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    • 1. 发明申请
    • ACCESSORY DEVICE FOR INNER EAR DRUG DELIVERY
    • 用于内部药物递送的附件装置
    • WO2013138106A2
    • 2013-09-19
    • PCT/US2013/029027
    • 2013-03-05
    • MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH
    • JOLLY, ClaudeDHANASINGH, AnandhanMISTRIK, PavelSCHILP, SoerenHESSLER, RolandMUGRIDGE, Kenneth
    • A61M31/00A61F11/00
    • A61M31/00A61F11/00A61F11/004A61M31/002A61N1/0541
    • An implantable drug delivery accessory is described. A middle ear guide member has a hollow interior enclosed by a non-permeable outer surface. A proximal end of the middle ear guide member is fixed to the tympanic membrane of an implanted patient. A distal end of the middle ear guide member penetrates through a fluid-tight sealed opening into the inner ear. An inner ear holding member has a proximal end connected to the distal end of the middle ear guide member at the sealed opening and a closed distal end terminating the inner ear holding member some predetermined distance within the cochlea. A hollow interior of the inner ear holding member contains a replaceable drug delivery member which stores a therapeutic drug. A semi-permeable outer surface of the inner ear holding member is connected to a cochlear implant electrode and adapted to release therapeutic drug from the hollow interior into adjacent tissue. The drug delivery member is removable and replaceable via the ear canal of the implanted patient through the proximal end of the middle ear.
    • 描述了可植入药物递送附件。 中耳引导构件具有由不可渗透的外表面封闭的中空内部。 中耳引导构件的近端固定在植入患者的鼓膜上。 中耳引导构件的远端穿过流体密封的密封开口进入内耳。 内耳保持构件具有在密封开口处连接到中耳导引构件的远端的近端,并且封闭的远端终止在耳蜗内部预定距离内耳保持构件。 内耳保持构件的中空内部包含存储治疗药物的可替换药物递送构件。 内耳保持构件的半透性外表面连接到耳蜗植入电极并且适于将治疗药物从中空内部释放到相邻组织中。 药物递送部件可通过植入患者的耳道通过中耳的近端移除和更换。