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1. 发明申请

WO2003008637A2 USE OF GENOTYPING IN THE INDIVIDUALIZATION OF THERAPY 审中-公开
标题翻译：基因治疗在治疗个体化中的应用
公开(公告)号：WO2003008637A2
公开(公告)日：2003-01-30
申请号：PCT/CA2002/001103
申请日：2002-07-17
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/00 , Y02A90/22 , Y02A90/26
摘要： The invention relates to the individualization of therapy. More specifically, the present invention relates to the use of genotyping for the individualization of therapy and/or individualization of drug dosing. More specifically, the present invention relates to the use of genotyping in the individualization of therapy with a therapeutic agent or a class of therapeutic agents.
摘要翻译：本发明涉及治疗的个体化。更具体地，本发明涉及用于个体化治疗和/或药物给药的个体化的基因分型。更具体地说，本发明涉及基因分型在用治疗剂或一类治疗剂的治疗个体化中的用途。

2. 发明申请

WO2002073196A2 INDIVIDUALIZATION OF THERAPY WITH ANTIPSYCHOTICS 审中-公开
标题翻译：用抗精神病药物进行个体化治疗
公开(公告)号：WO2002073196A2
公开(公告)日：2002-09-19
申请号：PCT/CA2002/000343
申请日：2002-03-14
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/53
CPC分类号： B82Y30/00 , C12Q1/26 , C12Q1/48 , G01N33/94 , G01N33/9426 , G01N33/9466 , G01N33/948 , G01N2333/90245 , G01N2333/91057 , G01N2333/91171 , G01N2333/91245
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with antipsychotic agents.
摘要翻译：本发明涉及基于个体的表型谱的个体化治疗。更具体地说，本发明涉及代谢表型用于抗精神病药物治疗的个体化的用途。

3. 发明申请

WO2002099422A2 INDIVIDUALIZATION OF THERAPY WITH ALZHEIMER'S DISEASE AGENTS 审中-公开
标题翻译：用阿尔茨海默病病毒治疗的个体化
公开(公告)号：WO2002099422A2
公开(公告)日：2002-12-12
申请号：PCT/CA2002/000838
申请日：2002-06-06
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/53
CPC分类号： G01N33/94 , A61K49/0004 , A61K51/04 , B82Y30/00 , G01N33/573 , G01N33/6896 , G01N2333/80 , G01N2800/2821
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with Alzheimer's disease agent.
摘要翻译：本发明涉及基于个体的表型谱的个体化治疗。更具体地，本发明涉及用阿尔茨海默氏病剂治疗个体化代谢表型的用途。

4. 发明申请

WO2002086508A2 ELISA KIT FOR THE DETERMINATION OF CYP2C19 METABOLIC PHENOTYPES AND USES THEREOF 审中-公开
标题翻译：用于测定CYP2C19代谢基因的ELISA试剂盒及其用途
公开(公告)号：WO2002086508A2
公开(公告)日：2002-10-31
申请号：PCT/CA2002/000598
申请日：2002-04-23
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/543
CPC分类号： B82Y30/00 , C07D233/74 , C07D233/76 , C07K16/40
摘要： The invention relates to an enzyme linked immunosorbent assay (ELISA) method and kit for the rapid determination of metabolic phenotypes for Cytochrome P450 2C19 (CYP2C19). The kit uses may include but are not limited to, use on a routine basis in a clinical laboratory to determine a Cytochrome P450 2C19 (CYP2C19) phenotype of an individual; to allow a physician to individualize an individual's treatment with respect to the numerous drugs metabolized by CYP2C19 based on a phenotypic determination; to predict an individual's susceptibility to carcinogen induced diseases including many cancers, and to screen individuals for a preferred metabolic phenotype in order to determine those individuals with a responsive phenotype for participation in clinical testing.
摘要翻译：本发明涉及用于快速测定细胞色素P450 2C19（CYP2C19）的代谢表型的酶联免疫吸附测定（ELISA）方法和试剂盒。试剂盒的用途可以包括但不限于在临床实验室中常规使用以确定个体的细胞色素P450 2C19（CYP2C19）表型; 允许医师根据CYP2C19代谢的许多药物基于表型测定来个体化个体治疗; 预测个体对包括许多癌症在内的致癌物质疾病的敏感性，并筛选个体以获得优选的代谢表型，以便确定具有参与临床测试的响应表型的那些个体。

5. 发明申请

WO2002086504A3 INDIVIDUALIZATION OF THERAPY WITH GASTROESOPHAGEAL REFLUX DISEASE AGENTS 审中-公开
公开(公告)号：WO2002086504A3
公开(公告)日：2002-10-31
申请号：PCT/CA2002/000607
申请日：2002-04-24
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/53
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with GERD agents.

6. 发明申请

WO2002093162A2 INDIVIDUALIZATION OF THERAPY WITH ANTIBIOTIC AGENTS 审中-公开
标题翻译：治疗与抗生素的个体化
公开(公告)号：WO2002093162A2
公开(公告)日：2002-11-21
申请号：PCT/CA2002/000725
申请日：2002-05-17
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/48
CPC分类号： B82Y30/00 , C12Q1/26 , C12Q1/48 , G01N33/5088 , G01N33/5091 , G01N2333/90245
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with antibiotic agents.
摘要翻译：本发明涉及基于个体的表型谱的个体化治疗。更具体地，本发明涉及代谢表型用于用抗生素剂治疗个体化的用途。

7. 发明申请

WO2002090994A2 INDIVIDUALIZATION OF THERAPY WITH ANALGESICS 审中-公开
标题翻译：治疗与分析的个体化
公开(公告)号：WO2002090994A2
公开(公告)日：2002-11-14
申请号：PCT/CA2002/000687
申请日：2002-05-07
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/94
CPC分类号： B82Y30/00 , G01N33/9486 , G01N2800/52
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with analgesics.
摘要翻译：本发明涉及基于个体的表型谱的个体化治疗。更具体地，本发明涉及代谢表型用于镇痛剂治疗个体化的用途。

8. 发明申请

WO2002088714A2 INDIVIDUALIZATION OF THERAPY WITH ANTINEOPLASTIC AGENTS 审中-公开
标题翻译：用抗生素代谢治疗的个体化
公开(公告)号：WO2002088714A2
公开(公告)日：2002-11-07
申请号：PCT/CA2002/000642
申请日：2002-04-29
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , B82Y30/00 , C12Q1/26 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/5308
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with antineoplastic agents.
摘要翻译：本发明涉及基于个体的表型谱的个体化治疗。更具体地，本发明涉及用抗肿瘤剂治疗个体化代谢表型的用途。

9. 发明申请

WO2002064816A3 MULTIPLE DETERMINANTS FOR METABOLIC PHENOTYPES 审中-公开
公开(公告)号：WO2002064816A3
公开(公告)日：2002-08-22
申请号：PCT/CA2002/000161
申请日：2002-02-08
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： C12Q1/00
摘要： The invention relates to the determination of multiple phenotypic determinants for human drug metabolizing enzymes. More specifically, the present invention relates to the characterization of metabolic phenotypes based on phenotypic determinants and applications and uses thereof.

10. 发明申请

WO2002095402A2 INDIVIDUALIZATION OF THERAPY WITH HYPERLIPIDEMIA AGENTS 审中-公开
标题翻译：治疗与高脂药物的个体化
公开(公告)号：WO2002095402A2
公开(公告)日：2002-11-28
申请号：PCT/CA2002/000526
申请日：2002-04-17
申请人： MCGILL UNIVERSITY , LEYLAND-JONES, Brian
发明人： LEYLAND-JONES, Brian
IPC分类号： G01N33/53
CPC分类号： B82Y30/00 , C12Q1/26 , C12Q1/48 , G01N33/573 , G01N33/82 , G01N33/94
摘要： The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with hyperlipidemia agents.
摘要翻译：本发明涉及基于个体的表型谱的个体化治疗。更具体地说，本发明涉及代谢分型用于高脂血症药物治疗个体化的应用。

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