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1. 发明申请

WO2010011584A3 PROCESS FOR MAKING A RENIN INHIBITOR AND RELATED INTERMEDIATES 审中-公开
标题翻译：制备瑞宁抑制剂及相关中间体的方法
公开(公告)号：WO2010011584A3
公开(公告)日：2010-07-29
申请号：PCT/US2009051101
申请日：2009-07-20
申请人： MERCK SHARP & DOHME , MERCK FROSST CANADA LTD , ANGELAUD REMY , DAVIES IAN , MAGUIRE COURTNEY , LAU STEPHEN , O'SHEA PAUL , SHULTZ SCOTT
发明人： ANGELAUD REMY , DAVIES IAN , MAGUIRE COURTNEY , LAU STEPHEN , O'SHEA PAUL , SHULTZ SCOTT
IPC分类号： C07D213/643
CPC分类号： C07D213/643
摘要： A salt of the compound (3'R,4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide selected from the group consisting of monoacetate salt and bis-D-tartrate salt. In one embodiment of the invention, the salt is (3',4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide monoacetate. In one embodiment of the invention, the salt is (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide bis-D-tartrate. The invention also describes a asymmetric synthesis of (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide as a monoacetate salt or as a bis-D-tartrate salt.
摘要翻译：化合物（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4'，5' 6'-六氢 - [3,4']联吡啶基-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基酰胺，其选自单乙酸盐和双 - D-酒石酸盐。在本发明的一个实施方案中，盐是（3'，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4' ，5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺单乙酸酯。在本发明的一个实施方案中，盐是（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4 '，5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺双-D-酒石酸盐。本发明还描述了（3'R，4'S）-6- [2-（2,6-二氯-4-甲基 - 苯氧基） - 乙氧基] -1'，2'，3'，4' 5'，6'-六氢 - [3,4']联吡啶-3'-羧酸[2-氯-5-（2-甲氧基 - 乙基） - 苄基] - 环丙基 - 酰胺，为单乙酸盐或二 -D-酒石酸盐。

2. 发明申请

WO2008088690A2 A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS 审中-公开
标题翻译：制备DIAZABICYCLO [3.3.1] NONANE化合物的方法
公开(公告)号：WO2008088690A2
公开(公告)日：2008-07-24
申请号：PCT/US2008000224
申请日：2008-01-08
申请人： MERCK & CO INC , MERCK FROSST CANADA LTD , GAUVREAU DANNY , HUFFMAN MARK A , HUGHES GREG , ITOH TETSUJI , YIN JINGJUN , LAU STEPHEN , O'SHEA PAUL
发明人： GAUVREAU DANNY , HUFFMAN MARK A , HUGHES GREG , ITOH TETSUJI , YIN JINGJUN , LAU STEPHEN , O'SHEA PAUL
IPC分类号： C07D471/08 , C07C237/20
CPC分类号： C07C237/20 , C07D471/08
摘要： The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C 1 -C 6 alkoxycarbonyl, and carbobenzyloxy; R 6 is selected from the group consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and benzyl; and R 9 , R 10 , and R 11 are independently selected from the group consisting of hydrogen, halogen, and C 1 -C 6 alkyl. wherein the process involves cyclizing I-I, formula (II).
摘要翻译：本发明是制备式（I）的二氮杂双环化合物的方法，用于制备式（I）的二氮杂双环化合物：其中X选自氢，C 1 -C 3烷基，烷氧基羰基和苄氧羰基; R 6选自C 1 -C 6 -C 6烷基，C 2 -C 6亚烷基，C 2 -C 6亚烷基 > 6 链烯基和苄基; R 9，R 10和R 11独立地选自氢，卤素和C 1〜 / C 1 -C 6烷基。其中该方法涉及使I-I，式（II）环化。

3. 发明申请

WO2006047455B1 TOY PLAY SET 审中-公开
标题翻译：玩具集
公开(公告)号：WO2006047455B1
公开(公告)日：2006-11-02
申请号：PCT/US2005038262
申请日：2005-10-21
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN
发明人： COLLINS GARY , LAU STEPHEN
IPC分类号： A63H33/08
CPC分类号： G09F19/08 , A63F7/045 , A63F2009/0012 , A63F2009/0033 , A63F2250/0414 , A63H23/16 , A63H33/00
摘要： A toy play set (10) for use in a vehicle having a beverage cup holder (80) includes a body (11) having first and second opposing ends (11a, 11b) and a side wall (11c) extending therebetween defining an at least partially hollow cavity (11d) within the body. The body has in a closed configuration (16) at least the first end sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a first generally upright orientation (20) with the second end forming a top end of the body. The body has an open configuration (18) in which the hollow cavity is at least partially accessible. A tank (30) with a pump (33) is disposed within the body and is capable of being at least partially filled with a fluid (50) in order to play at least one predetermined game.
摘要翻译：一种用于具有饮料杯架（80）的车辆中的玩具玩具组（10）包括具有第一和第二相对端（11a，11b）的主体（11）和在其间延伸的侧壁（11c），至少限定了至少在体内部分中空的空腔（11d）。主体具有封闭构造（16），至少第一端的尺寸和形状至少部分地装配到杯架中，以使杯架能够以第一大致直立的方向（20）支撑身体，第二端形成身体的顶端。主体具有打开构造（18），其中中空腔至少部分可接近。具有泵（33）的罐（30）设置在主体内并且能够至少部分地填充有流体（50）以便发挥至少一个预定游戏。

4. 发明申请

WO2006047309A3 TOY PLAY SET 审中-公开
标题翻译：玩具套装
公开(公告)号：WO2006047309A3
公开(公告)日：2006-07-27
申请号：PCT/US2005037947
申请日：2005-10-20
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN , O'BRYAN ALAN
发明人： COLLINS GARY , LAU STEPHEN , O'BRYAN ALAN
IPC分类号： A63H18/00
CPC分类号： A63H18/02
摘要： A toy play set (10, 110, 210) for use in a vehicle having a beverage cup holder (80) includes a body (11, 111, 211) having first and second opposing ends (11a, 11b) and a side wall (11c) therebetween, which define and generally surround an at least partially hollow cavity (11d, 111d, 211d) within the body in a closed configuration (17) of the body. In the closed configuration, at least the first end is sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a generally upright orientation (15). The body has an open configuration (18, 118, 218) in which the hollow cavity is at least partially accessible. A track (20, 120, 220) is sized and configured for storage within the cavity of the body in the closed configuration. The track is engaged with the body for play in the open configuration.
摘要翻译：一种用于具有饮料杯保持器（80）的车辆中的玩具游戏装置（10,110,210），包括具有第一和第二相对端部（11a，11b）和侧壁（11a，11b）的主体（11,111,211） 11c），其在主体的闭合构造（17）中限定并且大致围绕在主体内的至少部分中空的空腔（11d，111d，211d）。在关闭构造中，至少第一端的尺寸和形状被设计为至少部分地适合杯托，以使杯托以大致直立方向（15）支撑主体。该主体具有开放构型（18,118,218），其中空腔至少部分可进入其中。轨道（20,120,220）的尺寸和构造被设置为在闭合构造中存储在身体的腔内。轨道在开放配置下与身体接合以便玩耍。

5. 发明申请

WO2006047197B1 TRAVEL GAME 审中-公开
标题翻译：旅行游戏
公开(公告)号：WO2006047197B1
公开(公告)日：2006-08-17
申请号：PCT/US2005037683
申请日：2005-10-18
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN
发明人： COLLINS GARY , LAU STEPHEN
IPC分类号： A63F3/00
CPC分类号： A63F3/0023 , A63F2003/00233 , A63F2003/00255 , A63F2003/00293 , A63F2003/00949 , A63F2250/602
摘要： A toy set (10, 110) for containing at least one predetermined board game includes a generally elongated body (11, 111) having a hollow interior (11a, 111a), first and second opposing longitudinal ends (11b, 11c, 111b, 111c), and a generally curved side wall (11d, 111d) extending around the hollow interior between the first and second ends. The first and second ends and side wall generally surround the hollow interior in a closed configuration (30, 130) of the body. The body has an open configuration (32, 132) in which the hollow interior is at least partially accessible. A playing surface (20, 120) is operably engaged with the body and is configured to play the predetermined board game. The playing surface is shaped and sized to enable the playing surface to be completely stored within the hollow interior of the body with the body in the closed configuration. The playing surface is accessible at least with the body in the open configuration to play the predetermined board game.
摘要翻译：一种用于容纳至少一个预定棋盘游戏的玩具装置（10,110），包括具有中空内部（11a，111a）的大致细长主体（11,111），第一和第二相对纵向端部（11b，11c，111b，111c ）以及围绕第一端和第二端之间的中空内部延伸的大致弯曲的侧壁（11d，111d）。第一和第二端以及侧壁通常围绕主体的闭合构造（30,130）的中空内部。本体具有开放构型（32,132），其中中空内部至少部分可接近。游戏表面（20,120）可操作地与主体接合并且被配置为玩预定的棋盘游戏。游戏表面的形状和尺寸被确定为使得游戏表面能够在主体处于关闭配置的情况下被完全存储在主体的中空内部中。至少在打开配置中的身体可以进入比赛场地以进行预定的棋盘游戏。

6. 发明申请

WO2006047197A3 TRAVEL GAME 审中-公开
标题翻译：旅游游戏
公开(公告)号：WO2006047197A3
公开(公告)日：2006-06-22
申请号：PCT/US2005037683
申请日：2005-10-18
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN
发明人： COLLINS GARY , LAU STEPHEN
IPC分类号： A63F3/00
CPC分类号： A63F3/0023 , A63F2003/00233 , A63F2003/00255 , A63F2003/00293 , A63F2003/00949 , A63F2250/602
摘要： A toy set (10, 110) for containing at least one predetermined board game includes a generally elongated body (11, 111) having a hollow interior (11a, 111a), first and second opposing longitudinal ends (11b, 11c, 111b, 111c), and a generally curved side wall (11d, 111d) extending around the hollow interior between the first and second ends. The first and second ends and side wall generally surround the hollow interior in a closed configuration (30, 130) of the body. The body has an open configuration (32, 132) in which the hollow interior is at least partially accessible. A playing surface (20, 120) is operably engaged with the body and is configured to play the predetermined board game. The playing surface is shaped and sized to enable the playing surface to be completely stored within the hollow interior of the body with the body in the closed configuration. The playing surface is accessible at least with the body in the open configuration to play the predetermined board game.
摘要翻译：用于容纳至少一个预定板游戏的玩具组（10,110）包括具有中空内部（11a，111a）的大致细长主体（11,111），第一和第二相对纵向端部（11b，11c，111b，111c））和在第一和第二端之间围绕中空内部延伸的大致弯曲的侧壁（11d，111d）。第一和第二端和侧壁通常围绕主体的封闭构造（30,130）中的中空内部。主体具有打开构型（32,132），其中中空内部至少部分可接近。游戏表面（20,120）与身体可操作地接合并且被配置为播放预定的棋盘游戏。演奏表面的形状和大小使得演奏表面能够被完全地存储在身体的中空内部，身体处于关闭构型。至少与打开配置中的身体一起播放播放表面以播放预定的棋盘游戏。

7. 发明申请

WO2006047455A2 TOY PLAY SET 审中-公开
标题翻译：玩具套装
公开(公告)号：WO2006047455A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038262
申请日：2005-10-21
申请人： MATTEL INC , COLLINS GARY , LAU STEPHEN
发明人： COLLINS GARY , LAU STEPHEN
IPC分类号： A63H3/00
CPC分类号： G09F19/08 , A63F7/045 , A63F2009/0012 , A63F2009/0033 , A63F2250/0414 , A63H23/16 , A63H33/00
摘要： A toy play set (10) for use in a vehicle having a beverage cup holder (80) includes a body (11) having first and second opposing ends (11 a, l lb) and a side wall (11c) extending therebetween defining an at least partially hollow cavity (11 d) within the body. The body has in a closed configuration (16) at least the first end sized and shaped to fit at least partially into the cup holder sufficiently for the cup holder to support the body in a first generally upright orientation (20) with the second end forming a top end of the body. The body has an open configuration (18) in which the hollow cavity is at least partially accessible. A tank (30) with a pump (33) is disposed within the body and is capable of being at least partially filled with a fluid (50) in order to play at least one predetermined game.
摘要翻译：一种用于具有饮料杯保持器（80）的车辆的玩具游戏装置（10），包括具有第一和第二相对端（11a，11b）和在其间延伸的侧壁（11c）的主体（11）在主体内的至少部分中空的空腔（11d）。所述主体具有处于关闭构型（16）的至少第一端，所述第一端的尺寸和形状适合至少部分地配合到所述杯架中，以使所述杯架以第一大致直立取向（20）支撑所述主体，所述第二端部形成身体的顶端。该主体具有开放构型（18），其中空腔至少部分可接近。具有泵（33）的罐（30）设置在主体内并且能够至少部分地填充有流体（50）以便进行至少一个预定游戏。

8. 发明申请

WO0041368A9 DYNAMIC ASSIGNMENT OF TRAFFIC CLASSES TO A PRIORITY QUEUE IN A PACKET FORWARDING DEVICE 审中-公开
标题翻译：运输队伍中的优先队列的动态分配到分组装置中的优先队列
公开(公告)号：WO0041368A9
公开(公告)日：2001-10-04
申请号：PCT/US0000428
申请日：2000-01-07
申请人： NORTEL NETWORKS LTD , LAVIAN TAL I , LAU STEPHEN
发明人： LAVIAN TAL I , LAU STEPHEN
IPC分类号： H04L12/56 , H04L29/06
CPC分类号： H04L47/2458 , H04L47/10 , H04L47/11 , H04L47/20 , H04L47/2441
摘要： An apparatus and method for dynamic assignment of classes of traffic to a priority queue. Bandwidth consumption by one or more types of packet traffic received in the packet forwarding device is monitored to determine whether the bandwidth consumption exceeds a threshold. If the bandwidth consumption exceeds the threshold, assignment of at least one type of packet traffic of the one or more types of packet traffic is changed from a queue having a first priority to a queue having a second priority.
摘要翻译：一种用于将流量类别动态地分配给优先级队列的装置和方法。监视在分组转发设备中接收到的一种或多种类型的分组流量的带宽消耗，以确定带宽消耗是否超过阈值。如果带宽消耗超过阈值，则将一个或多个类型的分组业务中的至少一种类型的分组业务的分配从具有第一优先级的队列改变为具有第二优先级的队列。

9. 发明申请

WO0041368A2 DYNAMIC ASSIGNMENT OF TRAFFIC CLASSES TO A PRIORITY QUEUE IN A PACKET FORWARDING DEVICE 审中-公开
标题翻译：分组转发类动态分配到包转发设备中的优先级队列
公开(公告)号：WO0041368A2
公开(公告)日：2000-07-13
申请号：PCT/US0000428
申请日：2000-01-07
申请人： NORTEL NETWORKS CORP , LAVIAN TAL I , LAU STEPHEN
发明人： LAVIAN TAL I , LAU STEPHEN
IPC分类号： H04L12/56 , H04L12/64
CPC分类号： H04L47/2458 , H04L47/10 , H04L47/11 , H04L47/20 , H04L47/2441
摘要： An apparatus and method for dynamic assignment of classes of traffic to a priority queue. Bandwidth consumption by one or more types of packet traffic received in the packet forwarding device is monitored to determine whether the bandwidth consumption exceeds a threshold. If the bandwidth consumption exceeds the threshold, assignment of at least one type of packet traffic of the one or more types of packet traffic is changed from a queue having a first priority to a queue having a second priority.
摘要翻译：一种将流量类别动态分配到优先队列的设备和方法。监视分组转发设备中接收到的一种或多种类型的分组流量的带宽消耗，以确定带宽消耗是否超过阈值。如果带宽消耗超过阈值，则将一种或多种类型的分组业务的至少一种分组业务的分配从具有第一优先级的队列改变为具有第二优先级的队列。

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