专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016053771A1 INHIBITORS OF IRAK4 ACTIVITY 审中-公开
标题翻译： IRAK4活性抑制剂
公开(公告)号：WO2016053771A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/052111
申请日：2015-09-25
申请人： MERCK SHARP & DOHME CORP. , ALTMAN, Michael, D. , ANDRESEN, Brian, M. , BRUBAKER, Jason, D. , CHILDERS, Matthew, L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig, R. , KATTAR, Solomon, D. , LESBURG, Charles, A. , LIM, Jongwon , MACLEAN, John, K. F. , MANSOOR, Umar, F. , NORTHRUP, Alan, B. , SANDERS, John, M. , SMITH, Graham, F. , TORRES, Luis
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian, M. , BRUBAKER, Jason, D. , CHILDERS, Matthew, L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig, R. , KATTAR, Solomon, D. , LESBURG, Charles, A. , LIM, Jongwon , MACLEAN, John, K. F. , MANSOOR, Umar, F. , NORTHRUP, Alan, B. , SANDERS, John, M. , SMITH, Graham, F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： C07D498/04 , A61K31/517 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P37/00 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/048 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译：本发明涉及式（I）的IRAK4的抑制剂，并提供包含这些抑制剂的组合物，以及其用于治疗IRAK4介导的或相关的病症或疾病的方法。

2. 发明申请

WO2016053770A1 INHIBITORS OF IRAK4 ACTIVITY 审中-公开
标题翻译： IRAK4活性抑制剂
公开(公告)号：WO2016053770A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/052106
申请日：2015-09-25
申请人： MERCK SHARP & DOHME CORP. , ALTMAN, Michael, D. , ANDRESEN, Brian, M. , BRUBAKER, Jason, D. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig, R. , LESBURG, Charles, A. , LIM, Jongwon , MACLEAN, John, K. F. , MANSOOR, Umar, F. , NORTHRUP, Alan, B. , SANDERS, John, M. , SMITH, Graham, F. , TORRES, Luis
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian, M. , BRUBAKER, Jason, D. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig, R. , LESBURG, Charles, A. , LIM, Jongwon , MACLEAN, John, K. F. , MANSOOR, Umar, F. , NORTHRUP, Alan, B. , SANDERS, John, M. , SMITH, Graham, F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： A61K31/517 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译：本发明涉及式I的IRAK4的抑制剂，并提供了包含此类抑制剂的组合物，以及用于治疗IRAK4介导的或相关的病症或疾病的方法。

3. 发明申请

WO2014146493A1 ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 审中-公开
标题翻译：交联氰基乙基吡唑啉酮作为甘油激酶抑制剂
公开(公告)号：WO2014146493A1
公开(公告)日：2014-09-25
申请号：PCT/CN2014/000299
申请日：2014-03-19
申请人： MERCK SHARP & DOHME CORP. , DINSMORE, Christopher , FULLER, Peter , GUERIN, David , KATZ, Jason David , THOMPSON, Christopher F. , FALCONE, Danielle , DENG, Wei , TORRES, Luis , ZENG, Hongbo , BAI, Yunfeng , FU, Jianmin , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
发明人： DINSMORE, Christopher , FULLER, Peter , GUERIN, David , KATZ, Jason David , THOMPSON, Christopher F. , FALCONE, Danielle , DENG, Wei , TORRES, Luis , ZENG, Hongbo , BAI, Yunfeng , FU, Jianmin , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D487/04 , C07D487/08 , C07D487/14 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

4. 发明申请

WO2020092136A1 N-HETEROARYL INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
公开(公告)号：WO2020092136A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/057981
申请日：2019-10-25
申请人： MERCK SHARP & DOHME CORP. , SIMOV, Vladimir , KAPLAN, William, P. , ACTON, John, J., III , ARDOLINO, Michael, J. , CHEN, Joanna, L. , FULLER, Peter, H. , GUNAYDIN, Hakan , LI, Derun , LIU, Ping , LOGAN, Kaitlyn Marie , METHOT, Joey , MORRIELLO, Gregori, J. , NEELAMKAVIL, Santhosh, F. , TORRES, Luis , YAN, Xin , ZHOU, Hua
发明人： SIMOV, Vladimir , KAPLAN, William, P. , ACTON, John, J., III , ARDOLINO, Michael, J. , CHEN, Joanna, L. , FULLER, Peter, H. , GUNAYDIN, Hakan , LI, Derun , LIU, Ping , LOGAN, Kaitlyn Marie , METHOT, Joey , MORRIELLO, Gregori, J. , NEELAMKAVIL, Santhosh, F. , TORRES, Luis , YAN, Xin , ZHOU, Hua
IPC分类号： A61K31/4985 , A61K31/519 , C07D471/04
摘要： The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

5. 发明申请

WO2018071283A1 KDM5 INHIBITORS 审中-公开
标题翻译： KDM5抑制剂
公开(公告)号：WO2018071283A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/055464
申请日：2017-10-06
申请人： MERCK SHARP & DOHME CORP. , MANSOOR, Umar Faruk , FISCHER, Christian , SILIPHAIVANH, Phieng , TORRES, Luis , GUNAYDIN, Hakan , SLOMAN, David, L.
发明人： MANSOOR, Umar Faruk , FISCHER, Christian , SILIPHAIVANH, Phieng , TORRES, Luis , GUNAYDIN, Hakan , SLOMAN, David, L.
IPC分类号： A61K31/4353 , C07D471/04
摘要： The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.
摘要翻译：本发明提供了作为KDM5抑制剂的式（I）化合物（表示为互变异构体Ia和Ib）或其药学上可接受的盐。

6. 发明申请

WO2014146491A1 GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 审中-公开
标题翻译：作为JANUS KINASE抑制剂的GEMYALLY取代的氰基乙基吡唑啉吡啶
公开(公告)号：WO2014146491A1
公开(公告)日：2014-09-25
申请号：PCT/CN2014/000297
申请日：2014-03-19
申请人： MERCK SHARP & DOHME CORP. , CHILDERS, Matthew Lloyd , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , MARTINEZ, Michelle , FALCONE, Danielle , TORRES, Luis , DENG, Yongqi , KURUKLASURIYA, Ravi , ZENG, Hongbo , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
发明人： CHILDERS, Matthew Lloyd , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , MARTINEZ, Michelle , FALCONE, Danielle , TORRES, Luis , DENG, Yongqi , KURUKLASURIYA, Ravi , ZENG, Hongbo , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D471/04 , C07D309/02 , C07D211/00 , C07D205/04 , A61K31/437 , A61K31/444 , A61P37/00 , A61P29/00 , A61P19/02
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：本发明提供了作为JAK抑制剂的式（I）化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

7. 发明申请

WO2020247298A2 1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
公开(公告)号：WO2020247298A2
公开(公告)日：2020-12-10
申请号：PCT/US2020/035505
申请日：2020-06-01
申请人： MERCK SHARP & DOHME CORP. , ZHOU, Hua , ACTON, John, J., III , ARDOLINO, Michael, J. , CHEN, Yi-Heng , FULLER, Peter, H. , GULATI, Anmol , JOHNSON, Rebecca Elizabeth , KAPLAN, William, P. , KATTAR, Solomon, D. , KEYLOR, Mitchell, H. , LI, Derun , LOGAN, Kaitlyn Marie , LU, Min , MORRIELLO, Gregori, J. , NEELAMKAVIL, Santhosh, F. , PIO, Barbara , SCIAMMETTA, Nunzio , SIMOV, Vladimir , SU, Jing , TORRES, Luis , YAN, Xin
发明人： ZHOU, Hua , ACTON, John, J., III , ARDOLINO, Michael, J. , CHEN, Yi-Heng , FULLER, Peter, H. , GULATI, Anmol , JOHNSON, Rebecca Elizabeth , KAPLAN, William, P. , KATTAR, Solomon, D. , KEYLOR, Mitchell, H. , LI, Derun , LOGAN, Kaitlyn Marie , LU, Min , MORRIELLO, Gregori, J. , NEELAMKAVIL, Santhosh, F. , PIO, Barbara , SCIAMMETTA, Nunzio , SIMOV, Vladimir , SU, Jing , TORRES, Luis , YAN, Xin
IPC分类号： C07D471/02
摘要： The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6- disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

8. 发明申请

WO2014146490A1 CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 审中-公开
标题翻译：甘氨酸激酶抑制剂CYCLOALKYL NITRILE PYRAZOLO PYRIDONES
公开(公告)号：WO2014146490A1
公开(公告)日：2014-09-25
申请号：PCT/CN2014/000296
申请日：2014-03-19
申请人： MERCK SHARP & DOHME CORP. , CHILDERS, Matthew Lloyd , DINSMORE, Christopher , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , ZHANG, Hongjun , FALCONE, Danielle , TORRES, Luis , BRUBAKER, Jason , ZENG, Hongbo , CAI, Jiaqiang , DU, Xiaoxing , WANG, Chonggang , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
发明人： CHILDERS, Matthew Lloyd , DINSMORE, Christopher , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , ZHANG, Hongjun , FALCONE, Danielle , TORRES, Luis , BRUBAKER, Jason , ZENG, Hongbo , CAI, Jiaqiang , DU, Xiaoxing , WANG, Chonggang , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC分类号： C07D487/04 , C07D487/08 , C07D487/14 , A61K31/437 , A61K31/4375 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译：提供了式I化合物，其是JAK抑制剂，并且可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

9. 发明申请

WO2013081535A1 SCRAPER 审中-公开
标题翻译：刮刀
公开(公告)号：WO2013081535A1
公开(公告)日：2013-06-06
申请号：PCT/SE2012/051306
申请日：2012-11-27
申请人： TORRES, Luis
发明人： TORRES, Luis
IPC分类号： B60S3/04 , A47L1/06 , A47L1/16
CPC分类号： A47L1/06 , A47L1/16
摘要： A scraper (100) for removal of fogging, frost and/or ice from a surface having a concave profile comprises a grip part (120) and a flexible blade (140). The grip part (120) is adapted to be gripped by the hand of a user, and is connected to the flexible blade (140) along at least one proximal edge (140p) thereof. The flexible blade (140) is configured to be shape adapted along a distal edge (140d) to about against the concave profile of the surface. The scraper (100) also comprises a collecting means (160) for receiving removed fogging, frost and/or ice, which collecting means (160) is arranged essentially parallel to the distal edge (140d) of the flexible blade (140).
摘要翻译：用于从具有凹形轮廓的表面去除起雾，霜和/或冰的刮刀（100）包括握持部分（120）和柔性叶片（140）。握持部分（120）适于被使用者的手抓住，并且沿着其至少一个近侧边缘（140p）连接到柔性刀片（140）。柔性叶片（140）构造成沿着远端边缘（140d）适配成大致抵靠表面的凹形轮廓。刮刀（100）还包括用于接收除去的雾化，霜和/或冰的收集装置（160），该收集装置（160）基本上平行于柔性叶片（140）的远端边缘（140d）布置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式