产重组蛋白的方法。

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