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1. 发明申请

WO2005017491A3 LOOP DILUTION SYSTEM 审中-公开
标题翻译：循环稀释系统
公开(公告)号：WO2005017491A3
公开(公告)日：2005-06-09
申请号：PCT/US2004026303
申请日：2004-08-13
申请人： METARA INC , ANDERSON MARC R , WEST MICHAEL J , TAPPAN JAMES
发明人： ANDERSON MARC R , WEST MICHAEL J , TAPPAN JAMES
IPC分类号： B01L99/00 , G01N1/00 , G01N30/20 , G01N30/24 , B01L11/00 , G01N33/00
CPC分类号： G01N35/1097 , G01N30/24 , G01N2030/201 , G01N2030/202 , Y10T436/24
摘要： A loop dilution system (Figure 2a) includes a dual-loop multi-way valve (200). In a first configuration of the multi-way valve, a first loop (210) may be filled with a first solution and a second loop (205) may be filled with a second solution. In a second configuration of the multi-way valve, the first and second loops are serially connected with a pump so that their contents may be mixed with a diluent. In another aspect of the invention, an in-process mass spectrometry (IPMS) system is disclosed that uses an internal standard to determine the concentration of an analyte in a sample. The internal standard has a different molecular composition than the analyte but is sufficiently similar chemically and physically to the analyte such that it behaves substantially the same as the analyte during an ionization process in the mass spectrometer
摘要翻译：循环稀释系统（图2a）包括双回路多通阀（200）。在多通阀的第一构造中，可以用第一溶液填充第一回路（210），并且可以用第二溶液填充第二回路（205）。在多通阀的第二配置中，第一和第二回路与泵串联连接，使得它们的内容物可以与稀释剂混合。在本发明的另一方面，公开了一种使用内部标准来确定样品中分析物的浓度的过程中质谱（IPMS）系统。内标与分析物具有不同的分子组成，但与分析物的化学和物理性质充分相似，使得其在质谱仪中的离子化过程中与分析物基本相同

2. 发明申请

WO2005017492A3 MODULE FOR AUTOMATED MATRIX REMOVAL 审中-公开
标题翻译：自动矩阵去除模块
公开(公告)号：WO2005017492A3
公开(公告)日：2007-03-01
申请号：PCT/US2004026319
申请日：2004-08-13
申请人： METARA INC , ANDERSON MARC R , WEST MICHAEL J , TAPPAN JAMES
发明人： ANDERSON MARC R , WEST MICHAEL J , TAPPAN JAMES
IPC分类号： G01N25/26 , G01N1/28 , G01N1/34 , G01N31/02 , H01J49/04
CPC分类号： G01N31/02 , G01N1/34 , G01N1/4077 , H01J49/04 , Y10T436/25375
摘要： An automated matrix removal module is configurable to automatically withdraw a portion of sample containing an interferent. The module is further configurable to mix the portion of sample with a precipitating reagent selected to react with the interferent to form a precipitant and then filter mixture of sample and precipitant reagent through a filter. Finally, the module is further configurable to flush the precipitant from the filter.
摘要翻译：自动矩阵去除模块可配置为自动提取含有干扰物的样品的一部分。该模块还可配置为将样品的一部分与选择的与沉淀剂反应的沉淀剂混合以形成沉淀剂，然后通过过滤器过滤样品和沉淀剂的混合物。最后，该模块进一步可配置以从过滤器冲洗沉淀剂。

3. 发明申请

WO03006946A3 METHOD AND INSTRUMENT FOR AUTOMATED ANALYSIS OF FLUID-BASED PROCESSING SYSTEMS 审中-公开
标题翻译：基于流体加工系统自动分析的方法与仪器
公开(公告)号：WO03006946A3
公开(公告)日：2003-05-08
申请号：PCT/US0218023
申请日：2002-06-06
申请人： METARA INC
发明人： ANDERSON MARC R , STEWART LARRY N , KINGSTON HOWARD M
IPC分类号： G01N27/62 , G01N1/00 , G01N1/10 , G01N1/16 , G01N30/72 , G01N30/88 , G01N35/00 , G01N35/04 , G01N35/08 , B01D59/44 , G01N33/30 , G01N35/10
CPC分类号： G01N1/16 , G01N1/22 , G01N30/7206 , G01N30/7246 , G01N30/7266 , G01N35/08 , G01N2001/1087 , G01N2030/8804 , G01N2030/8868 , G01N2030/8881 , G01N2030/8886 , G01N2035/0097 , Y10T436/11 , Y10T436/115831 , Y10T436/13 , Y10T436/24 , Y10T436/25 , Y10T436/25625 , Y10T436/25875
摘要： An analytical apparatus to monitor fluid systems having at least one extraction module (301, 305, 309, 313, 317) with a raw-sample reservoir (303, 307, 311, 315, 319) connected to individual ones of the monitored fluid systems, to extract samples for analysis, one or more modification modules (331, 333, 335, 343, 345, 347, 349, 351, 353) containing materials for addition to the samples, an analytical device (231) to receive and analyze at least a portion of the samples in an ordered sequence, and a computerized control and management system to control operation of the modules and analytycal device (231) and report results. The apparatus extracts raw samples from each monitored fluid systems, modifies the samples as needed, sequncially introduces the samples into the analytical device and reports the analytical results on a continuous basis over plural cycles as directed by the control and management system (231).
摘要翻译：一种用于监测具有至少一个提取模块（301,305,309,313,317）的流体系统的分析装置，其具有连接到所监视的流体系统中的各个的原始样品储存器（303,307,311,315,319）提取用于分析的样品，一个或多个包含用于添加到样品中的材料的修饰模块（331,333,335,334,345,347,349,351,353），分析装置（231），用于接收和分析至少一部分样本以有序序列，以及计算机化的控制和管理系统，以控制模块和分析设备（231）的操作并报告结果。该装置从每个监测的流体系统中提取原始样品，根据需要修改样品，并将样品引入分析装置，并按照控制和管理系统（231）的指示在多个周期内连续地报告分析结果。

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