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1. 发明申请

WO2011102958A1 APPARATUS FOR CREATING A VENOUS VALVE FROM AUTOLOGOUS TISSUE 审中-公开
标题翻译：用于从自动组织创建静脉瓣的装置
公开(公告)号：WO2011102958A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/023168
申请日：2011-01-27
申请人： MEDTRONIC VASCULAR INC. , MAUCH, Kevin , JEFFRIES, Melissa , BIENVENU, Ryan , ARREGUIN, Maria
发明人： MAUCH, Kevin , JEFFRIES, Melissa , BIENVENU, Ryan , ARREGUIN, Maria
IPC分类号： A61F2/24 , A61B17/00
CPC分类号： A61F2/2475 , A61B2017/00783 , A61F2/2427 , A61F2/2442
摘要： An implantable prosthesis (316) for percutaneous placement within a vein (400) that forces opposing portions of the vessel wall of a vein together to create a new valve of autologous vein tissue to be operable to alternate between a valve closed configuration and a valve open configuration. When in a preset closed configuration, the implantable prosthesis pushes or pulls portions of the vessel wall of the vein together to substantially close the vein lumen and prevent retrograde blood flow from backflowing through the new valve in the valve closed configuration. The implantable prosthesis has leg portions (319, 323) that may be pushed apart in response to antegrade blood flow through the vein to allow the new valve to achieve the valve open configuration.
摘要翻译：一种植入式假体（316），用于经皮置于静脉内（400），其将静脉血管壁的相对部分压在一起，以创建自动静脉组织的新阀，以可操作地在阀关闭构型和阀打开之间交替组态。当处于预设的闭合配置中时，可植入假体将静脉血管壁的一部分推入或拉出，以基本上关闭静脉腔，并防止逆流血流在阀关闭构型中回流通过新阀。可植入假体具有腿部（319,323），其可以响应于穿过静脉的顺行血液流动被推开而允许新阀实现阀打开构造。

2. 发明申请

WO2012036864A1 STENT WITH HOLLOW DRUG-ELUTING ELEMENTS 审中-公开
标题翻译：具有中空药水的元素
公开(公告)号：WO2012036864A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/049212
申请日：2011-08-25
申请人： MEDTRONIC VASCULAR , BIENVENU, Ryan
发明人： BIENVENU, Ryan
IPC分类号： A61L31/02 , A61L31/16 , A61F2/86
CPC分类号： A61L31/16 , A61F2/86 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2250/0068 , A61L31/146
摘要： A stent includes a plurality of cylindrical elements joined along a common longitudinal axis to form a tube. The cylindrical elements include struts joined by crowns. Hollow, drug-eluting elements are disposed between adjacent cylindrical elements and connect adjacent cylindrical elements to each other. A therapeutic substance fills the lumen of the drug-eluting elements, and openings in the walls of the drug-eluting elements allow elution of therapeutic substance from the lumen for treatment of a vessel.
摘要翻译：支架包括沿着共同的纵向轴线连接以形成管的多个圆柱形元件。圆柱形元件包括由冠部连接的支柱。中空，药物洗脱元件设置在相邻的圆柱形元件之间并将相邻的圆柱形元件彼此连接。治疗性物质填充药物洗脱元件的内腔，并且药物洗脱元件的壁中的开口允许从管腔洗脱治疗物质用于处理血管。

3. 发明申请

WO2012036890A1 METHOD OF FORMING A DRUG-ELUTING MEDICAL DEVICE 审中-公开
标题翻译：形成药物治疗装置的方法
公开(公告)号：WO2012036890A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/049761
申请日：2011-08-30
申请人： MEDTRONIC VASCULAR , BIENVENU, Ryan
发明人： BIENVENU, Ryan
IPC分类号： A61L31/14 , A61L31/16 , A61L31/18
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91541 , A61F2002/91575 , A61F2230/0013 , A61F2230/0091 , A61F2240/001 , A61F2250/0068 , A61L31/121 , A61L2300/406 , A61L2300/416 , Y10T29/49885 , Y10T29/49995
摘要： A method of forming a stent includes the steps of forming an elongated composite member or plurality of elongated composite members into a stent pattern having struts interconnected by crowns, the composite member including an outer member and a core member. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from at least a plurality of the struts of the stent without adversely affecting the outer member and such that the core member is not removed from at least a plurality of the crowns of the stent, thereby leaving the outer member with a lumen in at least a plurality of the struts and the outer member with the core member in at least a plurality of the crowns. The lumens may then be filled with a biologically or pharmacologically active substance.
摘要翻译：形成支架的方法包括以下步骤：将细长复合构件或多个细长复合构件形成为具有由冠部互连的支柱的支架图案，所述复合构件包括外部构件和芯构件。通过复合构件的外部构件形成开口。处理复合构件以从支架的至少多个支柱移除芯构件，而不会不利地影响外构件，并且使得芯构件不从支架的至少多个冠部移除，从而留下所述外部构件在至少多个所述支柱中具有内腔，所述外部构件具有至少多个所述冠部中的所述芯构件。然后可以用生物学或药理学活性物质填充内腔。

4. 发明申请

WO2012036875A1 METHOD OF FORMING A DRUG-ELUTING MEDICAL DEVICE 审中-公开
标题翻译：形成药物治疗装置的方法
公开(公告)号：WO2012036875A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/049429
申请日：2011-08-26
申请人： MEDTRONIC VASCULAR , BIENVENU, Ryan , KANTOR, John
发明人： BIENVENU, Ryan , KANTOR, John
IPC分类号： A61L31/02 , A61L31/16 , A61F2/86
CPC分类号： A61F2/89 , A61F2/86 , A61F2/88 , A61F2230/0069 , A61F2250/0067 , A61F2250/0068 , A61L31/022 , A61L31/16 , A61L2400/18 , A61M31/002 , A61M2207/10 , B23P19/04 , C23F1/12 , Y10T29/4987
摘要： A method of forming a stent includes the steps of forming a composite member into a stent pattern, forming openings through an outer member of the composite member, processing the composite member to remove a portion of the composite member without adversely affecting the outer member, and swaging the outer member to create a plurality of lumens. The composite member may be formed of an outer member with an hourglass-shaped inner member, wherein the processing step removes the inner member and the swaging step forms two lumens from the hourglass shaped cavity. The composite member may be formed of an outer member, an inner member, and an intermediate member, wherein the processing step removes the intermediate member and the swaging step presses portions of the outer member into contact with the inner member to form two lumens separated by the inner member.
摘要翻译：形成支架的方法包括以下步骤：将复合构件形成支架图案，通过复合构件的外部构件形成开口，处理复合构件以去除复合构件的一部分而不会不利地影响外部构件;以及模制外部构件以形成多个流明。复合构件可以由具有沙漏形内部构件的外部构件形成，其中处理步骤移除内部构件，并且锻造步骤与沙漏形腔形成两个流明。复合构件可以由外部构件，内部构件和中间构件形成，其中加工步骤移除中间构件，并且锻造步骤将外部构件的部分按压与内部构件接触以形成由内部成员。

5. 发明申请

WO2018089697A1 STENTS FORMED FROM DISSIMILAR METALS FOR TISSUE GROWTH CONTROL 审中-公开
标题翻译：从异种金属形成的支架用于组织生长控制
公开(公告)号：WO2018089697A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060948
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： PETERSON, Justin , BIENVENU, Ryan , TUNEV, Stefan , HARMS, Michael
IPC分类号： A61F2/90 , A61F2/915
摘要： Stents formed from dissimilar materials configured to control tissue growth. A stent may be formed from a composite wire helically wound into a stent having a tubular configuration. The composite wire includes a first wire and a second wire coupled together, the first and second wires being formed from dissimilar metals such that a potential difference is formed when the dissimilar metals are exposed to bodily fluids. The potential difference is configured to inhibit cell proliferation and thereby control tissue growth around the stent after implantation. A stent may be formed from a hollow composite wire including an inner member that includes first and second longitudinal strips formed from dissimilar metals. A stent may be formed from a composite wire having a plurality of windows along a length of the composite wire. An insert formed from a dissimilar metal is disposed within each window of the plurality of windows.
摘要翻译：由配置成控制组织生长的不同材料形成的支架。支架可以由螺旋缠绕成具有管状构造的支架的复合线形成。复合导线包括连接在一起的第一导线和第二导线，第一导线和第二导线由不同金属形成，使得当异种金属暴露于体液时形成电位差。电位差配置成抑制细胞增殖并由此控制植入后支架周围的组织生长。支架可以由包括内部构件的中空复合金属丝形成，所述内部构件包括由不同金属形成的第一和第二纵向条。支架可由具有沿着复合线材的长度的多个窗口的复合线材形成。由不同种金属形成的插入件设置在多个窗口的每个窗口内。

6. 发明申请

WO2013154666A1 HOLLOW DRUG-FILLED STENT AND METHOD OF FORMING HOLLOW DRUG-FILLED STENT 审中-公开
标题翻译：中空药液填充瓶和形成中药液灌注液的方法
公开(公告)号：WO2013154666A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/025688
申请日：2013-02-12
申请人： MEDTRONIC VASCULAR INC.
发明人： BIENVENU, Ryan , MITCHELL, James E. , THOMPSON, Dustin
IPC分类号： A61F2/86 , A61L31/16 , A61K31/16
CPC分类号： A61F2/915 , A61F2/86 , A61F2002/91575 , A61F2230/0091 , A61F2240/001 , A61F2250/0068 , A61F2250/0098 , A61L31/022 , A61L31/16 , A61L31/18
摘要： A stent is formed from a wire (508) having an outer member (522) and a radiopaque core member (526) disposed within a portion of the outer member, and an annular lumen between the radiopaque core member and the outer member. A substance (512) is disposed in the annular lumen to be eluted through at least one opening (504) disposed through the outer member. A plurality of radiopaque core members are disposed within portions of the outer member and are separated by lumens defined by the inner surface of the outer member. The lumens and annular lumens are in fluid communication with each other. In a method for making the stent, a composite wire including an outer member, an intermediate member, and a core member is shaped into a stent pattern and processed to remove the intermediate member and portions of the radiopaque core member, without damaging the outer member.
摘要翻译：支架由具有外部构件（522）和设置在外部构件的一部分内的不透射线芯构件（526）的线（508）形成，以及位于不透射线芯构件和外部构件之间的环形腔。物质（512）设置在环形腔中以通过穿过外部构件设置的至少一个开口（504）被洗脱。多个不透射线的芯构件设置在外部构件的部分内并且由外部构件的内表面限定的腔分开。管腔和环形腔相互流体连通。在制造支架的方法中，将包括外部构件，中间构件和芯部构件的复合线材成形为支架图案并进行处理以去除不透射线的芯构件的中间构件和部分，而不损坏外部构件。

7. 发明申请

WO2018089696A1 DRUG-FILLED STENT WITH FILAMENTS FOR INCREASED LUMEN SURFACE AREA AND METHOD OF MANUFACTURE THEREOF 审中-公开
标题翻译：含药物的药物支架用于增加液体表面积及其制造方法
公开(公告)号：WO2018089696A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060947
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： BIENVENU, Ryan , PETERSON, Justin , TUNEV, Stefan , HARMS, Michael
IPC分类号： A61F2/88 , A61F2/915
摘要： A stent including a hollow wire formed into a stent pattern. The hollow wire includes an outer member having an outer surface and an inner surface, a lumen extending longitudinally within the hollow wire, at least one opening extending from the outer surface of the outer member to the lumen, and a plurality of filaments extending longitudinally within the lumen. The plurality of filaments increases the amount of surface area available for tissue in-growth within the lumen. Each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and the spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments.
摘要翻译：包括形成支架图案的中空丝的支架。中空线包括具有外表面和内表面的外部构件，在中空线内纵向延伸的内腔，从外部构件的外表面延伸到内腔的至少一个开口以及多个纵向延伸的细丝流明。多根细丝增加了可用于组织在内腔内生长的表面积的量。多根长丝中的每根长丝与多根长丝中的相邻长丝间隔开，并且多根长丝中相邻长丝之间的间隔被配置成允许组织在相邻长丝之间的内生长。

8. 发明申请

WO2018089705A1 DRUG-FILLED STENTS TO PREVENT VESSEL MICRO-INJURIES AND METHODS OF MANUFACTURE THEREOF 审中-公开
标题翻译：药物填充支架以防止血管微创伤及其制造方法
公开(公告)号：WO2018089705A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060958
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： TUNEV, Stefan , BIENVENU, Ryan , PETERSON, Justin , SULLIVAN, Carol , STORMENT, Christopher , HARMS, Michael
IPC分类号： A61F2/88 , A61F2/915
摘要： A stent includes a hollow wire formed into a stent pattern. The hollow wire includes an outer member, a lumen extending longitudinally within the hollow wire, at least one opening extending from an outer surface of the outer member to the lumen, and a surface area component within the hollow wire. The surface area component increases the amount of surface area available for tissue in-growth within the hollow wire. More than one surface area component may be utilized. Each surface area component may be disposed within the lumen or the at least one opening of the hollow wire. A pharmacologically or biologically active agent may be disposed within the lumen.
摘要翻译：支架包括形成为支架图案的中空丝。中空线包括外部构件，在中空线内纵向延伸的内腔，从外部构件的外表面延伸至内腔的至少一个开口以及中空线内的表面区域组件。表面积组分增加了空心丝内组织向内生长的表面积。可以使用多于一个的表面区域组件。每个表面区域组件可以布置在内腔或中空线的至少一个开口内。药理学或生物活性剂可置于腔内。

9. 发明申请

WO2013154667A1 HOLLOW DRUG-FILLED STENT AND METHOD OF FORMING HOLLOW DRUG-FILLED STENT 审中-公开
标题翻译：中空药液填充瓶和形成中药液灌注液的方法
公开(公告)号：WO2013154667A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/025788
申请日：2013-02-12
申请人： MEDTRONIC VASCULAR INC.
发明人： BIENVENU, Ryan , MITCHELL, James E. , THOMPSON, Dustin
IPC分类号： A61F2/86 , A61F2/91 , A61L31/16 , A61K9/00
CPC分类号： A61F2/86 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0068 , A61F2250/0098 , A61L31/022 , A61L31/16 , A61L31/18 , Y10T29/49817 , Y10T29/4998
摘要： A stent (300) is formed from a wire (302) having an outer member (322), a radiopaque member (324) lining at least a portion of the outer member inner surface, and a lumen (303) defined by the outer member inner surface or the radiopaque member inner surface. A pharmacologically active substance (312) is disposed in the lumen to be eluted through at least one opening (304) disposed through the outer member to the lumen. The radiopaque member may be substantially continuous along the length of the wire or disposed only along portions of the wire such as crowns. In a method for making the stent, a composite wire including an outer member, a radiopaque intermediate member, and a core member is shaped into a stent pattern and processed to remove the core member and optionally portions of the radiopaque intermediate member, without damaging the outer member.
摘要翻译：支架（300）由具有外部构件（322）的线（302），衬在外部构件内表面的至少一部分上的不透射体构件（324）和由外部构件限定的内腔（303）形成内表面或不透射线的构件内表面。药物活性物质（312）设置在内腔中，以通过穿过外部构件设置到内腔的至少一个开口（304）洗脱。不透射线的构件可以沿着导线的长度基本上是连续的，或者仅沿着线的部分如冠冠设置。在制造支架的方法中，将包括外部构件，不透射线中间构件和芯构件的复合线材成形为支架图案并且被处理以移除芯构件以及可选地部分不透射线的中间构件，而不损害外部成员。

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