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1. 发明申请

WO1982003174A1 CORPUSCLES CONTAINING DRUGS AND USE THEREOF IN MEDECINE AND SURGERY 审中-公开
标题翻译：含有药物的药物及其在医学和外科手术中的应用
公开(公告)号：WO1982003174A1
公开(公告)日：1982-09-30
申请号：PCT/DE1982000048
申请日：1982-03-10
申请人： MERCK PATENT GMBH , HAERLE ANTON
发明人： MERCK PATENT GMBH
IPC分类号： A61K09/44
CPC分类号： A61K9/0024 , A61B17/68 , A61L31/16 , A61L2300/00 , A61M31/002
摘要： Les corpuscules tenus ensemble forment un element principal renfermant des medicaments et resistant a la pression et a la traction. L'union des corpuscules peut etre obtenue en les juxtaposant ou en les collant. On peut obtenir, de facon simple, la liberation d'une quantite voulue de corpuscules a partir de l'element principal en utilisant des lignes de separation preetablies. Les corpuscules peuvent avoir n'importe quelle surface de facon a pouvoir les adapter a leur utilisation. Les corpuscules peuvent contenir des antibiotiques ou n'importe quel medicament connu. Les corpuscules, malgre leur implantation dans le tissu conjonctif, peuvent etre retires facilement de telle facon qu'on les enleve du corps totalement en evitant une irritation des tissus par formation d'un granulome.

2. 发明申请

WO1998027112A1 CYCLIC PEPTIDE DERIVATIVES 审中-公开
标题翻译： CYCLO肽衍生物
公开(公告)号：WO1998027112A1
公开(公告)日：1998-06-25
申请号：PCT/EP1997007048
申请日：1997-12-15
申请人： MERCK PATENT GMBH , HÖLZEMANN, Günter , FITTSCHEN, Claus , GOODMAN, Simon
发明人： MERCK PATENT GMBH
IPC分类号： C07K07/56
CPC分类号： C07K7/56 , A61K38/00
摘要： Compounds of the formula (I) Cyclo-(Arg-X-Asp-R ) in which X means Gly, Ala or NH-NH-CO, R means a radical of formula (II), and R , R , and R have the meanings given in claim 1, and their salts, can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, in cases of thrombosis, cardiac infarction, coronary heart disease, arteriosclerosis, pathological symptoms that are sustained or propagated by angiogenesis, and in tumour therapy.
摘要翻译：式（I）化合物：环 - （Arg-X-天冬氨酸-R <1>），其中X为Gly，Ala或NH-NH-CO，R <1>是下式基团（II），且R <2 >，R <3>，和R <4>具有权利要求1中给出的含义和它们的盐可以用作整联蛋白抑制剂，特别是用于循环，血栓形成障碍，心肌梗死，冠状动脉心脏疾病，动脉硬化，其中的预防和治疗其由血管发生维持或传播，并且在肿瘤治疗中使用的病理过程。

3. 发明申请

WO1998016521A1 AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译： AMINOTHIOPHENCARBONSÄUREAMIDE及其作为磷酸二酯酶抑制剂
公开(公告)号：WO1998016521A1
公开(公告)日：1998-04-23
申请号：PCT/EP1997005531
申请日：1997-10-08
申请人： MERCK PATENT GMBH , JONAS, Rochus , SCHELLING, Pierre , KLUXEN, Franz-Werner , CHRISTADLER, Maria
发明人： MERCK PATENT GMBH
IPC分类号： C07D333/68
CPC分类号： C07D409/12 , C07D333/38 , C07D333/68
摘要： Aminothiophene carboxylic acid amides having formula (I) and their physiologically harmless salts, wherein R , R , R , R , R , A and n have the meaning given in claim 1, demonstrate phosphodiesterase V inhibition and can be used to treat cardiovascular diseases and in therapy for disturbances of potency.
摘要翻译：式（I）的Aminothiophencarbonsäureamide及其它们的生理学上可接受的盐，其中R <1>，R <2>，R <3>，R <4>，R <5>，A和n具有权利要求1中给出的含义，显示磷酸二酯酶V抑制，并且可以用于治疗心血管系统的以及用于治疗勃起功能障碍的疾病。

4. 发明申请

WO1998006704A1 ARYLALKANOYL PYRIDAZINES 审中-公开
标题翻译： ARYLALKANOYLPYRIDAZINE
公开(公告)号：WO1998006704A1
公开(公告)日：1998-02-19
申请号：PCT/EP1997004191
申请日：1997-08-01
申请人： MERCK PATENT GMBH , ROCHUS, Jonas , BEIER, Norbert , KLUXEN, Franz-Werner , WOLF, Michael
发明人： MERCK PATENT GMBH
IPC分类号： C07D237/04
CPC分类号： C07D401/12 , C07D237/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Arylalkanoyl pyridazine derivatives of formula (I) as well as their physiologically harmless salts, wherein R , R , Q and B have the meanings indicated in claim 1, present a phosphodiesterase IV inhibition and can be employed to treat inflammatory processes such as allergies, asthma and autoimmune disorders.
摘要翻译：式Arylalkanoylpyridazinderivate（I）和它们的生理学上可接受的盐，其中，R <1>，R <2>，Q和B具有权利要求1中给出的含义，显示出磷酸二酯酶IV抑制，并且可以用于治疗炎性过程以及过敏，哮喘和自身免疫性疾病中采用。

5. 发明申请

WO1998003583A1 LASER-MARKABLE PLASTICS 审中-公开
标题翻译：激光标记塑料
公开(公告)号：WO1998003583A1
公开(公告)日：1998-01-29
申请号：PCT/EP1997003812
申请日：1997-07-16
申请人： MERCK PATENT GMBH , SOLMS, Hans-Jürgen , KIESER, Manfred
发明人： MERCK PATENT GMBH
IPC分类号： C08K07/00
CPC分类号： C08K9/02
摘要： The invention concerns laser-markable plastics characterized in that, as absorber material, they contain a mixture of pigments giving a pearly lustre or non-lustrous metal oxide-coated mica pigments and inorganic flake-like substrates.
摘要翻译：本发明涉及一种激光标记的塑料，其特征在于它们含有作为吸收材料，珠光颜料或不光滑的金属氧化物涂覆的云母颜料和无机片状基底的混合物。

6. 发明申请

WO1997036209A1 SOLUTIONS AND PROCESSES FOR REMOVAL OF SIDEWALL RESIDUE AFTER DRY-ETCHING________________________________________________________ 审中-公开
标题翻译：干蚀刻后拆除边墙残留物的方法和工艺
公开(公告)号：WO1997036209A1
公开(公告)日：1997-10-02
申请号：PCT/EP1997001190
申请日：1997-03-10
申请人： MERCK PATENT GMBH , LIAW, Ming-Chi , CHAO, Tien-Sheng , LEI, Tan-FU
发明人： MERCK PATENT GMBH
IPC分类号： G03F07/42
CPC分类号： H01L21/02071 , G03F7/423 , H01L21/31133
摘要： The present invention relates to a novel process for removing sidewall residue after dry-etching process. Conventionally, after dry-etching, photoresist and sidewall residues are removed by ozone ashing and hot sulfuric acid. Normally, they are hard to be removed completely. It was found in the present invention that the addition of fluorine-containing compound, preferably hydrogen fluoride and ammonium fluoride, in sulfuric acid results in complete removal of photoresist and sidewall residue without the need for stripper. The process is simple and does not affect the original procedures or the other films on the substrate. The present invention also relates to a novel solution for removing sidewall residue after dry-etching, which comprises sulfuric acid and a fluorine-containing compound, preferably hydrogen fluoride and ammonium fluoride, in the range of from 10:1 to 1000:1 by weight.
摘要翻译：本发明涉及一种在干蚀刻工艺之后去除侧壁残留物的新方法。通常，干蚀刻后，通过臭氧灰化和热硫酸除去光致抗蚀剂和侧壁残留物。通常，它们很难被完全清除。在本发明中发现，在硫酸中加入含氟化合物，优选氟化氢和氟化铵，导致完全去除光致抗蚀剂和侧壁残留物，而不需要剥离剂。该方法简单，不影响原始程序或其他底物上的膜。本发明还涉及一种用于在干法蚀刻之后除去侧壁残留物的新型溶液，其包含硫酸和含氟化合物，优选氟化氢和氟化铵，重量比为10:1至1000:1 。

7. 发明申请

WO1997030136A1 CHOLESTERIC FLAKES 审中-公开
标题翻译：柱状花瓶
公开(公告)号：WO1997030136A1
公开(公告)日：1997-08-21
申请号：PCT/EP1997000433
申请日：1997-02-01
申请人： MERCK PATENT GMBH , COATES, David , GOULDING, Mark , MAY, Alison
发明人： MERCK PATENT GMBH
IPC分类号： C09K19/00
CPC分类号： C09K19/38 , A61K8/0258 , A61K8/0295 , A61K8/8152 , A61K2800/436 , A61K2800/622 , A61K2800/654 , A61Q1/02 , A61Q19/00 , B41M3/14 , C09B67/0098 , C09D5/36 , C09D11/50 , C09K19/00
摘要： The invention relates to cholesteric polymer flakes obtainable from a chiral polymerizable mesogenic material, to methods of manufcturing such cholesteric flakes, to the use of certain chiral and achiral polymerizable compounds with one or more terminal polymerizable groups for the manufacturing of such flakes and to the use of such cholesteric flakes as effect pigments in spraying or printing inks or paints or coloured plastics for different applications, especially for automotive use, cosmetic products and security applications.
摘要翻译：本发明涉及可由手性可聚合介晶材料获得的胆甾型聚合物薄片，制造这种胆甾醇型薄片的方法，使用某些手性和非手性可聚合化合物与一种或多种用于制造这种薄片的端基可聚合基团以及使用的这种胆甾醇薄片作为喷涂或印刷油墨或油漆或着色塑料用于不同应用，特别是用于汽车用途，化妆品和安全应用的效果颜料。

8. 发明申请

WO1996030113A1 DEVICE FOR MIXING SMALL QUANTITIES OF LIQUIDS 审中-公开
标题翻译：设备技术混合液少量
公开(公告)号：WO1996030113A1
公开(公告)日：1996-10-03
申请号：PCT/EP1996001359
申请日：1996-03-28
申请人： MERCK PATENT GMBH , SCHWESINGER, Norbert , FRANK, Thomas
发明人： MERCK PATENT GMBH
IPC分类号： B01F05/06
CPC分类号： B01F5/0604 , B01F5/0641 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00889 , Y10S366/03
摘要： The object of the invention is to design a device which can homogenise even very small quantities of liquids very efficiently and is easy to manufacture. This is achieved according to the invention by provision of the following features: the device comprises at least one mixing element with at least one inlet channel and at least one outlet channel; at least two microchannels issue from the inlet channel, all such issuing channels lying in a single branching plane; the microchannels are led to a confluence element in a plane which is rotated 90 DEG in relation to the branching plane; the mixer element is arranged in the planar surface of a substrate, the planar surface being hermetically sealed by a covering. The invention concerns a device for mixing liquids in which mixing is effected by the flow of the liquids to be mixed through narrow channels.
摘要翻译：本发明的目的是提供能够均匀化已经非常少量的液体具有高效率和易于制造的器件的问题。该目的是这样达到的，该装置包括至少一个混合元件，该至少具有入口通道和至少一个出口管，从入口通道采取至少两个微通道，其中，所有输出通道都位于一个分支水平，微通道被供给到合流元件，其中，所述流入发生在一个平面旋转90°相对于分支平面布置，并且所述混合元件被设置在一个衬底上，其中用覆盖所述基板的平面表面是气密密封的平坦表面。本发明涉及一种用于混合液体的设备，其中，通过使通过窄信道执行要混合的液体混合。

9. 发明申请

WO1996029596A1 SEPARATING MATERIAL USED IN COMBINED THIN-LAYER CHROMATOGRAPHY AND FTIR SPECTROSCOPY 审中-公开
标题翻译：脱模剂DC-FTIR和电源
公开(公告)号：WO1996029596A1
公开(公告)日：1996-09-26
申请号：PCT/EP1996000965
申请日：1996-03-07
申请人： MERCK PATENT GMBH , KOVAR, Karl-Artur , FISCHER, Walter , HAUCK, Heinz, Emil
发明人： MERCK PATENT GMBH
IPC分类号： G01N30/93
CPC分类号： G01N30/93 , G01N2030/743 , Y10T436/255
摘要： The invention concerns separating materials for thin-layer chromatography, the materials comprising a sorbent layer formed from sorbent particles and disposed on a carrier. A reflection intensifier, preferably magnesium tungstate and/or Bi2O3, is added to the sorbent layer. This addition comprises at least 10 wt % relative to the amount of sorbent. In preferred embodiments, the particle size of the reflection intensifier is 3 to 5 mu m and the amount of the reflection intensifier is 0.6 to 1.5 times the amount of sorbent. These separating materials are particularly suitable for the in-situ measurement of FTIR spectra. The invention also concerns the use of these separating materials for the in-situ measurement of FTIR spectra.
摘要翻译：本发明涉及一种用于释放薄层色谱法，包括吸附剂颗粒在载体上形成的吸附剂层的材料，其中所述吸着剂层的反射放大器，优选钨酸镁和/或添加的Bi2O3。这种添加是基于吸附剂的量的至少10重量％。在优选的实施方案中，反射增强3-5微米颗粒大小和反射增强剂的量是吸附剂的0.6〜1.5倍的量。此释放的材料是特别适合于在FTIR光谱的现场测量。在FTIR光谱的现场测量使用这些分离材料的用于实施例中。

10. 发明申请

WO1996024647A1 DIREACTIVE MESOGENIC COMPOUNDS AND INTERMEDIATES 审中-公开
标题翻译： DIREACTIVE MESOGENIC化合物和中间体
公开(公告)号：WO1996024647A1
公开(公告)日：1996-08-15
申请号：PCT/EP1996000240
申请日：1996-01-22
申请人： MERCK PATENT GMBH , COATES, David , GREENFIELD, Simon
发明人： MERCK PATENT GMBH
IPC分类号： C09K19/20
CPC分类号： C07C69/54 , C07C43/23 , C07C69/92 , C08F246/00 , C09K19/12 , C09K19/2007 , C09K19/3852 , C09K2019/0448 , Y10T428/10
摘要： The invention relates to direactive mesogenic compounds or mixtures thereof comprising mesogene-containing molecule, said mesogens having two side chains attached thereto which contain a terminal polymerizable functional group, said mesogens and said functional groups being separated by at least two to twenty spacer atoms, wherein both spacer groups have different chain length.
摘要翻译：本发明涉及包含含mesogene的分子的方向性介晶化合物或其混合物，所述介晶体具有连接到其上的两个侧链，其含有末端可聚合官能团，所述介晶和所述官能团被至少二至二十个间隔子原子隔开，其中两个间隔基具有不同的链长。

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