发明申请
WO2014146491A1 GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
审中-公开
基本信息:
- 专利标题： GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
- 专利标题（中）：作为JANUS KINASE抑制剂的GEMYALLY取代的氰基乙基吡唑啉吡啶
- 申请号：PCT/CN2014/000297 申请日：2014-03-19
- 公开(公告)号：WO2014146491A1 公开(公告)日：2014-09-25
- 发明人： CHILDERS, Matthew Lloyd , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , MARTINEZ, Michelle , FALCONE, Danielle , TORRES, Luis , DENG, Yongqi , KURUKLASURIYA, Ravi , ZENG, Hongbo , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
- 申请人： MERCK SHARP & DOHME CORP. , CHILDERS, Matthew Lloyd , FULLER, Peter , GUERIN, David , KATZ, Jason David , PU, Qinglin , SCOTT, Mark E. , THOMPSON, Christopher F. , MARTINEZ, Michelle , FALCONE, Danielle , TORRES, Luis , DENG, Yongqi , KURUKLASURIYA, Ravi , ZENG, Hongbo , BAI, Yunfeng , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK SHARP & DOHME CORP.,CHILDERS, Matthew Lloyd,FULLER, Peter,GUERIN, David,KATZ, Jason David,PU, Qinglin,SCOTT, Mark E.,THOMPSON, Christopher F.,MARTINEZ, Michelle,FALCONE, Danielle,TORRES, Luis,DENG, Yongqi,KURUKLASURIYA, Ravi,ZENG, Hongbo,BAI, Yunfeng,KONG, Norman,LIU, Yumei,ZHENG, Zhixiang
- 当前专利权人： MERCK SHARP & DOHME CORP.,CHILDERS, Matthew Lloyd,FULLER, Peter,GUERIN, David,KATZ, Jason David,PU, Qinglin,SCOTT, Mark E.,THOMPSON, Christopher F.,MARTINEZ, Michelle,FALCONE, Danielle,TORRES, Luis,DENG, Yongqi,KURUKLASURIYA, Ravi,ZENG, Hongbo,BAI, Yunfeng,KONG, Norman,LIU, Yumei,ZHENG, Zhixiang
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： LIU, SHEN & ASSOCIATES
- 优先权： CNPCT/CN2013/072873 20130319
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D309/02 ; C07D211/00 ; C07D205/04 ; A61K31/437 ; A61K31/444 ; A61P37/00 ; A61P29/00 ; A61P19/02
摘要：
The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要（中）：
本发明提供了作为JAK抑制剂的式（I）化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物，C07D451/00至C07D463/00不包括的 |
| --------C07D471/02 | .在稠环系中含两个杂环 |
| ----------C07D471/04 | ..邻位稠环系 |