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1. 发明申请

WO2009124965A1 PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS 审中-公开
标题翻译：吡咯并[<我
公开(公告)号：WO2009124965A1
公开(公告)日：2009-10-15
申请号：PCT/EP2009/054209
申请日：2009-04-08
申请人： N.V. ORGANON , PHARMACOPEIA, LLC , ROUGHTON, Andrew Laird , HO, Koc-Kan , OHLMEYER, Michael , DILLER, David , NEAGU, Irina , KINGSBURY, Celia , CHAN, Jui-Hsiang , LOMMERSE, Johannes, Petrus, Maria , TEERHUIS, Neeltje, Miranda , WIJKMANS, Jacobus Cornelis Henricus Maria , PLATE, Ralf
发明人： ROUGHTON, Andrew Laird , HO, Koc-Kan , OHLMEYER, Michael , DILLER, David , NEAGU, Irina , KINGSBURY, Celia , CHAN, Jui-Hsiang , LOMMERSE, Johannes, Petrus, Maria , TEERHUIS, Neeltje, Miranda , WIJKMANS, Jacobus Cornelis Henricus Maria , PLATE, Ralf
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to a pyrrolo[2,3-d]pyrimidin-2-yl-amine derivative according to formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said pyrrolo[2,3-d]pyrimidine-2-ylamine derivatives and to their use in therapy, for instance in the treatment of PKCθ mediated disorders.
摘要翻译：本发明涉及式（I）的吡咯并[2,3-d]嘧啶-2-基 - 胺衍生物，其中变量如说明书中所定义，或其药学上可接受的盐或溶剂合物。本发明还涉及包含一种或多种所述吡咯并[2,3-d]嘧啶-2-基胺衍生物的药物组合物及其在治疗中的用途，例如用于治疗PKC？介导的疾病。

2. 发明申请

WO2008051826A2 PURINES AS PKC-THETA INHIBITORS 审中-公开
标题翻译：作为PKC-THETA抑制剂
公开(公告)号：WO2008051826A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/081899
申请日：2007-10-19
申请人： N.V. ORGANON , PHARMACOPEIA INC. , NEAGU, Irina , ROUGHTON, Andrew , HO, Koc-kan , DILLER, David , CHAN, Jui, Hsiang , KINGSBURY, Celia , OHLMEYER, Michael , WIJKMANS, Jacobus Cornelis, Henricus Maria , TEERHUIS, Neeltje, Miranda , LOMMERSE, Johannes Petrus, Maria
发明人： NEAGU, Irina , ROUGHTON, Andrew , HO, Koc-kan , DILLER, David , CHAN, Jui, Hsiang , KINGSBURY, Celia , OHLMEYER, Michael , WIJKMANS, Jacobus Cornelis, Henricus Maria , TEERHUIS, Neeltje, Miranda , LOMMERSE, Johannes Petrus, Maria
IPC分类号： C07D473/32 , A61K31/52 , A61P35/00
CPC分类号： C07D473/32
摘要： A chemical genus of purines, which are useful as PKC θ inhibitors, is disclosed. The genus is represented by the formula (I); A representative example is: (II)
摘要翻译：嘌呤的化学属，可用作PKC？抑制剂。该属由式（I）表示; 一个代表性的例子是：（二）

3. 发明申请

WO2010022358A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES AND 6-SUBSTITUTED 2-(IMIDAZOIO[4,5- C]PYRIDINYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译： 6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物和6-取代的2-（咪唑并[4,5- C]吡啶基）嘌呤和嘌呤衍生物用于免疫抑制
公开(公告)号：WO2010022358A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054663
申请日：2009-08-21
申请人： LIGAND PHARMACEUTICALS INC. , NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph, C. , OHLMEYER, Michael, J. , PARADKAR, Vidyadhar , ANSARI, Nasrin
发明人： NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph, C. , OHLMEYER, Michael, J. , PARADKAR, Vidyadhar , ANSARI, Nasrin
IPC分类号： C07D473/16 , A61P29/00 , C07D473/18 , A61K31/52 , A61P35/00 , C07D473/32 , A61K31/522 , A61P35/02 , C07D473/40 , A61P11/06 , A61P37/00 , C07D519/00 , A61P17/06 , A61P37/06
CPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the genera formulae I and II wherein R 1 , R 2 , R 3 , R 4 , R 9 , Q, A and y are as defined in the specification.
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。该化合物具有式I和II类，其中R 1，R 2，R 3，R 4，R 9，Q，A和y如说明书中所定义。

4. 发明申请

WO2008043031A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译： 6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物用于免疫抑制
公开(公告)号：WO2008043031A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/080464
申请日：2007-10-04
申请人： PHARMACOPEIA, INC. , NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph , OHLMEYER, Michael , PARADKAR, Vidyadhar , ANSARI, Nasrin
发明人： NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph , OHLMEYER, Michael , PARADKAR, Vidyadhar , ANSARI, Nasrin
IPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40 , A61K31/52 , A61P9/00 , A61P11/06 , A61P17/06 , A61P27/02 , A61P35/00 , A61P37/00
CPC分类号： C07D473/32 , C07D473/16 , C07D473/18 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II.
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。该化合物具有通式I和II。

5. 发明申请

WO2009062059A2 ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS 审中-公开
标题翻译：异构嘌呤和1H-咪唑并吡啶酮作为PKC-THETA抑制剂
公开(公告)号：WO2009062059A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/082832
申请日：2008-11-07
申请人： PHARMACOPEIA, INC. , ROUGHTON, Andrew , RONG, Yajing , HO, Koc-kan , OHLMEYER, Michael , DILLER, David , CHAN, Ray Jui-Hsiang , LAI, Gaifa
发明人： ROUGHTON, Andrew , RONG, Yajing , HO, Koc-kan , OHLMEYER, Michael , DILLER, David , CHAN, Ray Jui-Hsiang , LAI, Gaifa
IPC分类号： C07D471/04 , C07D473/28 , A61K31/52 , A61K31/4353 , A61P35/00 , A61P19/02
CPC分类号： C07D471/04 , C07D473/28
摘要： A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC θ inhibitors, and their methods of use are disclosed. The genus is represented by the Formula (I).
摘要翻译：公开了可用作PKCθθ抑制剂的嘌呤酮和1H-咪唑并吡啶酮的化学属及其使用方法。该属由公式（I）表示。

6. 发明申请

WO2008143674A1 PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS 审中-公开
标题翻译：嘌呤和1H-咪唑吡啶酮作为PKC-THETA抑制剂
公开(公告)号：WO2008143674A1
公开(公告)日：2008-11-27
申请号：PCT/US2007/069530
申请日：2007-05-23
申请人： PHARMACOPEIA, INC. , ROUGHTEN, Andrew , RONG, Yajing , HO, Koc Kan , OHLMEYER, Michael , DILLER, David
发明人： ROUGHTEN, Andrew , RONG, Yajing , HO, Koc Kan , OHLMEYER, Michael , DILLER, David
IPC分类号： C07D471/04 , C07D473/00 , C07D487/04 , A61K31/522 , A61P37/06
CPC分类号： C07D471/04 , C07D473/00 , C07D473/32 , C07D487/04
摘要： A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC Θ inhibitors, and their methods of use are disclosed. The genus is represented by the formula (I). A representative example is: (II).
摘要翻译：公开了可用作PKCT抑制剂的嘌呤酮和1H-咪唑并吡啶酮的化学属及其使用方法。该属由式（I）表示。一个代表性的例子是：（II）。

7. 发明申请

WO2012068546A1 HETEROCYCLE AMINES AND USES THEREOF 审中-公开
标题翻译：杂环胺及其用途
公开(公告)号：WO2012068546A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/061532
申请日：2011-11-18
申请人： LIGAND PHARMACEUTICALS INCORPORATED , HO, Koc-kan , DILLER, David , LETOURNEAU, Jeffrey, J. , MCGUINNESS, Brian, F. , COLE, Andrew, G. , ROSEN, David , VAN OEVEREN, Cornelis, A. , PICKENS, Jason, C. , ZHI, Lin , SHEN, Yixing , PEDRAM, Bijan
发明人： HO, Koc-kan , DILLER, David , LETOURNEAU, Jeffrey, J. , MCGUINNESS, Brian, F. , COLE, Andrew, G. , ROSEN, David , VAN OEVEREN, Cornelis, A. , PICKENS, Jason, C. , ZHI, Lin , SHEN, Yixing , PEDRAM, Bijan
IPC分类号： C07D235/02 , C07D269/02 , C07D277/42 , C07D277/60 , A61K31/407 , A61K31/4168 , A61K31/4353
CPC分类号： C07D513/04 , A61K31/407 , A61K31/4168 , A61K31/4353 , A61P29/00 , A61P37/00 , C07D235/02 , C07D269/02 , C07D277/42 , C07D277/60 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
摘要翻译：公开了化学和医学领域中的化合物和方法。一些所公开的实施方案包括使用杂环胺的化合物，组合物和方法。一些所公开的实施方案包括可用于治疗炎症性疾病的杂环胺。

8. 发明申请

WO2013006794A1 SYSTEM AND METHOD FOR NARROW BEAM SCANNING MICROSEISMIC MONITORING 审中-公开
标题翻译：用于窄光束扫描微观监测的系统和方法
公开(公告)号：WO2013006794A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045765
申请日：2012-07-06
申请人： DILLER, David
发明人： DILLER, David
IPC分类号： G01V1/30
CPC分类号： G01V1/288 , G01V2210/123 , G01V2210/65
摘要： Disclosed herein are various embodiments of methods and systems for optimizing signals generated by microseismic sources, comprising recording microseismic data using patches of geophones, filtering the data to impart a directionality to the data, and performing a source scan to determine the times and locations of microseismic events. The subsurface is divided into a voxel grid that is further subdivided into subgrids. Using a filter designed for each patch-subgrid pair, only data arriving within a predetermined angle of incidence are input to the source scan, thus reducing noise, and enhancing the quality and accuracy of the identified microseismic events. The method is also applicable to data previously recorded with sensor grids or other arrays such as star arrays.
摘要翻译：本文公开了用于优化由微震源产生的信号的方法和系统的各种实施例，包括使用地震检波器的区块记录微震数据，过滤数据以赋予数据的方向性，以及执行源扫描以确定微震的时间和位置事件。地下分为一个体素网格，进一步细分为子网格。使用为每个贴片 - 子网对设计的滤波器，仅将到达预定入射角的数据输入到源扫描，从而降低噪声，并且增强所识别的微震事件的质量和准确性。该方法也适用于以前使用传感器网格或其他阵列（如星形阵列）记录的数据。

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