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1. 发明申请

WO2011084204A1 HYDROGEN SULFIDE GENERATING POLYMERS 审中-公开
标题翻译：氢硫化物生成聚合物
公开(公告)号：WO2011084204A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/052691
申请日：2010-10-14
申请人： MEDTRONIC VASCULAR INC. , CHEN, Mingfei , STORMENT, Christopher , SHUMAKER, David
发明人： CHEN, Mingfei , STORMENT, Christopher , SHUMAKER, David
IPC分类号： C08F20/38 , C08F20/54 , A61L31/10 , A61L31/04
CPC分类号： C08F20/38 , A61L27/14 , A61L27/54 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , C08F20/54 , C08L101/02
摘要： Described herein are hydrogen sulfide (H 2 S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H 2 S generating polymers comprising at least one thioamide group. The H 2 S generating polymers can provide controlled site-specific release of H 2 S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H 2 S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.
摘要翻译：本文描述了产生适于涂覆或形成医疗装置的聚合物和聚合物系统的硫化氢（H 2 S）及其制备和使用方法。更具体地，描述了包含至少一个硫代酰胺基团的H 2 S生成聚合物。 H 2 S生成聚合物可以通过在生理介质中水解硫代酰胺基团一次植入到目标手术部位内或内部，从而提供控制的位点特异性释放H 2 S. 产生H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。还描述了使用这种医疗装置治疗再狭窄和炎症并促进血管扩张的方法。

2. 发明申请

WO2010087897A2 HYDROGEN SULFIDE DONATING POLYMERS 审中-公开
标题翻译：氢化硫化聚合物
公开(公告)号：WO2010087897A2
公开(公告)日：2010-08-05
申请号：PCT/US2009/066949
申请日：2009-12-07
申请人： MEDTRONIC VASCULAR INC. , CHEN, Mingfei , STORMENT, Christopher
发明人： CHEN, Mingfei , STORMENT, Christopher
IPC分类号： C08G63/688 , C08F12/30 , C08F20/18 , C08G69/42 , A61F2/06
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/10 , A61L2300/45 , A61L2300/61 , C08F220/18 , C08G69/42 , C08F220/34
摘要： Described herein are hydrogen sulfide (H 2 S) donating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H 2 S donating polymers comprising at least one monomer with at least one basic group that can be complexed with H 2 S to form a charged H 2 S complex. The H 2 S donating polymers can provide controlled release of H 2 S once implanted at or within the target surgical site. The H 2 S donating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system.
摘要翻译：本文描述了提供适于涂覆或形成医疗装置的聚合物和聚合物体系的硫化氢（H 2 S）及其制备和使用方法。更具体地，描述了包含至少一种具有至少一个碱性基团的单体的H 2 S供体聚合物，其可以与H 2 S络合以形成带电荷的H 2 S络合物。一旦植入到靶外科手术部位或其内部，H2S供体聚合物可以提供H2S的受控释放。提供的H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。

3. 发明申请

WO2011126676A1 STENT WITH THERAPEUTIC SUBSTANCE 审中-公开
标题翻译：具有治疗药物的STENT
公开(公告)号：WO2011126676A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/028349
申请日：2011-03-14
申请人： MEDTRONIC VASCULAR INC. , THOMPSON, Dustin , ADLER, Paus , ARREGUIN, Maria , MAUCH, Kevin , STORMENT, Christopher , ENSIGN, Lance , ZIMMERMAN, Stephen
发明人： THOMPSON, Dustin , ADLER, Paus , ARREGUIN, Maria , MAUCH, Kevin , STORMENT, Christopher , ENSIGN, Lance , ZIMMERMAN, Stephen
IPC分类号： A61F2/90 , A61F2/00
CPC分类号： A61F2/90 , A61F2250/0067 , A61F2250/0068 , B21F45/008
摘要： A stent (10) includes a wave form that includes a cable (14) including a plurality of strands (316). The wave form has a plurality of struts (18) and a plurality of crowns (20), with each crown connecting two adjacent struts. The wave form is wrapped around a longitudinal axis at a pitch to define a plurality of helical turns. The stent includes a filler located within the cable. The filler includes a therapeutic substance.
摘要翻译：支架（10）包括波形，其包括包括多个股线（316）的电缆（14）。波形具有多个支柱（18）和多个冠部（20），每个冠部连接两个相邻的支柱。波形以间距缠绕在纵向轴线上以限定多个螺旋形匝。支架包括位于电缆内的填充物。填料包括治疗物质。

4. 发明申请

WO2011005451A2 HOLLOW TUBULAR DRUG ELUTING MEDICAL DEVICES 审中-公开
标题翻译：中空管药物医疗器械
公开(公告)号：WO2011005451A2
公开(公告)日：2011-01-13
申请号：PCT/US2010/039087
申请日：2010-06-17
申请人： MEDTRONIC VASCULAR INC. , BIRDSALL, Matthew , STORMENT, Christopher , PERKINS, D.H. , THOMPSON, Dustin
发明人： BIRDSALL, Matthew , STORMENT, Christopher , PERKINS, D.H. , THOMPSON, Dustin
IPC分类号： A61L31/02
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译：一种形成空心的药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。该复合构件被成形为一种图案。通过复合构件的外部构件形成开口。处理复合构件以从外构件的内腔移除芯构件而不伤害外构件，留下已经形成为期望图案的中空管状构件。外部构件的内腔充满治疗物质。

5. 发明申请

WO2012009385A1 METHOD OF MAKING A STENT WITH HOLLOW STRUTS 审中-公开
标题翻译：制造具有中空条纹的手套的方法
公开(公告)号：WO2012009385A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/043765
申请日：2011-07-12
申请人： MEDTRONIC VASCULAR , STORMENT, Christopher
发明人： STORMENT, Christopher
IPC分类号： A61F2/90
CPC分类号： C25D1/20 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0068 , C25D1/08 , C25D5/022
摘要： A stent including hollow struts is formed on a cylindrical substrate. The struts of the stent are formed by electroforming metal layers of the strut in openings formed in a patterned photoresist material. A first metal layer (106) forming the inner strut material is formed in openings in a first photoresist material. A sacrificial material to form a cavity (126) to make the struts hollow is formed in openings in a second photoresist material. A second metal layer (122) forming the side walls and outer wall of the struts is formed in openings in a third photoresist material and around the sacrificial material. The photoresist materials are removed. The substrate and cavity sacrificial material are removed, leaving hollow struts formed into a stent pattern. The hollow struts may be filled with a therapeutic substance for elution. Openings (124) through the struts to the cavity may be formed during the forming process.
摘要翻译：包括中空支柱的支架形成在圆柱形基底上。支架的支柱通过在形成在图案化的光致抗蚀剂材料中的开口中电铸金属支柱而形成。在第一光致抗蚀剂材料的开口中形成形成内支柱材料的第一金属层（106）。在第二光致抗蚀剂材料的开口中形成用于形成用于制造支柱中空的空腔（126）的牺牲材料。在第三光致抗蚀剂材料的开口中并围绕牺牲材料形成形成支柱的侧壁和外壁的第二金属层（122）。去除光致抗蚀剂材料。去除衬底和腔牺牲材料，留下中空支柱形成支架图案。中空支柱可以填充用于洗脱的治疗物质。可以在成形过程中形成通过支柱到空腔的开口（124）。

6. 发明申请

WO2019213423A1 TIP ASSEMBLIES, SYSTEMS, AND METHODS FOR FRACTURING A FRAME OF A DEPLOYED PROSTHESIS 审中-公开
公开(公告)号：WO2019213423A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030439
申请日：2019-05-02
申请人： MEDTRONIC VASCULAR, INC.
发明人： GENOVESE, Matthew , STORMENT, Christopher
IPC分类号： A61B17/22 , A61F2/24 , A61B17/32
摘要： A system for fracturing a frame of a deployed prosthesis with ultrasonic vibration includes a shaft (303), a tip assembly, an ultrasonic electric generator (307), and an ultrasonic transducer (309). The shaft includes a proximal portion and a distal portion. The tip assembly is coupled to the distal portion of the shaft. The tip assembly includes a cutting edge (315). The ultrasonic transducer is electrically coupled to the ultrasonic generator. Ultrasonic vibration generated by the ultrasonic transducer is translated to the tip assembly. The cutting edge of the tip assembly is configured to focus the vibration of the tip assembly onto a frame of a deployed prosthesis to fracture the frame of the prosthesis. The ultrasonic transducer may be coupled to the proximal portion or the distal portion of the shaft.

7. 发明申请

WO2016073851A3 PROTECTED MAGNESIUM ALLOYS FOR BIORESORBABLE STENTS 审中-公开
公开(公告)号：WO2016073851A3
公开(公告)日：2016-05-12
申请号：PCT/US2015/059464
申请日：2015-11-06
申请人： MEDTRONIC VASCULAR, INC.
发明人： PULUGURTHA, Syamala Rani , ALLEN, Jeffrey , MITCHELL, James , STORMENT, Christopher , MENDELSON, Jill
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14
摘要： Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.

8. 发明申请

WO2018089705A1 DRUG-FILLED STENTS TO PREVENT VESSEL MICRO-INJURIES AND METHODS OF MANUFACTURE THEREOF 审中-公开
标题翻译：药物填充支架以防止血管微创伤及其制造方法
公开(公告)号：WO2018089705A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060958
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： TUNEV, Stefan , BIENVENU, Ryan , PETERSON, Justin , SULLIVAN, Carol , STORMENT, Christopher , HARMS, Michael
IPC分类号： A61F2/88 , A61F2/915
摘要： A stent includes a hollow wire formed into a stent pattern. The hollow wire includes an outer member, a lumen extending longitudinally within the hollow wire, at least one opening extending from an outer surface of the outer member to the lumen, and a surface area component within the hollow wire. The surface area component increases the amount of surface area available for tissue in-growth within the hollow wire. More than one surface area component may be utilized. Each surface area component may be disposed within the lumen or the at least one opening of the hollow wire. A pharmacologically or biologically active agent may be disposed within the lumen.
摘要翻译：支架包括形成为支架图案的中空丝。中空线包括外部构件，在中空线内纵向延伸的内腔，从外部构件的外表面延伸至内腔的至少一个开口以及中空线内的表面区域组件。表面积组分增加了空心丝内组织向内生长的表面积。可以使用多于一个的表面区域组件。每个表面区域组件可以布置在内腔或中空线的至少一个开口内。药理学或生物活性剂可置于腔内。

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