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2. 发明申请

WO2004073504A2 METHODS FOR THE TREATMENT AND PREVENTION OF DISEASES OF BIOLOGICAL CONDUITS 审中-公开
标题翻译：治疗和预防生物学疾病的方法
公开(公告)号：WO2004073504A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/005192
申请日：2004-02-20
申请人： PROTEON THERAPEUTICS, LLC , FRANANO, Nicholas, F. , ROMANO, Charles, P.
发明人： FRANANO, Nicholas, F. , ROMANO, Charles, P.
IPC分类号： A61B
CPC分类号： A61K38/488 , A61K38/195 , A61K38/4826 , A61K38/4833 , A61K38/484 , A61K38/486 , A61K38/4886 , A61K2300/00
摘要： Methods are described for dilating biological conduits by removing elastin and remodeling collagens in the wall of the conduit. Methods include the use of agents that increase the release of endogenous elastase and collagenase in the wall of the conduit, either by cells that are normally present in the wall of the conduit or by inflammatory cells that are attracted to the conduit, thereby providing additional conduit dilation. Methods also include the use of agents that increase conduit wall permeability and expose elastin and collagen fibers. Methods also include removing components of the extracellular matrix of arteries and veins leading to an inhibition of intimal hyperplasia in the wall of the vessels by decreasing biomechanical stimuli directed toward the cells in the wall of the vessel. Methods further include the use of agent that degrade microfibers, in addition to elastin, in order to decrease the resynthesis of elastin. Methods also include the use of agent that stabilize the diameter of aneurysmal arteries by blocking cell surface receptors in the wall of the aneurysmal artery that are important in the recruitment of inflammatory cells.
摘要翻译：描述了通过去除导管壁中的弹性蛋白和重塑胶原来扩张生物管道的方法。方法包括使用增加导管壁内源性弹性蛋白酶和胶原酶释放的试剂，通过通常存在于导管壁中的细胞或吸引到导管的炎性细胞，从而提供另外的导管扩张。方法还包括使用增加导管壁渗透性并暴露弹性蛋白和胶原纤维的试剂。方法还包括通过减少针对血管壁中的细胞的生物力学刺激来去除动脉和静脉细胞外基质的成分，从而导致血管壁内膜增生的抑制。方法还包括使用除弹性蛋白之外降解微纤维的试剂，以减少弹性蛋白的再合成。方法还包括使用通过阻断在炎性细胞募集中重要的动脉瘤动脉壁中的细胞表面受体来稳定动脉瘤动脉直径的药剂。

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