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1. 发明申请

WO2005027872A3 COMPOSITIONS FOR INACTIVATING PATHOGENIC MICROORGANISMS, METHODS OF MAKING THE COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于灭活病原微生物的组合物，制备组合物的方法及其使用方法
公开(公告)号：WO2005027872A3
公开(公告)日：2006-03-09
申请号：PCT/US2004017417
申请日：2004-06-03
申请人： NANOBIO CORP , BAKER JAMES R , ANNIS TED C , HAMOUDA TAREK , VENGROFF LINDA
发明人： BAKER JAMES R , ANNIS TED C , HAMOUDA TAREK , VENGROFF LINDA
IPC分类号： A61K9/51 , A61K9/00 , A61K9/107 , A61K31/7048
CPC分类号： A61K31/7048 , A61K9/1075
摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
摘要翻译：描述了显示出微生物的广谱灭活或预防疾病的低毒性的纳米乳剂组合物。纳米乳剂含有水相，包含油和有机溶剂的油相和一种或多种表面活性剂。还提供了制备纳米乳剂和灭活病原微生物的方法。

2. 发明申请

WO2009129470A3 METHODS FOR TREATING HERPES VIRUS INFECTIONS 审中-公开
标题翻译：用于治疗病毒性感染的方法
公开(公告)号：WO2009129470A3
公开(公告)日：2010-12-02
申请号：PCT/US2009040970
申请日：2009-04-17
申请人： NANOBIO CORP , FLACK MARY R , CIOTTI MARIE , HAMOUDA TAREK , SUTCLIFFE JOYCE A , BAKER JAMES R
发明人： FLACK MARY R , CIOTTI MARIE , HAMOUDA TAREK , SUTCLIFFE JOYCE A , BAKER JAMES R
IPC分类号： A61K9/107
CPC分类号： A61K9/1075 , A61K9/0014
摘要： The present invention relates to methods for treating, killing, and/or inhibiting the growth of Herpes viruses in human subjects comprising topically administering to a human subject in need thereof a nanoemulsion composition having antiviral properties.
摘要翻译：本发明涉及用于治疗，杀死和/或抑制人类受试者中疱疹病毒生长的方法，所述方法包括向有需要的人受试者局部施用具有抗病毒性质的纳米乳剂组合物。

3. 发明申请

WO2004030608A3 NANOEMULSION VACCINES 审中-公开
公开(公告)号：WO2004030608A3
公开(公告)日：2005-03-10
申请号：PCT/US0217765
申请日：2002-06-05
申请人： UNIV MICHIGAN , BAKER JAMES R , HAMOUDA TAREK
发明人： BAKER JAMES R , HAMOUDA TAREK
IPC分类号： A01N25/04 , A61K9/00 , A61K9/107 , A61K39/39 , A61K47/00
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
摘要翻译：本发明提供了用于刺激免疫应答的方法和组合物。具体地，本发明提供了使用纳米乳液化合物作为粘膜佐剂以诱导对环境病原体免疫的方法和组合物。因此，在一些实施方案中，本发明提供了包含纳米乳剂和衍生自病原体的灭活病原体或蛋白质的纳米乳剂疫苗。因此，本发明提供了针对各种环境和人释放的病原体的改进的疫苗。

4. 发明申请

WO2008051186A3 NANOEMULSION CONTAINING COMPOSITIONS HAVING ANT I -INFLAMMATORY ACTIVITY 审中-公开
标题翻译：含有I-INFLAMMATORY活性的含有纳米组合物
公开(公告)号：WO2008051186A3
公开(公告)日：2008-07-03
申请号：PCT/US2006031039
申请日：2006-08-09
申请人： NANOBIO CORP , BAKER JAMES R
发明人： BAKER JAMES R
IPC分类号： A61K9/107 , A61K9/51 , A61K31/14 , A61K39/00 , A61K39/02 , A61K39/07 , A61K39/12 , A61K47/10 , A61K47/24 , A61K47/44
CPC分类号： A61K9/1075 , A61K31/573
摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, at least one anti-inflammatory agent, and one or more surfactants, and particles having an average diameter of less than or equal to 250 nm. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
摘要翻译：描述了显示出微生物的广谱灭活或预防疾病的低毒性的纳米乳剂组合物。纳米乳剂含有水相，包含油和有机溶剂的油相，至少一种抗炎剂和一种或多种表面活性剂，以及平均直径小于或等于250nm的颗粒。还提供了制备纳米乳剂和灭活病原微生物的方法。

5. 发明申请

WO2009009203A2 DENDRIMER BASED COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：基于DENDRIMER的组合物及其使用方法
公开(公告)号：WO2009009203A2
公开(公告)日：2009-01-15
申请号：PCT/US2008061023
申请日：2008-04-21
申请人： UNIV MICHIGAN , BAKER JAMES R , THOMAS THOMMEY P , SHUKLA RAMESHWER
发明人： BAKER JAMES R , THOMAS THOMMEY P , SHUKLA RAMESHWER
IPC分类号： G06F19/00
CPC分类号： C08L101/005 , A61K47/64 , A61K49/0043 , A61K49/0054 , A61K49/0056 , Y02A90/26
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及用于疾病诊断和治疗（例如癌症诊断和治疗）的基于树枝状大分子的组合物和系统。组合物和系统包含用于靶向，成像，感测和/或提供治疗或诊断材料并监测对细胞或组织（例如肿瘤）的治疗的反应的一种或多种组分。

6. 发明申请

WO2009058885A3 SYSTEMS AND METHODS FOR OBTAINING AND USING DATA FROM A LOCALIZED LOCATION AND TELEMETRY SYSTEM IN A WIDE AREA LOCATION AND TELEMETRY SYSTEM 审中-公开
标题翻译：用于在广域定位和遥测系统中从本地化和遥测系统获取和使用数据的系统和方法
公开(公告)号：WO2009058885A3
公开(公告)日：2009-12-30
申请号：PCT/US2008081611
申请日：2008-10-29
申请人： S5 WIRELESS INC , BAKER JAMES R , PRESTWICH SY , BEVAN SCOTT
发明人： BAKER JAMES R , PRESTWICH SY , BEVAN SCOTT
IPC分类号： G08B13/14
CPC分类号： H04Q9/00 , G01S5/0009 , G01S5/0263 , G06Q10/08 , H04Q2209/43 , H04Q2209/47
摘要： A wide area location and telemetry system may include a wide area location and telemetry system server that is configured to determine wide area location and telemetry system data about an object when the object is located within the coverage area of the wide area location and telemetry system. The wide area location and telemetry system server may also be configured to receive localized location and telemetry system data about the object when the object is located within the coverage area of a localized location and telemetry system. The wide area location and telemetry system may also include a database and a database manager. The database manager may be configured to store the wide area location and telemetry system data and the localized location and telemetry system data in the database.
摘要翻译：广域位置和遥测系统可以包括广域位置和遥测系统服务器，其被配置为当对象位于广域位置和遥测系统的覆盖区域内时确定关于对象的广域定位和遥测系统数据。广域位置和遥测系统服务器还可以被配置为当对象位于局部位置和遥测系统的覆盖区域内时接收关于对象的本地化位置和遥测系统数据。广域位置和遥测系统还可以包括数据库和数据库管理器。数据库管理器可以被配置为将广域位置和遥测系统数据以及本地化位置和遥测系统数据存储在数据库中。

7. 发明申请

WO2008008483A2 DENDRIMER BASED COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：基于DENDRIMER的组合物及其使用方法
公开(公告)号：WO2008008483A2
公开(公告)日：2008-01-17
申请号：PCT/US2007015976
申请日：2007-07-12
申请人： UNIV MICHIGAN , SHI XIANGYANG , WANG SUHE , BAKER JAMES R
发明人： SHI XIANGYANG , WANG SUHE , BAKER JAMES R
IPC分类号： A61K31/785
CPC分类号： A61K31/785 , A61K47/551 , A61K47/595 , A61K47/62 , A61K47/645 , A61K47/6923 , A61K49/0043 , A61K49/0052 , A61K49/0054 , A61K49/1857 , A61K49/1872 , B82Y5/00
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。具体而言，本发明涉及用于疾病诊断和治疗（例如癌症诊断和治疗）的基于树枝状聚合物的组合物和系统。组合物和系统包含用于靶向，成像，感测和/或提供治疗或诊断材料并监测对细胞或组织（例如肿瘤）的治疗的响应的一种或多种组分。

8. 发明申请

WO2006034046A3 QUANTITATIVE TWO-PHOTON FLOW CYTOMETRY 审中-公开
标题翻译：定量双光子流式细胞术
公开(公告)号：WO2006034046A3
公开(公告)日：2006-09-14
申请号：PCT/US2005033189
申请日：2005-09-16
申请人： UNIV MICHIGAN , YE JING YONG , NORRIS THEODORE B , ZHONG CHENG FRANK , BAKER JAMES R
发明人： YE JING YONG , NORRIS THEODORE B , ZHONG CHENG FRANK , BAKER JAMES R
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/1484 , G01N2015/1075 , G01N2015/145 , G01N2015/1472 , G01N2015/1493
摘要： A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
摘要翻译：一种使用流式细胞仪对颗粒进行多染料分析的方法和设备。该方法包括使用两种或更多种染料将要检测的颗粒染色; 以不均匀的流动推动颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒，使得两种或更多种染料各自发荧光，从而分别产生第一输出信号和第二输出信号; 并检测第一输出信号和第二输出信号。使用多光子激发激光束激发毛细管内的第二颗粒，使得两种或更多种染料各自发荧光，由此分别产生第三输出信号和第四输出信号。该方法最终包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较以检测粒子中的期望变化。

9. 发明申请

WO2011060157A2 ANALYTICAL SYSTEM WITH PHOTONIC CRYSTAL SENSOR 审中-公开
标题翻译：光电晶体传感器分析系统
公开(公告)号：WO2011060157A2
公开(公告)日：2011-05-19
申请号：PCT/US2010056367
申请日：2010-11-11
申请人： UNIV MICHIGAN , YE JINGYONG , GESTWICKI JASON E , NORRIS THEODORE B , BAKER JAMES R , BERSANO-BEGEY TOMMASO F
发明人： YE JINGYONG , GESTWICKI JASON E , NORRIS THEODORE B , BAKER JAMES R , BERSANO-BEGEY TOMMASO F
CPC分类号： G02B1/005 , B82Y20/00 , G01N21/553
摘要： A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance.
摘要翻译：用于确定试验物质与目标物质之间是否发生相互作用的系统。该系统包括具有光子晶体结构的光子晶体传感器和邻近光子晶体结构设置的缺陷部件。缺陷构件限定能够接收目标物质和试验物质的手术表面。该系统还包括将光信号输入到光子晶体结构和缺陷部件的光源。光信号被内部反射，并输出合成的输出信号。输出信号涉及试验物质是否在手术表面与目标物质相互作用。此外，该系统包括识别与目标物质相互作用的试验物质的身份检测器。

10. 发明申请

WO2006089093A2 WHOLE SPECTRUM FLUORESCENCE DETECTION WITH ULTRAFAST WHITE LIGHT EXCITATION 审中-公开
标题翻译：全光谱荧光检测与超轻白光激发
公开(公告)号：WO2006089093A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005595
申请日：2006-02-17
申请人： UNIV MICHIGAN , YE JING YONG , NORRIS THEODORE B , BAKER JAMES R
发明人： YE JING YONG , NORRIS THEODORE B , BAKER JAMES R
IPC分类号： G01J3/30
CPC分类号： G01J3/4406 , G01J3/10 , G01J3/2889 , G01N21/6408 , G01N21/6458
摘要： A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.
摘要翻译：一种用于测试具有至少一个荧光团的样品的荧光检测系统。荧光检测系统包括输出白光脉冲的白光发生系统。白光脉冲具有第一频率范围和第一持续时间。白光脉冲激发样品的至少一个荧光团以发射荧光。荧光具有第二频率范围和第二持续时间，其中第一持续时间小于第二持续时间。时间分辨检测器接收荧光和白光脉冲的至少一部分，并将荧光与白光脉冲的该部分分离。

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