专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2014048564A8 "NOVEL CROSS-LINKERS FOR HYDROGELS, HYDROGELS INCLUDING THESE CROSS-LINKERS AND APPLICATIONS THEREOF" 审中-公开
标题翻译： “HYDROGELS，HYDROGELS，包括这些交叉连接器及其应用的新交叉连接器”
公开(公告)号：WO2014048564A8
公开(公告)日：2014-05-30
申请号：PCT/EP2013002876
申请日：2013-09-25
申请人： MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V
发明人： BÖHM HEIKE , HAGEL VALENTIN , MUNDINGER TABEA , NUSS ISABELL , WEGNER SERAPHINE VALESKA , LASCHAT SABINE , MATEESCU MARKUS MANFRED
IPC分类号： C07D213/80 , A61K31/4425 , A61P43/00 , C07D213/82 , C08B37/08
CPC分类号： C08J3/24 , C07D213/80 , C07D213/82 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L1/02 , C08L5/02 , C08L5/04 , C08L53/00 , C08L67/04 , C08L71/02
摘要： The present invention relates to novel cross-linkers for hydrogels, in particular for hyaluronan hydrogels, corresponding hydrogels including said cross-linkers and various applications thereof. The cross linker of the invention is a bi- or multifunctional cross-linker comprising or consisting of an aromatic or heteroaromatic ring system with 3-6 C atoms which is coupled via functional groups on at least 2 ring positions with at least 2 terminal groups capable to form a covalent bond with thiol or amino groups, in particular with thiol groups in a thiol-en reaction. The cross-linker may be charged or uncharged. In a specific embodiment, the terminal groups are coupled to carboxy groups of the aromatic or heteroaromatic ring system via an ester or amide bond. More specifically, the cross-linker of the invention is a derivative of pyridine-3, 5-dicarboxylic acid or a corresponding pyridinium salt thereof wherein 2 terminal groups are coupled to the carboxy groups of the pyridine or pyridinium core via an ester or amide bond. In a preferred embodiment, the cross-linker is N3,N5-bis(2-acrylamidoethyl) pyridine-3, 5-dicarboxamide or a 3,5-bis((2-acrylamidoethyl) carbamoyl) -1-methylpyridin-l-ium-halogenide.
摘要翻译：本发明涉及用于水凝胶，特别是透明质酸水凝胶的新型交联剂，包括所述交联剂的相应水凝胶及其各种应用。本发明的交联剂是包含或由具有3-6个C原子的芳族或杂芳族环系统组成的双官能或多功能交联剂，其通过官能团在至少2个环位置与至少2个具有端基的基团与硫醇或氨基形成共价键，特别是在硫醇-en反应中与硫醇基形成共价键。交联剂可以带电或不带电。在具体实施方案中，末端基团通过酯或酰胺键与芳族或杂芳族环系的羧基偶联。更具体地，本发明的交联剂是吡啶-3,5-二羧酸或其相应的吡啶鎓盐的衍生物，其中2个末端基通过酯或酰胺键与吡啶或吡啶鎓核心的羧基偶联。在优选的实施方案中，交联剂是N 3，N 5 - 双（2-丙烯酰胺基乙基）吡啶-3,5-二甲酰胺或3,5-双（（2-丙烯酰胺基乙基）氨基甲酰基）-1-甲基吡啶-1- -halogenide。

IPRDB

热门服务

关于我们

友情链接

联系方式