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1. 发明申请

WO2004080403A2 INFLUENZA VIRUS VACCINE 审中-公开
标题翻译：流感病毒疫苗
公开(公告)号：WO2004080403A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/006978
申请日：2004-03-05
申请人： MERCK & CO. INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , GARSKY, Victor, M. , IONESCU, Roxana , LIANG, Xiaoping , PRZYSIECKI, Craig, T. , SHI, Li , SHIVER, John, W. , BIANCHI, Elisabetta , INGALLINELLA, Paolo , PESSI, Antonello
发明人： GARSKY, Victor, M. , IONESCU, Roxana , LIANG, Xiaoping , PRZYSIECKI, Craig, T. , SHI, Li , SHIVER, John, W. , BIANCHI, Elisabetta , INGALLINELLA, Paolo , PESSI, Antonello
IPC分类号： A61K
CPC分类号： C07K14/005 , A61K2039/6068 , A61K2039/6075 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234
摘要： The present invention provides vaccines against disease caused by infection with influenza virus, and methods of vaccination. The vaccines comprise peptides derived from the M2 and/or HA proteins of influenza virus conjugated to a carrier protein.
摘要翻译：本发明提供了针对由流感病毒感染引起的疾病的疫苗以及接种疫苗的方法。疫苗包含衍生自与载体蛋白缀合的流感病毒的M2和/或HA蛋白质的肽。

2. 发明申请

WO2009053339A2 CHOLESTEROL DERIVATIVES OF INHIBITORS OF VIRAL FUSION 审中-公开
标题翻译：维生素D抑制剂的胆固醇衍生物
公开(公告)号：WO2009053339A2
公开(公告)日：2009-04-30
申请号：PCT/EP2008/064151
申请日：2008-10-20
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , PESSI, Antonello , BIANCHI, Elisabetta , INGALLINELLA, Paolo
发明人： PESSI, Antonello , BIANCHI, Elisabetta , INGALLINELLA, Paolo
IPC分类号： A61K47/48 , A61P31/18 , C07K17/02
CPC分类号： C07K14/005 , A61K47/554
摘要： The present invention relates to compounds comprising at least ten contigous amino acids of the HR2 domain of a Type 1 viral fusogenic protein of an enveloped virus, or a derivative thereof, attached at the C-terminal to cholesterol or a derivative thereof; or a pharmaceutically acceptable salt thereof which inhibit viral fusion. Thus compounds of the invention are useful to prevent or treat diseases caused by an enveloped virus.
摘要翻译：本发明涉及包含病毒包膜病毒的1型病毒融合蛋白或其衍生物的HR2结构域至少10个连接氨基酸的化合物，其在C-末端连接至胆固醇或其衍生物; 或其药学上可接受的盐，其抑制病毒融合。因此，本发明的化合物可用于预防或治疗由包膜病毒引起的疾病。

3. 发明申请

WO2011005611A1 NEUROMEDIN U RECEPTOR AGONISTS AND USES THEREOF 审中-公开
标题翻译： NEUROMEDIN U受体激素及其用途
公开(公告)号：WO2011005611A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/040272
申请日：2010-06-29
申请人： MERCK SHARP & DOHME CORP. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , PESSI, Antonello , BIANCHI, Elisabetta , INGALLINELLA, Paolo , MARSH, Donald, J. , PEIER, Andrea, M.
发明人： PESSI, Antonello , BIANCHI, Elisabetta , INGALLINELLA, Paolo , MARSH, Donald, J. , PEIER, Andrea, M.
IPC分类号： A61K38/00
CPC分类号： A61K38/16
摘要： Neuromedin U receptor agonists for use in the treatment of metabolic disorders such as obesity are described. In particular, described are neuromedin U receptor agonists that are analogs or derivatives of neuromedin U (NMU).
摘要翻译：描述了用于治疗代谢性疾病如肥胖症的神经介肽U受体激动剂。特别地，描述了作为神经介肽U（NMU）的类似物或衍生物的神经介肽U受体激动剂。

4. 发明申请

WO2010096052A1 OXYNTOMODULIN ANALOGS 审中-公开
标题翻译：氧自由基模拟物
公开(公告)号：WO2010096052A1
公开(公告)日：2010-08-26
申请号：PCT/US2009/034448
申请日：2009-02-19
申请人： MERCK SHARP & DOHME CORP. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION , BIANCHI, Elisabetta , CARRINGTON, Paul, E. , EIERMANN, George, J. , INGALLINELLA, Paolo , MARSH, Donald, J. , METZGER, Joseph, M. , PESSI, Antonello , POCAI, Alessandro , SINHA ROY, Ranabir , SANTOPRETE, Alessia , CAPITO, Elena , DIMARCHI, Richard , WARD, Brian
发明人： BIANCHI, Elisabetta , CARRINGTON, Paul, E. , EIERMANN, George, J. , INGALLINELLA, Paolo , MARSH, Donald, J. , METZGER, Joseph, M. , PESSI, Antonello , POCAI, Alessandro , SINHA ROY, Ranabir , SANTOPRETE, Alessia , CAPITO, Elena , DIMARCHI, Richard , WARD, Brian
IPC分类号： A61K38/26
CPC分类号： C07K14/605 , A61K38/00 , C07K14/575
摘要： Peptide analogs of oxyntomodulin (OXM, glucagon-37), which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to act as a dual GLP-1/glucagon receptor (GCGR) agonist, are described. The peptide analogs are useful for treatment of metabolic disorders such as diabetes and obesity.
摘要翻译：已经修饰为对二肽基肽酶IV（DPP-IV）的切割和失活具有抗性并且增加肽类似物的体内半衰期的胃泌酸调节蛋白（OXM，胰高血糖素-37）的肽类似物，作为双重GLP-1 /胰高血糖素受体（GCGR）激动剂。肽类似物可用于治疗代谢性疾病如糖尿病和肥胖症。

5. 发明申请

WO2007109135A2 NEUROMEDIN U RECEPTOR AGONISTS AND USES THEREOF 审中-公开
标题翻译： NEUROMEDIN U受体激素及其用途
公开(公告)号：WO2007109135A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006635
申请日：2007-03-16
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , MARSH, Donald, J. , PESSI, Antonello , BEDNAREK, Maria, A. , BIANCHI, Elisabetta , INGALLINELLA, Paolo , PEIER, Andrea, M.
发明人： MARSH, Donald, J. , PESSI, Antonello , BEDNAREK, Maria, A. , BIANCHI, Elisabetta , INGALLINELLA, Paolo , PEIER, Andrea, M.
IPC分类号： C07K14/43
CPC分类号： C07K14/575 , A61K38/00 , A61K47/543 , A61K47/554 , A61K47/60
摘要： Neuromedin U receptor agonists for use in the treatment of metabolic disorders such as obesity and diabetes are disclosed.
摘要翻译：公开了用于治疗代谢性疾病如肥胖症和糖尿病的神经介肽U受体激动剂。

6. 发明申请

WO2008156873A2 APOA-1 PEPTIDE MIMETICS 审中-公开
标题翻译： APOA-1肽类物质
公开(公告)号：WO2008156873A2
公开(公告)日：2008-12-24
申请号：PCT/US2008/007855
申请日：2008-06-18
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , BIANCHI, Elisabetta , PESSI, Antonello , INGENITO, Raffaele , WANG, Jun , CARBALLO-JANE, Ester , CHANG, Ching, H.
发明人： BIANCHI, Elisabetta , PESSI, Antonello , INGENITO, Raffaele , WANG, Jun , CARBALLO-JANE, Ester , CHANG, Ching, H.
IPC分类号： A61K38/10
CPC分类号： C07K14/775 , A61K38/00
摘要： The invention relates to peptide mimetics for treating disorders associated with hypercholesterolemia and cardiovascular disease. In particular, the invention relates to peptides that mimic the activity of apolipoprotein A-I (Apo AI).
摘要翻译：本发明涉及用于治疗与高胆固醇血症和心血管疾病相关的疾病的肽模拟物。特别地，本发明涉及模拟载脂蛋白A-1（Apo AI）的活性的肽。

7. 发明申请

WO2005118886A2 STABLE PEPTIDE MIMETIC OF HIV GP41 FUSION INTERMEDIATE 审中-公开
标题翻译：艾滋病毒GP41融合中间体的稳定肽蛋白质
公开(公告)号：WO2005118886A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/018808
申请日：2005-05-27
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, S.P.A. , BIANCHI, Elisabetta , PESSI, Antonello , GELEZIUNAS, Romas , BRAMHILL, David
发明人： BIANCHI, Elisabetta , PESSI, Antonello , GELEZIUNAS, Romas , BRAMHILL, David
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , G01N2333/16 , G01N2500/02
摘要： Methods of covalently-stabilizing alpha-helical, chimeric peptides constrained within a homotrimeric or heterotrimeric coiled-coil structure are disclosed. The coiled-coil structures made by the methods disclosed within this specification mimic all or a portion of the internal, trimeric coiled-coil motif contained within the fusogenic conformation of an enveloped virus membrane-fusion protein, particularly the internal coiled-coil domain of the HIV gp41 ectodomain. The HIV-derived, chimeric peptides disclosed comprise a non-HIV, soluble, trimeric form of a coiled-coil fused in helical phase to all or a portion of the N-helix of HIV gp41 and are covalently-stabilized in a homotrimeric or heterotrimeric coiled-coil structure through the formation of disulfide or chemoselective bonds between said peptides. The covalently-stabilized, HIV-derived, homotrimeric or heterotrimeric coiled-coil structures made by the methods disclosed herein represent a close mimetic of a HIV gp41 fusion intermediate and are potent inhibitors of HIV infectivity. These HIV-derived chimeric peptides may provide for therapeutic treatment against HIV infection by inhibiting the virus-host cell membrane fusion process.
摘要翻译：公开了限制在同三聚体或异三聚体卷曲螺旋结构内的共价稳定的α-螺旋嵌合肽的方法。通过本说明书中公开的方法制备的盘绕线圈结构模拟包含在包膜病毒膜 - 融合蛋白的融合构象内的内部，三聚体卷曲线粒体的全部或部分，特别是内部卷曲螺旋结构域 HIV gp41胞外域。所公开的HIV衍生的嵌合肽包含螺旋状螺旋状的非HIV，可溶性三聚体形式，其与HIV gp41的全部或部分N-螺旋融合，并以共三聚体或异三聚体共价稳定通过在所述肽之间形成二硫键或化学选择性键来进行卷曲螺旋结构。由本文公开的方法制备的共价稳定的HIV衍生的同源三聚体或异三聚体卷曲螺旋结构代表HIV gp41融合中间体的密切模拟物，并且是HIV感染性的有效抑制剂。这些HIV衍生的嵌合肽可以通过抑制病毒宿主细胞膜融合过程来提供针对HIV感染的治疗性治疗。

8. 发明申请

WO2005118887A2 HUMAN ANTIBODIES INTERACTING WITH HIV GP41 审中-公开
标题翻译：人类抗体与HIV GP41相互作用
公开(公告)号：WO2005118887A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019049
申请日：2005-05-31
申请人： MERCK & CO., INC. , WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , SHIVER, John, W. , MILLER, Michael, D. , GELEZIUNAS, Romas , HAZUDA, Daria, J. , KIM, Peter, S. , ROOT, Michael, J. , ECKERT, Debra, M. , LENNARD, Simon, N. , BIANCHI, Elisabetta
发明人： SHIVER, John, W. , MILLER, Michael, D. , GELEZIUNAS, Romas , HAZUDA, Daria, J. , KIM, Peter, S. , ROOT, Michael, J. , ECKERT, Debra, M. , LENNARD, Simon, N. , BIANCHI, Elisabetta
IPC分类号： C12Q1/70
CPC分类号： G01N33/56988 , C07K16/1063 , C07K2317/21 , C07K2317/622 , C07K2317/76 , G01N2500/00
摘要： Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as V H and V L chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.
摘要翻译：披露了人scFv，其与艾滋病病毒gp41的七重复重复1（HR1）区域内的前发夹，N-螺旋卷曲螺旋结构与构象表位相互作用。显示出这些抗体以及IgG转化中和多种HIV分离物。还公开了分离的核酸分子，其编码这些抗体的相关部分，以及所表达的抗体或相关抗体片段（例如VH和VL链）的纯化形式。在本说明书中公开的抗体组合物可通过降低受感染个体内的病毒载量水平来提供抗HIV感染的治疗性治疗，从而延长HIV感染的无症状期。这些抗体也可用于鉴定HIV抗病毒化合物的测定，以及允许鉴定候选的HIV疫苗，例如HIV肽疫苗。

9. 发明申请

WO2007100535A2 OXYNTOMODULIN DERIVATIVES 审中-公开
标题翻译：氧自由基衍生物
公开(公告)号：WO2007100535A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004306
申请日：2007-02-16
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , ROY, Ranabir Sinha , BIANCHI, Elisabetta , PESSI, Antonella , INGALLINELLA, Paola , MARSH, Donald, J. , EIERMANN, George , MU, James , ZHOU, Yun-Ping
发明人： ROY, Ranabir Sinha , BIANCHI, Elisabetta , PESSI, Antonella , INGALLINELLA, Paola , MARSH, Donald, J. , EIERMANN, George , MU, James , ZHOU, Yun-Ping
IPC分类号： C07K14/575 , A61K38/00
CPC分类号： C07K14/575 , A61K38/00
摘要： Modified oxyntomodulin derivatives. Such derivatives can be used for the treatment of metabolic diseases such as diabetes and obesity.
摘要翻译：改良的胃泌酸调节蛋白衍生物。这样的衍生物可用于治疗代谢性疾病如糖尿病和肥胖症。

10. 发明申请

WO2010138343A1 NEUROMEDIN U RECEPTOR AGONISTS 审中-公开
标题翻译： NEUROMEDIN U受体激素
公开(公告)号：WO2010138343A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/035260
申请日：2010-05-18
申请人： MERCK SHARP & DOHME CORP. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA , PESSI, Antonello , BIANCHI, Elisabetta , INGALLINELLA, Paolo , LAHM, Armin , NEUNER, Philippe , TALAMO, Fabio , BARBATO, Gaetano , MARSH, Donald, J. , PEIER, Andrea
发明人： PESSI, Antonello , BIANCHI, Elisabetta , INGALLINELLA, Paolo , LAHM, Armin , NEUNER, Philippe , TALAMO, Fabio , BARBATO, Gaetano , MARSH, Donald, J. , PEIER, Andrea
IPC分类号： A61K38/00
CPC分类号： A61K38/22 , A61K47/643 , A61K47/6835
摘要： Neuromedin U receptor agonists comprising neuromedin U or derivative or analog thereof conjugated to a carrier protein for use in the treatment of metabolic disorders such as obesity and diabetes are disclosed.
摘要翻译：公开了包含神经介肽U或其与载体蛋白缀合的衍生物或类似物用于治疗代谢性疾病如肥胖症和糖尿病的神经介肽U受体激动剂。

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