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1. 发明申请

WO2012037348A3 MOLDED AND PACKAGED ELASTOMERIC CHECK VALVE 审中-公开
标题翻译：模制和包装弹性体检查阀
公开(公告)号：WO2012037348A3
公开(公告)日：2012-05-10
申请号：PCT/US2011051759
申请日：2011-09-15
申请人： MINIPUMPS LLC , PECK RAYMOND , LI PO-YING , PANG CHANGLIN , SHIH JASON
发明人： PECK RAYMOND , LI PO-YING , PANG CHANGLIN , SHIH JASON
IPC分类号： F16K15/14
CPC分类号： F16K15/145 , Y10T29/494 , Y10T137/7837
摘要： Elastomeric check valves for use, e.g., in small pump devices, may include a molded elastomeric valve body (202) forming a pocket (204) that extends from an opening (205) at the valve inlet (206) to a terminus (208) inside the valve body, and having a slit (210) extending from the terminus to a valve outlet (212).
摘要翻译：用于例如在小型泵装置中的弹性止回阀可以包括形成弹性体阀体（202），其形成从阀入口（206）处的开口（205）延伸到终端（208）的凹穴（204）并且具有从终端延伸到阀出口（212）的狭缝（210）。

2. 发明申请

WO2014110507A3 DIAPHRAGM CHECK VALVES AND METHODS OF MANUFACTURE THEREOF 审中-公开
标题翻译：膜片检查阀及其制造方法
公开(公告)号：WO2014110507A3
公开(公告)日：2015-02-26
申请号：PCT/US2014011301
申请日：2014-01-13
申请人： MINIPUMPS LLC , TAI YU-CHONG , LI PO-YING , JIANG FUKANG , PANG CHANGLIN , BOUEY NATASHA YVETTE , CHOU MAN TING , LOTFI ATOOSA
发明人： TAI YU-CHONG , LI PO-YING , JIANG FUKANG , PANG CHANGLIN , BOUEY NATASHA YVETTE , CHOU MAN TING , LOTFI ATOOSA
IPC分类号： F16K99/00 , B29C39/10 , B29C41/20 , B29C70/76 , B29L31/00 , F16K15/14
CPC分类号： F16K15/147 , B29C39/10 , B29C41/20 , B29C45/14598 , B29C70/766 , B29L2031/753 , B29L2031/756 , F16K15/145 , F16K99/0057 , F16K2099/0078 , Y10T137/0497 , Y10T137/7895
摘要： Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded to the interior of a valve tube. A bump in the diaphragm and/or a backward- leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre- load the valve membrane to thereby increase the cracking pressure. LIBA/75849383.
摘要翻译：用于例如微型泵装置的微型阀可以由结合到阀管内部的狭缝隔膜形成。隔膜中的凸块和/或后泄漏塞可增加阀的击穿压力。可以使用推杆来预加载阀膜，从而增加开启压力。利巴/ 75849383。

3. 发明申请

WO2009137785A2 DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE 审中-公开
标题翻译：药物输送泵和制造方法
公开(公告)号：WO2009137785A2
公开(公告)日：2009-11-12
申请号：PCT/US2009043325
申请日：2009-05-08
申请人： REPLENISH PUMPS LLC , PANG CHANGLIN , JIANG FUKANG , SHIH JASON , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG , BRENNAN JEFFREY , PECK RAYMOND
发明人： PANG CHANGLIN , JIANG FUKANG , SHIH JASON , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG , BRENNAN JEFFREY , PECK RAYMOND
IPC分类号： A61M5/148 , A61N1/30
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
摘要翻译：可植入电解泵的实施例包括第一可膨胀隔膜和第二柔性隔膜，以及每个用于容纳流体的第一和第二室，其中第一可膨胀隔膜分隔第一和第二室并在其间提供流体阻挡物，第二室形成在第一可膨胀膜片和第二柔性膜片之间。泵还可以包括在第一室内的电解电极，用于在其中产生气体，从而使可膨胀隔膜膨胀，使得流体被迫从第二室进入套管。

4. 发明申请

WO2009137777A2 IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES 审中-公开
标题翻译：可植入药物递送装置，以及用于填充装置的装置和方法
公开(公告)号：WO2009137777A2
公开(公告)日：2009-11-12
申请号：PCT/US2009043313
申请日：2009-05-08
申请人： REPLENISH PUMPS LLC , SHIH JASON , PANG CHANGLIN , JIANG FUKANG , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG , PECK RAYMOND
发明人： SHIH JASON , PANG CHANGLIN , JIANG FUKANG , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG , PECK RAYMOND
IPC分类号： A61M5/142
CPC分类号： A61M5/14212 , A61F9/0017 , A61M5/14276 , A61M5/148 , A61M5/16881 , A61M5/36 , A61M39/0208 , A61M2005/1403 , A61M2039/0072 , A61M2039/0081 , A61M2039/0235 , A61M2209/045
摘要： In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.
摘要翻译：在各种实施方案中，使用工具填充药物递送装置。该工具可以包括例如通过药物递送装置的填充口进入的针。

5. 发明申请

WO2009137780A8 IMPLANTABLE PUMPS AND CANNULAS THEREFOR 审中-公开
标题翻译：可植入的泵和腋窝
公开(公告)号：WO2009137780A8
公开(公告)日：2010-04-29
申请号：PCT/US2009043317
申请日：2009-05-08
申请人： REPLENISH PUMPS LLC , PANG CHANGLIN , SHIH JASON , JIANG FUKANG , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG
发明人： PANG CHANGLIN , SHIH JASON , JIANG FUKANG , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61F9/00781 , A61M5/148 , A61M5/16804 , A61M5/16854 , A61M2005/14204 , A61M2205/3331 , A61M2205/3368 , A61M2210/0612 , A61M2210/0693
摘要： The implantable pump (100) comprises a drug reservoir (108), a cannula (120) for conducting liquid from the reservoir, means (112, 124, 134) for forcing the liquid from the reservoir through the cannula, a sensor (148) for monitoring at least one parameter relating to liquid flowing through the cannula, and circuitry (132) for adjusting the forcing means based on the monitored parameter. In another embodiment the pump includes a filter.
摘要翻译：可植入泵（100）包括药物储存器（108），用于从储存器传导液体的套管（120），用于迫使来自储存器的液体穿过套管的传感器（148）用于监测与流过套管的液体有关的至少一个参数，以及用于基于所监测的参数来调整强制装置的电路（132）。在另一个实施例中，泵包括过滤器。

6. 发明申请

WO2009137780A3 IMPLANTABLE PUMS AND CANNULAS THEREFOR 审中-公开
标题翻译：可植入的PUMS和腋窝
公开(公告)号：WO2009137780A3
公开(公告)日：2010-04-01
申请号：PCT/US2009043317
申请日：2009-05-08
申请人： REPLENISH PUMPS LLC , PANG CHANGLIN , SHIH JASON , JIANG FUKANG , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG
发明人： PANG CHANGLIN , SHIH JASON , JIANG FUKANG , CAFFEY SEAN , HUMAYUN MARK , TAI YU-CHONG
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61F9/00781 , A61M5/148 , A61M5/16804 , A61M5/16854 , A61M2005/14204 , A61M2205/3331 , A61M2205/3368 , A61M2210/0612 , A61M2210/0693
摘要： The implantable pump (100) comprises a drug reservoir (108), a cannula (120) for conducting liquid from the reservoir, means (112, 124, 134) for forcing the liquid from the reservoir through the cannula, a sensor (148) for monitoring at least one parameter relating to liquid flowing through the cannula, and circuitry (132) for adjusting the forcing means based on the monitored parameter. In another embodiment the pump includes a filter.
摘要翻译：可植入泵（100）包括药物储存器（108），用于从储存器传导液体的套管（120），用于迫使来自储存器的液体穿过套管的装置（112,124,134），传感器（148）用于监测与通过套管流动的液体有关的至少一个参数;以及电路（132），用于基于所监视的参数来调整强制装置。在另一个实施例中，泵包括过滤器。

7. 发明申请

WO2005018770A2 DESIGN OF AN IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT 审中-公开
标题翻译： IC加工聚合物纳米液相色谱系统的设计及其制备方法
公开(公告)号：WO2005018770A2
公开(公告)日：2005-03-03
申请号：PCT/US2004026657
申请日：2004-08-17
申请人： CALIFORNIA INST OF TECHN , HOPE CITY , TAI YU-CHONG , HE QING , XIE JUN , PANG CHANGLIN , LEE TERRY D
发明人： TAI YU-CHONG , HE QING , XIE JUN , PANG CHANGLIN , LEE TERRY D
IPC分类号： G01N30/60 , G01N30/64 , B01D
CPC分类号： H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, frits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
摘要翻译：根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。微制造的芯片包括柱状物，玻璃料/过滤器，注射器和检测器，以与传统上用于形成集成电路的那些兼容的方法制造。该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。集成在色谱柱出口处的电化学/电导率传感器测量分离信号。自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

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