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1. 发明申请

WO2007092821A2 A METHOD AND APPARATUS FOR A FLEXIBLE CIRCUIT AND HINGE 审中-公开
标题翻译：一种柔性电路和铰链的方法和装置
公开(公告)号：WO2007092821A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061635
申请日：2007-02-05
申请人： MOTOROLA INC. , DABBEEKEH, John H. , DOMBROWSKI, Richard J. , ALLORE, Joseph L. , CHUTAKANONTA, Puckpol , LOS, Oleg V. , STONE, Frank H. , WANG, Yajun
发明人： DOMBROWSKI, Richard J. , ALLORE, Joseph L. , CHUTAKANONTA, Puckpol , LOS, Oleg V. , STONE, Frank H. , WANG, Yajun
CPC分类号： H04M1/0216 , G06F1/1616 , G06F1/1681 , G06F1/1683 , H05K5/0226
摘要： Disclosed is a method and apparatus for routing a flex circuit (102) through a hinge (112). The device includes a first housing (108) having electronic circuitry (104) and a second housing (110) having electronic circuitry (106). A hinge coupling the first housing to the second housing wherein the hinge has a barrel wherein the barrel includes a chamber (114). A flex guide (116) is positioned in the chamber of the hinge barrel and a flexible circuit routed from the first housing into the hinge barrel and the hinge chamber, into the flex guide such that the flexible circuit engages the flex guide creating a dynamic folding region in the first housing that folds upon itself as a result of rotation of the first housing and the second housing.
摘要翻译：公开了一种通过铰链（112）布置柔性电路（102）的方法和装置。该装置包括具有电子电路（104）的第一壳体（108）和具有电子电路（106）的第二壳体（110）。铰链将第一壳体联接到第二壳体，其中铰链具有筒体，其中筒体包括腔室（114）。柔性引导件（116）被定位在铰链筒的腔室中，并且柔性电路从第一壳体引导到铰链筒和铰链室中，进入弯曲引导件，使得柔性电路接合柔性引导件，从而产生动态折叠区域，其由于第一壳体和第二壳体的旋转而折叠在自身上。

2. 发明申请

WO2006071414A1 HINGED ELECTRONIC DEVICE WITH HINGED SCREEN 审中-公开
标题翻译：铰链电子装置带铰链
公开(公告)号：WO2006071414A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/042550
申请日：2005-11-22
申请人： MOTOROLA, INC. , WANG, Yajun , ELLIOTT, Daniel, K. , TRAHAN, David, W.
发明人： WANG, Yajun , ELLIOTT, Daniel, K. , TRAHAN, David, W.
IPC分类号： G06F1/16
CPC分类号： G06F1/1616 , G06F1/1641 , G06F1/1643 , G06F1/1656
摘要： A hinged electronic device (100) includes housing hinge mechanism (130) holding together a first housing section (110) with a first screen portion (160) of a hinged screen (150) and a second housing section (120) with a recess (184) for a second screen portion (170) of the hinged screen (150). The first screen portion (160) and the second screen portion (170) are held together by a screen hinge mechanism (480). When the hinged electronic device (100) is closed, the hinged screen (150) is in a stowed position. When the hinged electronic device (100) is fully opened, the hinged screen (150) is in a fully deployed position, which has the first screen portion (160) and the second screen portion (170) within a single plane.
摘要翻译：铰链式电子设备（100）包括壳体铰链机构（130），其将第一壳体部分（110）与铰链屏幕（150）的第一屏幕部分（160）和具有凹部（120）的第二壳体部分（120） 184），用于铰链式筛网（150）的第二筛选部分（170）。第一屏幕部分（160）和第二屏幕部分（170）通过屏幕铰链机构（480）保持在一起。当铰接的电子设备（100）关闭时，铰接的屏幕（150）处于收起位置。当铰接的电子设备（100）完全打开时，铰接的屏幕（150）处于完全展开的位置，其具有在单个平面内的第一屏幕部分（160）和第二屏幕部分（170）。

3. 发明申请

WO2005071410A1 DETECTING AND QUANTIFYING HOST CELL PROTEINS IN RECOMBINANT PROTEIN PRODUCTS 审中-公开
标题翻译：检测和定量重组蛋白产品中的宿主细胞蛋白
公开(公告)号：WO2005071410A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/000416
申请日：2005-01-07
申请人： TANOX, INC. , WANG, Yajun , LIU, Meng, Yuan
发明人： WANG, Yajun , LIU, Meng, Yuan
IPC分类号： G01N33/53
CPC分类号： G01N33/54306 , G01N33/6854
摘要： A single-step immunoassay method, kit, and reagents for detecting and quantifying contaminant host cell proteins in a recombinant protein sample are described. The method includes the step of adding to immobilized medium comprising a capture reagent including anti-host cell protein antibodies, both the recombinant protein sample and a detection reagent comprising anti-host cell protein antibodies and a detectable moeity. The recombinant protein sample and two reagents are added simultaneously. This single-step format provides greater interaction between the capture antibody, the contaminant host cell proteins that may be present in the recombinant protein sample, and the detection antibody. By providing the opportunity for both antibodies and HCPs to interact at the same time, the one step format allows the formation of the "capture antibody-HCP-detection antibody" complex with all possible HCPs present. Thus, the HCP assay sensitivity is significantly improved, and the possibility of a false negative is significantly reduced. In addition, the one step format shortens the assay turnaround time and provides a convenient tool for measuring the HCP in the product during the course of the entire purification procedure. Quality control of the process is increased and the protein purification efficiency during process development can be measured.
摘要翻译：描述了用于检测和定量重组蛋白质样品中的污染宿主细胞蛋白质的单步免疫测定方法，试剂盒和试剂。该方法包括向包含抗宿主细胞蛋白抗体的捕获试剂的固定化培养基中添加重组蛋白质样品和包含抗宿主细胞蛋白抗体的检测试剂和可检测的可能性的步骤。重组蛋白样品和两种试剂同时加入。这种单步格式提供捕获抗体，可能存在于重组蛋白样品中的污染宿主细胞蛋白质和检测抗体之间的更大的相互作用。通过提供抗体和HCP两者同时相互作用的机会，一步形式允许形成所有可能的HCP存在的“捕获抗体-HCP检测抗体”复合物。因此，HCP测定灵敏度显着提高，并且假阴性的可能性显着降低。此外，一步式缩短了测定周转时间，并为整个纯化过程中产品中HCP的测量提供了便利的工具。提高过程的质量控制，可以测量过程开发过程中的蛋白质净化效率。

4. 发明申请

WO2015179449A9 METHODS AND APPARATUS FOR PROVIDING CONFIGURATION DISCOVERY USING INTRA-NODAL TEST CHANNEL 审中-公开
公开(公告)号：WO2015179449A9
公开(公告)日：2015-11-26
申请号：PCT/US2015/031641
申请日：2015-05-19
申请人： TELLABS OPERATIONS, INC. , YOUNCE, Richard, Y. , WANG, Yajun , LARIKOVA, Julia , SUKKAR, Rafid
发明人： YOUNCE, Richard, Y. , WANG, Yajun , LARIKOVA, Julia , SUKKAR, Rafid
IPC分类号： H04Q11/00 , H04J14/02
摘要： Method and apparatus of an optical routing system ("ORS") capable of automatically discovering intra-nodal fiber connections using a test channel transceiver ("TCT") are disclosed. ORS, in one embodiment, includes a set of reconfigurable optical add-drop multiplexer ("ROADM") modules, intra-nodal fiber connections, add-drop modules, and a test module. The ROADM modules are able to transmit or receive optical signals via optical fibers. The intra-nodal fiber connections are configured to provide optical connections. The add-drop modules are able to selectively make connections between input ports and output ports. The test module containing TCT is configured to identify at least a portion of intra-nodal connections of the ROADM via a test signal operating with a unique optical frequency.

5. 发明申请

WO2010124498A1 A RESISTANCE-SCREENED TUMOR STEM CELL, ITS ANTIGEN COMPOSITION, AN ANTI-TUMOR DENDRITIC CELL LOADING WITH SAID ANTIGENS, THEIR PREPARATION METHODS, USES AND KITS THEREOF AS WELL AS A DENDRITIC CELL VACCINE 审中-公开
标题翻译：抗性筛选的肿瘤干细胞，其抗原组合物，具有抗真菌剂的抗肿瘤细胞沉积细胞，其制备方法，用途和作为细胞细胞疫苗的试剂盒
公开(公告)号：WO2010124498A1
公开(公告)日：2010-11-04
申请号：PCT/CN2009/075307
申请日：2009-12-04
申请人： BEIJING CELLONIS BIOTECHNOLOGY CO., LTD , SHEN, Li , HAO, Limin , WANG, Yajun , MA, Yanling , HUANG, Qiming
发明人： SHEN, Li , HAO, Limin , WANG, Yajun , MA, Yanling , HUANG, Qiming
IPC分类号： C12N5/095 , C12N13/00 , C12Q1/02 , A61K41/00 , A61K39/00 , A61P35/00 , A61P35/04
CPC分类号： G01N33/5011 , C12N15/01 , G01N33/5073
摘要： Resistance-screened tumor stem cells, their preparation method, use of such tumor stem cells for manufacturing anti-tumor medicaments and a kit for preparing said tumor stem cells. An antigen composition of said tumor stem cells, its preparation method, use of such antigen composition for manufacturing anti-tumor medicaments and a kit for preparing said antigen composition. Dendritic cells loading with said antigens obtained by pulsing normal dendritic cells with said antigen composition of said tumor stem cells, its preparation method, use of such dendritic cells for manufacturing anti-tumor medicaments, a kit for preparing such dendritic cells, and a vaccine of such dendritic cells. The medicaments prepared from the resistance-screened tumor stem cells, the antigen composition of such tumor stem cells and the dendritic cells loading with said antigens provided by the present invention, can induce immune response in vitro and in vivo to kill tumor stem cells which cause tumor recurrence, which make it possible to overcome tumor resistance and to radically cure tumor recurrence and metastasis.
摘要翻译：抗性筛选的肿瘤干细胞，其制备方法，使用这种肿瘤干细胞制备抗肿瘤药物和用于制备所述肿瘤干细胞的试剂盒。所述肿瘤干细胞的抗原组合物，其制备方法，用于制备抗肿瘤药物的抗原组合物的用途和用于制备所述抗原组合物的试剂盒。通过用所述肿瘤干细胞的所述抗原组合物脉冲正常树突状细胞获得的所述抗原的树突状细胞，其制备方法，用于制备抗肿瘤药物的这种树突状细胞的用途，用于制备这种树突状细胞的试剂盒，以及疫苗这样的树突细胞。由抗性筛选的肿瘤干细胞制备的药物，这种肿瘤干细胞的抗原组合物和由本发明提供的所述抗原负载的树突状细胞可以在体外和体内诱导免疫应答以杀死肿瘤干细胞肿瘤复发，可以克服肿瘤的抵抗力，彻底治愈肿瘤的复发和转移。

6. 发明申请

WO2009079688A1 POROUS SILICA SHELL-MEDIATED ASSEMBLY OF MACROMOLECULAR CAPSULES 审中-公开
标题翻译：多孔硅胶壳介导的大分子胶囊组装
公开(公告)号：WO2009079688A1
公开(公告)日：2009-07-02
申请号：PCT/AU2008/001862
申请日：2008-12-18
申请人： THE UNIVERSITY OF MELBOURNE , BANSAL, Vipul , CARUSO, Francesco , WANG, Yajun , ZELIKIN, Alexander, Nikolay
发明人： BANSAL, Vipul , CARUSO, Francesco , WANG, Yajun , ZELIKIN, Alexander, Nikolay
IPC分类号： C08J5/00 , A61K9/51 , C08F6/00 , A61K9/50 , B82B1/00 , C08J9/00
CPC分类号： A61K9/501 , A61K9/1676 , A61K9/5015 , A61K9/5021 , A61K9/5026 , A61K9/5036 , A61K9/5089 , A61K31/704 , A61K47/593 , A61K47/6949 , B82Y5/00
摘要： The present invention relates to a process of preparing macromolecular capsules. In particular, the invention relates to the use of a template with a permeable shell and an impermeable core for preparing macromolecular capsules. The process of the present invention relates to infiltrating macromolecules such as polymers into a permeable shell and then crosslinking the macromolecules to form a macromolecular network within the pores of the permeable shell. In some cases, the permeable shell and impermeable core can both be removed to yield hollow capsules. The invention involves the use of macromolecules which may be conjugated to one or more functional molecules. In some cases the macromolecules used in the invention are conjugated to biologically active molecules to form particles useful for applications including, but not limited to, drug delivery and controlled release.
摘要翻译：本发明涉及制备大分子胶囊的方法。特别地，本发明涉及使用具有可渗透壳的模板和用于制备大分子胶囊的不渗透芯。本发明的方法涉及将聚合物等渗透性大分子渗透到可渗透的壳中，然后将大分子交联以形成可渗透壳的孔内的大分子网络。在一些情况下，可渗透的外壳和不渗透芯可以被去除以产生中空的胶囊。本发明涉及使用可与一个或多个功能性分子缀合的大分子。在一些情况下，本发明中使用的大分子与生物活性分子缀合以形成可用于包括但不限于药物递送和受控释放的应用的颗粒。

7. 发明申请

WO2006037160A1 POROUS POLYELECTROLYTE MATERIALS 审中-公开
标题翻译：多孔聚电解质材料
公开(公告)号：WO2006037160A1
公开(公告)日：2006-04-13
申请号：PCT/AU2005/001511
申请日：2005-10-04
申请人： THE UNIVERSITY OF MELBOURNE , CARUSO, Francesco , WANG, Yajun
发明人： CARUSO, Francesco , WANG, Yajun
IPC分类号： B32B5/20
CPC分类号： B32B27/308 , B32B3/26 , B32B5/18 , B32B5/32 , B32B7/10 , B32B9/02 , B32B9/04 , B32B27/08 , B32B27/286 , B32B2250/22 , B32B2250/24 , B32B2250/42 , B32B2264/02 , B32B2264/0214 , B32B2307/7163 , B32B2307/726 , B32B2535/00 , B32B2553/00 , H01M2300/0082 , H01M2300/0094 , Y10T428/249978 , Y10T428/249981
摘要： The present invention relates to porous polyelectrolyte materials, particularly nanoporous polyelectrolyte materials and to methods of making such materials. In a preferred embodiment, the invention relates to nanoporous polyelectrolyte spheres. In a preferred form of the invention, the materials are manufactured with the use of mesoporous silica spheres as templates. The invention also relates to a method of manufacturing such materials, and in particular, to a method of manufacturing such materials by a layer-by-layer process.
摘要翻译：本发明涉及多孔聚电解质材料，特别是纳米多孔聚电解质材料以及制造这种材料的方法。在一个优选的实施方案中，本发明涉及纳米多孔聚电解质球。在本发明的优选形式中，所述材料通过使用介孔二氧化硅球作为模板来制造。本发明还涉及制造这种材料的方法，具体涉及通过逐层工艺制造这种材料的方法。

8. 发明申请

WO2010123752A1 METHODS AND APPARATUS FOR PERFORMING DIRECTIONLESS WAVELENGTH ADDITION AND SUBTRACTION 审中-公开
标题翻译：用于执行无方向波长增加和分配的方法和装置
公开(公告)号：WO2010123752A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031233
申请日：2010-04-15
申请人： TELLABS OPERATIONS, INC. , BODUCH, Mark, E. , PAPAKOS, Kimon , WANG, Yajun
发明人： BODUCH, Mark, E. , PAPAKOS, Kimon , WANG, Yajun
IPC分类号： H04J14/02
CPC分类号： H04J14/0201 , H04J14/0204 , H04J14/0205 , H04J14/0206 , H04J14/021 , H04J14/0212 , H04J14/0217 , H04J14/0219 , H04J14/0283 , H04Q11/0005 , H04Q11/0062 , H04Q2011/0013 , H04Q2011/0018 , H04Q2011/0024 , H04Q2011/0039 , H04Q2011/0058 , H04Q2011/0092
摘要： In today's reconfϊgurable optical add/drop multiplexer (ROADM) based optical node, ROADMs multiplex (and demultiplex) colored optical signals to form wavelength-division multiplexed (WDM) signals. Transponders connected to the ROADMs' add/drop ports convert noncolored optical signals to colored optical signals (and vice versa). Dedicating transponders to given ports degrades the node's ability to route around network failures. Example embodiments of the invention include an optical node and corresponding method for routing optical signals within an optical node that compensate for this inflexibility. The optical node may include two ROADMs to transmit respective WDM signals onto at least two internode network paths and a routing module that can direct channels of the same wavelength along different internode network paths. Advantageously, a transponder may transmit (receive) different signals at the same wavelength to (from) different network node interfaces within the optical node, thereby improving the optical node's ability to route around network failures.
摘要翻译：在今天的可重构光分插复用器（ROADM）光路中，ROADM将彩色光信号复用（和解复用），形成波分复用（WDM）信号。连接到ROADM的添加/关闭端口的应答器将未着色的光信号转换为彩色光信号（反之亦然）。将转发器用于给定端口会降低节点绕过网络故障的能力。本发明的示例实施例包括光节点和用于在光节点内路由光信号以补偿该不灵活性的相应方法。光节点可以包括两个ROADM，以将相应的WDM信号发送到至少两个节点间网络路径上，以及路由模块，该路由模块可以沿着不同的节点间路径指导相同波长的信道。有利的是，应答器可以向（从）光节点内的不同网络节点接口发送（接收）相同波长的不同信号，从而提高光节点绕网络故障的路由能力。

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