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1. 发明申请

WO2007127977A2 METHODS OF EVALUATING PEPTIDE MIXTURES 审中-公开
标题翻译：评估胶囊混合物的方法
公开(公告)号：WO2007127977A2
公开(公告)日：2007-11-08
申请号：PCT/US2007067777
申请日：2007-04-30
申请人： MOMENTA PHARMACEUTICALS INC , SHRIVER ZACHARY , VENKATARAMAN GANESH , LANSING JONATHAN C , BAUER CORINNE , ZHU XIANGPING
发明人： SHRIVER ZACHARY , VENKATARAMAN GANESH , LANSING JONATHAN C , BAUER CORINNE , ZHU XIANGPING
IPC分类号： G01N33/50
CPC分类号： G01N33/9493 , A61K38/02 , G01N33/15 , G01N33/68 , G01N33/6806 , G01N33/6821 , G01N33/6848 , Y10T436/24 , Y10T436/25125
摘要： The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.
摘要翻译：目前公开的主题提供了用于评估和表征肽，肽混合物和多肽混合物的方法。更具体地，本发明公开的主题提供了用于评估或表征包含谷氨酸，丙氨酸，酪氨酸和赖氨酸的复合肽或多肽混合物的方法，例如共聚物-1或乙酸格拉默，包括但不限于鉴定，分离，定量和纯化具有二乙基酰胺基团而不是C-末端存在的羧基的氨基酸，肽，多肽及其组合。目前公开的方法可以用于确定在C末端具有二乙酰胺基团的多肽的摩尔百分数，并且可以用于评价一种多肽混合物的样品的一种或多种性质，与一种或多种不同样品的多肽混合物。

2. 发明申请

WO2004066808A3 GLYCAN MARKERS FOR DIAGNOSING AND MONITORING DISEASE 审中-公开
标题翻译：用于诊断和监测疾病的GLYCAN标记
公开(公告)号：WO2004066808A3
公开(公告)日：2006-03-02
申请号：PCT/US0340547
申请日：2003-12-19
申请人： MOMENTA PHARMACEUTICALS INC , SHRIVER ZACHARY , VENKATARAMAN GANESH , SASISEKHARAN RAM , SUNDARAM MALLIKARJUN
发明人： SHRIVER ZACHARY , VENKATARAMAN GANESH , SASISEKHARAN RAM , SUNDARAM MALLIKARJUN
IPC分类号： G01N33/574 , G06F19/00 , C12Q1/00
CPC分类号： G01N33/574 , G01N33/57473 , G01N33/57476 , G01N2400/10 , G06F19/28
摘要： The present invention provides ultra-sensitive methods for detecting changes in glycosylation that are correlated with pre-cancerous or early cancerous states. Because the chance of complete recovery is increased with earlier detection of cancer, the present invention provides therapeutically useful methods of early detection, diagnosis, staging and prognostication.
摘要翻译：本发明提供了用于检测与癌前或早期癌症状态相关的糖基化变化的超灵敏方法。因为随着癌症的早期检测，完全恢复的机会增加，本发明提供治疗有用的早期检测，诊断，分期和预后的方法。

3. 发明申请

WO2004083807A3 METHODS OF EVALUATING GLYCOMOLECULES FOR ENHANCED ACTIVITIES 审中-公开
标题翻译：评估增强型活性糖蛋白的方法
公开(公告)号：WO2004083807A3
公开(公告)日：2005-02-10
申请号：PCT/US2004004423
申请日：2004-02-13
申请人： MOMENTA PHARMACEUTICALS INC , VENKATARAMAN GANESH , SHRIVER ZACHARY , SASISEKHARAN RAM , WHORISKEY SUSAN K
发明人： VENKATARAMAN GANESH , SHRIVER ZACHARY , SASISEKHARAN RAM , WHORISKEY SUSAN K
IPC分类号： C07H1/00 , C07K1/00 , C07K9/00 , C07K14/00 , C07K17/00 , C08B37/00 , G01N20060101
CPC分类号： C07H1/00 , C08B37/00 , C08H1/00 , G01N2400/00
摘要： Methods to evaluate and rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, saccharide moiety. The method includes: determining the chemical composition and structure of all or a portion of the second, saccharide moiety, and evaluating or screening the molecule, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a ploysaccharide.
摘要翻译：已经开发了评估并快速产生和鉴定具有增强活性的多糖和其他糖结构的方法。所述方法包括产生分子，例如治疗分子，其包括第一非糖部分（例如蛋白质，多肽，肽，氨基酸或脂质）和第二糖部分。该方法包括：确定第二糖部分的全部或部分的化学组成和结构，以及评估或筛选分子，例如生物活性或其它化学或物理性质。在一些实施方案中，确定第二部分的化学结构和组成的步骤包括将第二部分的一种或多种性质与数据库进行比较，数据库例如将这样的一种或多种性质与结构或功能相关联的数据库 ploysaccharide。

4. 发明申请

WO2007140231A2 LOW MOLECULAR WEIGHT HEPARIN COMPOSITION AND USES THEREOF 审中-公开
标题翻译：低分子量肝素组合物及其用途
公开(公告)号：WO2007140231A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069626
申请日：2007-05-24
申请人： MOMENTA PHARMACEUTICAL INC , SUNDARAM MALLIK , VENKATARAMAN GANESH , OLIVER PATRICIA , YAO YIMING , MAMUWALA ZAINAB SIRAJBHAI , FIER IAN , QI YI WEI , SHRIVER ZACHARY , CAPILA ISHAN , GUNAY NUR SIBEL , BECCATI DANIELA , LIU CUIHUA , BAUER CORINNE , LI YING
发明人： SUNDARAM MALLIK , VENKATARAMAN GANESH , OLIVER PATRICIA , YAO YIMING , MAMUWALA ZAINAB SIRAJBHAI , FIER IAN , QI YI WEI , SHRIVER ZACHARY , CAPILA ISHAN , GUNAY NUR SIBEL , BECCATI DANIELA , LIU CUIHUA , BAUER CORINNE , LI YING
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译：本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。

5. 发明申请

WO03025133A3 METHODS OF MAKING GLYCOLMOLECULES WITH ENHANCED ACTIVITIES AND USES THEREOF 审中-公开
标题翻译：制备具有增强活性的甘油分子的方法及其用途
公开(公告)号：WO03025133A3
公开(公告)日：2003-10-16
申请号：PCT/US0229285
申请日：2002-09-16
申请人： MIMEON INC , VENKATARAMAN GANESH , SHRIVER ZACHARY , SASISEKHARAN RAM
发明人： VENKATARAMAN GANESH , SHRIVER ZACHARY , SASISEKHARAN RAM
IPC分类号： C08B37/00 , C12P21/00 , A61K38/16 , A61K51/00 , G01N33/48 , G01N33/544
CPC分类号： C08B37/00 , C12P21/005 , G01N2400/00
摘要： Methods to rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, polysaccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second moiety, modifying the structure of the second moiety to provide a modified second moiety, and evaluating or screening the molecule having the modified second moiety, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a polysaccharide.
摘要翻译：已经开发了快速生产和鉴定具有增强的活性的多糖和其他糖结构的方法。该方法包括产生包含第一非糖部分（例如，蛋白质，多肽，肽，氨基酸或脂质）和第二多糖部分的分子，例如治疗分子。该方法包括：确定第二部分的全部或一部分的化学组成和结构，修饰第二部分的结构以提供修饰的第二部分，以及评估或筛选具有修饰的第二部分的分子，例如用于生物活性或其他化学或物理性质。在一些实施方案中，确定第二部分的化学结构和组成的步骤包括比较第二部分的一种或多种性质与数据库，例如使这种一种或多种性质与α结构或功能相关的数据库多糖。

6. 发明申请

WO2004062592A3 2-O SULFATASE COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译： 2-O硫酸酯酶组合物和相关方法
公开(公告)号：WO2004062592A3
公开(公告)日：2004-09-16
申请号：PCT/US2004000332
申请日：2004-01-07
申请人： MASSACHUSETTS INST TECHNOLOGY , SASISEKHARAN RAM , MYETTE JAMES R , SHRIVER ZACHARY , VENKATARAMAN GANESH
发明人： SASISEKHARAN RAM , MYETTE JAMES R , SHRIVER ZACHARY , VENKATARAMAN GANESH
IPC分类号： C12N15/09 , A61K20060101 , A61K38/46 , A61P9/10 , A61P25/28 , A61P31/00 , A61P35/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/00 , C12Q1/44 , C12Q1/68
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGS) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。具体而言，本发明涉及重组产生的2-O硫酸酯酶，编码这些分子的功能变体和核酸分子。本发明还提供了用于多种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAGS）。例如，2-O硫酸酯酶可以用于确定样品中糖胺聚糖的纯度，同一性，组成和序列。本发明还涉及抑制血管生成和细胞增殖以及方法，用于使用由降解与2-O-硫酸酯酶产生的2-O-硫酸酯酶和/或GAG片段治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

7. 发明申请

WO2005032483A3 POLYSACCHARIDES FOR PULMONARY DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于脉冲递送活性剂的多糖
公开(公告)号：WO2005032483A3
公开(公告)日：2007-05-31
申请号：PCT/US2004032613
申请日：2004-10-01
申请人： MOMENTA PHARMACEUTICALS INC , RICHARDSON THOMAS , VENKATARAMAN GANESH , QI YI WEI , PICARD MICHELE
发明人： RICHARDSON THOMAS , VENKATARAMAN GANESH , QI YI WEI , PICARD MICHELE
IPC分类号： A61K31/727 , A61K20060101 , A61K9/00 , A61K9/14 , A61K31/715 , A61K38/17 , A61K38/18 , A61K38/22 , A61K38/28 , A61K47/36 , A61K48/00 , A61L9/04
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/0075 , A61K31/715 , A61K47/36 , A61K48/00
摘要： Formulation for pulmonary delivery of a therapeutic, prophylactic, or diagnostic agent including a low molecular weight heparin and a therapeutic, prophylactic, or diagnostic agent.
摘要翻译：包括低分子量肝素和治疗性，预防性或诊断剂在内的治疗性，预防性或诊断性试剂的肺部递送的制剂。

8. 发明申请

WO2016018471A1 PERSONALIZED SEARCH BASED ON SIMILARITY 审中-公开
标题翻译：基于类似性的个性化搜索
公开(公告)号：WO2016018471A1
公开(公告)日：2016-02-04
申请号：PCT/US2015023116
申请日：2015-03-27
申请人： SINHA SHAKTI DHIRENDRAJI , MAKHANI ASIF MANSOOR ALI , HA VIET THUC , GUO LIN , DOMMETI RAMESH , SUNDARAM SENTHIL , VENKATARAMAN GANESH
发明人： SINHA SHAKTI DHIRENDRAJI , MAKHANI ASIF MANSOOR ALI , HA VIET THUC , GUO LIN , DOMMETI RAMESH , SUNDARAM SENTHIL , VENKATARAMAN GANESH
IPC分类号： G06F17/30 , G06Q50/00
CPC分类号： G06F17/3053 , G06F17/30705 , G06F17/30867 , G06Q50/01 , H04L67/306
摘要： Personalized search based on similarity, or searcher interest, or using searcher features may include obtaining a search term from a member of a social network at a user device via the network interface. An initial result may be generated based on the search term, including a first group of content items from a social network and stored in a content database, the content items including member profiles of members of the social network. Each of the content items of the first group may be ranked based on information from an activity database storing the information related to the social network, the activities including interactions with search results that include ones of the member profiles. A second group of the content items may be displayed, including at least some of the first group of the content items, based on the rank of the first group of the content items.
摘要翻译：基于相似性或搜索者兴趣或使用搜索器特征的个性化搜索可以包括经由网络接口从用户设备的社交网络的成员获得搜索词。可以基于搜索项，包括来自社交网络的第一组来自社交网络并存储在内容数据库中的内容项来生成初始结果，所述内容项目包括社交网络的成员的成员简档。基于来自存储与社交网络有关的信息的活动数据库的信息，所述第一组的每个内容项可以被排序，所述活动包括与包括所述成员简档的搜索结果的交互。可以基于第一组内容项目的等级来显示第二组内容项目，包括第一组内容项目中的至少一些。

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