专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0238188A3 USE OF THE HUMAN LRP/MVP PROMOTOR FOR A VECTOR THAT CAN BE INDUCED BY THERAPY 审中-公开
标题翻译：人类LRP / MVP启动子用于治疗诱导性的载体的用途
公开(公告)号：WO0238188A3
公开(公告)日：2002-12-12
申请号：PCT/DE0104151
申请日：2001-11-08
申请人： MAX DELBRUECK CENTRUM , STEIN ULRIKE , LANGE CHRISTIAN , WALTHER WOLFGANG , SCHLAG PETER MICHAEL
发明人： STEIN ULRIKE , LANGE CHRISTIAN , WALTHER WOLFGANG , SCHLAG PETER MICHAEL
IPC分类号： A61K48/00 , C12N15/12 , C12N15/67 , C07K14/47 , C12N15/85 , C12N15/86
CPC分类号： A61K48/0058
摘要： The invention relates to a vector system which can be regulated by therapy, using the gene promoter of the human lung resistance protein (LRP/MVP). This vector system for the expression, inducible by therapy, of therapeutically relevant genes in mammal cells is to be applied in the pharmaceutical industry and in medicine. The aim of the invention is to regulate tumour gene therapy with therapeutic modalities such as chemotherapy or hyperthermy for the duration of these therapies, to ensure that such gene therapy with chemotherapy, hyperthermy and other means results in a controlled, more efficient treatment of the tumour disease. An essential feature of the invention is a vector which can be induced by therapy, for the expression of therapeutic genes based on vector base structures that are suitable for expression in mammal cells. The vector is characterised by a human LRP/MVP promotor or a defined sequence thereof which can be induced by chemotherapy, hyperthermy and with other agents and a gene which codes for a therapeutic protein or non-translated RNA.
摘要翻译：本发明涉及使用人肺抗性蛋白（LRP / MVP）的基因启动子的可治疗调节的Verktorsystem。用于治疗相关基因在哺乳动物细胞中治疗诱导表达的载体系统将用于制药工业和医药领域。本发明具有以下目的以调节由治疗方式例如化疗或热疗这些治疗期间肿瘤的基因治疗，所以用化学疗法，热疗，和肿瘤疾病引线的控制，有效的治疗的其他装置，其基因治疗。本发明的基本特征是用于表达适用于在哺乳动物细胞中表达的基于载体的基于支架的治疗性基因的治疗诱导型载体。其特征在于通过化疗，高热和其他手段或其确定的序列诱导的人LRP / MVP启动子和编码治疗性蛋白质或非翻译RNA的基因。

2. 发明申请

WO2012028622A2 PEPTIDE OR PEPTIDE COMPLEX BINDING TO 2 INTEGRIN AND METHODS AND USES INVOLVING THE SAME 审中-公开
标题翻译：肽或肽复合物结合至2个整合及其涉及的方法和用途
公开(公告)号：WO2012028622A2
公开(公告)日：2012-03-08
申请号：PCT/EP2011064926
申请日：2011-08-30
申请人： SANOFI SA , CORVEY CARSTEN , BLUM HORST , CAMERON BEATRICE , DABDOUBI TARIK , DECARY STEPHANIE , BAURIN NICOLAS , PAPIN DAVID , LANGE CHRISTIAN
发明人： CORVEY CARSTEN , BLUM HORST , CAMERON BEATRICE , DABDOUBI TARIK , DECARY STEPHANIE , BAURIN NICOLAS , PAPIN DAVID , LANGE CHRISTIAN
IPC分类号： A61K39/395
CPC分类号： C07K16/2842 , C07K16/2839 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6857 , G01N33/6872 , G01N2333/70546 , G01N2333/7055
摘要： The present invention relates to a peptide or peptide complex binding to a2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s)for use as a medicament, a method for detecting a2 integrin and a screening method.
摘要翻译：本发明涉及与α2整联蛋白结合的肽或肽复合物，一种或多种编码肽或肽复合物的核酸，产生肽或肽复合物的重组细胞，产生肽或肽的方法复合物，包含肽或肽复合物或用作药物的核酸的药物组合物，用于检测α2整联蛋白的方法和筛选方法。

3. 发明申请

WO2011073954A3 NOVEL ANTAGONIST ANTIBODIES AND THEIR FAB FRAGMENTS AGAINST GPVI AND USES THEREOF 审中-公开
标题翻译：新型拮抗剂抗体及其抗GPVI及其用途的FAB片段
公开(公告)号：WO2011073954A3
公开(公告)日：2012-03-08
申请号：PCT/IB2010055917
申请日：2010-12-17
申请人： SANOFI AVENTIS , BAURIN NICOLAS , BLANCHE FRANCIS , CAMERON BEATRICE , CORVEY CARSTEN , DABDOUBI TARIK , ENGEL CHRISTIAN , FLORIAN PETER , FOCKEN INGO , KROLL KATJA , KRUIP JOCHEN , LANGE CHRISTIAN , LANGER THOMAS , LORENZ MARTIN , MIKOL VINCENT , RAO ERCOLE , WONEROW PETER
发明人： BAURIN NICOLAS , BLANCHE FRANCIS , CAMERON BEATRICE , CORVEY CARSTEN , DABDOUBI TARIK , ENGEL CHRISTIAN , FLORIAN PETER , FOCKEN INGO , KROLL KATJA , KRUIP JOCHEN , LANGE CHRISTIAN , LANGER THOMAS , LORENZ MARTIN , MIKOL VINCENT , RAO ERCOLE , WONEROW PETER
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K1/1075 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： FR2009/113 PCT PATENT APPLICATION TITLE Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof SANOFI-AVENTIS ABSTRACT The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.
摘要翻译：本发明公开了特异性结合人血小板膜蛋白Glycoprotein VI（GPVI）及其单价片段或衍生物的新型抗体。本发明的抗体是来自杂交瘤克隆390的抗体及其能诱导GPVI消耗表型的片段抗体。这些抗体和Fab片段能够阻断胶原结合，从而阻止胶原的血小板活化。本发明还涉及用于产生所公开的抗体和Fab片段的杂交瘤克隆和表达质粒。本发明还涉及单价抗体片段用于制备用于治疗血栓形成和其它血管疾病的研究，诊断和免疫治疗剂的用途。本发明还涉及在C-末端具有分子的Fab，以及使用这种修饰的Fab预防用抗体识别Fab的方法。本发明涉及当使用抗GP VI Fab时预防血小板活化的方法。

4. 发明申请

WO2008052774A2 METHODS FOR DETECTION OF A SINGLE- OR DOUBLE-STRANDED NUCLEIC ACID MOLECULE 审中-公开
标题翻译：检测单链或双链核酸分子的方法
公开(公告)号：WO2008052774A2
公开(公告)日：2008-05-08
申请号：PCT/EP2007009473
申请日：2007-10-31
申请人： NOXXON PHARMA AG , JAROSCH FLORIAN , HANSEN HILKE , LANGE CHRISTIAN
发明人： JAROSCH FLORIAN , HANSEN HILKE , LANGE CHRISTIAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2565/549 , C12Q2565/519 , C12Q2561/108
摘要： The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: i) providing a sample containing the nucleic acid molecule; j) providing a capture probe, whereby the capture probe is at least partially complementary to a part of the nucleic acid molecule; k) allowing the capture probe to react with the nucleic acid molecule or a part thereof; and d) detecting whether or not the capture probe is hybridized to the nucleic acid molecule or part thereof.
摘要翻译：本发明涉及一种检测核酸分子的方法，所述核酸分子至少包含含有样品中核苷酸序列的链，其中所述方法包括以下步骤：i）提供含有核酸分子的样品; j）提供捕获探针，其中捕获探针与核酸分子的一部分至少部分互补; k）允许捕获探针与核酸分子或其一部分反应; 和d）检测捕获探针是否与核酸分子或其一部分杂交。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式