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1. 发明申请

WO2011075506A3 SINTERED ELECTRODES TO STORE ENERGY IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：烧结电极在可植入医疗器械中储存能量
公开(公告)号：WO2011075506A3
公开(公告)日：2012-01-26
申请号：PCT/US2010060432
申请日：2010-12-15
申请人： CARDIAC PACEMAKERS INC , SHERWOOD GREGORY J , ROOT MICHAEL J , KUHN PETER JAY , BYRON MARY M , STEMEN ERIC
发明人： SHERWOOD GREGORY J , ROOT MICHAEL J , KUHN PETER JAY , BYRON MARY M , STEMEN ERIC
IPC分类号： H01G9/08 , A61N1/375 , H01G9/008 , H01G9/052 , H01G9/06
CPC分类号： H01G9/08 , A61N1/375 , A61N1/3782 , H01G9/008 , H01G9/052 , H01G9/06 , Y10T29/417
摘要： An example includes a capacitor case sealed to retain electrolyte, at least one anode disposed in the capacitor case, the at least one anode comprising a sintered portion disposed on a substrate, an anode conductor coupled to the substrate in electrical communication with the sintered portion, the anode conductor sealingly extending through the capacitor case to an anode terminal disposed on the exterior of the capacitor case with the anode terminal in electrical communication with the sintered portion, a cathode disposed in the capacitor case, a separator disposed between the cathode and the anode and a cathode terminal disposed on an exterior of the capacitor case and in electrical communication with the cathode, with the anode terminal and the cathode terminal electrically isolated from one another.
摘要翻译：一个实例包括密封以保持电解质的电容器壳体，设置在电容器壳体中的至少一个阳极，所述至少一个阳极包括设置在基板上的烧结部分，连接到与烧结部分电连通的基板的阳极导体，所述阳极导体密封地延伸穿过所述电容器壳体到设置在所述电容器壳体的外部上的阳极端子，所述阳极端子与所述烧结部分电连通，设置在所述电容器壳体中的阴极，设置在所述阴极和所述阳极之间的隔板以及设置在电容器壳体的外部并与阴极电连通的阴极端子，阳极端子和阴极端子彼此电隔离。

2. 发明申请

WO2011075506A2 SINTERED ELECTRODES TO STORE ENERGY IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：烧结电极在可植入医疗器械中储存能量
公开(公告)号：WO2011075506A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/060432
申请日：2010-12-15
申请人： CARDIAC PACEMAKERS, INC. , SHERWOOD, Gregory, J. , ROOT, Michael J. , KUHN, Peter Jay , BYRON, Mary M. , STEMEN, Eric
发明人： SHERWOOD, Gregory, J. , ROOT, Michael J. , KUHN, Peter Jay , BYRON, Mary M. , STEMEN, Eric
IPC分类号： H01G9/08
CPC分类号： H01G9/08 , A61N1/375 , A61N1/3782 , H01G9/008 , H01G9/052 , H01G9/06 , Y10T29/417
摘要： An example includes a capacitor case sealed to retain electrolyte, at least one anode disposed in the capacitor case, the at least one anode comprising a sintered portion disposed on a substrate, an anode conductor coupled to the substrate in electrical communication with the sintered portion, the anode conductor sealingly extending through the capacitor case to an anode terminal disposed on the exterior of the capacitor case with the anode terminal in electrical communication with the sintered portion, a cathode disposed in the capacitor case, a separator disposed between the cathode and the anode and a cathode terminal disposed on an exterior of the capacitor case and in electrical communication with the cathode, with the anode terminal and the cathode terminal electrically isolated from one another.
摘要翻译：一个实例包括密封以保持电解质的电容器壳体，设置在电容器壳体中的至少一个阳极，至少一个阳极包括设置在基板上的烧结部分，与该烧结部分电连通的与该基板相连的阳极导体，所述阳极导体密封地延伸穿过所述电容器壳体到设置在所述电容器外壳的外部的阳极端子，所述阳极端子与所述烧结部分电连通，设置在所述电容器壳体中的阴极，设置在所述阴极和所述阳极之间的隔板以及设置在电容器壳体的外部并与阴极电连通的阴极端子，阳极端子和阴极端子彼此电隔离。

3. 发明申请

WO2007070718A3 METHOD AND APPARATUS FOR A SMALL POWER SOURCE FOR AN IMPLANTABLE DEVICE 审中-公开
标题翻译：用于可移植设备的小功率源的方法和装置
公开(公告)号：WO2007070718A3
公开(公告)日：2007-11-08
申请号：PCT/US2006048127
申请日：2006-12-15
申请人： CARDIAC PACEMAKERS INC , ROOT MICHAEL J , YOUKER NICK A , MAILE KEITH R
发明人： ROOT MICHAEL J , YOUKER NICK A , MAILE KEITH R
IPC分类号： A61N1/378 , A61N1/372 , H01M6/16 , H01M6/40
CPC分类号： A61N1/3787 , A61B5/02 , A61B2562/0217 , A61N1/3752 , A61N1/378 , H01M2/1055 , H01M6/08 , H01M10/0422 , H01M10/0436 , H05K13/0023 , Y10T29/49108 , Y10T29/4911
摘要： One embodiment of the present subject matter includes an apparatus including a non-thin-film battery, the apparatus including a cylindrical implantable housing (102), electronics disposed in the implantable housing, and a battery disposed in the implantable housing, the battery comprising: a stack including at least one substantially planar anode (103) having a thickness greater than 1 micrometer and at least one substantially planar cathode (107) having a thickness greater than 1 micrometer, a housing enclosing the stack of substantially planar anodes and cathodes, and terminals interconnecting the battery and the electronics, wherein the battery has a volume of less than 0.024 cubic centimeters. The present subject matter includes an implantable medical device having a bobbin battery.
摘要翻译：本主题的一个实施例包括一种包括非薄膜电池的装置，该装置包括圆柱形可植入壳体（102），设置在可植入壳体中的电子设备和设置在可植入壳体中的电池，所述电池包括：包括至少一个具有大于1微米厚度的基本上平面的阳极（103）和至少一个具有大于1微米厚度的基本上平面的阴极（107）的堆叠的堆叠，包围基本平坦的阳极和阴极堆叠的壳体，以及将电池和电子设备互连的端子，其中电池具有小于0.024立方厘米的体积。本主题包括具有线轴电池的可植入医疗装置。

4. 发明申请

WO2011082236A1 IMPLANTABLE DEVICE INCLUDING EDDY CURRENT REDUCING BATTERY 审中-公开
标题翻译：包括EDDY电流减少电池的可植入设备
公开(公告)号：WO2011082236A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062368
申请日：2010-12-29
申请人： CARDIAC PACEMAKERS, INC. , LYDEN, Michael, J. , ROOT, Michael, J. , KOSHIOL, Kurt, E. , SCHMALHURST, Lisa, B. , LI, Yingbo , AMERI, Masoud
发明人： LYDEN, Michael, J. , ROOT, Michael, J. , KOSHIOL, Kurt, E. , SCHMALHURST, Lisa, B. , LI, Yingbo , AMERI, Masoud
IPC分类号： A61N1/375 , A61N1/378 , H01M2/20
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/375 , A61N1/378 , H01M4/06 , H01M4/40 , H01M4/661 , H01M4/669 , H01M4/70 , H01M6/14 , Y10T29/49108 , Y10T29/49112
摘要： An implantable device, such as a pacer, defibrillator, or other cardiac rhythm management device, can include one or more MRI Safe components. In an example, the implantable device includes a battery including a first electrode and a second electrode separate from the first electrode. The second electrode includes a first surface and a second surface. The second electrode includes a slot through the second electrode from the first surface toward the second surface. The slot extends from a perimeter of the second electrode to an interior of the second electrode. The slot is configured to at least partially segment a surface area of the second electrode to reduce a radial current loop size in the second electrode.
摘要翻译：诸如起搏器，除颤器或其他心律管理装置的可植入装置可以包括一个或多个MRI安全部件。在一个示例中，可植入装置包括包括与第一电极分离的第一电极和第二电极的电池。第二电极包括第一表面和第二表面。第二电极包括从第一表面朝向第二表面穿过第二电极的槽。槽从第二电极的周边延伸到第二电极的内部。该槽配置成至少部分地分段第二电极的表面区域，以减小第二电极中的径向电流环尺寸。

5. 发明申请

WO2007070718A2 METHOD AND APPARATUS FOR A SMALL POWER SOURCE FOR AN IMPLANTABLE DEVICE 审中-公开
标题翻译：用于可移植设备的小功率源的方法和装置
公开(公告)号：WO2007070718A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/048127
申请日：2006-12-15
申请人： CARDIAC PACEMAKERS, INC. , ROOT, Michael J. , YOUKER, Nick A. , MAILE, Keith R.
发明人： ROOT, Michael J. , YOUKER, Nick A. , MAILE, Keith R.
CPC分类号： A61N1/3787 , A61B5/02 , A61B2562/0217 , A61N1/3752 , A61N1/378 , H01M2/1055 , H01M6/08 , H01M10/0422 , H01M10/0436 , H05K13/0023 , Y10T29/49108 , Y10T29/4911
摘要： One embodiment of the present subject matter includes an apparatus including a non-thin-film battery, the apparatus including a cylindrical implantable housing, electronics disposed in the implantable housing, and a battery disposed in the implantable housing, the battery comprising: a stack including at least one substantially planar anode having a thickness greater than 1 micrometer and at least one substantially planar cathode having a thickness greater than 1 micrometer, a housing enclosing the stack of substantially planar anodes and cathodes, and terminals interconnecting the battery and the electronics, wherein the battery has a volume of less than 0.024 cubic centimeters. The present subject matter includes an implantable medical device having a bobbin battery.
摘要翻译：本主题的一个实施例包括一种包括非薄膜电池的装置，该装置包括圆柱形可植入壳体，设置在可植入壳体中的电子设备和设置在可植入壳体中的电池，该电池包括：包括：至少一个具有大于1微米厚度的基本上平面的阳极和至少一个具有大于1微米厚度的基本上平面的阴极，包围基本上平面的阳极和阴极的堆叠的壳体以及将电池和电子装置相互连接的端子，其中电池的体积小于0.024立方厘米。本主题包括具有线轴电池的可植入医疗装置。

6. 发明申请

WO2005118887A3 HUMAN ANTIBODIES INTERACTING WITH HIV GP41 审中-公开
标题翻译：人类抗体与HIV GP41相互作用
公开(公告)号：WO2005118887A3
公开(公告)日：2006-06-22
申请号：PCT/US2005019049
申请日：2005-05-31
申请人： MERCK & CO INC , WHITEHEAD BIOMEDICAL INST , CAMBRIDGE ANTIBODY TECH , ANGELETTI P IST RICHERCHE BIO , SHIVER JOHN W , MILLER MICHAEL D , GELEZIUNAS ROMAS , HAZUDA DARIA J , KIM PETER S , ROOT MICHAEL J , ECKERT DEBRA M , LENNARD SIMON N , BIANCHI ELISABETTA
发明人： SHIVER JOHN W , MILLER MICHAEL D , GELEZIUNAS ROMAS , HAZUDA DARIA J , KIM PETER S , ROOT MICHAEL J , ECKERT DEBRA M , LENNARD SIMON N , BIANCHI ELISABETTA
IPC分类号： A61K39/395 , C07K16/10 , C12Q1/70
CPC分类号： G01N33/56988 , C07K16/1063 , C07K2317/21 , C07K2317/622 , C07K2317/76 , G01N2500/00
摘要： Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as V H and V L chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.
摘要翻译：披露了人scFv，其与艾滋病病毒gp41的七重复重复1（HR1）区域内的前发夹N-螺旋卷曲螺旋结构与构象表位相互作用。显示出这些抗体以及IgG转化中和多种HIV分离物。还公开了分离的核酸分子，其编码这些抗体的相关部分，以及所表达的抗体或相关抗体片段的纯化形式，例如V H H和V L >链。在本说明书中公开的抗体组合物可通过降低受感染个体内的病毒载量水平来提供抗HIV感染的治疗性治疗，从而延长HIV感染的无症状期。这些抗体也可用于鉴定HIV抗病毒化合物的测定，以及允许鉴定候选的HIV疫苗，例如HIV肽疫苗。

7. 发明申请

WO2005118887A2 HUMAN ANTIBODIES INTERACTING WITH HIV GP41 审中-公开
标题翻译：人类抗体与HIV GP41相互作用
公开(公告)号：WO2005118887A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019049
申请日：2005-05-31
申请人： MERCK & CO., INC. , WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , SHIVER, John, W. , MILLER, Michael, D. , GELEZIUNAS, Romas , HAZUDA, Daria, J. , KIM, Peter, S. , ROOT, Michael, J. , ECKERT, Debra, M. , LENNARD, Simon, N. , BIANCHI, Elisabetta
发明人： SHIVER, John, W. , MILLER, Michael, D. , GELEZIUNAS, Romas , HAZUDA, Daria, J. , KIM, Peter, S. , ROOT, Michael, J. , ECKERT, Debra, M. , LENNARD, Simon, N. , BIANCHI, Elisabetta
IPC分类号： C12Q1/70
CPC分类号： G01N33/56988 , C07K16/1063 , C07K2317/21 , C07K2317/622 , C07K2317/76 , G01N2500/00
摘要： Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as V H and V L chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.
摘要翻译：披露了人scFv，其与艾滋病病毒gp41的七重复重复1（HR1）区域内的前发夹，N-螺旋卷曲螺旋结构与构象表位相互作用。显示出这些抗体以及IgG转化中和多种HIV分离物。还公开了分离的核酸分子，其编码这些抗体的相关部分，以及所表达的抗体或相关抗体片段（例如VH和VL链）的纯化形式。在本说明书中公开的抗体组合物可通过降低受感染个体内的病毒载量水平来提供抗HIV感染的治疗性治疗，从而延长HIV感染的无症状期。这些抗体也可用于鉴定HIV抗病毒化合物的测定，以及允许鉴定候选的HIV疫苗，例如HIV肽疫苗。

8. 发明申请

WO2007070717A3 METHOD AND APPARATUS FOR FLEXIBLE BATTERY FOR IMPLANTABLE DEVICE 审中-公开
公开(公告)号：WO2007070717A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/048125
申请日：2006-12-15
申请人： CARDIAC PACEMAKERS, INC. , ROOT, Michael J. , YOUKER, Nick A.
发明人： ROOT, Michael J. , YOUKER, Nick A.
IPC分类号： H01M2/10 , H01M2/20
摘要： One embodiment of the present subject matter includes an apparatus for storing energy, the apparatus having a first portion comprising a flexible substrate containing a polymer electrolyte and a second portion adapted to provide a conformable housing surrounding the first portion; wherein the apparatus is adapted to provide a source of energy to an implantable device. The apparatus defines a flexible implantable device capable of traversing the circulatory system of a body with minimal obstruction of flow within the circulatory system. Further provided is a method of implanting an power source within the circulatory system of a subject's body.

9. 发明申请

WO0144286A3 FIVE-HELIX PROTEIN 审中-公开
标题翻译： FIVE-HELIX蛋白
公开(公告)号：WO0144286A3
公开(公告)日：2002-01-24
申请号：PCT/US0034194
申请日：2000-12-15
申请人： WHITEHEAD BIOMEDICAL INST , ROOT MICHAEL J , KAY MICHAEL S , CHAN DAVID C , KIM PETER S
发明人： ROOT MICHAEL J , KAY MICHAEL S , CHAN DAVID C , KIM PETER S
IPC分类号： G01N33/50 , A61K38/00 , A61K38/16 , A61K39/00 , A61P31/18 , A61P37/04 , C07K14/155 , C07K14/16 , C07K19/00 , C12N5/06 , C12N15/09 , C12Q1/02 , G01N33/15 , C07K16/10 , C12N15/49
CPC分类号： C07K14/005 , A61K38/162 , A61K39/00 , C07K2319/00 , C12N2740/16122
摘要： Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which inlcudes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.
摘要翻译：由螺旋体（如氨基酸残基连接体）分离的HIV-gp41三聚体发夹结构的C-螺旋的三个N-螺旋和至少两个但不是三个C-螺旋的五螺旋蛋白是披露。还公开了六螺旋蛋白，其包括由接头分离的HIV gp41的三聚体发夹结构的三个N-螺旋和三个C-螺旋。

10. 发明申请

WO2010040065A1 BIOSORBABLE BATTERY AND RELATED METHODS 审中-公开
标题翻译：可生物电池及相关方法
公开(公告)号：WO2010040065A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/059397
申请日：2009-10-02
申请人： CARDIAC PACEMAKERS, INC. , ROOT, Michael, J. , ATANASOSKA, Ljiljana, Liliana
发明人： ROOT, Michael, J. , ATANASOSKA, Ljiljana, Liliana
IPC分类号： A61N1/378
CPC分类号： A61N1/378 , H01M2/0202 , H01M2/026 , H01M2/028 , H01M2/1653 , H01M4/36 , H01M4/38 , H01M4/50 , H01M4/52 , H01M4/5825 , H01M4/602 , H01M6/34 , H01M2220/00 , Y10T29/49108
摘要： Embodiments of the invention are related to biosorbable batteries, amongst other things. In an embodiment, the invention includes a biosorbable battery assembly including an anode, a cathode, and a biosorbable separation element. The anode can include an anode material, wherein electrochemical oxidation of the anode material results in the formation of reaction products that are substantially non-toxic. The cathode can include a cathode material, wherein electrochemical reduction of the cathode material results in the formation of reaction products that are substantially non-toxic, the cathode material having a larger standard reduction potential than the material of the anode. The biosorbable separation element can be disposed between the anode and the cathode and can be configured to provide electrical insulation between the anode and the cathode. In an embodiment, the invention includes a medical device system including an implanted medical device and a biosorbable battery in electrical communication with the implanted medical device. Other embodiments are also included herein.
摘要翻译：除其他之外，本发明的实施例涉及生物可吸收电池。在一个实施方案中，本发明包括一种包括阳极，阴极和生物可吸收分离元件的生物可吸收电池组件。阳极可以包括阳极材料，其中阳极材料的电化学氧化导致基本上无毒的反应产物的形成。阴极可以包括阴极材料，其中阴极材料的电化学还原导致形成基本无毒的反应产物，阴极材料具有比阳极材料更大的标准还原电位。生物可吸收分离元件可以设置在阳极和阴极之间，并且可以被配置为在阳极和阴极之间提供电绝缘。在一个实施例中，本发明包括医疗装置系统，其包括与植入的医疗装置电通信的植入医疗装置和生物可吸收电池。本文还包括其它实施例。

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