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1. 发明申请

WO2010036760A1 METHODS FOR CULTIVATING CELLS, PROPAGATING AND PURIFYING VIRUSES 审中-公开
标题翻译：用于培养细胞，传播和净化病毒的方法
公开(公告)号：WO2010036760A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058157
申请日：2009-09-24
申请人： MEDIMMUNE, LLC , LIU, Jonathan , THOMPSON, Mark , MARANGA, Luis, J. , CATANIAG, Floro , HSU, Simon, S.
发明人： LIU, Jonathan , THOMPSON, Mark , MARANGA, Luis, J. , CATANIAG, Floro , HSU, Simon, S.
IPC分类号： C12N7/00
CPC分类号： C12N7/02 , A61K39/12 , A61K39/145 , C12N7/00 , C12N2760/16051 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251
摘要： A novel serum-free cell culture medium and methods for cultivating MDCK cells are presented. In particular, non-tumorigenic MDCK cells. Methods for producing influenza viruses (e.g., particularly cold-adapted, and/or temperature sensitive, and/or attenuated influenza viruses) that eliminate the need for a cell culture medium exchange step are provided. The novel medium and methods are useful to grow influenza viruses, in cell culture to high titer. The present invention further provides purification methods for purifying influenza viruses with high overall recovery of live virus and result in levels of host cell DNA (HCD), host cell protein (HCP) and non-specific endonuclease (e.g., Benzonase), which are below the specifications required by regulatory agencies.
摘要翻译：提出了一种新型的无血清细胞培养基和培养MDCK细胞的方法。特别是非致瘤性MDCK细胞。提供了不需要细胞培养基交换步骤的生产流感病毒（例如特别冷适应和/或温度敏感和/或减毒的流感病毒）的方法。新型培养基和方法可用于在细胞培养物中高效滴加流感病毒。本发明还提供了用于纯化具有高活性病毒总体回收率的流感病毒的纯化方法，并导致宿主细胞DNA（HCD），宿主细胞蛋白（HCP）和非特异性内切核酸酶（例如，Benzonase）的水平，其低于监管机构要求的规格。

2. 发明申请

WO2008105931A2 MDCK CELL LINES SUPPORTING VIRAL GROWTH TO HIGH TITERS AND BIOREACTOR PROCESS USING THE SAME 审中-公开
标题翻译：使用相同的MDCK细胞系支持病毒生长到高TITERS和生物反应器过程
公开(公告)号：WO2008105931A2
公开(公告)日：2008-09-04
申请号：PCT/US2007/078527
申请日：2007-09-14
申请人： MEDIMMUNE VACCINES, INC. , LIU, Jonathan , SCHWARTZ, Richard , THOMPSON, Mark , MARANGA, Luis , HSU, Simon , GHOSH, Mridul , SUBRAMANIAN, Ajit
发明人： LIU, Jonathan , SCHWARTZ, Richard , THOMPSON, Mark , MARANGA, Luis , HSU, Simon , GHOSH, Mridul , SUBRAMANIAN, Ajit
IPC分类号： C12N5/06
CPC分类号： C12N7/00 , C12N2760/16151 , C12N2760/16152 , C12N2760/16251 , C12N2760/16252
摘要： The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.
摘要翻译：本发明涉及可以在细胞培养中将病毒（例如流感病毒）生长至比先前可能更高滴度的新型MDCK细胞。 MDCK细胞可适应于无血清培养基。本发明还涉及包含MDCK细胞的细胞培养组合物和用于培养MDCK细胞的培养方法。本发明还涉及使用本发明的MDCK细胞在细胞培养中生产流感病毒的方法。

3. 发明申请

WO2013162642A1 TWO-PHASE OPERATION OF PLASMA CHAMBER BY PHASE LOCKED LOOP 审中-公开
标题翻译：通过相位锁定环进行等离子体室的两相操作
公开(公告)号：WO2013162642A1
公开(公告)日：2013-10-31
申请号：PCT/US2012/060194
申请日：2012-10-15
申请人： APPLIED MATERIALS, INC. , KOBAYASHI, Satoru , WONG, Lawrence , LIU, Jonathan , YANG, Yang , RAMASWAMY, Kartik , RAUF, Shahid , NEVIL, Shane, C. , BERA, Kallol , COLLINS, Kenneth, S.
发明人： KOBAYASHI, Satoru , WONG, Lawrence , LIU, Jonathan , YANG, Yang , RAMASWAMY, Kartik , RAUF, Shahid , NEVIL, Shane, C. , BERA, Kallol , COLLINS, Kenneth, S.
IPC分类号： H05H1/46 , H03H7/40 , H03L7/08
CPC分类号： C23C16/505 , B05C9/00 , H01J37/32091 , H01J37/32174 , H01J37/3299
摘要： Plasma distribution is controlled in a plasma reactor by controlling the phase difference between opposing RF electrodes,, in accordance with a desired or user-selected phase difference, by a phase-lock feedback control loop.
摘要翻译：通过相位锁定反馈控制回路根据期望的或用户选择的相位差来控制相对的RF电极之间的相位差，等离子体反应器中的等离子体分布被控制。

4. 发明申请

WO2017058440A1 Q-COMPENSATED FULL WAVEFIELD INVERSION 审中-公开
标题翻译： Q补偿全波形反演
公开(公告)号：WO2017058440A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/049392
申请日：2016-08-30
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , SUN, Hongchuan , WILDERMUTH, Eric, G. , LIU, Jonathan , BANSAL, Reeshidev , LAZARATOS, Spyridon, K.
发明人： SUN, Hongchuan , WILDERMUTH, Eric, G. , LIU, Jonathan , BANSAL, Reeshidev , LAZARATOS, Spyridon, K.
IPC分类号： G01V1/30
CPC分类号： G01V1/282 , G01V1/303 , G01V1/362 , G01V2210/512 , G01V2210/584 , G01V2210/74
摘要： A method, including: obtaining a velocity model generated by an acoustic full wavefield inversion process; generating, with a computer, a variable Q model by applying pseudo-Q migration on processed seismic data of a subsurface region, wherein the velocity model is used as a guided constraint in the pseudo-Q migration; and generating, with a computer, a final subsurface velocity model that recovers amplitude attenuation caused by gas anomalies in the subsurface region by performing a visco-acoustic full wavefield inversion process, wherein the variable Q model is fixed in the visco-acoustic full wavefield inversion process.
摘要翻译：一种方法，包括：获得由声全波场反演过程产生的速度模型; 通过在地下区域的经处理的地震数据上应用伪Q迁移，通过计算机生成变量Q模型，其中速度模型用作伪Q迁移中的引导约束; 并且利用计算机生成最终的地下速度模型，其通过执行粘弹性全波场反演过程来恢复由地下区域中的气体异常引起的振幅衰减，其中可变Q模型固定在粘声全波场反演中处理。

5. 发明申请

WO2007018869A1 METHOD FOR TOMOGRAPHIC INVERSION BY MATRIX TRANSFORMATION 审中-公开
标题翻译：基于矩阵变换的方法
公开(公告)号：WO2007018869A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/026477
申请日：2006-07-05
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , LIU, Jonathan , BEAR, Lorie, K. , KREBS, Jerome, R.
发明人： LIU, Jonathan , BEAR, Lorie, K. , KREBS, Jerome, R.
IPC分类号： G01V1/28
CPC分类号： G01V1/303
摘要： Method for reducing instability and increasing computational efficiency in tomographic inversion for velocity model building. A system of tomographic equations is developed for a uniform grid. A non-uniform parameterization is found for which a linear mapping exists between the space of the uniform grid and the space of the non-uniform grid. The matrix that relates velocity to the tomographic data in the non-uniform representation is then given by the matrix product of the corresponding matrix in the uniform grid representation and the mapping matrix. Inversion can then be performed for the non-uniform parameterization on a smaller, more stable matrix.
摘要翻译：降低速度模型建立断层反演中不稳定性和提高计算效率的方法。开发了一种用于统一网格的断层方程系统。在均匀网格的空间与非均匀网格的空间之间存在线性映射，发现非均匀参数化。然后在均匀网格表示和映射矩阵中，通过相应矩阵的矩阵乘积给出将速度与非均匀表示中的断层数据相关联的矩阵。然后可以对较小，更稳定的矩阵进行非均匀参数化的反转。

6. 发明申请

WO2016064462A1 VELOCITY TOMOGRAPHY USING PROPERTY SCANS 审中-公开
标题翻译：使用物业扫描的速度测量
公开(公告)号：WO2016064462A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/043804
申请日：2015-08-05
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , LIU, Jonathan
发明人： LIU, Jonathan
IPC分类号： G01V1/30
CPC分类号： G01V1/282 , G01V1/301 , G01V1/303 , G01V1/306 , G01V2210/51 , G01V2210/52 , G01V2210/614 , G01V2210/622 , G01V2210/626 , G01V2210/671 , G01V2210/675
摘要： Method for building a subsurface model of velocity or other elastic property from seismic reflection data using tomography. The method uses velocity scans to pick a focusing velocity model at each image point (40). The focusing velocities are used to pick depth errors from tables (60) generated using a tomographic inversion matrix (30) and a suite of different velocity models (10). The depth errors are then reconstructed at each image point from the velocity scans based on the difference between the base velocity model and the most coherent velocity from the scan (70). The reconstructed depth errors are used to compute the velocity model update (80).
摘要翻译：使用断层扫描从地震反射数据建立速度或其他弹性特性地下模型的方法。该方法使用速度扫描在每个图像点选择聚焦速度模型（40）。聚焦速度用于从使用断层反演矩阵（30）和一组不同速度模型（10）生成的表（60）中挑取深度误差。然后根据基本速度模型与扫描中最相干速度的差异，从速度扫描的每个图像点重建深度误差（70）。重建深度误差用于计算速度模型更新（80）。

7. 发明申请

WO2013032839A2 RAMAN IMAGING DEVICES AND METHODS OF MOLECLAR IMAGING 审中-公开
标题翻译：拉曼成像装置和分子成像方法
公开(公告)号：WO2013032839A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/051999
申请日：2012-08-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GARAI, Ellis , ZAVALETA, Cristina , MANDELLA, Michael, J. , LIU, Jonathan , GAMBHIR, Sanjiv, Sam , CONTAG, Christopher, H.
发明人： GARAI, Ellis , ZAVALETA, Cristina , MANDELLA, Michael, J. , LIU, Jonathan , GAMBHIR, Sanjiv, Sam , CONTAG, Christopher, H.
CPC分类号： A61B5/0075 , A61B1/07 , A61B5/0079 , A61B5/0084 , A61B10/02 , A61B34/20 , A61B2034/2057 , A61K49/0095 , B82Y15/00 , G01J1/0433 , G01J3/0213 , G01J3/0218 , G01J3/18 , G01J3/2803 , G01J3/44 , G01N21/658
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes) or systems, methods of using Raman agents, Raman imaging devices, and/or systems to image or detect a signal, and the like.
摘要翻译：根据本公开的目的，如在此体现和广泛描述的，本公开的实施方式在一个方面涉及拉曼成像装置（例如，拉曼内窥镜探针）或系统，使用拉曼试剂，拉曼成像装置和/或系统来成像或检测信号的方法等。

8. 发明申请

WO2009123790A1 METHOD FOR PERFORMING PSEUDO-Q MIGRATION OF SEISMIC DATA 审中-公开
标题翻译：用于执行地震数据的PSEUDO-Q移动的方法
公开(公告)号：WO2009123790A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/033438
申请日：2009-02-06
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , LIU, Jonathan
发明人： LIU, Jonathan
IPC分类号： G01V1/00
CPC分类号： G01V1/28 , G01V2210/66
摘要： A method for creating a visualization of a subsurface region based on a plurality of migrated seismic data traces (201) is provided. An exemplary embodiment of the method comprises creating a plurality of derivatives of Q integration values based on a velocity model (204) and applying a Q model to the plurality of derivatives of Q integration values to create a plurality of Q integration values (205). The exemplary method further comprises applying the plurality of Q integration values to the plurality of migrated seismic data traces to create β-corrected seismic data (206). The exemplary method additionally comprises creating the visualization of the subsurface region based on the β-corrected seismic data.
摘要翻译：提供了一种用于基于多个迁移的地震数据迹线（201）创建地下区域的可视化的方法。该方法的示例性实施例包括基于速度模型（204）创建Q积分值的多个导数，并将Q模型应用于Q积分值的多个导数以创建多个Q积分值（205）。该示例性方法还包括将多个Q积分值应用于多个迁移的地震数据轨迹以创建经校正的地震数据（206）。该示例性方法还包括基于经修正的地震数据创建地下区域的可视化。

9. 发明申请

WO2006050290A2 TRANSFERRING A VIDEO FRAME FROM MEMORY INTO AN ON-CHIP BUFFER FOR VIDEO PROCESSING 审中-公开
标题翻译：将视频帧从内存传输到片上缓冲器以进行视频处理
公开(公告)号：WO2006050290A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039325
申请日：2005-10-27
申请人： INTEL CORPORATION , NICKERSON, Brian , WONG, Samuel , CHAUDHURI, Santanu , LIU, Jonathan , KURUPATI, Sreenath
发明人： NICKERSON, Brian , WONG, Samuel , CHAUDHURI, Santanu , LIU, Jonathan , KURUPATI, Sreenath
IPC分类号： H04N7/01
CPC分类号： H04N7/0125 , G09G5/391 , G09G5/395 , G09G2340/0407 , H04N7/0135
摘要： A portion of a video frame is transferred via a memory burst transfer, from memory to an on-chip buffer. The on-chip buffer has a width that is the same as the memory burst width for the memory. Video processing is performed upon the transferred portion. Other embodiments are also described and claimed.
摘要翻译：视频帧的一部分通过存储器突发传输从存储器传输到片上缓冲器。片上缓冲器的宽度与内存的内存突发宽度相同。视频处理在被传送的部分上执行。其他实施例也被描述和要求保护。

10. 发明申请

WO2006036571A1 AN APPARATUS AND METHOD FOR EDGE HANDLING IN IMAGE PROCESSING 审中-公开
标题翻译：图像处理边缘处理的装置和方法
公开(公告)号：WO2006036571A1
公开(公告)日：2006-04-06
申请号：PCT/US2005/032932
申请日：2005-09-13
申请人： INTEL CORPORATION , KURUPATI, Sreenath , NICKERSON, Brian , WONG, Samuel , CHAUDHARI, Sunil , LIU, Jonathan
发明人： KURUPATI, Sreenath , NICKERSON, Brian , WONG, Samuel , CHAUDHARI, Sunil , LIU, Jonathan
IPC分类号： G06T3/40
CPC分类号： G06T3/403
摘要： A method and apparatus for hardware-base edge handling in video post-processing. In one embodiment, the method includes the identification of at least one unstored input pixel required to compute an output pixel during output pixel computation. Once identified, a pixel value is generated for the at least one unstored input pixel according to a detected edge handling mode. The generation of the pixel value for the unstored input pixel is performed, in one embodiment, if a position of the unstored input pixel is outside a pixel frame boundary. For example, in one embodiment, for output pixel computation of a scaling operation, the frame boundaries include a left (top) edge and a right (bottom) edge for which input pixels required to compute output pixels at or near the frame boundaries do not exist. Other embodiments are described and claimed.
摘要翻译：一种用于视频后处理中的硬件边缘处理的方法和装置。在一个实施例中，该方法包括在输出像素计算期间识别计算输出像素所需的至少一个未输入输入像素。一旦被识别，根据检测到的边缘处理模式，为至少一个未填充的输入像素生成像素值。在一个实施例中，如果无输入输入像素的位置在像素帧边界之外，则执行无输入输入像素的像素值的生成。例如，在一个实施例中，对于缩放操作的输出像素计算，帧边界包括左边（上）边和右（底）边，对于边缘边缘或其附近计算输出像素所需的输入像素存在。描述和要求保护其他实施例。

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