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1. 发明申请

WO2007127135A3 ANTIBIOTIC COMPOUNDS 审中-公开
公开(公告)号：WO2007127135A3
公开(公告)日：2008-10-02
申请号：PCT/US2007009640
申请日：2007-04-20
申请人： MERCK & CO INC , MEINKE PETER T , LIU KUN , XU LIBO , DEBENHAM SHERYL D , HASLER AMY , SHI GUO Q , ZHANG YONG , ZHANG FENGQI
发明人： MEINKE PETER T , LIU KUN , XU LIBO , DEBENHAM SHERYL D , HASLER AMY , SHI GUO Q , ZHANG YONG , ZHANG FENGQI
IPC分类号： C07K7/50
CPC分类号： C07D513/22
摘要： The present invention relates to novel carboxylic acid derivatives of thiazolyl peptide antibiotics capable of treating serious bacterial infections in mammals, and particularly, in humans. These carboxylic acid analogs can also be versatile intermediates for the preparation of new derivatives with useful antibacterial activity.

2. 发明申请

WO2007127200A3 ANTIBIOTIC COMPOUNDS 审中-公开
标题翻译：抗生素化合物
公开(公告)号：WO2007127200A3
公开(公告)日：2008-10-30
申请号：PCT/US2007009939
申请日：2007-04-20
申请人： MERCK & CO INC , MEINKE PETER T , LIU KUN , XU LIBO , DEBENHAM SHERYL D , ZHANG FENGQI , HASLER AMY
发明人： MEINKE PETER T , LIU KUN , XU LIBO , DEBENHAM SHERYL D , ZHANG FENGQI , HASLER AMY
IPC分类号： A61K38/12 , C12P21/04
CPC分类号： C07D513/22 , C07K5/06139
摘要： The present invention relates to novel carboxylic acid derivatives of thiazolyl peptide antibiotics capable of treating serious bacterial infections in mammals, and particularly, in humans. These carboxylic acid analogs can also be versatile intermediates for the preparation of new derivatives with useful antibacterial activity.
摘要翻译：本发明涉及能够治疗哺乳动物，特别是人类中的严重细菌感染的噻唑基肽抗生素的新型羧酸衍生物。这些羧酸类似物也可以是用于制备具有有用的抗菌活性的新衍生物的通用中间体。

3. 发明申请

WO2007127136A3 ANTIBIOTIC COMPOUNDS 审中-公开
标题翻译：抗生素化合物
公开(公告)号：WO2007127136A3
公开(公告)日：2008-10-02
申请号：PCT/US2007009641
申请日：2007-04-20
申请人： MERCK & CO INC , MEINKE PETER T , LIU KUN , XU LIBO , DEBENHAM SHERYL D
发明人： MEINKE PETER T , LIU KUN , XU LIBO , DEBENHAM SHERYL D
IPC分类号： A61K38/12 , C12P21/04
CPC分类号： C07K5/06182
摘要： The present invention relates to novel carboxylic acid derivatives of thiazolyl peptide antibiotics capable of treating serious bacterial infections in mammals, and particularly, in humans. These carboxylic acid analogs can also be versatile intermediates for the preparation of new derivatives with useful antibacterial activity.
摘要翻译：本发明涉及能够治疗哺乳动物，特别是人类的严重细菌感染的噻唑基肽抗生素的新型羧酸衍生物。这些羧酸类似物也可以是用于制备具有有用抗菌活性的新衍生物的通用中间体。

4. 发明申请

WO2006014262A3 INDOLES HAVING ANTI-DIABETIC ACTIVITY 审中-公开
标题翻译：具有抗糖尿病活性的药物
公开(公告)号：WO2006014262A3
公开(公告)日：2006-08-03
申请号：PCT/US2005022906
申请日：2005-06-28
申请人： MERCK & CO INC , LIU KUN , MEINKE PETER T , WOOD HAROLD B
发明人： LIU KUN , MEINKE PETER T , WOOD HAROLD B
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D413/14 , C07D413/10
摘要： Indoles of Formula (I) having -X-aryl-(CH 2 )x#191-oxazolidinedione and -X-heteroaryl-(CH 2 ) X -oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH 2 -, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
摘要翻译：具有-X-芳基 - （CH 2 2）x＃191-恶唑烷二酮和-X-杂芳基 - （CH 2 2）X的式（I）其中x为0或1，-X-为键或-CH 2 - ，并且它们的噻唑烷二酮类似物为吲哚环的N原子上的/ 激动剂或部分激动剂，并且可用于治疗和控制II型糖尿病，包括通常与2型糖尿病相关的高血糖症，血脂异常，高脂血症，高胆固醇血症，高甘油三酯血症和肥胖症。

5. 发明申请

WO02064094A3 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS 审中-公开
公开(公告)号：WO02064094A3
公开(公告)日：2003-06-12
申请号：PCT/US0204680
申请日：2002-02-05
申请人： MERCK & CO INC , ADAMS ALAN D , JONES A BRIAN , BERGER JOEL P , DROPINSKI JAMES F , ELBRECHT ALEXANDER , LIU KUN , MACNAUL KAREN LAMB , SHI GUO-QIANG , VON LANGEN DEREK J , ZHOU GAOCHAO
发明人： ADAMS ALAN D , JONES A BRIAN , BERGER JOEL P , DROPINSKI JAMES F , ELBRECHT ALEXANDER , LIU KUN , MACNAUL KAREN LAMB , SHI GUO-QIANG , VON LANGEN DEREK J , ZHOU GAOCHAO
IPC分类号： A61K31/192 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/41 , A61K31/423 , A61K31/427 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/28 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/06 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07C59/60 , C07C59/90 , C07D213/55 , C07D257/04 , C07D261/20 , C07D263/32 , C07D263/58 , C07D413/12 , C07D417/12 , C07C59/48
CPC分类号： C07D257/04 , C07C59/90 , C07D213/55 , C07D261/20 , C07D263/32 , C07D263/58 , C07D413/12 , C07D417/12
摘要： A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.
摘要翻译：一类2-芳氧基-2-芳基链烷酸包括作为PPARα和/或γ的有效激动剂的化合物，因此可用于治疗，控制或预防非胰岛素依赖型糖尿病（NIDDM），高血糖症，血脂异常高脂血症，高胆固醇血症，高甘油三酯血症，动脉粥样硬化，肥胖症，血管再狭窄，炎症和其他PPARα和/或γ介导的疾病，病症和病症。

6. 发明申请

WO2006089949A3 METHOD FOR CONTROLLING QUALITY OF SERVICE IN A COMMUNICATION SYSTEM BY USING POLICY DECISION FUNCTION MODULE 审中-公开
标题翻译：通过使用策略决策功能模块来控制通信系统中的服务质量的方法
公开(公告)号：WO2006089949A3
公开(公告)日：2006-11-02
申请号：PCT/EP2006060262
申请日：2006-02-24
申请人： SIEMENS AG , LIU KUN
发明人： LIU KUN
IPC分类号： H04L12/56 , H04L29/06
CPC分类号： H04W28/16 , H04L63/0807 , H04W80/10
摘要： This invention provides a method for controlling quality of service in a communication system by using a policy decision function (PDF) module, which method comprises: sending by user equipment (UE) a service request message to an application function (AF) module; generating an authorization token (AT) by the application function module, and sending an authentication authorization request message carrying the AT to a PDF via a Gq interface; storing the AT at the PDF and returning via the Gq interface an authentication authorization answer message carrying the AT to the AF; sending by the UE an IP packet message to a gateway GPRS supporting node (GGSN); generating by the GGSN an AT identical to the above-mentioned AT; sending via a Go interface a request message carrying said AT to the PDF; comparing by the PDF the two ATs received, if they are the same, notifying the GGSN said user's success of authentication for using the quality of service required by the service. This invention can still achieve QoS control provided by PDF even without a secondary PDP context.
摘要翻译：本发明提供了一种通过策略决策功能模块控制通信系统中的服务质量的方法，该方法包括：用户设备UE向应用功能模块发送服务请求消息; 由应用功能模块生成授权令牌（AT），并将携带AT的认证授权请求消息通过Gq接口发送给PDF; 将AT存储在PDF中，并通过Gq接口返回带有AT的认证授权应答消息给AF; UE向网关GPRS支持节点（GGSN）发送IP分组消息; 由GGSN生成与上述AT相同的AT; 经由Go接口发送携带所述AT到所述PDF的请求消息; 通过PDF比较接收到的两个AT（如果它们相同的话），通知GGSN所述用户使用服务所需的服务质量的认证成功。即使没有辅助PDP上下文，本发明仍然可以实现由PDF提供的QoS控制。

7. 发明申请

WO2005065417A2 COLD CATHODE ION GAUGE 审中-公开
标题翻译：冷阴离子测量仪
公开(公告)号：WO2005065417A2
公开(公告)日：2005-07-21
申请号：PCT/US2004044070
申请日：2004-12-17
申请人： FEI CO , LIU KUN
发明人： LIU KUN
IPC分类号： G01L21/30 , G01L21/34
CPC分类号： G01L21/34 , H01J41/06
摘要： A cold cathode ion gauge is provided that is suitable for use in a high vacuum and in the presence of contaminating gases. By decreasing the discharge current and, more precisely, decreasing the charge current density received by the gauge electrodes, and using certain type of materials for the gauge electrodes, the mechanism by which insulating films are deposited on surface of the electrodes is attenuated and the life of the gauge is significantly prolonged. The gauge discharge current can be decreased by providing a large resistor in series with the anode, while the charge current density can be decreased by using an electrode with larger surface area, which can be achieved by fabricating grooves or fans on electrodes and by using low electron backscattering and low secondary emission materials, like carbon. Another concept of constant current mode is also proposed in this invention for extending the lifetime of CCIGs that are used for vacuum containing unfriendly gases.
摘要翻译：提供了一种适用于高真空和有污染气体存在的冷阴极离子计。通过减小放电电流，更准确地说，降低了由电极接收的充电电流密度，并且使用某些类型的用于量规电极的材料，绝缘膜沉积在电极表面上的机制被衰减并且寿命的量规显着延长。可以通过提供与阳极串联的大电阻器来减小表压放电电流，同时可以通过使用具有较大表面积的电极来降低充电电流密度，这可以通过在电极上制造凹槽或风扇并且通过使用低电子后向散射和低二次发射材料，如碳。在本发明中还提出了恒流模式的另一概念，用于延长用于含有不友好气体的真空的CCIG的寿命。

8. 发明申请

WO2010133440A3 SYSTEMS AND METHODS FOR MANAGING SECURITY AND/OR PRIVACY SETTINGS 审中-公开
标题翻译：用于管理安全和/或隐私设置的系统和方法
公开(公告)号：WO2010133440A3
公开(公告)日：2011-02-03
申请号：PCT/EP2010055854
申请日：2010-04-29
申请人： IBM , GRANDISON TYRONE WILBERFORCE , LIU KUN , MAXIMILIEN EUGENE MICHAEL , TERZI EVIMARIA
发明人： GRANDISON TYRONE WILBERFORCE , LIU KUN , MAXIMILIEN EUGENE MICHAEL , TERZI EVIMARIA
IPC分类号： G06F21/24
CPC分类号： G06F21/6245
摘要： Systems and methods for managing security and/or privacy settings are described. In one embodiment, the method may include communicably coupling a first client to a second client. The method may further include propagating a portion of a plurality of security and/or privacy settings for the first client from the first client to the second client. The method may also include, upon receiving at the second client the portion of the plurality of security and/or privacy settings for the first client, incorporating the received portion of the plurality of security and/or privacy settings for the first client into a plurality of security and/or privacy settings for the second client.
摘要翻译：描述用于管理安全和/或隐私设置的系统和方法。在一个实施例中，该方法可以包括将第一客户端可通信地耦合到第二客户端。该方法还可以包括将第一客户端的多个安全和/或隐私设置的一部分从第一客户端传播到第二客户端。该方法还可以包括，在第二客户端接收到第一客户端的多个安全和/或隐私设置的部分，将接收到的第一客户端的多个安全和/或隐私设置的部分合并成多个的第二客户端的安全和/或隐私设置。

9. 发明申请

WO2014014794A3 MINERALOCORTICOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译：矿物胆碱受体拮抗剂
公开(公告)号：WO2014014794A3
公开(公告)日：2015-07-16
申请号：PCT/US2013050427
申请日：2013-07-15
申请人： MERCK SHARP & DOHME , CERNAK TIMOTHY A , DYKSTRA KEVIN D , SHEN DONG-MING , LIU KUN , STAMFORD ANDREW , TAN JOHN QIANG
发明人： CERNAK TIMOTHY A , DYKSTRA KEVIN D , SHEN DONG-MING , LIU KUN , STAMFORD ANDREW , TAN JOHN QIANG
IPC分类号： A61K31/404 , A61K31/416 , C07D209/10 , C07D231/56 , C07D403/06
CPC分类号： A61K31/416 , A61K45/06 , C07D231/56 , A61K2300/00
摘要： The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosteronemediated diseases. The invention furthermore relates to specific diastereomers and enantiomers of the compounds, to processes for preparing compounds of the Formula (I), to their potential use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其可用于治疗醛固酮增多症。本发明还涉及该化合物的具体非对映异构体和对映异构体，制备式（I）化合物的方法，以及其用于治疗和预防上述疾病和用于制备用于该目的的药物和药物组合物其包含式（I）的化合物。

10. 发明申请

WO2011150885A3 METHOD AND DEVICE FOR MANAGING VOICE MESSAGE 审中-公开
标题翻译：用于管理语音信息的方法和设备
公开(公告)号：WO2011150885A3
公开(公告)日：2012-05-10
申请号：PCT/CN2011076208
申请日：2011-06-23
申请人： HUAWEI DEVICE CO LTD , LU CHAOQUN , LIU KUN
发明人： LU CHAOQUN , LIU KUN
IPC分类号： H04M1/65 , H04W4/12
CPC分类号： H04M1/7255
摘要： The present invention discloses a method and a device for managing a voice message, and relates to the field of communications. It solves the problem that the prior art cannot support a remote terminal to manage a voice message. The technical solution provided in the embodiment of the present invention includes the following steps: when a user manages a voice message of a local terminal through a remote terminal, the local terminal sends a voice message management prompt to the remote terminal (101); the local terminal receives a management instruction sent by the remote terminal according to the voice message management prompt (102); the local terminal executes a corresponding management operation on the voice message according to the management instruction (103). The embodiment of the present invention is applicable to terminals such as a mobile phone.
摘要翻译：本发明公开了一种用于管理语音消息的方法和装置，涉及通信领域。解决了现有技术不能支持远程终端来管理语音消息的问题。本发明实施例提供的技术方案包括以下步骤：当用户通过远程终端管理本地终端的语音消息时，本地终端向远程终端发送语音消息管理提示; 本地终端根据语音消息管理提示（102）接收远程终端发送的管理指令; 本地终端根据管理指令（103）对语音消息执行对应的管理操作。本发明的实施例可应用于移动电话等终端。

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