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1. 发明申请

WO2012000770A1 METHODS TO DIAGNOSE LIVER DISEASES 审中-公开
标题翻译：诊断肝病的方法
公开(公告)号：WO2012000770A1
公开(公告)日：2012-01-05
申请号：PCT/EP2011/059650
申请日：2011-06-10
申请人： METANOMICS HEALTH GMBH , UNIKLINIKUM SCHLESWIG-HOLSTEIN , KAMP, Hennicke , RENNEFAHRT, Ulrike , FUHRMANN, Jens , REIN, Dietrich , HAMPE, Jochen , SCHAFMEYER, Clemens
发明人： KAMP, Hennicke , RENNEFAHRT, Ulrike , FUHRMANN, Jens , REIN, Dietrich , HAMPE, Jochen , SCHAFMEYER, Clemens
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G01N33/50 , G01N33/6812 , G01N33/6893 , G01N33/92 , G01N2800/085 , Y02A90/26
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing a liver disease in a subject and a method of differentiating between NASH and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
摘要翻译：本发明涉及诊断方法领域。具体地，本发明考虑了用于诊断受试者中的肝脏疾病的方法和区分NASH和NAFLD的方法。本发明还涉及用于执行上述方法的工具，例如诊断装置。

2. 发明申请

WO2014001451A1 METHODS FOR IDENTIFYING DIABETES DRUGS 审中-公开
标题翻译：鉴定糖尿病药物的方法
公开(公告)号：WO2014001451A1
公开(公告)日：2014-01-03
申请号：PCT/EP2013/063509
申请日：2013-06-27
申请人： METANOMICS HEALTH GMBH , BASF SCHWEIZ AG
发明人： REIN, Dietrich , NIKIFOROVA, Victoria , PADBERG, Inken , LIEBENBERG, Volker
IPC分类号： G01N33/50
CPC分类号： G01N33/5038 , G01N30/7206 , G01N33/5008 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/04 , G01N2800/042
摘要： The present invention relates to screening methods for diabetes drugs. In particular, the invention concerns a method for identifying a drug against diabetes comprising determining the amount of glyoxylate in a test sample of a subject suffering from diabetes or a diabetes-like condition, wherein said test sample has been taken after the subject has been brought into contact with a compound suspected to be a drug against diabetes and comparing the determined amount to a reference amount for glyoxylate, whereby a compound being a drug against diabetes is identified. Further contemplated is a method for identifying a drug against diabetes comprising contacting test cells which produce glyoxylate with a compound suspected to be a drug against diabetes for a time and under conditions which allow for said compound to interact with the cells and to affect glyoxylate production, determining the amount of glyoxylate produced in said cells, and comparing the determined amount to a reference amount for glyoxylate, whereby a compound being a drug against diabetes is identified. Finally, a method for the manufacture of a drug against diabetes is provided.
摘要翻译：本发明涉及糖尿病药物的筛选方法。特别地，本发明涉及用于鉴定抗糖尿病药物的方法，包括测定患有糖尿病或糖尿病状况的受试者的测试样品中乙醛酸的量，其中所述测试样品已经在受试者被带到与怀疑是药物对抗糖尿病的化合物接触，并将确定的量与乙醛酸盐的参考量进行比较，从而鉴定作为抗糖尿病药物的化合物。进一步考虑的是用于鉴定抗糖尿病药物的方法，其包括将产生乙醛酸盐的试验细胞与怀疑是药物的化合物在一段时间内和在允许所述化合物与细胞相互作用并影响乙醛酸生产的条件下接触，确定所述细胞中产生的乙醛酸的量，并将确定的量与乙醛酸的参考量进行比较，从而鉴定出抗药性的药物。最后，提供了制备抗糖尿病药物的方法。

3. 发明申请

WO2010007106A1 MEANS AND METHODS DIAGNOSING GASTRIC BYPASS AND CONDITIONS RELATED THERETO 审中-公开
标题翻译：方法和方法诊断与之相关的气体旁路和条件
公开(公告)号：WO2010007106A1
公开(公告)日：2010-01-21
申请号：PCT/EP2009/059091
申请日：2009-07-15
申请人： METANOMICS HEALTH GMBH , INSERM-TRANSFERT SA , FUHRMANN, Jens , REIN, Dietrich , KAMLAGE, Beate , WIEMER, Jan C , HEROLD, Michael Manfred , CLEMENT, Karine , MUTCH, David M.
发明人： FUHRMANN, Jens , REIN, Dietrich , KAMLAGE, Beate , WIEMER, Jan C , HEROLD, Michael Manfred , CLEMENT, Karine , MUTCH, David M.
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N33/5023 , G01N2800/042 , G01N2800/044
摘要： The present invention relates to the field of diagnostic measures. Specifically, it contemplates a method for assessing whether gastric bypass therapy was successful in a subject, a method of predicting whether gastric bypass therapy will be beneficial for a subject in need thereof, and a method of diagnosing whether a supportive therapy accompanying gastric bypass has beneficial effects on a subject in need thereof. Further provided are diagnostic methods for diabetes and body lean mass. Furthermore, the invention relates to a method for identifying a treatment against diabetes and/or obesity.
摘要翻译：本发明涉及诊断措施领域。具体地，本发明涉及一种用于评估胃旁路治疗是否成功的方法，预测胃旁路治疗是否有益于有需要的受试者的方法，以及诊断伴随胃旁路的支持治疗是否具有益处的方法对有需要的受试者的影响。还提供了糖尿病和身体瘦体重的诊断方法。此外，本发明涉及鉴定抗糖尿病和/或肥胖症的治疗方法。

4. 发明申请

WO2019122342A1 METHOD FOR THE ASSESSMENT OF NAFLD 审中-公开
公开(公告)号：WO2019122342A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086616
申请日：2018-12-21
申请人： METANOMICS HEALTH GMBH
发明人： SCHULZE-PELLENGAHR, Silke , WAGNER-GOLBS, Antje , REIN, Dietrich , SCHATZ, Philipp , CHRISTIANSEN, Nicole , BERG, Thomas , HAMPE, Jochen , DATZ, Christian , STICKEL, Felix , LERCH, Markus
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/085
摘要： The present invention relates to a method for assessing non-alcoholic fatty liver disease (NAFLD) com- prising determining in a sample from a subject suffering from NAFLD at least the amounts of two metabolite biomarkers, wherein said two metabolite biomarkers are: (i) at least one eicosatrienoic acid metabolite biomarker and (ii) at least one androgen metabolite biomarker and/or at least one bile acid metabolite biomarker. Further, the present invention relates to the vitro use of the at least two metabolite biomarkers for assessing non-alcoholic fatty liver disease (NAFLD).

5. 发明申请

WO2012085890A1 MEANS AND METHOD FOR PREDICTING DIABETES 审中-公开
标题翻译：用于预测糖尿病的手段和方法
公开(公告)号：WO2012085890A1
公开(公告)日：2012-06-28
申请号：PCT/IB2011/055935
申请日：2011-12-23
申请人： METANOMICS HEALTH GMBH , BASF (CHINA) COMPANY LIMITED , WIEMER, Jan , REIN, Dietrich , PADBERG, Inken , SCHMITZ, Oliver , LIEBENBERG, Volker , NIKIFOROVA, Viktoria
发明人： WIEMER, Jan , REIN, Dietrich , PADBERG, Inken , SCHMITZ, Oliver , LIEBENBERG, Volker , NIKIFOROVA, Viktoria
IPC分类号： G01N33/53 , G01N33/58 , G01N33/62 , G01N33/64 , G01N33/66
CPC分类号： G01N33/53 , G01N33/6893 , G01N2800/042
摘要： A method for diagnosing diabetes or a predisposition for diabetes is provided, which comprises determining the amount of glyoxylate in a test sample of a subject suspected to suffer from diabetes or to have a predisposition for diabetes and comparing said amount to a reference, whereby diabetes or a predisposition for diabetes is to be diagnosed. Further, the use of glyoxylate or a detection agent for glyoxylate for diagnosing diabetes or a predisposition for diabetes is provided. Moreover, a device and a kit for diagnosing diabetes or a predisposition for diabetes are also provided.
摘要翻译：提供了用于诊断糖尿病或糖尿病倾向的方法，其包括测定怀疑患有糖尿病的受试者或具有糖尿病倾向性并将所述量与参考比较的乙型醛酸盐的量，其中糖尿病或要诊断糖尿病的倾向。此外，提供了乙醛酸盐或乙醛酸盐检测剂用于诊断糖尿病或糖尿病倾向的用途。此外，还提供了用于诊断糖尿病或糖尿病倾向的装置和试剂盒。

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