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1. 发明申请

WO2009058638A1 IMPLANTABLE SYSTEM FOR FLOW MEASUREMENT INCLUDING CHARGE AMPLIFIER 审中-公开
标题翻译：用于流量测量的可扩展系统，包括充电放大器
公开(公告)号：WO2009058638A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/080864
申请日：2008-10-23
申请人： MEDTRONIC, INC , CINBIS, Can , FEREK-PETRIC, Bozidar , BREYER, Branko
发明人： CINBIS, Can , FEREK-PETRIC, Bozidar , BREYER, Branko
IPC分类号： A61B5/027 , A61N1/37
CPC分类号： A61N1/056 , A61B5/027 , A61N1/08 , A61N1/36514 , A61N1/36571 , A61N1/375
摘要： An implantable medical device lead (70) having a flow measurement sensor (14', 16') mounted thereon is provided with a capsule (72) mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.
摘要翻译：具有安装在其上的流量测量传感器（14'，16'）的可植入医疗装置引线（70）设置有靠近传感器安装的胶囊（72）。胶囊用于容纳对应于传感器的电路，以便防止在慢性期逐渐减少的导线上的阻抗直接影响传感器和电路之间的信号传输。电路包括用于处理来自传感器的信号的电荷放大器。在某些情况下，可以对放大器进行初始校准并定期调谐，以便在慢性期间与传感器具有一致的功能。

2. 发明申请

WO2005055849A1 ULTRASONICALLY MARKED SYSTEM FOR THERAPY DELIVERY 审中-公开
标题翻译：用于治疗传播的超声波标记系统
公开(公告)号：WO2005055849A1
公开(公告)日：2005-06-23
申请号：PCT/HR2004/000059
申请日：2004-11-25
申请人： BREYER, Branko , CIKES, Ivo
发明人： BREYER, Branko , CIKES, Ivo
IPC分类号： A61B19/00
CPC分类号： A61B90/36 , A61B90/39 , A61B2010/045 , A61B2017/00247 , A61B2017/22082 , A61B2018/00392 , A61B2090/062 , A61B2090/0811 , A61B2090/3925 , A61B2090/3929 , A61M25/0084
摘要： The aim of the invention is to enable controlled therapeutic or diagnostic punctures within the heart or other structures in the body that are normally accessible only with catheters or similar devices. The said medical agent may be stem cells, a gene agent, a chemotherapy agent or any type of injectable drug. This system can strictly control the puncture depth. The device consists of a hollow introducer catheter and inside another catheter with a puncture needle. The internal puncture catheter or flexible needle is pushed out to perform a therapeutic or diagnostic puncture. The method for positive ultrasonic localization of a point on an indwelled device, e.g. the said outer or the said inner needle catheter, consists of ultrasonic marking of the catheter and the needle and the use of a transponder to generate a visible mark on the ultrasound scanner screen.
摘要翻译：本发明的目的是使得在体内的心脏或其他结构内的受控的治疗或诊断穿刺能够仅通过导管或类似装置才能进入。所述药剂可以是干细胞，基因药剂，化疗剂或任何类型的可注射药物。该系统可以严格控制穿刺深度。该装置由中空导引导管和具有穿刺针的另一个导管内组成。将内部穿刺导管或柔性针推出以进行治疗或诊断性穿刺。用于对位于设备上的点进行正超声定位的方法，例如，所述外针或所述内针导管由导管和针的超声波标记以及使用应答器在超声扫描仪屏幕上产生可见标记组成。

3. 发明申请

WO2005007228A1 ULTRASONICALLY MARKED DELIVERY SYSTEM FOR LEFT HEART PACING LEAD 审中-公开
标题翻译：超声波输送系统，用于左心脏引导
公开(公告)号：WO2005007228A1
公开(公告)日：2005-01-27
申请号：PCT/HR2004/000018
申请日：2004-07-05
申请人： BREYER, Branko , CIKES, Ivo
发明人： BREYER, Branko , CIKES, Ivo
IPC分类号： A61M25/00
CPC分类号： A61M25/0108 , A61B90/36 , A61B2090/3782 , A61M25/0082 , A61M25/0127 , A61N2001/0585
摘要： A method of ultrasonic guidance of the aiming and steering of the pacing lead into the coronary vein via the coronary sinus (CS) is disclosed. The aim is to place a pacing electrode into the left coronary vein enabling left heart pacing with or without concurrent right heart pacing. The placement may be done via the coronary sinus. The procedure must include visualization of the coronary sinus, preferably by ultrasound scanning, localization of the pacing catheter tip, directing - steering the tip along the CS axis and thus its placement into the coronary sinus. A marking piezoelectric transducer is mounted at or near the tip of the steerable delivery catheter that we want to localize in the vicinity of the coronary sinus. When this piezoelectric transducer comes within the scanning plane of an ultrasonic scanner, the pulses transmitted by it hit the said marker transducer. Such signals can in different ways be used for generation of visible guiding marks on the scanner screen. A representative method of such application is the use of a transponder connected to the said ultrasonic transducer. Additionally an ultrasonically marked wire, comprising an ultrasonic transducer at its tip may be implanted into the left ventricular venous system through said catheter. The wire is used to guide the pacing electrode, which is slid over the wire into the coronary vein. In this case a second transponder is used to ultrasonically control the placement of the guide wire into the left coronary vein system.
摘要翻译：公开了通过冠状动脉窦（CS）将起搏引线的瞄准和转向超声引导到冠状静脉中的方法。目的是将起搏电极置于左冠状动脉静脉，使心脏起搏有或没有并发右心脏起搏。放置可以通过冠状窦进行。该过程必须包括冠状动脉窦的可视化，优选通过超声波扫描，起搏导管尖端的定位，引导 - 沿CS轴转向尖端，并因此将其放置到冠状窦中。标记压电换能器安装在可转向输送导管的尖端处或附近，我们想要定位在冠状窦附近。当该压电传感器进入超声波扫描器的扫描平面内时，由其传送的脉冲撞击所述标记换能器。这些信号可以以不同的方式用于在扫描仪屏幕上产生可见的引导标记。这种应用的代表性方法是使用连接到所述超声换能器的应答器。此外，包括其尖端处的超声换能器的超声波标记的线可以通过所述导管植入左心室静脉系统。线用于引导起搏电极，其在线上滑动到冠状静脉中。在这种情况下，第二应答器用于超声波地控制导丝进入左冠状静脉系统的位置。

4. 发明申请

WO2003090860A3 ULTRASOUND METHODS AND IMPLANTABLE MEDICAL DEVICES USING SAME 审中-公开
公开(公告)号：WO2003090860A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/012595
申请日：2003-04-24
申请人： MEDTRONIC, INC.
发明人： BREYER, Branko , FEREK-PETRIC, Bozidar
IPC分类号： A61N1/365
摘要： An ultrasound method and medical devices using same provide for various techniques of sampling blood flow velocity, e.g., at several sampling rates. To minimize the energy required for ultrasound monitoring, pulsed Doppler signal packages provided by a pulsed ultrasound circuit are switched in such a way that the repetition rate is the lowest possible and yet sufficiently high to be able to record the blood flow velocity within the heart. For example, an ultrasound circuit may be activated only within a part of the cardiac cycle designated as the Doppler Measurement Interval (DMI); the ultrasound circuit may be switched between an on state and an off state during the DMI; and/or the ultrasound circuit may also be switched on and off in different sampling modes: detection mode and measurement mode (e.g., using different sampling rates).

5. 发明申请

WO2003090860A2 ULTRASOUND METHODS AND IMPLANTABLE MEDICAL DEVICES USING SAME 审中-公开
标题翻译：超声方法和使用相同的可植入医疗装置
公开(公告)号：WO2003090860A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/012595
申请日：2003-04-24
申请人： MEDTRONIC, INC.
发明人： BREYER, Branko , FEREK-PETRIC, Bozidar
IPC分类号： A61N1/365
CPC分类号： A61N1/36528 , A61N1/36571

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