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1. 发明申请

WO2008042733A3 REPLACEMENT INDICATOR TIMER FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：用于植入式医疗设备的替换指示器定时器
公开(公告)号：WO2008042733A3
公开(公告)日：2008-06-26
申请号：PCT/US2007079805
申请日：2007-09-28
申请人： MEDTRONIC INC , BETZOLD ROBERT A , BUSACKER JAMES W
发明人： BETZOLD ROBERT A , BUSACKER JAMES W
IPC分类号： A61N1/00 , A61N1/37
CPC分类号： A61N1/3708
摘要： A system and method is provided for reliably indicating that an implantable medical device is in need of replacement. An implantable medical device includes a battery and a replacement indicator timer. The battery provides power to the implantable medical device. The replacement indicator timer counts a replacement time period to a determined replacement date for the implantable medical device. The replacement indicator timer starts the counting when an operational characteristic of the battery reaches a selected value.
摘要翻译：提供了用于可靠地指示可植入医疗装置需要更换的系统和方法。可植入医疗装置包括电池和替换指示器计时器。电池为植入式医疗设备提供电力。替换指示器计时器将替换时间段计数为植入式医疗设备的确定替换日期。当电池的操作特性达到选定值时，更换指示器计时器开始计数。

2. 发明申请

WO2004093973A3 ATRIAL TRACKING RECOVERY TO RESTORE CARDIAC RESYNCHRONIZATION THERAPY IN DUAL CHAMBER TRACKING MODES 审中-公开
标题翻译：双向跟踪模式恢复心脏再生治疗的ATRIAL跟踪恢复
公开(公告)号：WO2004093973A3
公开(公告)日：2005-02-24
申请号：PCT/US2004011582
申请日：2004-04-15
申请人： MEDTRONIC INC , KLECKNER KAREN K , BETZOLD ROBERT A , LYNN THOMAS G JR
发明人： KLECKNER KAREN K , BETZOLD ROBERT A , LYNN THOMAS G JR
IPC分类号： A61N1/362 , A61N1/368 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/24 , A61N1/26 , A61N1/28 , A61N1/30 , A61N1/40
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A feature named "atrial tracking recovery" (ATR) provides a means of restoring delivery of cardiac pacing therapy upon identification of an AR-VS pattern of cardiac activity. The present invention incorporates a method of monitoring such patterns to determine if they are terminable. Once the AR-VS pattern is identified, according to the present invention the PVARP is shortened to allow sensing of the atrial event, which previously was unable to initiate an SAV interval. Subsequent SAV intervals are shortened until an atrial event is sensed so that a ventricular pacing stimulus is delivered after the SAV interval expires. Since the SAV interval is normally programmed to an interval that is shorter than the intrinsic conduction time, ventricular pacing stimulus is provided after the SAV ends, thereby effectively restoring delivery of a ventricular pacing modality such as cardiac resynchronization therapy (CRT).
摘要翻译：称为“心房跟踪恢复”（ATR）的特征提供了在识别心脏活动的AR-VS模式时恢复心脏起搏治疗递送的方法。本发明包括监视这些模式以确定它们是否可终止的方法。一旦AR-VS模式被识别，根据本发明，PVARP被缩短以允许感测心房事件，其先前不能发起SAV间隔。随后的SAV间隔被缩短直到心房事件被感测到，使得在SAV间隔期满之后输出心室起搏刺激。由于SAV间隔通常被编程为短于内在传导时间的间隔，所以在SAV结束之后提供心室起搏刺激，从而有效地恢复心室再同步治疗（CRT）之类的心室起搏模式的传递。

3. 发明申请

WO03103767B1 METHOD TO PREVENT PACEMAKER INDUCED NON-REENTRANT VA SYNCHRONY USING ADAPTIVE ATRIAL PACING OUTPUT 审中-公开
标题翻译：使用自适应ATRIAL PAC输出的方法预防诱导型非依赖性VA同步物
公开(公告)号：WO03103767B1
公开(公告)日：2004-03-04
申请号：PCT/US0318329
申请日：2003-06-10
申请人： MEDTRONIC INC
发明人： CASAVANT DAVID A , SWEENEY MICHAEL D , BETZOLD ROBERT A
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3688
摘要： The present invention is directed to the problem of preventing episodes of "AV Desynchronization Arrhythmia" (AVDA), a dual-chamber pacing behavior that is initiated by a PVC or other ventricular event that is not closely preceded by an atrial depolarization event. If the initiating PVC creates retrograde conduction resulting in an atrial refractory-sensed event, and should the succeeding AP fail to capture due to pacing within the atrial (physiological) refractory period (ARP) a repetitive AVDA pattern (of APineffectual - VP - ARrefractory) can persist for an extended period of time during which symptoms of pacemaker syndrome can occur. According to the present invention, after detection of AVDA, the following may occur: an dynamically increased magnitude of delivered atrial pacing energy, a delay interval may be increased to allow the atrial myocardial tissue to recover, a pacing modality mode-switch, a patient notification, record or process a histogram, and/or a combination thereof may be used in response to detection of a deleterious AVDA sequence.
摘要翻译：本发明涉及防止“AV脱相同步心律失常”（AVDA）发作的问题，这是双室起搏行为，其由PVC或其他心室事件发起，其不紧密地在心房去极化事件之前。如果引发的PVC产生逆行传导，导致心房难治性感觉事件，并且如果后续AP由于心房（生理）不应期（ARP）中的起搏而不能捕获，则重复的AVDA模式（APineffective-VP-ARRPractory）可以持续长时间的时间，在此期间可能发生起搏器综合征的症状。根据本发明，在检测到AVDA后，可能发生以下情况：动态地增加递送的心房起搏能量的幅度，可以增加延迟间隔以允许心房心肌组织恢复，起搏模式切换，患者响应于有害AVDA序列的检测，可以使用通知，记录或处理直方图和/或其组合。

4. 发明申请

WO0038782A9 REGULARIZATION OF VENTRICULAR RATE DURING ATRIAL TACHYARRHYTHMIA 审中-公开
标题翻译：心律失常的心室速率的定量
公开(公告)号：WO0038782A9
公开(公告)日：2002-04-11
申请号：PCT/US9930915
申请日：1999-12-22
申请人： MEDTRONIC INC
发明人： IGEL DAVID A , MARKOWITZ H TOBY , BETZOLD ROBERT A , KLECKNER KAREN J , SCHROETTER JERAMY A
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622
摘要： A pacing system provided with a mode switching feature and ventricular rate regularization (VRR) function adapted to stabilize or regularize ventricular heart rate during chronic or paroxysmal atrial tachyarrhythmia. In a preferred embodiment, the pacing system nominally operates in an atrial synchronized pacing mode such as DDD or DDDR pacing mode. In response to detection of atrial rhythm characteristics consistent with an atrial tachyarrhythmia, e.g., atrial fibrillation, a mode switch into a non-atrial synchronized, ventricular rate regularization pacing mode, e.g. DDIR or VDIR pacing mode, is made. If the VRR function is programmed on, the ventricular pacing rate based upon a rate responsive sensor derived ventricular pacing rate modulated on a beat by beat basis by preceding intrinsic or paced ventricular events, the stability of the intrinsic ventricular heart rate, and any atrial pace events to regularize the ventricular pacing rate. The pacing system may also be permanently programmed to the DDIR pacing mode with the VRR feature functioning continuously. The pacing system may also be permanently programmed to the VVIR pacing mode with VRR function activated, but without consideration of atrial pace events.
摘要翻译：具有模式切换特征和心室率正常化（VRR）功能的起搏系统适于在慢性或阵发性房性快速性心律失常期间稳定或规范心室心率。在优选实施例中，起搏系统名义地以心房同步起搏模式（例如DDD或DDDR起搏模式）操作。响应于检测与房性快速性心律失常（例如心房颤动）一致的心房节律特征，模式切换到非心房同步的心室速率正则化起搏模式，例如心房颤动。 DDIR或VDIR起搏模式。如果VRR功能被编程，则基于速率响应传感器导出的心室起搏速率的心室起搏速率通过先前的内在或节奏心室事件，内部心室心率的稳定性和任何心房起搏事件来规范心室起搏率。起搏系统也可以永久编程到DDIR起搏模式，VRR功能连续工作。起搏系统也可以被永久编程到VVIR起搏模式，VRR功能被激活，但不考虑心房速度事件。

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