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1. 发明申请

WO1994017369A1 METHOD AND APPARATUS FOR SENSING FLOW IN TWO DIRECTIONS AND AUTOMATIC CALIBRATION THEREOF 审中-公开
标题翻译：两种方向感测流量的方法和装置及其自动校准
公开(公告)号：WO1994017369A1
公开(公告)日：1994-08-04
申请号：PCT/US1994001080
申请日：1994-01-31
申请人： MIRIS MEDICAL CORPORATION
发明人： MIRIS MEDICAL CORPORATION , LLOYD, Peter, M. , RITSON, Carl , JOHANSSON, Eric, T. , RUBSAMEN, Reid, M.
IPC分类号： G01F01/44
CPC分类号： A61M15/00 , A61J7/0418 , A61M15/0021 , A61M15/0066 , A61M15/0068 , A61M15/008 , A61M15/009 , A61M15/0091 , A61M15/0093 , A61M15/0098 , A61M16/0858 , A61M16/202 , A61M2016/0021 , A61M2016/0036 , A61M2016/0039 , A61M2205/50 , A61M2205/60 , A61M2205/6018 , A61M2205/6027 , A61M2205/6036 , A61M2205/6045 , A61M2205/8206 , A61M2205/8212 , B01F3/04049 , B01F15/0201 , B01F15/0254 , F16H35/00 , G01F1/363 , G01F1/40 , G01F1/44 , G01F1/50 , G01F7/005 , G01F13/006 , G01F15/002 , G01F25/0007
摘要： A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body (2) and a medication cassette (4) inserted in the durable body (2). The cassette (4) includes a housing (40) for containing a canister of medication (30), bears an identification code, and permits the canister (30) to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body (2). The durable body (2) includes an actuator mechanism (200) for engaging an inserted cassette (4) and its canister (30), and an actuator release mechanism (300) for controlling the actuator mechanism (200) to depress the canister (30) for a selected period of time to release the desired dose of medication and then to release the canister (30). The actuator mechanism (200) includes a compression spring (210) for depressing the canister (30) and a torsion spring (220) for reloading the compression spring (210). The torsion spring (220) is reloaded by rotating the cassette (4) from an open position for delivering aerosol to a closed position. The actuator release mechanism (300) includes a motor (321) and trigger pin (312) assembly that controls the release of the compression spring (210) and the torsion spring (220), and, hence, the time that the canister is depressed. The motor (321) operates in response to sensed flow satisfying a selected delivery threshold. The durable body (2) includes a flow sensor (600) having an asymmetrical orifice that is calibrated, independent of the cassette (4), to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer (505) offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.
摘要翻译：一种便携式，电池供电的手持式系统，用于释放由患者吸入的受控剂量的气溶胶药物，包括耐久体（2）和插入耐久体（2）中的药盒（4）。盒（4）包括用于容纳药物罐（30）的壳体（40），具有识别码，并且允许手动压下罐（30）以释放剂量，例如计量剂量的耐用体（2）。耐用体（2）包括用于接合插入的盒（4）和其罐（30）的致动器机构（200）和用于控制致动器机构（200）以压下罐（30）的致动器释放机构（300））以选择一段时间以释放所需剂量的药物，然后释放罐（30）。致动器机构（200）包括用于压缩罐（30）的压缩弹簧（210）和用于重新装载压缩弹簧（210）的扭簧（220）。通过将盒（4）从打开位置旋转以将气溶胶传送到关闭位置来重新加载扭簧（220）。致动器释放机构（300）包括电动机（321）和触发销（312）组件，其控制压缩弹簧（210）和扭转弹簧（220）的释放，并且因此控制罐被压下的时间。电动机（321）响应于感测到的流量而满足所选择的输送阈值。耐用体（2）包括具有不对称孔口的流量传感器（600），其被独立于盒（4）进行校准，以将感测到的由于流动的压力转换成流量。针对吸入流量范围和选定数量的已知流速的呼气流量范围，单独校准孔。针对传感器（505）偏移漂移校正检测到的压力值，并使用校准数据和分段线性插值将其转换为流量。

2. 发明申请

WO1994016759A1 AN AUTOMATIC AEROSOL MEDICATION DELIVERY SYSTEM AND METHODS 审中-公开
标题翻译：自动药物输送系统和方法
公开(公告)号：WO1994016759A1
公开(公告)日：1994-08-04
申请号：PCT/US1994001083
申请日：1994-01-31
申请人： MIRIS MEDICAL CORPORATION
发明人： MIRIS MEDICAL CORPORATION , RITSON, Carl , RUBSAMEN, Reid, M.
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61J7/0418 , A61M15/0021 , A61M15/008 , A61M15/009 , A61M16/0858 , A61M16/202 , A61M2016/0021 , A61M2016/0039 , A61M2205/50 , A61M2205/60 , A61M2205/6018 , A61M2205/6027 , A61M2205/6036 , A61M2205/6045 , A61M2205/8206 , A61M2205/8212 , B01F3/04049 , B01F15/0201 , B01F15/0254 , G01F1/363 , G01F1/40 , G01F1/50 , G01F13/006 , G01F15/002
摘要： A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body (2) and a medication cassette (4) inserted in the durable body (2). The cassette (4) includes a housing (40) for containing a canister of medication (30), bears an identification code, and permits the canister (30) to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body (2). The durable body (2) includes an actuator mechanism (200) for engaging an inserted cassette (4) and its canister (30), and an actuator release mechanism (300) for controlling the actuator mechanism (200) to depress the canister (30) for a selected period of time to release the desired dose of medication and then to release the canister (30). The actuator mechanism (200) includes a compression spring (210) for depressing the canister (30) and a torsion spring (220) for reloading the compression spring (210). The torsion spring (220) is reloaded by rotating the cassette (4) from an open position for delivering aerosol to a closed position. The actuator release mechanism (300) includes a motor (321) and trigger pin (312) assembly that controls the release of the compression spring (210) and the torsion spring (220), and, hence, the time that the canister is depressed. The motor (321) operates in response to sensed flow satisfying a selected delivery threshold. The durable body (2) includes a flow sensor (600) having an asymmetrical orifice that is calibrated, independent of the cassette (4), to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer (505) offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.
摘要翻译：一种便携式，电池供电的手持式系统，用于释放由患者吸入的受控剂量的气溶胶药物，包括耐久体（2）和插入耐久体（2）中的药盒（4）。盒（4）包括用于容纳药物罐（30）的壳体（40），具有识别码，并且允许手动压下罐（30）以释放剂量，例如计量剂量的耐用体（2）。耐用体（2）包括用于接合插入的盒（4）和其罐（30）的致动器机构（200）和用于控制致动器机构（200）以压下罐（30）的致动器释放机构（300））以选择一段时间以释放所需剂量的药物，然后释放罐（30）。致动器机构（200）包括用于压缩罐（30）的压缩弹簧（210）和用于重新装载压缩弹簧（210）的扭簧（220）。通过将盒（4）从打开位置旋转以将气溶胶传送到关闭位置来重新加载扭簧（220）。致动器释放机构（300）包括电动机（321）和触发销（312）组件，其控制压缩弹簧（210）和扭转弹簧（220）的释放，并且因此控制罐被压下的时间。电动机（321）响应于感测到的流量而满足所选择的输送阈值。耐用体（2）包括具有不对称孔口的流量传感器（600），其被独立于盒（4）进行校准，以将感测到的由于流动的压力转换成流量。针对吸入流量范围和选定数量的已知流速的呼气流量范围，单独校准孔。针对传感器（505）偏移漂移校正检测到的压力值，并使用校准数据和分段线性插值将其转换为流量。

3. 发明申请

WO1994016758A1 A MEDICATION CASSETTE FOR AN AUTOMATIC AEROSOL MEDICATION DELIVERY SYSTEM 审中-公开
标题翻译：一种用于自动喷雾药物输送系统的药物盒
公开(公告)号：WO1994016758A1
公开(公告)日：1994-08-04
申请号：PCT/US1994001081
申请日：1994-01-31
申请人： MIRIS MEDICAL CORPORATION
发明人： MIRIS MEDICAL CORPORATION , RITSON, Carl , RUBSAMEN, Reid, M.
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61J7/0418 , A61M15/0021 , A61M15/008 , A61M15/009 , A61M16/0858 , A61M16/202 , A61M2016/0021 , A61M2016/0039 , A61M2205/50 , A61M2205/60 , A61M2205/6018 , A61M2205/6027 , A61M2205/6036 , A61M2205/6045 , A61M2205/8206 , A61M2205/8212 , B01F3/04049 , B01F15/0201 , B01F15/0254 , G01F1/363 , G01F1/40 , G01F1/50 , G01F13/006 , G01F15/002
摘要： A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body (2) and a medication cassette (4) inserted in the durable body (2). The cassette (4) includes a housing (40) for containing a canister of medication (30), bears an identification code, and permits the canister (30) to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body (2). The durable body (2) includes an actuator mechanism (200) for engaging an inserted cassette (4) and its canister (30), and an actuator release mechanism (300) for controlling the actuator mechanism (200) to depress the canister (30) for a selected period of time to release the desired dose of medication and then to release the canister (30). The actuator mechanism (200) includes a compression spring (210) for depressing the canister (30) and a torsion spring (220) for reloading the compression spring (210). The torsion spring (220) is reloaded by rotating the cassette (4) from an open position for delivering aerosol to a closed position. The actuator release mechanism (300) includes a motor (321) and trigger pin (312) assembly that controls the release of the compression spring (210) and the torsion spring (220), and, hence, the time that the canister is depressed. The motor (321) operates in response to sensed flow satisfying a selected delivery threshold. The durable body (2) includes a flow sensor (600) having an asymmetrical orifice that is calibrated, independent of the cassette (4), to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer (505) offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.
摘要翻译：一种便携式，电池供电的手持式系统，用于释放由患者吸入的受控剂量的气溶胶药物，包括耐久体（2）和插入耐久体（2）中的药盒（4）。盒（4）包括用于容纳药物罐（30）的壳体（40），具有识别码，并且允许手动压下罐（30）以释放剂量，例如计量剂量的耐用体（2）。耐用体（2）包括用于接合插入的盒（4）和其罐（30）的致动器机构（200）和用于控制致动器机构（200）以压下罐（30）的致动器释放机构（300））以选择一段时间以释放所需剂量的药物，然后释放罐（30）。致动器机构（200）包括用于压缩罐（30）的压缩弹簧（210）和用于重新装载压缩弹簧（210）的扭簧（220）。通过将盒（4）从打开位置旋转以将气溶胶传送到关闭位置来重新加载扭簧（220）。致动器释放机构（300）包括电动机（321）和触发销（312）组件，其控制压缩弹簧（210）和扭转弹簧（220）的释放，并且因此控制罐被压下的时间。电动机（321）响应于感测到的流量而满足所选择的输送阈值。耐用体（2）包括具有不对称孔口的流量传感器（600），其被独立于盒（4）进行校准，以将感测到的由于流动的压力转换成流量。针对吸入流量范围和选定数量的已知流速的呼气流量范围，单独校准孔。针对传感器（505）偏移漂移校正检测到的压力值，并使用校准数据和分段线性插值将其转换为流量。

4. 发明申请

WO1994016757A2 APPARATUS FOR PROVIDING A TIMED RELEASE OF AN AMOUNT OF AEROSOL MEDICATION 审中-公开
标题翻译：用于提供定时释放一定数量的气溶胶药物的装置
公开(公告)号：WO1994016757A2
公开(公告)日：1994-08-04
申请号：PCT/US1994001079
申请日：1994-01-31
申请人： MIRIS MEDICAL CORPORATION
发明人： MIRIS MEDICAL CORPORATION , JOHANSSON, Eric, T. , RITSON, Carl , RUBSAMEN, Reid, M.
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61J7/0418 , A61M15/0021 , A61M15/008 , A61M15/009 , A61M16/0858 , A61M16/202 , A61M2016/0021 , A61M2016/0039 , A61M2205/50 , A61M2205/60 , A61M2205/6018 , A61M2205/6027 , A61M2205/6036 , A61M2205/6045 , A61M2205/8206 , A61M2205/8212 , B01F3/04049 , B01F15/0201 , B01F15/0254 , G01F1/363 , G01F1/40 , G01F1/50 , G01F13/006 , G01F15/002
摘要： A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body (2) and a medication cassette (4) inserted in the durable body (2). The cassette (4) includes a housing (40) for containing a canister of medication (30), bears an identification code, and permits the canister (30) to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body (2). The durable body (2) includes an actuator mechanism (200) for engaging an inserted cassette (4) and its canister (30), and an actuator release mechanism (300) for controlling the actuator mechanism (200) to depress the canister (30) for a selected period of time to release the desired dose of medication and then to release the canister (30). The actuator mechanism (200) includes a compression spring (210) for depressing the canister (30) and a torsion spring (220) for reloading the compression spring (210). The torsion spring (220) is reloaded by rotating the cassette (4) from an open position for delivering aerosol to a closed position. The actuator release mechanism (300) includes a motor (321) and trigger pin (312) assembly that controls the release of the compression spring (210) and the torsion spring (220), and, hence, the time that the canister is depressed. The motor (321) operates in response to sensed flow satisfying a selected delivery threshold. The durable body (2) includes a flow sensor (600) having an asymmetrical orifice that is calibrated, independent of the cassette (4), to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer (505) offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.
摘要翻译：一种便携式，电池供电的手持式系统，用于释放由患者吸入的受控剂量的气溶胶药物，包括耐久体（2）和插入耐久体（2）中的药盒（4）。盒（4）包括用于容纳药物罐（30）的壳体（40），具有识别码，并且允许手动压下罐（30）以释放剂量，例如计量剂量的耐用体（2）。耐用体（2）包括用于接合插入的盒（4）和其罐（30）的致动器机构（200）和用于控制致动器机构（200）以压下罐（30）的致动器释放机构（300））以选择一段时间以释放所需剂量的药物，然后释放罐（30）。致动器机构（200）包括用于压缩罐（30）的压缩弹簧（210）和用于重新装载压缩弹簧（210）的扭簧（220）。通过将盒（4）从打开位置旋转以将气溶胶传送到关闭位置来重新加载扭簧（220）。致动器释放机构（300）包括电动机（321）和触发销（312）组件，其控制压缩弹簧（210）和扭转弹簧（220）的释放，并且因此控制罐被压下的时间。电动机（321）响应于感测到的流量而满足所选择的输送阈值。耐用体（2）包括具有不对称孔口的流量传感器（600），其被独立于盒（4）进行校准，以将感测到的由于流动的压力转换成流量。针对吸入流量范围和选定数量的已知流速的呼气流量范围，单独校准孔。针对传感器（505）偏移漂移校正检测到的压力值，并使用校准数据和分段线性插值将其转换为流量。

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