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1. 发明申请

WO2013005060A3 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：质谱仪中蛋白质和肽的光解离
公开(公告)号：WO2013005060A3
公开(公告)日：2013-07-04
申请号：PCT/GB2012051609
申请日：2012-07-06
申请人： MICROMASS LTD , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH , GILES KEVIN , BROWN JEFFERY MARK
发明人： KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH , GILES KEVIN , BROWN JEFFERY MARK
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
摘要翻译：公开了质谱法，包括自动重复执行多个操作循环，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将所述第一离子暴露于第一光离解装置以形成多个第二离子并对所述第二离子进行质量分析; 和（iii）将第一离子暴露于第一光离解装置以形成多个第二离子，将第二离子碎裂以形成多个第三离子并且质量分析第三离子。

2. 发明申请

WO2013005061A3 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：蛋白质和蛋白质在质谱仪中的照片分离
公开(公告)号：WO2013005061A3
公开(公告)日：2013-06-27
申请号：PCT/GB2012051610
申请日：2012-07-06
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GILES KEVIN , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH
发明人： BROWN JEFFERY MARK , GILES KEVIN , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
摘要翻译：公开了一种质谱法，其包括将来自激光器的第一光子引导到位于2D或线性离子导向器或离子阱内的离子上。扫描第一光子的频率，并检测由离子发射的第一光子和/或第二光子。然后使用飞行时间质量分析仪对离子进行质量分析。

3. 发明申请

WO2007018769A2 DISTRIBUTED TEMPERO-SPATIAL QUERY SERVICE 审中-公开
标题翻译：分布式TEMPERO-SPATIAL QUERY SERVICE
公开(公告)号：WO2007018769A2
公开(公告)日：2007-02-15
申请号：PCT/US2006024366
申请日：2006-06-22
申请人： BOEING CO , WAN MING , MURRAY PAUL , ERIGNAC CHARLES A
发明人： WAN MING , MURRAY PAUL , ERIGNAC CHARLES A
IPC分类号： H04L12/28
CPC分类号： H04L29/12009 , H04L29/12047 , H04L61/15 , H04L67/1002 , H04L67/1008 , H04L67/104 , H04L67/1089
摘要： A distributed tempero-spatial query service uses a plurality of service agents each having an assigned area of responsibility. The service agents are organized into a spatial hierarchy based upon each service agent's area of responsibility. The spatial hierarchy is distributed and hosted on each of the service agents. The spatial hierarchy enables matching of requests from subscribing agents with publishing agents based upon spatial attributes. The spatial hierarchy is dynamically maintained in a distributed manner on each of the service agents. The service agents can be arranged into a tree- based spatial hierarchy having a limited depth.
摘要翻译：分布式温和空间查询服务使用多个服务代理，每个服务代理都具有分配的责任区域。服务代理基于每个服务代理的责任区域被组织成空间层级。在每个服务代理上分布和托管空间层次结构。空间层次结构使得能够基于空间属性来匹配订阅代理与发布代理的请求。在每个服务代理上以分布式的方式动态地维护空间层级。服务代理可以被布置成具有有限深度的基于树的空间层级。

4. 发明申请

WO2008013648A3 FEEDBACK MOTION CONTROL USING CAMERAS 审中-公开
标题翻译：使用摄像机的反馈运动控制
公开(公告)号：WO2008013648A3
公开(公告)日：2009-05-07
申请号：PCT/US2007015164
申请日：2007-06-29
申请人： BOEING CO , TROY JAMES J , ERIGNAC CHARLES A , MURRAY PAUL
发明人： TROY JAMES J , ERIGNAC CHARLES A , MURRAY PAUL
IPC分类号： G05D13/62
CPC分类号： G05D1/0234 , G05D1/0033
摘要： Systems and methods for closed-loop feedback control of controllable devices using motion capture systems are disclosed. In one embodiment, a system includes a motion capture system configured to measure one or more motion characteristics of one or more controllable devices as the one or more controllable devices are operating within a control volume. A processor receives the measured motion characteristics from the motion capture system and determines a control signal based on the measured motion characteristics. A position control system receives the control signal and continuously adjusts at least one motion characteristic of the one or more controllable devices in order to maintain or achieve a desired motion state. The controllable device may be equipped with passive retro-reflective markers. The motion capture system, the processor, and the position control system comprise a complete closed-loop feedback control system.
摘要翻译：公开了使用运动捕捉系统的可控制装置的闭环反馈控制的系统和方法。在一个实施例中，系统包括运动捕捉系统，其配置成当一个或多个可控设备在控制体积内操作时测量一个或多个可控设备的一个或多个运动特性。处理器从运动捕捉系统接收测量的运动特性，并且基于所测量的运动特性来确定控制信号。位置控制系统接收控制信号并连续地调整一个或多个可控设备的至少一个运动特性，以维持或达到期望的运动状态。可控设备可以配备无源回射标记。运动捕捉系统，处理器和位置控制系统包括完整的闭环反馈控制系统。

5. 发明申请

WO2008057141A9 AUTONOMOUS VEHICLE RAPID DEVELOPMENT TESTBED SYSTEMS AND METHODS 审中-公开
标题翻译：自动车辆快速开发测试系统和方法
公开(公告)号：WO2008057141A9
公开(公告)日：2008-08-14
申请号：PCT/US2007011138
申请日：2007-05-08
申请人： BOEING CO , MASSACHUSETTS INST OF TECHNLOG , VIAN JOHN L , VALENTI MARIO J , PROVINE RONALD C , TROY JAMES J , MURRAY PAUL , ERIGNAC CHARLES A , CLARK GREGORY J , PIGG PAUL E , MANSOURI ALI R , ABDEL-MOTAGALY KHALED , BIENIAWSKI STEFAN R , SAAD EMAD W , HOW JONATHAN B , BETHKE BRETT M
发明人： VIAN JOHN L , VALENTI MARIO J , PROVINE RONALD C , TROY JAMES J , MURRAY PAUL , ERIGNAC CHARLES A , CLARK GREGORY J , PIGG PAUL E , MANSOURI ALI R , ABDEL-MOTAGALY KHALED , BIENIAWSKI STEFAN R , SAAD EMAD W , HOW JONATHAN B , BETHKE BRETT M
CPC分类号： F41G7/303 , G05D1/0027 , G05D1/0033
摘要： Systems and methods for development testing of vehicles and components are disclosed. In one embodiment, a system includes a position reference system and a command and control architecture. The position reference system is configured to repetitively measure one or more position and motion characteristics of one or more vehicles operating within a control volume. The command and control architecture is configured to receive the repetitively measured characteristics from the position reference system, and to determine corresponding control signals based thereon. The control signals are then transmitted to the one or more vehicles to control at least one of position, movement, and stabilization of the one or more vehicles in a closed-loop feedback manner. The system may further include a health monitoring component configured to monitor health conditions of the one or more vehicles, the control signals being determined at least in part on the health conditions.
摘要翻译：公开了用于车辆和部件的开发测试的系统和方法。在一个实施例中，系统包括位置参考系统和命令和控制架构。位置参考系统被配置为重复地测量在控制体积内操作的一个或多个车辆的一个或多个位置和运动特性。命令和控制架构被配置为从位置参考系统接收重复测量的特性，并且基于此来确定相应的控制信号。然后，控制信号被传送到一个或多个车辆，以闭环反馈方式控制一个或多个车辆的位置，移动和稳定中的至少一个。该系统可以进一步包括健康监测组件，其被配置为监视一个或多个车辆的健康状况，所述控制信号至少部分地基于健康状况来确定。

6. 发明申请

WO2010144913A3 MEMORY CHANGE TRACK LOGGING 审中-公开
标题翻译：内存更改跟踪记录
公开(公告)号：WO2010144913A3
公开(公告)日：2011-02-24
申请号：PCT/US2010038541
申请日：2010-06-14
申请人： SEAKR ENGINEERING INC , TROXEL IAN , MURRAY PAUL
发明人： TROXEL IAN , MURRAY PAUL
IPC分类号： G06F12/02 , G06F11/30 , G06F13/16
CPC分类号： G06F11/1438 , G06F11/1658 , G06F11/3471 , G06F11/348
摘要： A method for tracking memory changes includes defining a change-track area of memory including at least one memory address range for which changes will be tracked. The method also includes allocating a protected log region of memory for storing a change- track log and selecting an operational mode for change tracking from among a plurality of modes, the selected operational mode having criteria for tracking memory changes. The method includes detecting memory transactions using a memory logging module and generating a transaction record for each memory transaction that occurs in the change- track are of memory and which meets the criteria. The transaction records can be stored in the change-track log.
摘要翻译：用于跟踪存储器改变的方法包括定义存储器的改变轨道区域，其包括至少一个将被跟踪改变的存储器地址范围。该方法还包括分配用于存储更改轨道日志的存储器的受保护对准区域，并且从多个模式中选择用于变化追踪的操作模式，所选择的操作模式具有跟踪存储器改变的准则。该方法包括使用存储器记录模块来检测存储器事务，并且为存储器的变化轨迹中发生的并且符合标准的每个存储器事务生成事务记录。事务记录可以存储在更改轨道日志中。

7. 发明申请

WO2009099939A2 SYSTEMS AND METHODS FOR EX VIVO LUNG CARE 审中-公开
标题翻译： EXVIVO LUNG CARE的系统和方法
公开(公告)号：WO2009099939A2
公开(公告)日：2009-08-13
申请号：PCT/US2009032619
申请日：2009-01-30
申请人： TRANSMEDICS INC , FISHMAN ROBERT , HAVENER ROBERT , FATTAH IHAB ABDEL , ABDELAZIM ANAS , NEWELL SCOTT , BISHOP TOM , KHAYAL TAMER , KYI STANLEY , TAYLOR RONALD , HARRIOTT DOUG , DE REMER MATTHEW , MURRAY PAUL , SULLIVAN JOHN , ANDERSON MARK , BRINGHAM RICHARD , VAN DRIEL MICHAEL , HASSANEIN WALEED
发明人： FISHMAN ROBERT , HAVENER ROBERT , FATTAH IHAB ABDEL , ABDELAZIM ANAS , NEWELL SCOTT , BISHOP TOM , KHAYAL TAMER , KYI STANLEY , TAYLOR RONALD , HARRIOTT DOUG , DE REMER MATTHEW , MURRAY PAUL , SULLIVAN JOHN , ANDERSON MARK , BRINGHAM RICHARD , VAN DRIEL MICHAEL , HASSANEIN WALEED
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247
摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
摘要翻译：维持，评估和提供肺外治疗的方法和系统。所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所花费的时间。

8. 发明申请

WO2014140628A3 DATA DIRECTED ACQUISITION OF IMAGING MASS 审中-公开
标题翻译：数据指向采集成像质量
公开(公告)号：WO2014140628A3
公开(公告)日：2014-11-13
申请号：PCT/GB2014050808
申请日：2014-03-14
申请人： MICROMASS LTD
发明人： BROWN JEFFERY MARK , CHAPMAN RICHARD , MURRAY PAUL , RICHARDSON KEITH , HOYES EMMY MARIA
IPC分类号： H01J49/00
CPC分类号： H01J49/0004 , H01J49/164
摘要： A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location. A determination is then made as to whether or not the first mass spectral data satisfies a condition, wherein if it is determined that the first mass spectral data does satisfy the condition then the method further comprises:(i) switching to acquire second mass spectral data related to a second pixel location which is substantially adjacent to the first pixel location so that the second mass spectral data is acquired at a second resolution which is higher than the first resolution; and(ii) determining whether or not the second mass spectral data satisfies the condition, wherein if it is determined that the second mass spectral data does satisfy the condition then the method further comprises acquiring third mass spectral data related to a third pixel location which is substantially adjacent to the first or second pixel locations so that the third mass spectral is acquired at the second resolution and wherein if it is determined that the second or third mass spectral data does not satisfy the condition then the method further comprises switching back to scanning the sample at the first resolution.
摘要翻译：公开了一种离子成像方法，包括以第一分辨率扫描样品并获取与第一像素位置相关的第一质谱数据。然后确定第一质谱数据是否满足条件，其中如果确定第一质谱数据确实满足条件，则该方法还包括：（i）切换以获取第二质谱数据涉及与第一像素位置基本相邻的第二像素位置，使得以高于第一分辨率的第二分辨率获取第二质谱数据; 以及（ii）确定所述第二质谱数据是否满足所述条件，其中如果确定所述第二质谱数据确实满足所述条件，则所述方法还包括获取与第三像素位置有关的第三质谱数据，所述第三质谱数据是基本上与第一或第二像素位置相邻，使得以第二分辨率获取第三质谱，并且其中如果确定第二或第三质谱数据不满足条件，则该方法还包括切换回扫描以第一分辨率进行抽样。

9. 发明申请

WO2014083109A2 PROCESS FOR THE REMOVAL AND RETURN OF A CATALYST TO A LIQUID PHASE MEDIUM 审中-公开
标题翻译：将催化剂移除和返回到液相介质的方法
公开(公告)号：WO2014083109A2
公开(公告)日：2014-06-05
申请号：PCT/EP2013074974
申请日：2013-11-28
申请人： PHOSPHONICS LTD , MURRAY PAUL
发明人： MURRAY PAUL , WILKES ROBIN , NORTH CHRISTOPHER
IPC分类号： C08G77/385 , B01J20/32 , C08G77/388 , C08G77/392 , C08G77/395
CPC分类号： C07F7/10 , B01J31/069 , B01J31/1633 , B01J31/1658 , B01J31/2409 , B01J2231/321 , B01J2231/42 , B01J2231/4211 , B01J2531/0205 , B01J2531/16 , B01J2531/80 , B01J2531/824 , B01J2531/842 , B01J2531/847 , C07F7/0834 , C07F17/02 , C08G77/385 , C08G77/388 , C08G77/392 , C08G77/395 , Y02P20/588
摘要： A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, C02R, F, Cl, N02 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions.
摘要翻译：公开了一种从液相中选择性除去组分并随后将组分返回到液相的方法。其中L是连接基团的式（I）[SUP] - [[L] - [G]] a（I）的新型化合物，G是具有选自Cl，Br，I ，磺酸盐如三氟甲磺酸盐，重氮基团，腈，酯和烷氧基，取代基Q选自H，NR2，OR，CO 2 R，F，Cl，NO 2 CN，而SUP是具有多个基团的支链 - 与载体接触的[L] - [G]与液相接触以将组分与化合物I结合，从而形成捕获的组分，该捕获组分与液相分离并返回到液相。化合物I特别可用于结合均匀的催化剂以将其从反应介质中除去并且在稍后阶段选择性地将催化剂返回到反应介质中。该化合物特别可用于交叉偶联反应，例如在Suzuki反应中。

10. 发明申请

WO2013093482A3 AN IMAGING MASS SPECTROMETER AND A METHOD OF MASS SPECTROMETRY 审中-公开
标题翻译：成像质谱仪及质谱分析方法
公开(公告)号：WO2013093482A3
公开(公告)日：2013-11-28
申请号：PCT/GB2012053215
申请日：2012-12-20
申请人： MICROMASS LTD
发明人： MURRAY PAUL , BROWN GEOFF
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/164 , H01J49/0004 , H01J49/0418 , H01J49/40 , H01J49/405
摘要： An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.
摘要翻译：一种成像质谱仪，包括适于基本上同时向样品上的多个点提供能量以通过解吸过程从样品产生离子的能量源; 以及分析器，适于检测由所述解吸过程产生的离子的到达时间和斑点原点。

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