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1. 发明申请

WO2003038558A3 DEVICE AND METHODS FOR DIRECTED SYNTHESIS OF CHEMICAL LIBRARIES 审中-公开
公开(公告)号：WO2003038558A3
公开(公告)日：2003-05-08
申请号：PCT/US2002/034775
申请日：2002-10-30
申请人： NANOMICS BIOSYSTEMS PTY, LTD. , BATTERSBY, Bronwyn, J. , MILLER, Christopher, R. , TRAU, Mathias , WAY, Jeffrey, C. , JOHNSTON, Angus
发明人： BATTERSBY, Bronwyn, J. , MILLER, Christopher, R. , TRAU, Mathias , WAY, Jeffrey, C. , JOHNSTON, Angus
IPC分类号： C12Q1/00
摘要： The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.

2. 发明申请

WO2003038558A2 DEVICE AND METHODS FOR DIRECTED SYNTHESIS OF CHEMICAL LIBRARIES 审中-公开
标题翻译：用于化学文库的指导性合成的装置和方法
公开(公告)号：WO2003038558A2
公开(公告)日：2003-05-08
申请号：PCT/US2002/034775
申请日：2002-10-30
申请人： NANOMICS BIOSYSTEMS PTY, LTD. , BATTERSBY, Bronwyn, J. , MILLER, Christopher, R. , TRAU, Mathias , WAY, Jeffrey, C. , JOHNSTON, Angus
发明人： BATTERSBY, Bronwyn, J. , MILLER, Christopher, R. , TRAU, Mathias , WAY, Jeffrey, C. , JOHNSTON, Angus
IPC分类号： G06F
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00286 , B01J2219/00454 , B01J2219/00463 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00545 , B01J2219/00554 , B01J2219/00576 , B01J2219/00585 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B70/00
摘要： The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.
摘要翻译：本发明的特征在于一种分类计算机，其与分选装置接口，以便通过珠基来控制珠子上的珠粒的分选。本发明还涉及用于定向合成寡核苷酸（例如寡核苷酸）的编码文库的新颖方法。这些方法允许合成足够大的文库以进行复杂的基因组分析。还描述了使用编码库的新方法。

3. 发明申请

WO2003002633A1 SYNTHESIS AND USE OF ORGANOSILICA PARTICLES 审中-公开
标题翻译：合成和使用有机硅颗粒
公开(公告)号：WO2003002633A1
公开(公告)日：2003-01-09
申请号：PCT/IB2002/003375
申请日：2002-07-01
申请人： NANOMICS BIOSYSTEMS PTY, LTD. , TRAU, Mathias , JOHNSTON, Angus
发明人： TRAU, Mathias , JOHNSTON, Angus
IPC分类号： C08G77/04
CPC分类号： C08G77/06 , C08G77/28 , C08G77/38 , C08G77/392 , Y10T428/2995
摘要： Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 μm to over 100 μm. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 μm that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.
摘要翻译：描述了高功能化的多孔有机二氧化硅颗粒及其合成方法，其使用大量的功能性硅烷如3-巯基丙基三甲氧基硅烷。硅烷粒子直径从小于1微米到超过100微米。这些颗粒由于其有利的内部结构而具有高的表面积，该内部结构由通常高达10微米的大孔组成，通常通常为约20nm直径的小通道连接。异硫氰酸酯改性荧光染料可以进入和与孔内的硫醇基反应。本发明还提供具有受控厚度的透明二氧化硅壳，以保护荧光信号，并提供用于基于不同尺寸颗粒的光散射来区分颗粒类型的独立参数。颗粒是稳定的并且可用于许多目的，特别是用于组合合成聚合物如核酸，多肽和其它合成分子的光学条编码。

4. 发明申请

WO2011066609A1 WATER TREATMENT 审中-公开
标题翻译：水处理
公开(公告)号：WO2011066609A1
公开(公告)日：2011-06-09
申请号：PCT/AU2010/001617
申请日：2010-12-01
申请人： UNIVERSITY OF QUEENSLAND , TRAU, Mathias
发明人： TRAU, Mathias
IPC分类号： C02F1/44 , B01D61/00 , B01D63/00
CPC分类号： B01D61/002 , B01D61/005 , C02F1/445 , C02F2103/002
摘要： A method of producing a non-potable, functionally useful solution, which method comprises: providing on respective sides of a semi-permeable membrane a feed solution and a draw solution, wherein the draw solution comprises an osmotic agent that is functionally useful and that creates an osmotic pressure difference between the feed solution and the draw solution; and allowing solvent to diffuse through the semi-permeable membrane from the feed solution to the draw solution in order to produce the functionally useful solution. The invention also provides a method of producing a potable solution, which method comprises: providing on respective sides of a semi-permeable membrane an aqueous feed solution and a draw solution, wherein the draw solution comprises an osmotic agent that creates an osmotic pressure difference between the feed solution and the draw solution and an additional agent that serves to maintain or prolong the osmotic pressure difference as the draw solution is diluted and/or increase the rate of flux of solvent molecules moving from the feed solution to the draw solution when compared with an equivalent draw solution absent the additional agent; and allowing water to diffuse through the semi-permeable membrane from the feed solution to the draw solution to produce a potable solution.
摘要翻译：一种生产不可饮用的功能上有用的溶液的方法，该方法包括：在半透膜的相应侧面上提供进料溶液和拉伸溶液，其中所述拉伸溶液包含功能上有用的渗透剂，进料溶液和溶液之间的渗透压差; 并允许溶剂通过半透膜从进料溶液扩散到拉伸溶液中，以产生功能上有用的溶液。本发明还提供一种生产饮用溶液的方法，该方法包括：在半透膜的相应侧面上提供含水进料溶液和拉伸溶液，其中所述拉伸溶液包含渗透剂，其形成渗透压差进料溶液和拉伸溶液以及另外的试剂，其用于在拉伸溶液稀释时维持或延长渗透压差，和/或提高溶剂分子从进料溶液流向拉伸溶液的流量，当与不含额外试剂的等效溶液; 并且允许水通过半透膜从进料溶液扩散到拉伸溶液以产生饮用溶液。

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