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1. 发明申请

WO2001059081A3 METHODS FOR USING 20893, A HUMAN PROTEIN KINASE 审中-公开
公开(公告)号：WO2001059081A3
公开(公告)日：2001-08-16
申请号：PCT/US2001/004281
申请日：2001-02-09
申请人： MILLENNIUM PHARMACEUTICALS, INC. , GALVIN, Katherine, M. , KAPELLER-LIBERMANN, Rosana , WEICH, Nadine, S.
发明人： GALVIN, Katherine, M. , KAPELLER-LIBERMANN, Rosana , WEICH, Nadine, S.
IPC分类号： C12N9/12
摘要： The present invention relates to methods for using a human protein kinase belonging to the superfamily of mammalian protein kinases. The invention also relates to methods for using polynucleotides encoding the protein kinase. The invention relates to methods using the protein kinase polypeptides and polynucleotides as a target for diagnosis and treatment in protein kinase-mediated or related disorders. The invention further relates to drug-screening methods using the protein kinase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the protein kinase polypeptides and polynucletides. The invention further relates to agonists and antagonists identified by drug screening methods with the protein kinase polypeptides and polynucleotides as a target.

2. 发明申请

WO2002033061A3 32229, A HUMAN ACYL-COA DEHYDROGENASE FAMILY MEMBER AND USES THEREOF 审中-公开
公开(公告)号：WO2002033061A3
公开(公告)日：2002-04-25
申请号：PCT/US2001/046720
申请日：2001-10-22
申请人： MILLENNIUM PHARMACEUTICALS, INC. , KAPELLER-LIBERMANN, Rosana , HUNTER, John, J. , RUDOLPH-OWEN, Laura, A.
发明人： KAPELLER-LIBERMANN, Rosana , HUNTER, John, J. , RUDOLPH-OWEN, Laura, A.
IPC分类号： C12N9/00
摘要： The invention provides isolated nucleic acids molecules, designated 32229 nucleic acid molecules, which encode novel acyl-CoA dehydrogenase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32229 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32229 gene has been introduced or disrupted. The invention still further provides isolated 32229 proteins, fusion proteins, antigenic peptides and anti-32229 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

3. 发明申请

WO2003029434A2 NOVEL MOLECULES OF THE HKID-1-RELATED PROTEIN FAMILY AND USES THEREOF 审中-公开
标题翻译：与HKID-1有关的蛋白质家族的新分子及其用途
公开(公告)号：WO2003029434A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031948
申请日：2002-10-04
申请人： MILLENNIUM PHARMACEUTICALS INC. , KAPELLER-LIBERMANN, Rosana , RUDOLPH-OWEN, Laura, A. , MACBETH, Kyle
发明人： KAPELLER-LIBERMANN, Rosana , RUDOLPH-OWEN, Laura, A. , MACBETH, Kyle
IPC分类号： C12N
CPC分类号： C12N9/1205 , C07K2319/00
摘要： Novel HKID-l polypeptides, proteins, and nucleic acid molecules are disclosed. fu addition to isolated, full-length HKID-l proteins, the invention further provides isolated HKID-l fusion proteins, antigenic peptides and anti-HKID-l antibodies. The invention also provides HKID-l nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an HKID-l gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新颖的HKID-1多肽，蛋白质和核酸分子。除了分离的全长HKID-1蛋白外，本发明进一步提供了分离的HKID-1融合蛋白，抗原肽和抗HKID-1抗体。本发明还提供了HKID-1核酸分子，含有本发明核酸分子的重组表达载体，导入了表达载体的宿主细胞和其中导入了HKID-1基因的非人转基因动物或破坏。还提供了利用本发明组合物的诊断，筛选和治疗方法。

4. 发明申请

WO2002077233A2 38650, 28472, 5495, 65507, 81588 and 14354 METHODS AND COMPOSITIONS OF HUMAN PROTEINS AND USES THEREOF 审中-公开
标题翻译： 38650,28472,5495,65507,81588和14354人蛋白质的方法和组合物及其用途
公开(公告)号：WO2002077233A2
公开(公告)日：2002-10-03
申请号：PCT/US2001/046724
申请日：2001-11-08
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LEIBY, Kevin, R. , KAPELLER-LIBERMANN, Rosana , GLUCKSMANN, Maria
发明人： LEIBY, Kevin, R. , KAPELLER-LIBERMANN, Rosana , GLUCKSMANN, Maria
IPC分类号： C12N15/12
CPC分类号： C12N9/6489 , C07K14/705 , C07K2319/00 , C12N9/78 , C12Y304/24057 , C12Y305/04004
摘要： The invention provides isolated nucleic acids molecules, designated 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, which encode novel adenosine deaminase, glycoprotease, or seven transmembrane receptor family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38650, 28472, 5495, 65507, 81588 or 14354 gene has been introduced or disrupted. The invention still further provides isolated 38650, 28472, 5495, 65507, 81588 or 14354 proteins, fusion proteins, antigenic peptides and anti-38650, 28472, 5495, 65507,81588 or 14354 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为38650,28472,5495,65507,81588或14354核酸分子，其编码新的腺苷脱氨酶，糖蛋白酶或七个跨膜受体家族成员。本发明还提供反义核酸分子，含有38650,28472,5495,65507,81588或14354核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中38650,28472， 5495,65507,81588或14354基因被引入或破坏。本发明还进一步提供分离的38650,28472,5495,65507,81588或14354蛋白，融合蛋白，抗原肽和抗-38650,28472,5495,65507,81588或14354抗体。还提供了利用本发明组合物的诊断方法。

5. 发明申请

WO2003035840A3 69583 AND 85924, NOVEL HUMAN PROTEIN KINASE FAMILY MEMBERS AND USES THEREFOR 审中-公开
公开(公告)号：WO2003035840A3
公开(公告)日：2003-05-01
申请号：PCT/US2002/034037
申请日：2002-10-24
申请人： MILLENNIUM PHARMACEUTICALS, INC. , KAPELLER-LIBERMANN, Rosana , SPURLING, Heidi, Lynn
发明人： KAPELLER-LIBERMANN, Rosana , SPURLING, Heidi, Lynn
IPC分类号： C12Q1/48
摘要： The invention provides isolated nucleic acids molecules, designated 69583 and 85924 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 69583 or 85924 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 69583 or 85924 gene has been introduced or disrupted. The invention still further provides isolated 69583 or 85924 proteins, fusion proteins, antigenic peptides and anti-69583 or -85924 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

6. 发明申请

WO2002010401A3 18431 AND 32374, HUMAN PROTEIN KINASE FAMILY MEMBERS AND USES THEREFOR 审中-公开
公开(公告)号：WO2002010401A3
公开(公告)日：2002-02-07
申请号：PCT/US2001/023653
申请日：2001-07-27
申请人： MILLENNIUM PHARMACEUTICALS, INC. , MEYERS, Rachel , KAPELLER-LIBERMANN, Rosana , SILOS-SANTIAGO, Inmaculada
发明人： MEYERS, Rachel , KAPELLER-LIBERMANN, Rosana , SILOS-SANTIAGO, Inmaculada
IPC分类号： C12N15/54
摘要： The invention provides isolated nucleic acids molecules, designated 32374 or 18431 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32374 or 18431 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32374 or 18431 gene has been introduced or disrupted. The invention still further provides isolated 32374 or 18431 proteins, fusion proteins, antigenic peptides and anti-32374 or -18431 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

7. 发明申请

WO2001066763A3 23436, A HUMAN UBIQUITIN PROTEASE FAMILY MEMBER AND USES THEREOF 审中-公开
公开(公告)号：WO2001066763A3
公开(公告)日：2001-09-13
申请号：PCT/US2001/007074
申请日：2001-03-05
申请人： MILLENNIUM PHARMACEUTICALS, INC. , KAPELLER-LIBERMANN, Rosana , WEICH, Nadine
发明人： KAPELLER-LIBERMANN, Rosana , WEICH, Nadine
IPC分类号： C12N15/57
摘要： The invention provides isolated nucleic acids molecules, designated 23436 nucleic acid molecules, which encode novel ubiquitin carboxy-terminal hydrolase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 23436 gene has been introduced or disrupted. The invention still further provides isolated 23436 proteins, fusion proteins, antigenic peptides and anti-23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided as are methods for identifying compounds that alter a 23436 activity.

8. 发明申请

WO2001064911A3 18232, A DUAL SPECIFICITY PHOSPHATASE 审中-公开
公开(公告)号：WO2001064911A3
公开(公告)日：2001-09-07
申请号：PCT/US2001/006177
申请日：2001-02-27
申请人： MILLENNIUM PHARMACEUTICALS, INC. , KAPELLER-LIBERMANN, Rosana
发明人： KAPELLER-LIBERMANN, Rosana
IPC分类号： C12N15/55
摘要： The invention provides isolated nucleic acids molecules, designated 18232 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18232 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18232 gene has been introduced or disrupted. The invention still further provides isolated 18232 proteins, fusion proteins, antigenic peptides and anti-18232 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating the differentiation and proliferation of hematopoietic cells (e.g., erythroid cells) utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing erythroid-associated disorders such as anemias, leukemias, and erythrocytosis are disclosed.

9. 发明申请

WO2001059082A1 27802, AN ADENYLATE KINASE 审中-公开
标题翻译：丙烯酸激酶27802
公开(公告)号：WO2001059082A1
公开(公告)日：2001-08-16
申请号：PCT/US2001/004573
申请日：2001-02-12
申请人： MILLENNIUM PHARMACEUTICALS, INC. , KAPELLER-LIBERMANN, Rosana , CHUN, Miyoung
发明人： KAPELLER-LIBERMANN, Rosana , CHUN, Miyoung
IPC分类号： C12N9/12
CPC分类号： C12N9/1229
摘要： Novel adenylate kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length adenylate kinase proteins, the invention further provides isolated adenylate kinase fusion proteins, antigenic peptides, and anti-adenylate kinase antibodies. The invention also provides adenylate kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an adenylate kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新颖的腺苷酸激酶多肽，蛋白质和核酸分子。除了分离的全长腺苷酸激酶蛋白之外，本发明还提供了分离的腺苷酸激酶融合蛋白，抗原肽和抗腺苷酸激酶抗体。本发明还提供了腺苷酸激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已引入或破坏腺苷酸激酶基因的非人转基因动物。还提供了利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

WO2001023589A3 23431, A NOVEL HUMAN UBIQUITIN PROTEASE 审中-公开
公开(公告)号：WO2001023589A3
公开(公告)日：2001-04-05
申请号：PCT/US2000/026962
申请日：2000-09-29
申请人： MILLENNIUM PHARMACEUTICALS, INC. , KAPELLER-LIBERMANN, Rosana
发明人： KAPELLER-LIBERMANN, Rosana
IPC分类号： C12N15/57
摘要： The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding he ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.

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