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1. 发明申请

WO2004073690A8 SELF-EXPANDING DEVICE FOR THE GASTROINTESTINAL OR UROGENITAL AREA 审中-公开
标题翻译：用于胃肠道或胃肠道的自扩张装置
公开(公告)号：WO2004073690A8
公开(公告)日：2004-11-04
申请号：PCT/US2004004776
申请日：2004-02-18
申请人： MNEMOSCIENCE GMBH , LENDLEIN ANDREAS , LANGER ROBERT S
发明人： LENDLEIN ANDREAS , LANGER ROBERT S
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0065 , A61F2/04 , A61F6/00 , A61F2210/0004 , A61K9/0034 , A61K9/0036
摘要： Devices for treatments of diseases and disorders associated with the gastrointestinal tract, especially the stomach, or urinogenital tract are described herein. Initially, the device is in a temporary form which is suitable for oral or rectal administration. After exposure to a stimulus, such as a temperature or pH change, the device changes shape to a permanent form, which allows it to become mechanically fixed in the stomach, esophagus or intestine. In one embodiment, the device is used to reduce the volume of the stomach, esophagus or intestine without interfering with the flow of the food through the gastrointestinal tract. The device may be used to help overweight patients lose weight and to deliver drugs to treat disorders and diseases in the in the stomach or intestine. The devices are manufactured from a stimuli-sensitive polymeric material, which is biocompatible and primarily adapted to the mechanical properties and geometry in the area to which it is applied. In the preferred embodiment, the material is a shape memory polymer. Depending on the desired application, the polymer may be either biodegradable or non-degradable.

2. 发明申请

WO9942528A3 SHAPE MEMORY POLYMERS 审中-公开
标题翻译：形状记忆聚合物
公开(公告)号：WO9942528A3
公开(公告)日：1999-11-04
申请号：PCT/US9903923
申请日：1999-02-23
申请人： MNEMOSCIENCE GMBH , LANGER ROBERT S
发明人： LANGER ROBERT S , LENDLEIN ANDREAS
IPC分类号： A61L27/00 , B29C61/00 , C08F299/04 , C08G81/00 , C08L101/00 , C08L101/16
CPC分类号： G01K5/483 , A61B2017/00871 , B29C61/003 , C08L101/00 , Y10S525/903 , Y10S977/754
摘要： Shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof are described. The shape memory polymer compositions can hold more than one shape in memory. Suitable compositions include at least one hard segment and at least one soft segment. The Ttrans of the hard segment is preferably between -30 and 270 DEG C. At least one of the hard or soft segments can contain a cross-linkable group, and the segments can be linked by formation of an interpenetrating network or a semi-interpenetrating network, or by physical interactions of the blocks. Objects can be formed into a given shape at a temperature above the Ttrans of the hard segment, and cooled to a temperature below the Ttrans of the soft segment. If the object is subsequently formed into a second shape, the object can return to its original shape by heating the object above the Ttrans of the soft segment and below the Ttrans of the hard segment. The compositions can also include two soft segments which are linked via functional groups which are cleaved in response to application of light, electric field, magnetic field or ultrasound. The cleavage of these groups causes the object to return to its original shape.
摘要翻译：描述形状记忆聚合物组合物，其制备方法及其制备和使用方法。形状记忆聚合物组合物可以在存储器中保持多于一种形状。合适的组合物包括至少一个硬链段和至少一个软链段。硬链段的Ttrans优选在-30至270℃之间。至少一个硬链段或软链段可以包含可交联基团，并且链段可以通过形成互穿网络或半互穿网络网络或通过块的物理交互。物体可以在高于硬链段的Ttrans的温度下形成给定的形状，并且被冷却到低于软链段的Ttrans的温度。如果对象随后形成第二形状，则可以通过将软部分的Ttrans上方的物体加热到硬片段的Ttrans下面，物体可以返回到其原始形状。组合物还可以包括通过官能团连接的两个软链段，所述官能团响应于光，电场，磁场或超声的应用而被切割。这些组的裂开导致物体返回其原始形状。

3. 发明申请

WO2004006885A2 SYSTEMS FOR RELEASING ACTIVE INGREDIENTS, BASED ON BIODEGRADABLE OR BIOCOMPATIBLE POLYMERS WITH A SHAPE MEMORY EFFECT 审中-公开
标题翻译：基于带有形状记忆效应可生物降解和生物相容的聚合物的活性物质释放系统
公开(公告)号：WO2004006885A2
公开(公告)日：2004-01-22
申请号：PCT/EP0307515
申请日：2003-07-10
申请人： MNEMOSCIENCE GMBH , LENDLEIN ANDREAS , STEUER SUSI , TULEWEIT ANNIKA
发明人： LENDLEIN ANDREAS , STEUER SUSI , TULEWEIT ANNIKA
IPC分类号： A61K9/00 , A61K31/4178 , A61K31/435 , A61K31/496 , A61K31/7036 , A61K47/34 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61K9/70 , A61L31/14
CPC分类号： A61K9/0024 , A61K31/4178 , A61K31/435 , A61K31/496 , A61K31/7036 , A61K47/34 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2400/16 , C08L67/04
摘要： The invention relates to systems for releasing active ingredients by means of shape memory materials.
摘要翻译：本发明涉及Wirkstoffreisetzungssysteme使用形状记忆材料。

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