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1. 发明申请

WO2017053216A3 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF 审中-公开
标题翻译： 4'-取代的核苷反义转录酶抑制剂及其制备
公开(公告)号：WO2017053216A3
公开(公告)日：2017-05-18
申请号：PCT/US2016052409
申请日：2016-09-19
申请人： MERCK SHARP & DOHME , MERCK SHARP & DOHME , GIRIJAVALLABHAN VINAY M , MCLAUGHLIN MARK , CLEATOR EDWARD , KONG JONGROCK , GIBSON ANDREW WILLIAM , LIEBERMAN DAVID R , DIEGUEZ VAZQUEZ ALEJANDRO , KEEN STEPHEN PHILIP , WILLIAMS MICHAEL J , MOORE JEFFREY C , MILCZEK ERIKA M , PENG FENG , BELYK KEVIN M , SONG ZHIGUO JAKE
发明人： GIRIJAVALLABHAN VINAY M , MCLAUGHLIN MARK , CLEATOR EDWARD , KONG JONGROCK , GIBSON ANDREW WILLIAM , LIEBERMAN DAVID R , DIEGUEZ VAZQUEZ ALEJANDRO , KEEN STEPHEN PHILIP , WILLIAMS MICHAEL J , MOORE JEFFREY C , MILCZEK ERIKA M , PENG FENG , BELYK KEVIN M , SONG ZHIGUO JAKE
IPC分类号： A61K38/44 , C12N1/20
CPC分类号： A61K45/06 , C07D307/33 , C07H1/00 , C07H19/14 , C07H19/16 , C07H23/00
摘要： The present invention is directed to 4'-substituted nucleoside derivatives of Formula (I) and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4'-substituted nucleoside derivatives of Formula (I) and derivatives thereof.
摘要翻译：本发明涉及式（I）的4'-取代的核苷衍生物及其在抑制HIV逆转录酶，预防HIV感染，HIV感染治疗以及预防，治疗和延迟在艾滋病和/或ARC的发病或进展中。本发明还提供了制备式（I）的4'-取代的核苷衍生物及其衍生物的方法。

2. 发明申请

WO2007030807A2 LIQUID VISUAL DISPLAY 审中-公开
标题翻译：液体视觉显示
公开(公告)号：WO2007030807A2
公开(公告)日：2007-03-15
申请号：PCT/US2006035231
申请日：2006-09-08
申请人： STANADYNE CORP , JANIK LEON P , FERREIRA DAVID , WILLIAMS MICHAEL J
发明人： JANIK LEON P , FERREIRA DAVID , WILLIAMS MICHAEL J
IPC分类号： B01D35/00
CPC分类号： B01D35/143 , B01D29/606 , B01D46/0086 , B01D46/4254 , B01D46/446
摘要： A display provides indicates the remaining useful life of a filter element by providing a visible level of fluid in the display corresponding to the remaining useful life. The fluid level is adjusted by a valve responsive to a pressure differential across the filter element. An increasing pressure differential produces an increased fluid level in the display. The display may be provided with markings indicating that a particular fluid level in the display corresponds to the need to change a filter cartridge containing the filter element.
摘要翻译：显示器提供通过在显示器中提供与剩余使用寿命相对应的可见水平的流体来指示过滤元件的剩余使用寿命。通过响应于过滤元件上的压力差的阀来调节流体液位。增加的压力差在显示器中产生增加的液位。显示器可以设置有指示显示器中的特定流体水平对应于需要改变包含过滤元件的滤筒的标记。

3. 发明申请

WO2012054506A3 CARPET CLEANING SYSTEM AND METHOD 审中-公开
标题翻译：地毯清洁系统和方法
公开(公告)号：WO2012054506A3
公开(公告)日：2012-07-19
申请号：PCT/US2011056742
申请日：2011-10-18
申请人： DIVERSEY INC , KRON RYAN E , WILLIAMS MICHAEL J , JONES RONALD
发明人： KRON RYAN E , WILLIAMS MICHAEL J , JONES RONALD
IPC分类号： A47L11/34 , A47L11/162 , A47L11/283
CPC分类号： A47L11/283 , A46B13/008 , A47L11/34 , A47L11/4038 , A47L11/4083 , A47L11/4088
摘要： A carpet cleaning system including a cleaning agent that is one of dilutable with and dissolvable in water to generate a cleaning solution. The cleaning system includes a brush disc that has a substantially bowl-shaped glide plate, and bristles disposed in a bristle region. The cleaning system further includes a carpet cleaning apparatus that has a reservoir for containing the cleaning solution, a motor, an aeration device, a power source, and a control system. The motor rotatably actuates the brush disc. The aeration device is fluidly coupled to the reservoir for aerating the cleaning solution to generate foam. The aeration device dispenses foam into at least one of the opening of the glide plate and the bristle region at a rate equivalent to between about 0.028 gallons per minute and about 0.042 gallons per minute.
摘要翻译：一种地毯清洁系统，其包括清洁剂，所述清洁剂是可用水稀释并溶于水中以产生清洁溶液的清洁剂。该清洁系统包括具有基本上碗形滑动板的刷盘和布置在刷毛区域中的刷毛。清洁系统还包括地毯清洁装置，其具有用于容纳清洁溶液的容器，马达，曝气装置，电源和控制系统。马达可旋转地驱动刷盘。通气装置流体连接到储存器，用于通气清洁溶液以产生泡沫。通气装置以等于约0.028加仑/分钟和约0.042加仑/分钟之间的速率将泡沫分配到滑动板和刷毛区域的至少一个开口中。

4. 发明申请

WO2007030608A2 FILTER CHANGE INDICATOR 审中-公开
标题翻译：滤波器变化指示器
公开(公告)号：WO2007030608A2
公开(公告)日：2007-03-15
申请号：PCT/US2006034838
申请日：2006-09-08
申请人： STANADYNE CORP , WILLIAMS MICHAEL J , FERREIRA DAVID , VARDION STEPHEN J
发明人： WILLIAMS MICHAEL J , FERREIRA DAVID , VARDION STEPHEN J
IPC分类号： B01D35/14
CPC分类号： B01D29/606 , B01D35/143
摘要： A filter change indicator includes two indicators visible through a window. The first indicator is disposed in the viewing window in a fixed position. The second indicator covers the first indicator in a first position and is moveable relative to the first indicator to a second position revealing the first indicator. The filter change indicator also includes a spring and flexible diaphragm arranged such that changes in the pressure of a fluid system moves the second indicator to expose the first indicator to provide a visual indication of filter occlusion.
摘要翻译：过滤器更换指示器包括通过窗口可见的两个指示器。第一指示器以固定位置设置在观察窗中。第二指示器将第一指示器覆盖在第一位置，并且可相对于第一指示器移动到露出第一指示器的第二位置。过滤器更换指示器还包括布置成使得流体系统的压力的变化使第二指示器移动以暴露第一指示器以提供过滤器闭塞的视觉指示的弹簧和柔性隔膜。

5. 发明申请

WO9924990A2 INERTIAL ELECTROSTATIC CONFINEMENT (IEC) FUSION DEVICE WITH GATE-VALVE PULSING 审中-公开
标题翻译：具有门阀脉冲的惯性静电装置（IEC）熔断装置
公开(公告)号：WO9924990A2
公开(公告)日：1999-05-20
申请号：PCT/US9824034
申请日：1998-11-12
申请人： MILEY GEORGE H , JURCZYK BRIAN E , GU YIBIN , STUBBERS ROBERT A , WILLIAMS MICHAEL J
发明人： MILEY GEORGE H , JURCZYK BRIAN E , GU YIBIN , STUBBERS ROBERT A , WILLIAMS MICHAEL J
IPC分类号： G21B1/03 , H05H3/06 , G21G
CPC分类号： H05H3/06
摘要： A pulsed neutron/proton source based upon the design of a steady-state spherical inertial electrostatic confinement (IEC) configuration and using a pulsed gate valve grid (GVP). The IEC-GVP device comprises a grounded conductive vessel, serving as an anode, and a central cathode or primary grid that is connected to a high voltage source. In addition, an intermediate second grid and an outside third grid are disposed concentrically with the central cathode within the vessel. Electron extractor/emitter devices are disposed substantially symmetrically about the perimeter of the vessel and include electron extractor deflector grids and electron emitters that contribute to the enhanced timed ion flow in the device. Two techniques for pulsing the second grid are used. A first is a low repetition rate GVP (LR-GVP) operation and a second is a tuned high-frequency pulsing, termed Resonant Ion Driven Oscillation (RIDO) GVP operation.
摘要翻译：基于稳态球形惯性静电限制（IEC）配置和使用脉冲闸阀网格（GVP）的设计的脉冲中子/质子源。 IEC-GVP装置包括用作阳极的接地导电容器和连接到高电压源的中央阴极或主电网。此外，中间第二格栅和外部第三格栅与中心阴极同心地设置在容器内。电子提取器/发射器件围绕容器的周边基本上对称地设置，并且包括有助于器件中增强的定时离子流的电子提取器偏转器栅格和电子发射器。使用两种用于脉冲第二格栅的技术。第一个是低重复率GVP（LR-GVP）操作，第二个是调谐的高频脉冲，称为谐振离子驱动振荡（RIDO）GVP操作。

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