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1. 发明申请

WO2007012643A1 MEANS AND METHODS FOR ANALYZING A SAMPLE BY MEANS OF CHROMATOGRAPHY-MASS SPECTROMETRY 审中-公开
标题翻译：用于通过色谱质谱法分析样品的方法和方法
公开(公告)号：WO2007012643A1
公开(公告)日：2007-02-01
申请号：PCT/EP2006/064628
申请日：2006-07-25
申请人： METANOMICS GMBH , WALK, Tilmann B. , LOOSER, Ralf , BETHAN, Bianca , HEROLD, Michael Manfred , KAMLAGE, Beate , SCHMITZ, Oliver , RAVENZWAAY, Bennard van , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , EHRHARDT, Thomas , WIEMER, Jan , PROKOUDINE, Alexandre , KRENNRICH, Gerhard
发明人： WALK, Tilmann B. , LOOSER, Ralf , BETHAN, Bianca , HEROLD, Michael Manfred , KAMLAGE, Beate , SCHMITZ, Oliver , RAVENZWAAY, Bennard van , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , EHRHARDT, Thomas , WIEMER, Jan , PROKOUDINE, Alexandre , KRENNRICH, Gerhard
IPC分类号： G06F19/00
CPC分类号： G01N30/8675 , G01N30/8668 , G01N2030/8813 , G01N2030/8818 , G01N2030/8822 , G06F19/703 , G06F19/707
摘要： The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method. Moreover, the present invention further encompasses a system for carrying out said method comprising operatively linked to each other: (a) means for determining a compound; (b) means for monitoring process parameters, (c) means for analyzing raw results obtained from the means according to (a), wherein said means for analyzing raw results comprise: (i) a first database comprising raw results received from the means according to (a); (ii) a second database comprising monitored process parameters received from the means according to (b); (iii) a third database comprising rules for evaluating the raw results; and (iv) a fourth database comprising allocated results of identified compounds; wherein at least the second, third and fourth database are operatively linked to the first database.
摘要翻译：本发明涉及用于分析至少一种测试样品的方法，其中所述测试样品包含至少一种化合物，所述方法包括以下步骤：a）提供至少一种包含至少一种化合物的测试样品; b）确定所述测试样品中的所述至少一种化合物，从而产生原始结果; 以及c）分析在步骤b）中获得的原始结果，其中所述至少一个测试样品的分析伴随着至少一个参考样品的分析; 并且其中在该方法的每个步骤中以相同的顺序分析测试样品和参考样品。此外，本发明还包括用于执行所述方法的系统，其包括彼此可操作地连接：（a）用于确定化合物的装置; （b）用于监视过程参数的装置，（c）用于分析根据（a）的装置获得的原始结果的装置，其中所述用于分析原始结果的装置包括：（i）第一数据库，包括从根据至（a）; （ii）第二数据库，包括从根据（b）的装置接收的监测过程参数; （iii）包含用于评估原始结果的规则的第三数据库; 和（iv）第四个数据库，其中包括所鉴别化合物的分配结果; 其中至少所述第二，第三和第四数据库可操作地链接到所述第一数据库。

2. 发明申请

WO2007110357A2 MEANS AND METHOD FOR DIAGNOSING DIABETES 审中-公开
标题翻译：用于诊断糖尿病的手段和方法
公开(公告)号：WO2007110357A2
公开(公告)日：2007-10-04
申请号：PCT/EP2007/052691
申请日：2007-03-21
申请人： METANOMICS GmbH , BETHAN, Bianca , BUSCH, Kristina , WIEMER, Jan , GIPMANS, Martijn , LEIBOLD, Edgar , SPRANGER, Jochen , BOBBERT, Thomas , PFEIFFER, Andreas Friedrich Hermann
发明人： BETHAN, Bianca , BUSCH, Kristina , WIEMER, Jan , GIPMANS, Martijn , LEIBOLD, Edgar , SPRANGER, Jochen , BOBBERT, Thomas , PFEIFFER, Andreas Friedrich Hermann
IPC分类号： G01N33/62 , G01N33/66 , G01N33/68 , G01N33/70 , G01N33/92 , G01N33/82
CPC分类号： G01N33/92 , G01N33/6848 , G01N33/6893 , G01N2800/042 , G01N2800/52 , Y10T436/144444 , Y10T436/24
摘要： The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites.
摘要翻译：本发明涉及一种用于诊断糖尿病或其易感性的方法，包括测定怀疑患有糖尿病的受试者的测试样品中的至少一种代谢物或具有易感性并将所述至少一种代谢物与参考对比，由此要诊断糖尿病或其倾向。此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。本发明进一步包括的是包含至少一种代谢物和所述至少一种代谢产物用于制造用于诊断糖尿病的诊断装置的诊断方法。最后，本发明涉及鉴定糖尿病相关代谢物的方法。

3. 发明申请

WO2007110358A2 MEANS AND METHOD FOR PREDICTING DIABETES 审中-公开
标题翻译：手段和方法预测糖尿病
公开(公告)号：WO2007110358A2
公开(公告)日：2007-10-04
申请号：PCT/EP2007/052692
申请日：2007-03-21
申请人： METANOMICS GmbH , BETHAN, Bianca , BUSCH, Kristina , WIEMER, Jan , GIPMANS, Martijn , LEIBOLD, Edgar , SPRANGER, Jochen , BOBBERT, Thomas , PFEIFFER, Andreas Friedrich Hermann
发明人： BETHAN, Bianca , BUSCH, Kristina , WIEMER, Jan , GIPMANS, Martijn , LEIBOLD, Edgar , SPRANGER, Jochen , BOBBERT, Thomas , PFEIFFER, Andreas Friedrich Hermann
IPC分类号： G01N33/62 , G01N33/66 , G01N33/68 , G01N33/70 , G01N33/92 , G01N33/82
CPC分类号： G01N33/92 , G01N33/6848 , G01N33/6893 , G01N2800/042 , G01N2800/52 , Y10T436/144444 , Y10T436/24
摘要： The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes. Finally, the present invention pertains to a method for identifying diabetes- related metabolites.
摘要翻译：本发明涉及一种用于诊断糖尿病倾向的方法，其包括测定疑似患有糖尿病倾向的对象的测试样品中的至少一种代谢物，并将所述至少一种代谢物与参考对比，其中糖尿病的倾向是被诊断。此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。本发明进一步包括的是包含至少一种代谢物和所述至少一种代谢产物用于制备用于诊断糖尿病倾向的诊断装置的诊断方法。最后，本发明涉及鉴定糖尿病相关代谢物的方法。

4. 发明申请

WO2012085890A1 MEANS AND METHOD FOR PREDICTING DIABETES 审中-公开
标题翻译：用于预测糖尿病的手段和方法
公开(公告)号：WO2012085890A1
公开(公告)日：2012-06-28
申请号：PCT/IB2011/055935
申请日：2011-12-23
申请人： METANOMICS HEALTH GMBH , BASF (CHINA) COMPANY LIMITED , WIEMER, Jan , REIN, Dietrich , PADBERG, Inken , SCHMITZ, Oliver , LIEBENBERG, Volker , NIKIFOROVA, Viktoria
发明人： WIEMER, Jan , REIN, Dietrich , PADBERG, Inken , SCHMITZ, Oliver , LIEBENBERG, Volker , NIKIFOROVA, Viktoria
IPC分类号： G01N33/53 , G01N33/58 , G01N33/62 , G01N33/64 , G01N33/66
CPC分类号： G01N33/53 , G01N33/6893 , G01N2800/042
摘要： A method for diagnosing diabetes or a predisposition for diabetes is provided, which comprises determining the amount of glyoxylate in a test sample of a subject suspected to suffer from diabetes or to have a predisposition for diabetes and comparing said amount to a reference, whereby diabetes or a predisposition for diabetes is to be diagnosed. Further, the use of glyoxylate or a detection agent for glyoxylate for diagnosing diabetes or a predisposition for diabetes is provided. Moreover, a device and a kit for diagnosing diabetes or a predisposition for diabetes are also provided.
摘要翻译：提供了用于诊断糖尿病或糖尿病倾向的方法，其包括测定怀疑患有糖尿病的受试者或具有糖尿病倾向性并将所述量与参考比较的乙型醛酸盐的量，其中糖尿病或要诊断糖尿病的倾向。此外，提供了乙醛酸盐或乙醛酸盐检测剂用于诊断糖尿病或糖尿病倾向的用途。此外，还提供了用于诊断糖尿病或糖尿病倾向的装置和试剂盒。

5. 发明申请

WO2004102191A3 SERUM PROTEIN PROFILING FOR THE DIAGNOSIS OF EPITHELIAL CANCERS 审中-公开
公开(公告)号：WO2004102191A3
公开(公告)日：2004-11-25
申请号：PCT/EP2004/005295
申请日：2004-05-17
申请人： EUROPROTEOME AG , EBERT, Matthias , MEUER, Jörn , WIEMER, Jan
发明人： EBERT, Matthias , MEUER, Jörn , WIEMER, Jan
IPC分类号： G01N33/48
摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion, subjects having an epithelial cancer or a metastasised epithelial cancer or subjects having an acute and chronic inflammation of the epithelium. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of epithelial cancers or an acute and chronic inflammation of the epithelium.

6. 发明申请

WO2004102190A1 DIFFERENTIAL DIAGNOSIS OF COLORECTAL CANCER AND OTHER DISEASES OF THE COLON 审中-公开
标题翻译：阴道癌和其他疾病的差异诊断
公开(公告)号：WO2004102190A1
公开(公告)日：2004-11-25
申请号：PCT/EP2004/005294
申请日：2004-05-17
申请人： EUROPROTEOME AG , MEUER, Jörn , WIEMER, Jan
发明人： MEUER, Jörn , WIEMER, Jan
IPC分类号： G01N33/48
CPC分类号： G01N33/57419
摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of colorectal cancer or a non-malignant disease of the large intestine. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion of the large intestine, subjects having a colorectal cancer or a metastasised colorectal cancer or subjects having a non-malignant disease of the large intestine. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of colorectal cancer or a non-malignant disease of the large intestine.
摘要翻译：本发明提供生物分子以及这些生物分子用于大肠癌或大肠非恶性疾病鉴别诊断的用途。特别地，本发明提供了用于检测测试样品内的生物分子的方法以及包含对于健康受试者，具有大肠癌前病变的受试者，具有结肠直肠癌或转移性结肠直肠癌的受试者的生物分子的质量分布的数据库或具有大肠非恶性疾病的受试者。此外，本发明提供了使用气相离子光谱法表征所述生物分子的方法。此外，本发明提供鉴定所述生物分子的方法，只要它们是蛋白质或多肽即可。本发明还提供了用于大肠癌或大肠非恶性疾病鉴别诊断的试剂盒。

7. 发明申请

WO2004102189A1 BIOMARKERS FOR THE DIFFERENTIAL DIAGNOSIS OF PANCREATITIS AND PANCREATIC CANCER 审中-公开
标题翻译：胰腺癌和胰腺癌差异诊断的生物标志物
公开(公告)号：WO2004102189A1
公开(公告)日：2004-11-25
申请号：PCT/EP2004/005293
申请日：2004-05-17
申请人： EUROPROTEOME AG , WIEMER, Jan , SEIBERT, Volker , MEUER, Jörn
发明人： WIEMER, Jan , SEIBERT, Volker , MEUER, Jörn
IPC分类号： G01N33/48
CPC分类号： G01N33/57438 , G01N33/57419
摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of pancreatitis and/or pancreatic cancer. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion of the pancreas, subjects having a pancreatic cancer or a metastasised pancreatic cancer or subjects having pancreatitis. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of pancreatitis or pancreatic cancer.
摘要翻译：本发明提供了生物分子和这些生物分子用于胰腺炎和/或胰腺癌鉴别诊断的用途。特别地，本发明提供了用于检测测试样品内的生物分子的方法以及包含对于健康受试者，具有胰腺癌前病变的受试者，具有胰腺癌或转移性胰腺癌的受试者的特异性生物分子的质量分布的数据库，或受试者患有胰腺炎。此外，本发明提供了使用气相离子光谱法表征所述生物分子的方法。此外，本发明提供鉴定所述生物分子的方法，只要它们是蛋白质或多肽即可。本发明还提供了用于胰腺炎或胰腺癌鉴别诊断的试剂盒。

8. 发明申请

WO2004102188A1 METHODS AND APPLICATIONS OF BIOMARKER PROFILES IN THE DIAGNOSIS AND TREATMENT OF BREAST CANCER 审中-公开
标题翻译：生物标记物在诊断和治疗乳腺癌方面的应用
公开(公告)号：WO2004102188A1
公开(公告)日：2004-11-25
申请号：PCT/EP2004/005292
申请日：2004-05-17
申请人： EUROPROTEOME AG , MEUER, Jörn , WIEMER, Jan
发明人： MEUER, Jörn , WIEMER, Jan
IPC分类号： G01N33/48
CPC分类号： G01N33/57438 , G01N33/57419
摘要： The present invention provides biomolecules and the use of these biomolecules for the differential diagnosis of a breast cancer and/or a non-malignant disease of the breast. In particular the present invention provides methods for detecting biomolecules within a test sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a precancerous lesion of the breast, subjects having a breast cancer or a metastasised breast cancer or subjects having a non-malignant disease of the breast. Furthermore, the present invention provides methods for the characterization of said biomolecules using gas phase ion spectrometry. In addition, the present invention provides methods for the identification of said biomolecules provided that they are proteins or polypeptides. The invention further provides kits for the differential diagnosis of a non-malignant disease of the breast or breast cancer.
摘要翻译：本发明提供生物分子以及这些生物分子用于乳腺癌和/或乳腺非恶性疾病鉴别诊断的用途。特别地，本发明提供了用于检测测试样品内的生物分子的方法以及数据库，其包含对于健康受试者，具有乳腺癌前病变的受试者，具有乳腺癌或转移性乳腺癌的受试者的特异性生物分子的质量曲线，或受试者具有乳腺的非恶性疾病。此外，本发明提供了使用气相离子光谱法表征所述生物分子的方法。此外，本发明提供鉴定所述生物分子的方法，只要它们是蛋白质或多肽即可。本发明还提供了用于乳腺癌或乳腺癌的非恶性疾病的鉴别诊断的试剂盒。

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