专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018039094A1 PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS 审中-公开
标题翻译：吡啶-1-氧化物衍生物及其作为因子XIA抑制剂的用途
公开(公告)号：WO2018039094A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/047718
申请日：2017-08-21
申请人： MERCK SHARP & DOHME CORP. , SHEN, Dong-Ming , KUANG, Rongze , KUMAR, Puneet , DUFFY, Joseph, L. , ZHU, Cheng , ALI, Amjad , YANG, Meng , DEBENHAM, John, S.
发明人： SHEN, Dong-Ming , KUANG, Rongze , KUMAR, Puneet , DUFFY, Joseph, L. , ZHU, Cheng , ALI, Amjad , YANG, Meng , DEBENHAM, John, S.
IPC分类号： C07D213/89 , A61K31/4425 , A61P7/02
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译：本发明提供式（I）化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。这些化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。

2. 发明申请

WO2020243049A1 FACTOR XI ACTIVATION INHIBITORS 审中-公开
公开(公告)号：WO2020243049A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034468
申请日：2020-05-26
申请人： MERCK SHARP & DOHME CORP. , HICKS, Jacqueline, D. , DEBENHAM, John, S. , ALI, Amjad , WEI, Lan , JIAN, Tianying , YANG, Dexi , OGAWA, Anthony, K. , FU, Wenlang , LOMBARDO, Matthew , KUANG, Rongze , YANG, Meng , SO, Sung-Sau , ELLSWORTH, Kenneth , NIZNER, Peter , TATOSIAN, Daniel, A. , WILKENING, Robert, R. , WANG, Jun
发明人： HICKS, Jacqueline, D. , DEBENHAM, John, S. , ALI, Amjad , WEI, Lan , JIAN, Tianying , YANG, Dexi , OGAWA, Anthony, K. , FU, Wenlang , LOMBARDO, Matthew , KUANG, Rongze , YANG, Meng , SO, Sung-Sau , ELLSWORTH, Kenneth , NIZNER, Peter , TATOSIAN, Daniel, A. , WILKENING, Robert, R. , WANG, Jun
IPC分类号： A61K31/4162 , A61P7/02
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

3. 发明申请

WO2017074832A1 FACTOR XIa INHIBITORS 审中-公开
标题翻译：因子XIa抑制剂
公开(公告)号：WO2017074832A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058362
申请日：2016-10-24
申请人： MERCK SHARP & DOHME CORP. , XU, Jiayi , ALI, Amjad , ZHOU, Wei , GAO, Ying-Duo , EDMONDSON, Scott, D. , MERTZ, Eric , NEELAMKAVIL, Santhosh, F. , LIU, Weiguo , SUN, Wanying , SHEN, Dong-Ming , HARPER, Bart , ZHU, Cheng , BARA, Thomas , LIM, Yeon-Hee , YANG, Meng
发明人： XU, Jiayi , ALI, Amjad , ZHOU, Wei , GAO, Ying-Duo , EDMONDSON, Scott, D. , MERTZ, Eric , NEELAMKAVIL, Santhosh, F. , LIU, Weiguo , SUN, Wanying , SHEN, Dong-Ming , HARPER, Bart , ZHU, Cheng , BARA, Thomas , LIM, Yeon-Hee , YANG, Meng
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4427 , C07D213/02 , C07D213/04 , C07D401/06
CPC分类号： C07D513/08 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/14 , C07D471/08 , C07D487/04 , C07D487/08
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
摘要翻译：本发明提供式（I）化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。这些化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。

4. 发明申请

WO2016183741A1 PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS 审中-公开
标题翻译：作为PDE2抑制剂的吡咯烷酮酰胺化合物
公开(公告)号：WO2016183741A1
公开(公告)日：2016-11-24
申请号：PCT/CN2015/079091
申请日：2015-05-15
申请人： MERCK SHARP & DOHME CORP. , SHEN, Dong-Ming , QIAN, XiaoXia , HARPER, Bart , YANG, Meng , WANG, Deping , BO, Yingjian
发明人： SHEN, Dong-Ming , QIAN, XiaoXia , HARPER, Bart , YANG, Meng , WANG, Deping , BO, Yingjian
IPC分类号： C07D239/28 , C07D239/36 , A61K31/495 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D487/04 , C07D239/38 , C07D239/42 , C07D239/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译：本发明涉及可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统和/或周围疾病的治疗剂的嘧啶酮酰胺化合物。本发明还涉及这些化合物用于治疗精神分裂症，精神病，阿尔茨海默氏症，认知障碍，焦虑症，抑郁症，偏头痛或亨廷顿氏病，帕金森病，帕金森病痴呆（PDD）和神经系统疾病与纹状体功能不全或基底神经节功能障碍相关的其他疾病。

5. 发明申请

WO2016154081A1 PYRAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS 审中-公开
标题翻译： PYRAZOLYL PYRIMIDINONE化合物作为PDE2抑制剂
公开(公告)号：WO2016154081A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023344
申请日：2016-03-21
申请人： MERCK SHARP & DOHME CORP. , SHEN, Dong-Ming , YANG, Meng , CRESPO, Alexander , WILSON, Jonathan, E. , MCCRACKEN, Troy , WANG, Deping , PARKER, Dann , GUO, Zack Zhiqiang
发明人： SHEN, Dong-Ming , YANG, Meng , CRESPO, Alexander , WILSON, Jonathan, E. , MCCRACKEN, Troy , WANG, Deping , PARKER, Dann , GUO, Zack Zhiqiang
IPC分类号： A01N43/90 , A61K31/535
CPC分类号： C07D403/04 , C07D401/14 , C07D405/14
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译：本发明涉及可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病的治疗剂的式I的嘧啶甲酰胺化合物。本发明还涉及这些化合物用于治疗精神分裂症，精神病，帕金森病，帕金森病痴呆（PDD）或亨廷顿舞蹈症等神经和精神疾病以及与纹状体功能不全或基底神经节功能障碍相关的疾病的用途。

6. 发明申请

WO2016186888A1 PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS 审中-公开
标题翻译：嘧啶酮酰胺化合物作为PDE2抑制剂
公开(公告)号：WO2016186888A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/031559
申请日：2016-05-10
申请人： MERCK SHARP & DOHME CORP. , SHEN, Dong-Ming , QIAN, XiaoXia , HARPER, Bart , YANG, Meng , WANG, Deping , BO, Yingjian
发明人： SHEN, Dong-Ming , QIAN, XiaoXia , HARPER, Bart , YANG, Meng , WANG, Deping , BO, Yingjian
IPC分类号： A61K31/505 , A61K31/513 , C07D233/96 , C07D239/24
CPC分类号： C07D487/04 , C07D239/38 , C07D239/42 , C07D239/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译：本发明涉及嘧啶酮酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统和/或外周病症的治疗剂。本发明还涉及这些化合物用于治疗神经和精神疾病如精神分裂症，精神病，阿尔茨海默氏症，认知障碍，焦虑症，抑郁症，偏头痛或亨廷顿病，帕金森病，帕金森病痴呆（PDD）和其他与纹状体功能减退或基底节功能障碍相关的疾病。

7. 发明申请

WO2011019538A1 SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 审中-公开
标题翻译：取代的环丙基化合物，包含这些化合物的组合物和处理方法
公开(公告)号：WO2011019538A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/044181
申请日：2010-08-03
申请人： MERCK SHARP & DOHME CORP. , WOOD, Harold, B. , ADAMS, Alan, D. , SZEWCZYK, Jason, W. , ZHANG, Yong , YANG, Meng
发明人： WOOD, Harold, B. , ADAMS, Alan, D. , SZEWCZYK, Jason, W. , ZHANG, Yong , YANG, Meng
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D401/14 , C07D401/04 , C07D413/14
摘要： Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译：式I的取代的环丙基化合物被公开用于治疗或预防2型糖尿病和类似病症。也包括药学上可接受的盐。该化合物可用作g-蛋白偶联受体GPR-119的激动剂。

8. 发明申请

WO2016133793A1 FACTOR IXa INHIBITORS 审中-公开
标题翻译：因子IXa抑制剂
公开(公告)号：WO2016133793A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/017652
申请日：2016-02-12
申请人： MERCK SHARP & DOHME CORP. , MENG, Dongfang , LI, Hong , YANG, Meng , RUIZ, Manuel de Lera , DEWNANI, Sunita, V. , JIAN, Tianying , PARKER, Dann, L., Jr. , ZHANG, Ting , CAMPEAU, Louis-Charles , HARPER, Bart , WOOD, Harold, B. , XU, Jiayi , BERGER, Richard , WU, Jane Yang , ORR, Robert, K. , WALSH, Shawn, P.
发明人： MENG, Dongfang , LI, Hong , YANG, Meng , RUIZ, Manuel de Lera , DEWNANI, Sunita, V. , JIAN, Tianying , PARKER, Dann, L., Jr. , ZHANG, Ting , CAMPEAU, Louis-Charles , HARPER, Bart , WOOD, Harold, B. , XU, Jiayi , BERGER, Richard , WU, Jane Yang , ORR, Robert, K. , WALSH, Shawn, P.
IPC分类号： A61K31/33 , A61K31/41 , A61K31/395 , A61K31/4164 , A61K31/4184
CPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D417/14 , C07D471/14 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
摘要翻译：本发明提供式I化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防不稳定型心绞痛，难治性心绞痛，心肌梗死，短暂性脑缺血发作，心房颤动，血栓性中风，栓塞性中风的方法，深静脉血栓形成，弥散性血管内凝血，眼纤维蛋白增多，以及再通血管再狭窄或再狭窄。该化合物是选择性因子IXa抑制剂。

9. 发明申请

WO2015096651A1 PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS 审中-公开
标题翻译： PYRIMIDONE羧酰胺化合物作为PDE2抑制剂
公开(公告)号：WO2015096651A1
公开(公告)日：2015-07-02
申请号：PCT/CN2014/094092
申请日：2014-12-17
申请人： MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD.
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译：公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。

10. 发明申请

WO2005057488A2 MODULAR SYSTEM FOR MULTI-COLOR, WHOLE BODY FLUORESCENCE IMAGING 审中-公开
标题翻译：多色，全身荧光成像的模块化系统
公开(公告)号：WO2005057488A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/040787
申请日：2004-12-02
申请人： ANTICANCER, INC. , BARANOV, Eugene , YANG, Meng
发明人： BARANOV, Eugene , YANG, Meng
IPC分类号： G06T
CPC分类号： A61B5/0059 , A61B2503/40 , G01N35/025
摘要： The disclosed invention relates to a modular system (10) for multi-color, whole-body fluorescence imaging, comprising a primary conveyor (100) comprising a holding cell (105) for holding a subject; and optico-mechanical chamber (110) comprising an entry port (111) and an exit port (112), wherein the entry port is adapted to receive the subject from the holding cell; a secondary conveyor (115) comprising the optico-mechanical chamber; a two-sided double imaging chamber (120) adapted to receive the optico-mechanical chamber provided by the secondary conveyor; an illuminator (130) comprising a plurality of optical guides (131), wherein the optical guides illuminate the two-sided double imaging chamber; and an imaging system (140) comprising a camera (141) and a controller (142), wherein the camera is positioned to image the subject within the optico-mechanical chamber within the two-sided double imaging chamber and the controller can access images of the gathered by the camera.
摘要翻译：所公开的发明涉及一种用于多色全身荧光成像的模块化系统（10），包括：主传送器（100），包括用于保持对象的保持单元（105）; 以及光学机械腔室（110），其包括进入口（111）和出口（112），其中所述入口适于从所述保持单元接收所述受试者; 包括光学机械室的次级输送机（115）双面双成像室（120），适于接收由次级输送机提供的光学机械室; 包括多个光导（131）的照明器（130），其中所述光导照射所述双面双成像室; 以及包括相机（141）和控制器（142）的成像系统（140），其中所述照相机被定位成在所述双面双成像室内的光学机械室内成像所述对象，并且所述控制器可以访问由相机聚集。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式