专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007095269A2 NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开
标题翻译：用于治疗RNA依赖性RNA病毒感染的核苷类ARYL磷酸酯
公开(公告)号：WO2007095269A2
公开(公告)日：2007-08-23
申请号：PCT/US2007003862
申请日：2007-02-12
申请人： MERCK & CO INC , ANGELETTI P IST RICHERCHE BIO , MACCOSS MALCOLM , OLSEN DAVID B , DONGHI MONICA , GARDELLI CRISTINA , HARPER STEVEN , MEPPEN MALTE , NARJES FRANK , PACINI BARBARA
发明人： MACCOSS MALCOLM , OLSEN DAVID B , DONGHI MONICA , GARDELLI CRISTINA , HARPER STEVEN , MEPPEN MALTE , NARJES FRANK , PACINI BARBARA
CPC分类号： C07H19/06
摘要： The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.
摘要翻译：本发明提供结构式（I）的核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种核苷芳基氨基磷酸酯的药物组合物。还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

2. 发明申请

WO2007021610A3 RIBONUCLEOSIDE CYCLIC ACETAL DERIVATIVES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开
标题翻译：核糖核苷环状乙酰基衍生物用于治疗RNA依赖性RNA病毒感染
公开(公告)号：WO2007021610A3
公开(公告)日：2007-10-04
申请号：PCT/US2006030549
申请日：2006-08-04
申请人： MERCK & CO INC , BUTORA GABOR , KOEPLINGER KENNETH ALAN , MACCOSS MALCOLM , MCMASTERS DANIEL R , OLSEN DAVID B , YANG LIHU
发明人： BUTORA GABOR , KOEPLINGER KENNETH ALAN , MACCOSS MALCOLM , MCMASTERS DANIEL R , OLSEN DAVID B , YANG LIHU
IPC分类号： A01N43/04 , A01N57/00 , A61K31/519
CPC分类号： C07H19/06 , C07H19/16
摘要： The present invention provides ribonucleoside 2',3'-cyclic acetals of structural formula I which are precursors or prodrugs of inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors of inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors or prodrugs of inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors or prodrugs of inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such ribonucleoside 2',3'-cyclic acetals alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the ribonucleoside 2',3'-cyclic acetals of the present invention.
摘要翻译：本发明提供结构式I的核糖核苷2'，3'-环状缩醛，其为RNA依赖性RNA病毒聚合酶抑制剂的前体或前体药物。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，并且可用于治疗RNA依赖性RNA病毒感染。它们作为丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体或前体药物，作为HCV复制抑制剂的前体或前体药物和/或用于治疗丙型肝炎感染特别有用。本发明还描述了含有这种核糖核苷2'，3'-环状缩醛的药物组合物，所述组合物单独地或与其它对RNA依赖性RNA病毒感染特别是HCV感染有活性的药物组合。还公开了抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或用本发明的核糖核苷2'，3'-环缩醛治疗RNA依赖性RNA病毒感染的方法。

3. 发明申请

WO02057287A2 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO02057287A2
公开(公告)日：2002-07-25
申请号：PCT/US0203086
申请日：2002-01-18
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , CARROLL STEVEN S , MACCOSS MALCOLM , OLSEN DAVID B , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , PRAKASH THAZHA P , PRHAVC MARIJA , SONG QUANLAI
发明人： CARROLL STEVEN S , MACCOSS MALCOLM , OLSEN DAVID B , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , PRAKASH THAZHA P , PRHAVC MARIJA , SONG QUANLAI
IPC分类号： C07D487/04 , A61K31/519 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/712 , A61K38/21 , A61K45/00 , A61K45/06 , A61P1/16 , A61P31/14 , A61P43/00 , C07D473/00 , C07D487/02 , C07H20060101 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/173 , C07H19/19 , C07H19/20 , C12N20060101
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

4. 发明申请

WO2007022073A3 NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES 审中-公开
标题翻译：新型2'-C-甲基和4'-C-甲基核苷衍生物
公开(公告)号：WO2007022073A3
公开(公告)日：2007-11-15
申请号：PCT/US2006031614
申请日：2006-08-14
申请人： MERCK & CO INC , METABASIS THERAPEUTICS INC , ERION MARK D , REDDY K RAJA , MACCOSS MALCOLM , OLSEN DAVID B
发明人： ERION MARK D , REDDY K RAJA , MACCOSS MALCOLM , OLSEN DAVID B
IPC分类号： A01N43/00 , A61K31/70
CPC分类号： C07H19/10
摘要： Novel 2'-C-methyl nucleoside 5 '-monophosphate and 4'-C-methyl nucleoside 5'- monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described.
摘要翻译：新型2'-C-甲基核苷5'-单磷酸酯和4'-C-甲基核苷5'-单磷酸酯衍生物，立体异构体及其药学上可接受的盐或前药，它们的制备及其治疗丙型肝炎病毒感染的用途被描述。

5. 发明申请

WO2006012078A2 NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开
标题翻译：用于治疗RNA依赖性RNA病毒感染的核苷类ARYL磷酸酯
公开(公告)号：WO2006012078A2
公开(公告)日：2006-02-02
申请号：PCT/US2005021684
申请日：2005-06-20
申请人： MERCK & CO INC , MACCOSS MALCOLM , OLSEN DAVID B
发明人： MACCOSS MALCOLM , OLSEN DAVID B
IPC分类号： C12Q1/68
CPC分类号： C07H19/20 , C07H19/14 , C07H19/16
摘要： The present invention provides nucleoside aryl phosphoramidates which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.
摘要翻译：本发明提供核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。本发明还描述了单独含有这种核苷芳基氨基磷酸酯或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的药物组合物。还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

6. 发明申请

WO2004003138A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO2004003138A3
公开(公告)日：2006-12-28
申请号：PCT/US0319776
申请日：2003-06-23
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , OLSEN DAVID B , MACCOSS MALCOLM , BHAT BALKRISHEN , ELDRUP ANNE B
发明人： OLSEN DAVID B , MACCOSS MALCOLM , BHAT BALKRISHEN , ELDRUP ANNE B
IPC分类号： A61K31/70 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/20
CPC分类号： C07H19/22 , C07H19/14 , C07H19/16 , C07H19/20
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

7. 发明申请

WO2006065335A3 FLUORINATED PYRROLO[2,3-D]PYRIMIDINE NUCLEOSIDES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开
标题翻译：用于治疗RNA依赖性RNA病毒感染的氟化吡咯烷[2,3-D]嘧啶核苷
公开(公告)号：WO2006065335A3
公开(公告)日：2006-09-14
申请号：PCT/US2005037224
申请日：2005-10-17
申请人： MERCK & CO INC , MACCOSS MALCOLM , OLSEN DAVID B , LEONE JOSEPH , DURETTE PHILIPPE L
发明人： MACCOSS MALCOLM , OLSEN DAVID B , LEONE JOSEPH , DURETTE PHILIPPE L
IPC分类号： A61K31/7052 , A61K31/7042 , C07H19/14
CPC分类号： C07H19/14
摘要： The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaeutical compositions containing such fluorinated pyrrolo[2,3-d]pyrimidine nucleoside alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the fluorinated pyrrolo[2,3-d]pyrimidine nucleoside of the present invention.
摘要翻译：本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂的氟化吡咯并[2,3，d]嘧啶核苷化合物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。本发明还描述了含有这种氟化吡咯并[2,3-d]嘧啶核苷的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。还公开了本发明的氟化吡咯并[2,3-d]嘧啶核苷抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

8. 发明申请

WO02057425A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO02057425A3
公开(公告)日：2005-04-21
申请号：PCT/US0201531
申请日：2002-01-18
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , CARROLL STEVEN S , LAFEMINA ROBERT L , HALL DAWN L , HIMMELBERGER AMY L , KUO LAWRENCE C , MACCOSS MALCOLM , OLSEN DAVID B , RUTKOWSKI CARRIE A , TOMASSINI JOANNE E , AN HAOYUN , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , GUINOSSO CHARLES J , PRHAVC MARIJA , PRAKASH THAZHA P
发明人： CARROLL STEVEN S , LAFEMINA ROBERT L , HALL DAWN L , HIMMELBERGER AMY L , KUO LAWRENCE C , MACCOSS MALCOLM , OLSEN DAVID B , RUTKOWSKI CARRIE A , TOMASSINI JOANNE E , AN HAOYUN , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , GUINOSSO CHARLES J , PRHAVC MARIJA , PRAKASH THAZHA P
IPC分类号： C07D487/04 , A61K31/519 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/712 , A61K38/21 , A61K45/00 , A61K45/06 , A61P1/16 , A61P31/14 , A61P43/00 , C07D473/00 , C07D487/02 , C07H20060101 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/173 , C07H19/19 , C07H19/20 , C12N20060101
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的药物组合物。还公开了本发明的核苷衍生物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

9. 发明申请

WO2004007512A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
公开(公告)号：WO2004007512A3
公开(公告)日：2004-04-08
申请号：PCT/US0321589
申请日：2003-07-11
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , BHAT BALKRISHEN , CARROLL STEVEN S , ELDRUP ANNE B , MACCOSS MALCOLM , OLSEN DAVID B , PRAKASH THAZHA P
发明人： BHAT BALKRISHEN , CARROLL STEVEN S , ELDRUP ANNE B , MACCOSS MALCOLM , OLSEN DAVID B , PRAKASH THAZHA P
IPC分类号： C12N9/99 , A61K31/7056 , A61K31/7064 , A61K38/21 , A61K45/00 , A61P1/16 , A61P31/14 , A61P43/00 , C07H19/14 , A61K31/70
CPC分类号： C07H19/14 , C07H19/22
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

10. 发明申请

WO2005123087A2 C-PURINE NUCLEOSIDE ANALOGS AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的C-嘌呤核苷类似物
公开(公告)号：WO2005123087A2
公开(公告)日：2005-12-29
申请号：PCT/US2005020757
申请日：2005-06-10
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , BUTORA GABOR , MACCOSS MALCOLM , BHAT BALKRISHEN , ELDRUP ANNE B
发明人： BUTORA GABOR , MACCOSS MALCOLM , BHAT BALKRISHEN , ELDRUP ANNE B
IPC分类号： A61K31/513 , A61K31/522 , C07D487/04 , C07D491/04 , C07D498/04
CPC分类号： C07D491/04 , C07D487/04 , C07H19/16 , C07H19/20
摘要： The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such C-nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the C-nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的C-嘌呤核苷类似物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种C-核苷化合物的药物组合物。还公开了本发明的C-核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式