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1. 发明申请

WO2010051425A3 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 审中-公开
标题翻译：可植入医疗设备串扰评估和缓解
公开(公告)号：WO2010051425A3
公开(公告)日：2010-06-24
申请号：PCT/US2009062719
申请日：2009-10-30
申请人： MEDTRONIC INC , KRAUSE PAUL G , BURNES JOHN E , DONOFRIO WILLIAM T , PEICHEL DAVID J , ARNE GERALD P , ZHOU XIAOHONG , REINKE JAMES D , DAVIS TIMOTHY
发明人： KRAUSE PAUL G , BURNES JOHN E , DONOFRIO WILLIAM T , PEICHEL DAVID J , ARNE GERALD P , ZHOU XIAOHONG , REINKE JAMES D , DAVIS TIMOTHY
IPC分类号： A61N1/362 , A61N1/36 , A61N1/368 , A61N1/372
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3688
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或常见可植入医疗装置的两个不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗设备或治疗模块中的一个将电刺激递送至非心肌组织部位或非脉管心脏组织部位，并且另一个可植入医疗设备或治疗模块将心律管理治疗递送至患者的心脏。

2. 发明申请

WO2010051482A2 INTERFERENCE MITIGATION FOR IMPLANTABLE DEVICE RECHARGING 审中-公开
标题翻译：可植入设备再充电的干扰缓解
公开(公告)号：WO2010051482A2
公开(公告)日：2010-05-06
申请号：PCT/US2009062833
申请日：2009-10-30
申请人： MEDTRONIC INC , KRAUSE PAUL G , DONOFRIO WILLIAM T , ARNE GERALD P , REINKE JAMES D , PEICHEL DAVID J , DAVIS TIMOTHY , BURNES JOHN E
发明人： KRAUSE PAUL G , DONOFRIO WILLIAM T , ARNE GERALD P , REINKE JAMES D , PEICHEL DAVID J , DAVIS TIMOTHY , BURNES JOHN E
IPC分类号： A61N1/378 , A61N1/372
CPC分类号： A61N1/3787 , A61N1/3704 , A61N1/3718 , A61N1/37264 , A61N1/37288
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.
摘要翻译：治疗或监测系统可实施一种或多种技术以减轻对植入患者中的第一可植入医疗装置（IMD）和植入患者中的第二IMD进行充电的充电装置的操作之间的干扰。在一些示例中，所述技术可以包括响应于接收到第二IMD植入患者体内的指示而修改充电设备的操作参数。该技术还可以包括响应于检测到充电设备的存在或操作而修改第二IMD的操作参数。

3. 发明申请

WO2010051485A1 INTERFERENCE MITIGATION FOR IMPLANTABLE DEVICE RECHARGING 审中-公开
标题翻译：用于可移植设备充电的干扰减轻
公开(公告)号：WO2010051485A1
公开(公告)日：2010-05-06
申请号：PCT/US2009062838
申请日：2009-10-30
申请人： MEDTRONIC INC , DONOFRIO WILLIAM T , KRAUSE PAUL GORDON , ARNE GERALD P , REINKE JAMES D , PEICHEL DAVID JEROME , DAVIS TIMOTHY , BURNES JOHN E
发明人： MEDTRONIC INC , DONOFRIO WILLIAM T , KRAUSE PAUL GORDON , ARNE GERALD P , REINKE JAMES D , PEICHEL DAVID JEROME , DAVIS TIMOTHY , BURNES JOHN E
IPC分类号： A61N1/37 , A61N1/378
CPC分类号： A61N1/37 , A61N1/3718 , A61N1/3787 , H02M1/44
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.
摘要翻译：治疗或监测系统可以实施一种或多种技术，以减轻对植入患者中的第一可植入医疗装置（IMD）充电的充电装置的操作与植入患者体内的第二IMD之间的干扰。在一些示例中，技术可以包括响应于接收到将第二IMD植入患者中的指示来修改充电装置的操作参数。这些技术还可以包括响应于检测到充电装置的存在或操作来修改第二IMD的操作参数。

4. 发明申请

WO2013101292A3 FLUID VOLUME MONITORING FOR PATIENTS WITH RENAL DISEASE 审中-公开
标题翻译：对肾病患者进行流量监测
公开(公告)号：WO2013101292A3
公开(公告)日：2013-10-03
申请号：PCT/US2012034327
申请日：2012-04-19
申请人： MEDTRONIC INC , GERBER MARTIN T , BURNES JOHN E , LYU SUPING , VENKATESH MANDA R , PUDIL BRYANT J
发明人： GERBER MARTIN T , BURNES JOHN E , LYU SUPING , VENKATESH MANDA R , PUDIL BRYANT J
IPC分类号： A61M1/16 , A61B5/00 , A61B5/026 , A61B5/053 , A61B5/145 , A61M1/34 , B01D61/00 , B01D61/32 , B01D65/02
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40
摘要： A use includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the use.
摘要翻译：用途包括启动患者的血液移除会话; 在血液流体移除时段期间监测患者或其一部分的组织液体积指标; 在血液流体移除会话期间监视患者的血液流体体积的指标; 确定组织液体积指标与血液体积指标之间的比率是否在预定范围之外; 并且如果所述比率被确定为在所述预定范围之外，则改变所述血液流体去除期间的流体去除速率。血液流体去除系统可以被配置为执行使用。

5. 发明申请

WO2006069033A9 AUTOMATIC LV / RV CAPTURE VERIFICATION AND DIAGNOSTICS 审中-公开
标题翻译：自动LV / RV捕获验证和诊断
公开(公告)号：WO2006069033A9
公开(公告)日：2006-10-12
申请号：PCT/US2005046055
申请日：2005-12-20
申请人： MEDTRONIC INC , SHETH NIRAV VIJAY , RUETER JOHN C , BURNES JOHN E , MONGEON LUC R , KLECKNER KAREN J , YERICH CHARLES G
发明人： SHETH NIRAV VIJAY , RUETER JOHN C , BURNES JOHN E , MONGEON LUC R , KLECKNER KAREN J , YERICH CHARLES G
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3712
摘要： The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT"). The invention also provides for ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the ventricular pacing stimulus captured the chamber. If a loss-of-capture (LOC) signal results from the capture management testing, then the characteristics of the applied pacing pulses are modified and the conduction test repeated. In the event that the LOC signal persists, a pacing mode-switch to an atrial-based pacing therapy and/or non-bi-ventricular pacing regimen can be implemented.
摘要翻译：本发明提供了一种用于验证心室的起搏捕获的技术，特别是确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的期望递送。本发明还通过递送单个心室起搏刺激和在时间窗口期间检查心室间传导来确定心室起搏刺激是否捕获腔室来提供心室捕获管理。如果捕获管理测试产生捕获损失（LOC）信号，则应用起搏脉冲的特性被修改，并重复传导测试。在LOC信号持续存在的情况下，可以实现起搏模式切换到基于心房的起搏治疗和/或非双心室起搏方案。

6. 发明申请

WO2009134960A3 EXTRA-CARDIAC IMPLANTABLE DEVICE WITH FUSION PACING CAPABILITY 审中-公开
标题翻译：具有融合能力的外部可植入装置
公开(公告)号：WO2009134960A3
公开(公告)日：2010-04-08
申请号：PCT/US2009042217
申请日：2009-04-30
申请人： MEDTRONIC INC , BURNES JOHN E , DOLAN BECKY L
发明人： BURNES JOHN E , DOLAN BECKY L
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3682
摘要： According to this disclosure, a non-transvenous pacing and, optionally defibrillation, therapy device is implanted subcutaneously and oriented to provide cardiac sensing from electrodes spaced from a heart and deliver pacing and/or defibrillation from 0.one or more non-transvenous electrodes (e.g., an epicardial or pericardial electrode or electrode patch). A subject receiving a device according to this disclosure is monitored to confirm a relatively stable bundle branch block (i.e., delayed activation) of one ventricle. The subcutaneous device has electrodes disposed on the housing and/or having an electrode on a subcutaneous medical lead is oriented so that the pacing (and sensing) vector impinges mainly upon the one ventricle, and/or optionally an epicardial or pericardial lead is deployed to a last-to-depolarize ventricle (e.g., a left ventricle) so that single-ventricular pacing is delivered to achieve fusion depolarization of both ventricles.
摘要翻译：根据本公开，非静脉起搏和（可选地除颤）疗法装置被植入皮下并定向以提供来自与心脏间隔开的电极的心脏感测，并且从一个或多个非经静脉电极输送起搏和/或除颤例如，心外膜或心包电极或电极贴片）。监测接收根据本公开的装置的受试者以确认一个心室的相对稳定的束支传导阻滞（即，延迟激活）。皮下装置具有设置在壳体上和/或具有皮下医疗引线上的电极的电极被定向成使得起搏（和感测）载体主要照射在一个心室上，和/或可选地将心外膜或心包引线部署到最终到去极化的心室（例如，左心室），以便输送单心室起搏以实现两个心室的融合去极化。

7. 发明申请

WO2006115774A8 SYSTEM FOR ENHANCED CARDIAC FUNCTION WITH COMBINED PESP/NES 审中-公开
标题翻译：具有组合PESP / NES的增强心脏功能的系统
公开(公告)号：WO2006115774A8
公开(公告)日：2008-06-19
申请号：PCT/US2006013592
申请日：2006-04-11
申请人： MEDTRONIC INC , BURNES JOHN E , MULLIGAN LAWRENCE J , KNOLL RANDALL L
发明人： BURNES JOHN E , MULLIGAN LAWRENCE J , KNOLL RANDALL L
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36564

8. 发明申请

WO2009070675A2 DEVICE TO MONITOR GLUCOSE LEVELS AND ISCHEMIA 审中-公开
标题翻译：监测葡萄糖水平和ISCHEMIA的装置
公开(公告)号：WO2009070675A2
公开(公告)日：2009-06-04
申请号：PCT/US2008084863
申请日：2008-11-26
申请人： MEDTRONIC INC , BURNES JOHN E , WARMAN EDUARDO N
发明人： BURNES JOHN E , WARMAN EDUARDO N
IPC分类号： G06F19/00
CPC分类号： A61M5/1723 , A61M5/14244 , G06F19/3456
摘要： The disclosure relates to systems, methods, and devices for monitoring a patient's blood and cardiac condition. Patients with diabetes oftentimes wear diabetes management equipment (e.g., a glucose monitor, an external insulin pump, or a device having dual functionality). Such patients risk silent myocardial infarction. Herein described is regular cardiac ischemia/infarction monitoring - which if not monitored can lead to (silent) myocardial infarction. Moreover herein described are combined blood monitoring functionality and cardiac condition monitoring functionality via a single device, meaning that the patient is not required to wear additional equipment. Adding this functionality to already-existing equipment is significantly less invasive than requiring a patient to wear one piece of equipment to monitor his/her blood and a second piece of equipment to monitor his/her cardiac condition. This reduction in invasiveness can lead to significantly greater patient participation and compliance, which can improve health and save the lives of many patients.
摘要翻译：本公开涉及用于监测患者的血液和心脏状况的系统，方法和装置。患有糖尿病的患者通常佩戴糖尿病管理设备（例如，葡萄糖监测器，外部胰岛素泵或具有双重功能的装置）。这种患者存在无心肌梗塞的风险。这里描述的是常规心脏缺血/梗死监测 - 如果不监测可导致（沉默）心肌梗死。此外，这里描述的是通过单个装置组合的血液监测功能和心脏状态监测功能，这意味着患者不需要佩戴附加设备。将此功能添加到已存在的设备中比要求患者佩戴一件设备来监测他/她的血液和第二件设备来监测他/她的心脏状况的侵入性要小得多。这种侵袭性的降低可以导致患者参与和顺应性的显着增加，这可以改善健康并节省许多患者的生命。

9. 发明申请

WO2007067883A3 METHOD AND APPARATUS FOR OPTIMIZING PACING PARAMETERS 审中-公开
标题翻译：用于优化PAC参数的方法和装置
公开(公告)号：WO2007067883A3
公开(公告)日：2007-07-26
申请号：PCT/US2006061567
申请日：2006-12-04
申请人： MEDTRONIC INC , BURNES JOHN E
发明人： BURNES JOHN E
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36564 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： A program and apparatus for optimizing a pacing interval in an implantable medical device. The program includes setting the pacing interval to a baseline and measuring a physiologic sensor variable. The program measures the transient change in the physiologic sensor variable each time the pacing interval is changed. The pacing interval setting associated with the maximum transient change is deemed to be the optimal setting.
摘要翻译：一种用于优化可植入医疗装置中的起搏间隔的程序和装置。该程序包括将起搏间隔设置为基线并测量生理传感器变量。该程序测量每次起搏间隔改变时生理传感器变量的瞬时变化。与最大瞬态变化相关联的起搏间隔设置被认为是最佳设置。

10. 发明申请

WO2006060806A2 PATIENT MANAGEMENT NETWORK 审中-公开
标题翻译：患者管理网络
公开(公告)号：WO2006060806A2
公开(公告)日：2006-06-08
申请号：PCT/US2005044034
申请日：2005-12-02
申请人： MEDTRONIC INC , GOTTESMAN JANELL M , MARKOWITZ H TOBY , WILLENBRING JAMES E , MANRODT CHRISTOPHER M , VANDANACKER JOHN P , BURNES JOHN E , RUETER JOHN C , DVORAK DAVID P , AUDET SARAH A , CARNEY JAMES K , HILL GERALD J
发明人： GOTTESMAN JANELL M , MARKOWITZ H TOBY , WILLENBRING JAMES E , MANRODT CHRISTOPHER M , VANDANACKER JOHN P , BURNES JOHN E , RUETER JOHN C , DVORAK DAVID P , AUDET SARAH A , CARNEY JAMES K , HILL GERALD J
IPC分类号： G06F19/00
CPC分类号： G06F19/3418 , G06Q50/22 , G16H80/00
摘要： An intelligent patient management system collects data from a variety of sources, processes that information, and provides relevant information to an appropriate caregiver in context at the proper time. The system has multiple information sources available from which to gather additional information based upon conclusions drawn or issues identified from the patient data.
摘要翻译：智能患者管理系统从各种来源收集数据，处理这些信息，并在适当的时候向适当的护理人员提供相关信息。该系统具有多种信息来源，可根据患者数据识别的结论或问题收集附加信息。

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