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1. 发明申请

WO2022133205A1 SYNTHESIS OF ANTIVIRAL NUCLEOSIDES 审中-公开
公开(公告)号：WO2022133205A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/064021
申请日：2021-12-17
申请人： MERCK SHARP & DOHME CORP. , BENKOVICS, Tamas , FIER, Patrick, S. , FRYSZKOWSKA, Anna , HUFFMAN, Mark, A. , ITOH, Tetsuji , KONG, Jongrock , MALIGRES, Peter, E. , MALONEY, Kevin, M. , MCINTOSH, John , MURPHY, Grant, S. , SILVERMAN, Steven, M. , YANG, Hao
发明人： BENKOVICS, Tamas , FIER, Patrick, S. , FRYSZKOWSKA, Anna , HUFFMAN, Mark, A. , ITOH, Tetsuji , KONG, Jongrock , MALIGRES, Peter, E. , MALONEY, Kevin, M. , MCINTOSH, John , MURPHY, Grant, S. , SILVERMAN, Steven, M. , YANG, Hao
IPC分类号： A61K31/7068 , A61K31/7072 , A61K31/14 , C07H1/00 , C07H19/067 , C07H19/10
摘要： The present invention relates to efficient synthetic processes useful in the preparation of antiviral nucleosides, particularly uridine 4-oxime 5'-(2-methylpropanoate) {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]oxolan-2-yl}methyl 2-methylpropanoate and pharmaceutically acceptable salts, derivatives, tautomers, isomers, and prodrugs of, which may be active as antiviral agents, as well as compositions and methods thereof. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

2. 发明申请

WO2022132543A1 S-METHYLTHIORIBOSE KINASE POLYPEPTIDES AND PROCESSES FOR MAKING AND USING S-METHYLTHIORIBOSE KINASE POLYPEPTIDES 审中-公开
公开(公告)号：WO2022132543A1
公开(公告)日：2022-06-23
申请号：PCT/US2021/062503
申请日：2021-12-09
申请人： MERCK SHARP & DOHME CORP. , BENKOVICS, Tamas , HO, Hsing-I , MCINTOSH, John, A. , MURPHY, Grant, S. , PAN, Weilan , VERMA, Deeptak , YANG, Hao
发明人： BENKOVICS, Tamas , HO, Hsing-I , MCINTOSH, John, A. , MURPHY, Grant, S. , PAN, Weilan , VERMA, Deeptak , YANG, Hao
IPC分类号： C12N9/12 , C12P19/30 , C12N15/54
摘要： The present disclosure provides MTR kinase polypeptides having improved properties as compared to a naturally occurring wild-type MTR kinase polypeptide including the capability of phosphorylating D-ribose and 5'-D-isobutyrylribose to give alpha-D-ribose-1-phosphate and alpha 5'-D-isobutyrylribose-1-phosphate. Also provided are polynucleotides encoding the MTR kinase polypeptides, host cells capable of expressing the MTR kinase polypeptides, and methods of using the MTR kinase polypeptides to synthesize alpha-D-ribose-1-phosphate and alpha 5'-D-isobutyrylribose-1-phosphate.

3. 发明申请

WO2014036685A1 METHOD AND APPARATUS FOR LOCATION-BASED PUBLICATIONS AND SUBSCRIPTIONS 审中-公开
标题翻译：基于位置的出版物和订阅的方法和装置
公开(公告)号：WO2014036685A1
公开(公告)日：2014-03-13
申请号：PCT/CN2012/080964
申请日：2012-09-04
申请人： NOKIA CORPORATION , CHOW, Likhang , YANG, Hao , LIU, Zhen
发明人： CHOW, Likhang , YANG, Hao , LIU, Zhen
IPC分类号： H04L12/56
CPC分类号： H04L67/18 , G06Q30/0259 , G06Q30/0261 , H04W4/021
摘要： A method, apparatus, computer program product and system are provided for providing mobile services via a scalable location-based publication/subscription system. In this regard, a method is provided that includes receiving at least one subscription comprising a subscription area and at least one publication comprising a publication location. The method further includes determining a geohash representation of the subscription area and determining whether the at least one publication matches the at least one subscription based at least on the publication location and the geohash representation of the subscription area. The method further includes causing content associated with the at least one publication to be transmitted in an instance in which the at least one publication matches the at least one subscription.
摘要翻译：提供了一种方法，装置，计算机程序产品和系统，用于通过可扩展的基于位置的发布/订阅系统提供移动服务。在这方面，提供了一种方法，其包括接收包括订阅区域的至少一个订阅和包含发布位置的至少一个发布。所述方法还包括确定所述订阅区域的地理位置表示，以及至少基于所述发布位置和所述订阅区域的所述地理位置表示来确定所述至少一个发布是否匹配所述至少一个订阅。所述方法还包括在所述至少一个出版物与所述至少一个订阅匹配的实例中引起与所述至少一个发布相关联的内容。

4. 发明申请

WO2013113172A1 METHOD AND APPARATUS FOR ADVERTISEMENTS IN MOBILE CONTENT DISTRIBUTION SYSTEMS 审中-公开
标题翻译：移动内容分发系统广告的方法和装置
公开(公告)号：WO2013113172A1
公开(公告)日：2013-08-08
申请号：PCT/CN2012/070879
申请日：2012-02-03
申请人： NOKIA CORPORATION , LIU, Dong E. , YANG, Hao , TIAN, Jilei
发明人： LIU, Dong E. , YANG, Hao , TIAN, Jilei
IPC分类号： H04N7/00
CPC分类号： G06Q30/0267 , G06Q30/0251
摘要： An approach is provided for optimally matching advertisements to content items for targeted consumers using the content distribution characteristics. A distribution processor determines one or more distribution characteristics of one or more first content items that are distributed among one or more devices. The distribution processor then processes and/or facilitates processing of the one or more distribution characteristics to cause, at least in part, a selection of one or more second content items. In one scenario, the one or more second content items may include advertisements. From there, the distribution processor processes and/or facilitates a processing of the one or more first content items to cause, at least in part, an embedding of the one or more second content items in the one or more first content items.
摘要翻译：提供了一种用于使用内容分发特征将广告与目标消费者的内容项目进行最佳匹配的方法。分配处理器确定分布在一个或多个设备之间的一个或多个第一内容项的一个或多个分布特性。分配处理器然后处理和/或促进对一个或多个分布特征的处理，以至少部分地导致选择一个或多个第二内容项。在一种情况下，一个或多个第二内容项目可以包括广告。从那里，分发处理器处理和/或促进对一个或多个第一内容项的处理，以至少部分地使一个或多个第二内容项在一个或多个第一内容项中嵌入。

5. 发明申请

WO2012075643A1 METHOD AND APPARATUS FOR PROVIDING CONTEXT-BASED COUPON SHARING 审中-公开
标题翻译：提供基于语境分析的方法和装置
公开(公告)号：WO2012075643A1
公开(公告)日：2012-06-14
申请号：PCT/CN2010/079667
申请日：2010-12-10
申请人： NOKIA CORPORATION , LIU, Dong , LI, Jiang , YANG, Hao , SONG, Zhanjiang
发明人： LIU, Dong , LI, Jiang , YANG, Hao , SONG, Zhanjiang
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0269 , G06Q30/02
摘要： An approach is provided for context-based coupon sharing. A coupon management platform receives a request specifying an exchange of one or more coupons. The request includes, at least in part, one or more attribute-condition pairs associated with the one or more coupons, one or more participants of the exchange, or a combination thereof. The coupon management platform determines context data associated with a first user, at least one device associated with the first user, at least one second user, at least one other device associated with the at least one second user, or a combination thereof. The coupon management platform then causes, at least in part, processing of the one or more attribute-condition pairs, the context data, or a combination thereof for initiating the exchange between the first user and the at least one second user.
摘要翻译：为基于上下文的优惠券共享提供了一种方法。优惠券管理平台收到指定一个或多个优惠券交换的请求。该请求至少部分地包括与一个或多个优惠券相关联的一个或多个属性条件对，交换的一个或多个参与者或其组合。优惠券管理平台确定与第一用户相关联的上下文数据，与第一用户相关联的至少一个设备，至少一个第二用户，与至少一个第二用户相关联的至少一个其他设备或其组合。优惠券管理平台至少部分地对一个或多个属性条件对，上下文数据或其组合进行处理，用于启动第一用户与至少一个第二用户之间的交换。

6. 发明申请

WO2008119672A3 METHOD AND SYSTEM FOR RESILIENT PACKET TRACEBACK IN WIRELESS MESH AND SENSOR NETWORKS 审中-公开
公开(公告)号：WO2008119672A3
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053325
申请日：2008-03-19
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , LIU, Zhen , YANG, Hao , YE, Fan
发明人： LIU, Zhen , YANG, Hao , YE, Fan
IPC分类号： H04L29/06 , H04L12/22
摘要： A system and method for packet traceback in a network includes maintaining an identity number (ID) for each node in a network and generating a signature (e.g., a message authentication code (MAC)) using a secret key shared between each node on a forwarding path and a sink. Each forwarding node leaves a mark by appending its ID and a signature in the packet, either in a deterministic manner or with a probability. Upon receiving a packet at the sink, correctness of the signatures included in each packet is verified in the reverse order by which these signatures were appended. A last valid MAC is determined in the forwarding path to determine the locations of compromised nodes that collude in false data injection attacks.

7. 发明申请

WO2013170443A1 METHOD AND APPARATUS FOR COUPON REDEMPTION BASED ON CONNECTIVITY AND SPATIAL CONFIGURATION 审中-公开
标题翻译：基于连通性和空间配置的赎回方法和装置
公开(公告)号：WO2013170443A1
公开(公告)日：2013-11-21
申请号：PCT/CN2012/075516
申请日：2012-05-15
申请人： NOKIA CORPORATION , JOSHI, Dhaval Jitendra , YANG, Hao
发明人： JOSHI, Dhaval Jitendra , YANG, Hao
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0225 , G06Q30/0233 , G06Q30/06 , H04L43/08 , H04L67/1095 , H04W4/02
摘要： An approach is provided for validating redemption of a coupon. The coupon management module causes, at least in part, presentation of a coupon via a device. Next, the coupon management module receives a first code in response to the presentation. Next, the coupon management module causes, at least in part, validation of a redemption of the coupon based, at least in part, on the first code. The validation is performed at the device, at a server, or a combination thereof. Next, the coupon management module retrieves a second code based, at least in part, on the coupon, the first code, or a combination thereof. Next, the coupon management module causes, at least in part, presentation of the second code for verification. The validation of the redemption of the coupon is further based, at least in part, on the verification of the second code.
摘要翻译：提供了一种验证兑换优惠券的方法。优惠券管理模块至少部分地通过设备呈现优惠券。接下来，优惠券管理模块响应于呈现而接收第一代码。接下来，优惠券管理模块至少部分地至少部分地基于第一代码来验证优惠券的兑换。验证在设备，服务器或其组合处执行。接下来，优惠券管理模块至少部分地基于优惠券，第一代码或其组合来检索第二代码。接下来，优惠券管理模块至少部分地导致第二代码的呈现用于验证。抵押券的兑换的验证进一步基于第二个代码的验证。

8. 发明申请

WO2011066043A1 SYSTEM AND METHOD FOR PROVIDING QUALITY OF SERVICE IN WIDE-AREA MESSAGING FABRIC 审中-公开
标题翻译：提供广域服务质量的系统和方法
公开(公告)号：WO2011066043A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/053032
申请日：2010-10-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , KARENOS, Kyriakos , YE, Fan , KIM, Minkyong , LEI, Hui , PENDARAKIS, Dimitrios , YANG, Hao
发明人： KARENOS, Kyriakos , YE, Fan , KIM, Minkyong , LEI, Hui , PENDARAKIS, Dimitrios , YANG, Hao
IPC分类号： G06F15/173
CPC分类号： H04L45/00 , H04L45/24 , H04L45/302
摘要： Techniques for transmitting data according to at least one quality of service requirement. A message path is calculated specifying a sequence of broker computers selected from a network of interconnected broker computers. The message path is statistically estimated to fulfill the at least one quality of service requirement. Quality of service metrics are received about the network of interconnected broker computers. If the message path is determined not to fulfill the quality of service requirement, a new message path is calculated specifying a new sequence of broker computers selected from the network of interconnected broker computers. The new message path is statistically estimated to fulfill the at least one quality of service requirement.
摘要翻译：根据至少一种服务质量要求传输数据的技术。计算消息路径，指定从互连代理计算机的网络中选择的代理计算机的序列。统计估计消息路径以满足至少一个服务质量要求。收到关于互联经纪电脑网络的服务质量指标。如果消息路径被确定为不满足服务质量要求，则计算新的消息路径，指定从互连代理计算机的网络中选择的新的代理计算机序列。统计估计新消息路径以满足至少一个服务质量要求。

9. 发明申请

WO2010037763A1 EXCHANGEABLE CARRIERS PRE-LOADED WITH REAGENT DEPOTS FOR DIGITAL MICROFLUIDICS 审中-公开
标题翻译：与数字微流控试剂预付的可交换载体
公开(公告)号：WO2010037763A1
公开(公告)日：2010-04-08
申请号：PCT/EP2009/062657
申请日：2009-09-30
申请人： TECAN TRADING AG , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , WHEELER, Aaron R. , BARBULOViC-NAD, Irena , YANG, Hao , ABDELGAWAD, Mohamed
发明人： WHEELER, Aaron R. , BARBULOViC-NAD, Irena , YANG, Hao , ABDELGAWAD, Mohamed
IPC分类号： B01L3/00
CPC分类号： B01L3/502784 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0867 , B01L2300/161 , B01L2400/0427
摘要： The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital microfluidic (DMF) device (14). The carrier (10) facilitates virtually un-limited re-use of the DMF devices (14) avoiding cross- contamination on the electrode array (16) itself, as well as enabling rapid exchange of pre-loaded reagents (12) while bridging the world-to-chip interface of DMF devices (14). The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications.
摘要翻译：本发明提供可更换的试剂预加载载体（10），优选为塑料片的形式，其可暂时施加到数字微流体（DMF）装置（14）上的电极阵列（16）。载体（10）有助于几乎不受限制地使用DMF装置（14），以避免电极阵列（16）本身上的交叉污染，并且能够快速交换预加载的试剂（12），同时桥接 DMF设备的世界到芯片接口（14）。本发明允许将DMF转化成用于芯片实验室的通用平台。

10. 发明申请

WO2008144970A1 A NOVEL AND HIGHLY STEREOSELECTIVE PROCESS FOR PREPARING GEMCITABINE AND INTERMEDIATES THEREOF 审中-公开
标题翻译：一种用于制备化合物及其中间体的新型高选择性方法
公开(公告)号：WO2008144970A1
公开(公告)日：2008-12-04
申请号：PCT/CN2007/002672
申请日：2007-09-07
申请人： NANJING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD. , XU, Yongxiang , YANG, Hao , HOU, Wen
发明人： XU, Yongxiang , YANG, Hao , HOU, Wen
IPC分类号： C07H19/073 , C07H3/08
CPC分类号： C07H19/073 , C07H3/08
摘要： The present invention provides a novel and highly stereoselective process for preparing gemcitabine, which is suitable for industrial production, wherein, it includes the following reactions. Additionally, the invention discloses the key intermediates. The definition for the groups of G1, G2, G3, G4, and G5 are described in the specification.
摘要翻译：本发明提供了一种适用于工业生产的吉西他滨的新型高度立体选择性方法，其中包括以下反应。此外，本发明公开了关键中间体。说明书中描述了G1，G2，G3，G4和G5组的定义。

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