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1. 发明申请

WO2023059266A2 PROGRAMMABLE SELECTIVE ACYLATION OF POLYOLS 审中-公开
公开(公告)号：WO2023059266A2
公开(公告)日：2023-04-13
申请号：PCT/SG2022/050711
申请日：2022-10-05
申请人： NANYANG TECHNOLOGICAL UNIVERSITY
发明人： CHI, Yonggui , LYU, Wenxin
摘要： Disclosed herein is a method to selectively acylate a polyol, the method comprising the steps of: (a) providing a mixture comprising a polyol, an acylation agent, a N-heterocyclic carbene (NHC) precursor, a base and a solvent; and (b) subjecting the mixture to an elevated temperature for a period of time to provide a selectively acylated polyol, optionally wherein the mixture further comprises a boronic acid.

2. 发明申请

WO2016013976A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND 审中-公开
标题翻译：形成多取代苯甲醛化合物的方法
公开(公告)号：WO2016013976A1
公开(公告)日：2016-01-28
申请号：PCT/SG2015/050223
申请日：2015-07-22
申请人： NANYANG TECHNOLOGICAL UNIVERSITY
发明人： CHI, Yonggui , ZHU, Tingshun
IPC分类号： C07C2/52 , C07C69/78 , C07C49/784 , C07C49/796 , C07C49/84 , C07C49/813 , C07D307/46 , C07D333/22 , C07C205/35 , C07D209/46 , C07C13/465
CPC分类号： C07C2/52 , C07C45/72 , C07C67/343 , C07C201/12 , C07C2602/08 , C07D209/46 , C07D307/46 , C07D333/22 , C07C205/35 , C07C13/465 , C07C49/784 , C07C49/796 , C07C49/84 , C07C49/813 , C07C69/76 , C07C69/94
摘要： The invention relates to a method of forming a multi-substituted benzene compound. In particular, the method involves benzene construction via organocatalytic formal [3+3] cycloaddition reaction.
摘要翻译：本发明涉及形成多取代苯化合物的方法。特别地，该方法涉及通过有机催化形式[3 + 3]环加成反应的苯构建。

3. 发明申请

WO2014142755A1 ACTIVATION OF CARBONYL β-CARBONS FOR CHEMICAL TRANSFORMATIONS 审中-公开
标题翻译：用于化学转化的碳和碳的活化
公开(公告)号：WO2014142755A1
公开(公告)日：2014-09-18
申请号：PCT/SG2014/000123
申请日：2014-03-14
申请人： NANYANG TECHNOLOGICAL UNIVERSITY
发明人： CHI, Yonggui , FU, Zhenqian
IPC分类号： C07D249/16
CPC分类号： C07D487/04 , C07C201/12 , C07C2601/10 , C07D207/26 , C07D207/28 , C07D207/50 , C07D307/33 , C07D307/36 , C07D333/06 , C07D409/04 , C07C205/06
摘要： The present invention relates to a method for synthesizing a compound of Formula (I) as defined herein, comprising: (i) activating a compound of Formula (II) as defined herein, by reacting said compound of Formula (II) with a compound of Formula (III) as defined herein, in the presence of a base, to obtain a compound of Formula (IV) as defined herein; and (ii) reacting the compound of Formula (IV) with an electrophile to obtain the compound of Formula (I). The present invention further relates to the organocatalysts used in the described methods and their respective uses.
摘要翻译：本发明涉及一种合成本文定义的式（I）化合物的方法，其包括：（i）通过使式（II）化合物与式（II）化合物与在碱的存在下，如本文所定义的式（III），以获得本文定义的式（IV）化合物; 和（ii）使式（IV）化合物与亲电试剂反应，得到式（I）化合物。本发明还涉及用于所述方法及其各自用途的有机催化剂。

4. 发明申请

WO2013095301A1 METHOD OF PREPARING CHIRAL KETONES FROM ALDEHYDES 审中-公开
标题翻译：从ALDEHYDES制备CHALALKETONES的方法
公开(公告)号：WO2013095301A1
公开(公告)日：2013-06-27
申请号：PCT/SG2012/000474
申请日：2012-12-13
申请人： NANYANG TECHNOLOGICAL UNIVERSITY
发明人： CHI, Yonggui , TIWARI, Bhoopendra
IPC分类号： C07B41/06 , C07C225/14 , C07C225/16 , C07C221/00 , C07C205/44 , C07C205/02 , C07C201/12
CPC分类号： C07C221/00 , C07B41/06 , C07C201/12 , C07C205/02 , C07C205/44 , C07C225/14 , C07C225/16
摘要： Present invention relates to a method of preparing a chiral α- or β-substituted ketone from the corresponding β- or γ-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula (II), (IV) or (VI), respectively, the method comprising reacting the aldehyde of formula (II), (IV) or (VI) in the presence of an amine, oxygen and an organic solvent, wherein the reaction is carried out in the absence of a metal-based catalyst or a metal-based oxidant, wherein: R is H, a substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 2 -C 15 alkenyl, substituted or unsubstituted C 2 -C 15 alkynyl, substituted or unsubstituted C 3 -C 15 cycloalkyl, substituted or unsubstituted C 3 -C 15 cycloalkenyl, substituted or unsubstituted C 3 -C 15 heterocycloalkyl, substituted or unsubstituted C 3 -C 15 heterocycloalkenyl, substituted or unsubstituted C 6 -C 15 aryl, or substituted or unsubstituted C 6 -C 15 heteroaryl; and R' is H, a substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 2 -C 15 alkenyl, substituted or unsubstituted C 2 -C 15 alkynyl, substituted or unsubstituted C 3 -C 15 cycloalkyl, substituted or unsubstituted C 3 -C 15 cycloalkenyl, substituted or unsubstituted C 3 -C 15 heterocycloalkyl, substituted or unsubstituted C 3 -C 15 heterocycloalkenyl, substituted or unsubstituted C 6 -C 15 aryl, or substituted or unsubstituted C 6 -C 15 heteroaryl.
摘要翻译：本发明涉及从相应的β-或γ-取代的醛制备手性α-或β-取代的酮的方法，其中酮具有式（I），（III）或（V），并且相应的醛具有式（II），（IV）或（VI）的方法，包括在胺，氧和有机溶剂的存在下使式（II），（IV）或（VI）的醛反应，其中反应在不存在金属基催化剂或金属基氧化剂的情况下进行，其中：R是H，取代或未取代的C 1 -C 10烷基，取代或未取代的C 2 -C 15烯基，取代或未取代的C 2 -C 15炔基，取代或未取代的C 3 -C 15环烷基，取代或未取代的C 3 -C 15环烯基，取代或未取代的C 3 -C 15杂环烷基，取代或未取代的C 3 -C 15杂环烯基，取代或未取代的C 6 -C 15芳基或取代或未取代的C 6 -C 15杂芳基; 取代或未取代的C 1 -C 15烷基，取代或未取代的C 2 -C 15烯基，取代或未取代的C 2 -C 15炔基，取代或未取代的C 3 -C 15环烷基，取代或未取代的C 3 -C 15环烯基，取代或未取代的 C 3 -C 15杂环烷基，取代或未取代的C 3 -C 15杂环烯基，取代或未取代的C 6 -C 15芳基或取代或未取代的C 6 -C 15杂芳基。

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