专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004065576A2 METHODS AND COMPOSITIONS FOR TREATING UROLOGICAL DISORDERS USING 44390, 54181, 211, 5687, 884, 1405, 636, 4421, 5410, 30905, 2045, 16405, 18560, 2047, 33751, 52872, 14063, 20739, 32544, 43239, 44373, 51164, 53010, 16852, 1587, 2207, 22245, 2387, 52908, 69112, 14990, 18547, 115, 579, 15985, 15625, 760, 18603, 2395, 2554, 867 审中-公开
标题翻译：用于使用44390,54181,211,5687,884,1405,636,4421,5410,30905,2045,16405,18560,2047,33751,52872,14063,20739,32544,43239,443373的治疗尿路疾病的方法和组合物， 51164,53010,16852,1587,2207,22245,2377,52908,69112,14990,18547,115,579,15985,15525,760,18603,2355,2554,867
公开(公告)号：WO2004065576A2
公开(公告)日：2004-08-05
申请号：PCT/US2004000750
申请日：2004-01-14
申请人： MILLENNIUM PHARM INC , KARICHETI VENKATESWARLU , SILOS-SANTIAGO INMACULADA , ELIASOF SCOTT D
发明人： KARICHETI VENKATESWARLU , SILOS-SANTIAGO INMACULADA , ELIASOF SCOTT D
IPC分类号： C07K14/47 , C12N
CPC分类号： C07K14/47
摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 44390, 54181, 211, 5687, 884, 1405, 636, 4421, 5410, 30905, 2045, 16405, 18560, 2047, 33751, 52872, 14063, 20739, 32544, 43239, 44373, 51164, 53010, 16852, 1587, 2207, 22245, 2387, 52908, 69112, 14990, 18547, 115, 579, 15985, 15625, 760, 18603, 2395, 2554, 8675, 32720, 4809, 14303, 16816, 17827, 32620, 577, 619, 1423, 2158, 8263, 15402, 16209, 16386, 21165, 30911, 41897, 1643, 2543, 9626, 13231, 32409, 84260, 2882, 8203, 32678 and 55053 genes in tissues relating to urological disorder, relative to their expression in normal, or non-urological disorder disease states, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.
摘要翻译：本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。具体地，本发明鉴定了44390,54181,211,5687,884,1405,636,4421,5410,30905,2045,16405,18560,2047,33751,52872,14063,20739,32544,43239的差异表达， 44373,51164,53010,16852,1587,2207,22245,2377,52908,69112,14990,188547,115,59,15985,15525,760,18603,2355,2554,8675,32720,4809,14303,16816,165,145,125,118,129,119,109,109,109,109， 17827,3262,577,619,1423,2188,8263,15402,16209,166386,21165,30911,41897,1643,2534,9626,13231,32409,84260,28282,8203,32678和55053基因在与泌尿系统疾病相对于在正常或非泌尿疾病疾病状态中的表达，和/或响应于与泌尿系统疾病相关的操作。本发明描述了各种泌尿疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。

2. 发明申请

WO0250256A3 53010, A HUMAN CARBOXYLESTERASE FAMILY MEMBER AND USES THEREOF 审中-公开
标题翻译： 53010，人类羧酸酶家族成员及其用途
公开(公告)号：WO0250256A3
公开(公告)日：2003-07-24
申请号：PCT/US0149075
申请日：2001-12-18
申请人： MILLENNIUM PHARM INC , CURTIS RORY A J , SILOS-SANTIAGO INMACULADA
发明人： CURTIS RORY A J , SILOS-SANTIAGO INMACULADA
IPC分类号： C12N9/18 , C12N15/52
CPC分类号： C12N9/18
摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人类转基因动物。本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。还提供了利用本发明组合物的诊断方法。

3. 发明申请

WO03027254A2 15625 RECEPTOR, A NOVEL G-PROTEIN COUPLED RECEPTOR 审中-公开
标题翻译： 15625受体，新型G蛋白偶联受体
公开(公告)号：WO03027254A2
公开(公告)日：2003-04-03
申请号：PCT/US0230572
申请日：2002-09-26
申请人： MILLENNIUM PHARM INC , GLUCKSMANN MARIA ALEXANDRA , GU WEI , WEICH NADINE S , SILOS-SANTIAGO INMACULADA
发明人： GLUCKSMANN MARIA ALEXANDRA , GU WEI , WEICH NADINE S , SILOS-SANTIAGO INMACULADA
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/395 , A61P25/04 , C07H21/04 , C07K14/705 , C12N20060101 , C12N5/06 , C12N15/12 , C12N
CPC分类号： G01N33/5044 , A01K2217/05 , A61K38/00 , C07K14/705 , G01N33/5058 , G01N33/6893 , G01N33/6896 , G01N2333/726 , G01N2500/00 , G01N2500/04 , G01N2800/2842
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译：本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。本发明还涉及编码受体的多核苷酸。本发明还涉及使用受体多肽和多核苷酸作为在受体介导的病症中进行诊断和治疗的靶标的方法。本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生受体多肽和多核苷酸的方法。

4. 发明申请

WO2003025201A2 METHODS OF USING 5433, A HUMAN CALCIUM CHANNEL FAMILY MEMBER 审中-公开
标题翻译：使用5433，人类钙通道家族成员的方法
公开(公告)号：WO2003025201A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029455
申请日：2002-09-17
申请人： MILLENNIUM PHARMACEUTICALS, INC. , SILOS-SANTIAGO, Inmaculada
发明人： SILOS-SANTIAGO, Inmaculada
IPC分类号： C12Q
CPC分类号： C07K14/705 , C12Q1/6883 , C12Q2600/158
摘要： The invention provides isolated nucleic acids molecules, designated 5433 nucleic acid molecules, which encode calcium channel family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 5433 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 5433 gene has been introduced or disrupted. The invention still further provides isolated 5433 proteins, fusion proteins, antigenic peptides and anti-5433 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的核酸分子，命名为5433核酸分子，其编码钙通道家族成员。本发明还提供了反义核酸分子，含有5433个核酸分子的重组表达载体，导入了表达载体的宿主细胞，以及导入或破坏了5433基因的非人转基因动物。本发明还进一步提供了分离的5433蛋白，融合蛋白，抗原肽和抗5433抗体。还提供了利用本发明组合物的诊断方法。

5. 发明申请

WO2003008621A3 87144, HUMAN AMINO ACID TRANSPORTER FAMILY MEMBER AND USES THEREFOR 审中-公开
公开(公告)号：WO2003008621A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/021518
申请日：2002-07-09
申请人： MILLENNIUM PHARMACEUTICALS, INC. , CURTIS, Rory, A., J. , SILOS-SANTIAGO, Inmaculada
发明人： CURTIS, Rory, A., J. , SILOS-SANTIAGO, Inmaculada
IPC分类号： A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 87144 nucleic acid molecules, which encode novel amino acid transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 87144 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 87144 gene has been introduced or disrupted. The invention still further provides isolated 87144 proteins, fusion proteins, antigenic peptides and anti-87144 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

6. 发明申请

WO2002020800A2 16658, 14223, and 16002, NOVEL HUMAN KINASES AND USES THEREFOR 审中-公开
标题翻译： 16658，14223和16002，新的人类激酶和用途
公开(公告)号：WO2002020800A2
公开(公告)日：2002-03-14
申请号：PCT/US2001/024601
申请日：2001-08-03
申请人： MILLENNIUM PHARMACEUTICALS, INC. , MEYERS, Rachel, E. , SILOS-SANTIAGO, INMACULADA
发明人： MEYERS, Rachel, E. , SILOS-SANTIAGO, INMACULADA
IPC分类号： C12N15/54
CPC分类号： C12N9/12
摘要： The invention provides isolated nucleic acids molecules, designated 16658, 14223, and 16002 nucleic acid molecules, which encode novel kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16658, 14223, and 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16658, 14223, and 16002 gene has been introduced or disrupted. The invention still further provides isolated 16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, -14223, and -16002 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的核酸分子，命名为16658,14223和16002核酸分子，其编码新的激酶家族成员。本发明还提供了反义核酸分子，含有16658,14223和16002核酸分子的重组表达载体，导入了表达载体的宿主细胞和其中已经存在16658,14223和16002基因的非人转基因动物介绍或中断。本发明还提供了分离的16658,14223和16002蛋白，融合蛋白，抗原肽和抗16658,14223和16002蛋白，融合蛋白，抗原肽和抗16658,14223和-16002抗体。还提供了利用本发明组合物的诊断方法。

7. 发明申请

WO0164882A2 1983, 52881, 2398, 45449, 50289, AND 52872, NOVEL G PROTEIN-COUPLED RECEPTORS AND USES THEREFOR 审中-公开
标题翻译： 1983年52881号，2398号，45449号，50289号和52872号，新型G蛋白偶联受体及其用途
公开(公告)号：WO0164882A2
公开(公告)日：2001-09-07
申请号：PCT/US0106543
申请日：2001-02-28
申请人： MILLENNIUM PHARM INC , GLUCKSMANN MARIA ALEXANDRA , GALVIN KATHERINE M , SILOS SANTIAGO INMACULADA
发明人： GLUCKSMANN MARIA ALEXANDRA , GALVIN KATHERINE M , SILOS-SANTIAGO INMACULADA
IPC分类号： C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acids molecules, designated 1983, 52881, 2398, 45449, 50289, and 52872 nucleic acid molecules, which encode novel G protein-coupled receptor members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 1983, 52881, 2398, 45449, 50289, or 52872 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 1983, 52881, 2398, 45449, 50289, or 52872 gene has been introduced or disrupted. The invention still further provides isolated 1983, 52881, 2398, 45449, 50289, or 52872 proteins, fusion proteins, antigenic peptides and anti-1983, 52881, 2398, 45449, 50289, or 52872 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的G蛋白偶联受体成员的分离的核酸分子，命名为1983,52881,29898,45449,50289和52872核酸分子。本发明还提供反义核酸分子，含有1983,52881,29898,45449,50289或52872核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中1983,52881 ，2398,45449,50289或52872基因被引入或破坏。本发明还进一步提供了分离的1983,52881,2398,45449,50289或52872蛋白质，融合蛋白质，抗原性肽和抗-1923,52881,2998,45449,50289或52872抗体。还提供了利用本发明组合物的诊断方法。

8. 发明申请

WO03037254A3 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF PAIN DISORDERS USING 46566 审中-公开
标题翻译：用于治疗和诊断疼痛疾病的方法和组合物，使用46566
公开(公告)号：WO03037254A3
公开(公告)日：2003-08-21
申请号：PCT/US0234567
申请日：2002-10-28
申请人： MILLENNIUM PHARM INC , SILOS-SANTIAGO INMACULADA
发明人： SILOS-SANTIAGO INMACULADA
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P43/00 , C12N5/06 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/68 , A01N43/04 , A61K31/07 , C07H21/04
CPC分类号： G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N2500/00
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of pain disorders, including, but not limited to, inflammatory pain, chronic pain and/or neuropathic pain. The invention further provides methods for identifying a compound capable of treating a pain disorder or modulating pain and/or inflammation response. The invention further provides a method for modulating pain and/or inflammation in a subject. In addition, the invention provides a method for treating a subject having a pain disorder characterized by aberrant 46566 polypeptide activity or aberrant 46566 nucleic acid expression.
摘要翻译：本发明涉及用于治疗和诊断疼痛病症的方法和组合物，所述疼痛病症包括但不限于炎症性疼痛，慢性疼痛和/或神经性疼痛。本发明进一步提供了鉴定能够治疗疼痛病症或调节疼痛和/或炎症反应的化合物的方法。本发明进一步提供了用于调节受试者的疼痛和/或炎症的方法。另外，本发明提供了治疗具有以异常46566多肽活性或异常46566核酸表达为特征的疼痛疾病的受试者的方法。

9. 发明申请

WO2003061573A3 METHODS AND COMPOSITIONS FOR TREATING UROLOGICAL DISORDERS USING 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 OR 6351 MO 审中-公开
公开(公告)号：WO2003061573A3
公开(公告)日：2003-07-31
申请号：PCT/US2003/001450
申请日：2003-01-16
申请人： MILLENNIUM PHARMACEUTICALS, INC. , SILOS-SANTIAGO, Inmaculada , KARICHETI, Venkateswarlu
发明人： SILOS-SANTIAGO, Inmaculada , KARICHETI, Venkateswarlu
IPC分类号： C12Q1/68
摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 and 6351 genes in tissues relating to urological disorders, relative to their expression in normal, or non-urological disorders, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.

10. 发明申请

WO03061573A2 METHODS AND COMPOSITIONS FOR TREATING UROLOGICAL DISORDERS USING 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 OR 6351 MO 审中-公开
标题翻译：使用1435,559,34021,44099,25278,641,260,55089,21407,42032,4656,52553,302,323,12303,985,13237,13601,18926,318,2058的治疗尿路疾病的方法和组合物或 6351 MO
公开(公告)号：WO03061573A2
公开(公告)日：2003-07-31
申请号：PCT/US0301450
申请日：2003-01-16
申请人： MILLENNIUM PHARM INC , SILOS-SANTIAGO INMACULADA , KARICHETI VENKATESWARLU
发明人： SILOS-SANTIAGO INMACULADA , KARICHETI VENKATESWARLU
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P5/00 , A61P5/26 , A61P5/28 , A61P5/38 , A61P5/44 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12 , A61P25/00 , A61P25/02 , A61P35/00 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , A61K
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 and 6351 genes in tissues relating to urological disorders, relative to their expression in normal, or non-urological disorders, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.
摘要翻译：本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。具体而言，本发明鉴别1435,549,34021,44099,25278,641,260,55089,21407,42032,4656,65353,302,232,12303,985,13237,13601,18926,318的差异表达，相对于其在正常或非泌尿系统疾病中的表达和/或响应于与泌尿系统疾病相关的操作，与泌尿系统疾病相关的组织中的2058和6351个基因。本发明描述了各种泌尿系统疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式