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1. 发明申请

WO2018071822A2 ANTIBODIES THAT BIND ZIKA VIRUS ENVELOPE PROTEIN AND USES THEREOF 审中-公开
标题翻译：结合ZIKA病毒包膜蛋白的抗体及其用途
公开(公告)号：WO2018071822A2
公开(公告)日：2018-04-19
申请号：PCT/US2017/056596
申请日：2017-10-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NATIONAL UNIVERSITY OF SINGAPORE
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , CHAN, Kuan, Rong , WATANABE, Satoru , VASUDEVAN, Subhash, G. , OOI, Eng, Eong
IPC分类号： A61K39/12
摘要： Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
摘要翻译：公开了与寨卡病毒包膜蛋白和相关的基于抗体的组合物和分子结合的分离的单克隆抗体。还公开了使用抗体的治疗和诊断方法。

2. 发明申请

WO2018071822A8 ANTIBODIES THAT BIND ZIKA VIRUS ENVELOPE PROTEIN AND USES THEREOF 审中-公开
公开(公告)号：WO2018071822A8
公开(公告)日：2018-04-19
申请号：PCT/US2017/056596
申请日：2017-10-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NATIONAL UNIVERSITY OF SINGAPORE
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , CHAN, Kuan, Rong , WATANABE, Satoru , VASUDEVAN, Subhash, G. , OOI, Eng, Eong
IPC分类号： A61K39/12 , A61K39/395 , C07K16/10 , C07K14/18 , A61P31/12 , A61K39/00
摘要： Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

3. 发明申请

WO2018071822A3 ANTIBODIES THAT BIND ZIKA VIRUS ENVELOPE PROTEIN AND USES THEREOF 审中-公开
公开(公告)号：WO2018071822A3
公开(公告)日：2018-04-19
申请号：PCT/US2017/056596
申请日：2017-10-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NATIONAL UNIVERSITY OF SINGAPORE
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , CHAN, Kuan, Rong , WATANABE, Satoru , VASUDEVAN, Subhash, G. , OOI, Eng, Eong
IPC分类号： A61K39/12 , A61K39/395 , C07K16/10 , C07K14/18 , A61P31/12 , A61K39/00
摘要： Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

4. 发明申请

WO2017117179A1 BISPECIFIC ANTIBODIES HAVING CONSTANT REGION MUTATIONS AND USES THEREFOR 审中-公开
标题翻译：具有恒定区域突变的双特异性抗体及其用途
公开(公告)号：WO2017117179A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068808
申请日：2016-12-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , SUBRAMANIAN, Vidya , FLEISCHER, Eduardo , HATAS, Andrew, Peter
IPC分类号： C07K16/46 , C07K16/32 , C07K16/28 , C07K16/22
CPC分类号： C07K16/468 , C07K16/22 , C07K16/2818 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/526 , C07K2317/92
摘要： Described herein are mutations in the CHl/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
摘要翻译：本文描述了促进异二聚化的双特异性抗体的CH1 / CL界面和CH3恒定区中的突变以及有效产生双特异性抗体的方法。还公开了使用抗体的治疗和诊断方法。

5. 发明申请

WO2015123362A1 NOVEL FULL SPECTRUM ANTI-DENGUE ANTIBODY 审中-公开
标题翻译：全新的抗体抗体抗体
公开(公告)号：WO2015123362A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015510
申请日：2015-02-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan
IPC分类号： A61K39/395 , A61K39/42 , C12P21/08 , C07K16/00
CPC分类号： C07K16/10 , A61K39/42 , A61K45/06 , C07K16/1081 , C07K2317/92
摘要： The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.
摘要翻译：本发明尤其提供了与DV表位结合的抗体试剂（例如，抗体和/或其抗原结合片段），以及含有它们的组合物以及设计，提供，制定，使用，鉴定和 /或表征他们。在一些实施方案中，所提供的抗体试剂显示与多种DV血清型的显着结合。在一些实施方案中，所提供的抗体试剂显示与所有四种DV血清型的显着结合。这样的抗体试剂可用于例如DV的预防，治疗，诊断和/或研究。

6. 发明申请

WO2009075774A2 GLYCOSAMINOGLYCAN-COATED PARTICLES AND USES THEREOF 审中-公开
标题翻译：谷氨酰胺糖包覆颗粒及其用途
公开(公告)号：WO2009075774A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/013387
申请日：2008-12-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BAN, Zhihui , BOSQUES, Carlos , SASISEKHARAN, Ram
发明人： BAN, Zhihui , BOSQUES, Carlos , SASISEKHARAN, Ram
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , B82Y5/00 , C12Q1/34 , C12Q1/527 , G01N2400/40 , Y10T428/2991
摘要： The present invention is directed to metallic particles coated with glycosaminoglycans and methods for preparing them. Methods of using such glycosaminoglycan-coated metallic particles in biomedical and other applications are also disclosed. In certain embodiments, methods for assaying glycosaminoglycan-degrading activity in biological fluids, test samples, and/or therapeutic formulations using the glycosaminoglycan-coated particles are provided. Such methods may be used, for example, in diagnostic tests for diseases such as cancer, inflammatory diseases, or autoimmune diseases and to test activity of enzymes being developed as therapeutics.
摘要翻译：本发明涉及涂有糖胺聚糖的金属颗粒及其制备方法。还公开了在生物医学和其它应用中使用这种糖胺聚糖包被的金属颗粒的方法。在某些实施方案中，提供了使用糖胺聚糖包衣颗粒测定生物流体中的糖胺聚糖降解活性的方法，测试样品和/或治疗制剂。这样的方法可以用于例如癌症，炎性疾病或自身免疫性疾病等疾病的诊断试验，并测试作为治疗剂开发的酶的活性。

7. 发明申请

WO2007044471A2 METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES 审中-公开
标题翻译：与改进的碳水化合物分析相关的方法和产品
公开(公告)号：WO2007044471A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/038988
申请日：2006-10-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PARIVID LLC , BOSQUES, Carlos , KEISER, Nishla , SRINIVASAN, Aravind , RAMAN, Rahul , VISWANATHAN, Karthik , SASISEKHARAN, Ram , GANDHE, Pankaj , RAGURAM, Sasi
发明人： BOSQUES, Carlos , KEISER, Nishla , SRINIVASAN, Aravind , RAMAN, Rahul , VISWANATHAN, Karthik , SASISEKHARAN, Ram , GANDHE, Pankaj , RAGURAM, Sasi
IPC分类号： G06F19/00
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O- glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycocoηjugates with the desired glycosylation.
摘要翻译：本发明部分涉及碳水化合物的改进分析。特别地，本发明涉及对附着于脂质的蛋白质和糖类上发现的碳水化合物如N-聚糖和O-聚糖的分析。因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。还提供了这样的方法。进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖多糖。

8. 发明申请

WO2006099445A2 NANOCELLS FOR DIAGNOSIS AND TREATMENT OF DISEASES AND DISORDERS 审中-公开
标题翻译：用于诊断和治疗疾病和疾病的纳米技术
公开(公告)号：WO2006099445A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009213
申请日：2006-03-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SENGUPTA, Shiladitya , SASISEKHARAN, Ram , BOSQUES, Carlos, J.
发明人： SENGUPTA, Shiladitya , SASISEKHARAN, Ram , BOSQUES, Carlos, J.
CPC分类号： A61K51/1241 , A61K9/1271 , A61K9/14 , A61K45/06 , A61K47/6923 , A61K47/6929 , A61K51/1244 , B82Y5/00 , B82Y10/00
摘要： The present invention relates to novel nanocell compositions and their use in imaging, diagnostic and treatment methods. In one embodiment, nanocells tailored for imaging methods comprise a nanocore surrounded by a lipid matrix, and are modified to contain a radionuclide core or a nanocore with an emission spectra. The nanocells may be size restricted such as being greater than about 60 nm so that they selectively extravasate at sites of angiogenesis (e.g. tumor) and do not pass through normal vasculature or enter non-tumor bearing tissue. In this way, angiogenic sites can be both detected and treated. In another embodiment, nanocells are tailored for various treatment methods, including the treatment of brain cancer, asthma, Grave's Disease, Cystic Fibrosis, and Pulmonary Fibrosis.
摘要翻译：本发明涉及新型纳米细胞组合物及其在成像，诊断和治疗方法中的用途。在一个实施方案中，针对成像方法定制的纳细胞包括被脂质基质包围的纳米孔，并且被修饰成包含具有发射光谱的放射性核素核心或纳米核心。纳米细胞的尺寸可能受限于大于约60nm，使得它们在血管生成位点（例如肿瘤）选择性地外渗，并且不通过正常脉管系统或进入非肿瘤携带组织。以这种方式，可以检测和处理血管生成位点。在另一个实施方案中，针对各种治疗方法，包括治疗脑癌，哮喘，格雷夫斯病，囊性纤维化和肺纤维化，为纳米细胞定制。

9. 发明申请

WO2006076627A2 METHODS AND COMPOSITIONS RELATED TO MODULATING THE EXTRACELLULAR STEM CELL ENVIRONMENT 审中-公开
标题翻译：与调节细胞间干细胞环境相关的方法和组合
公开(公告)号：WO2006076627A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001321
申请日：2006-01-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SASISEKHARAN, Ram
发明人： SASISEKHARAN, Ram
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： A61K31/726 , A61K31/727 , A61K38/47 , C12N5/0606 , C12N5/0691 , C12N2501/70 , C12N2506/02
摘要： This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.
摘要翻译：本发明部分涉及调节干细胞环境的方法和组合物。更具体地，本发明部分地涉及用于调节干细胞分化的方法和组合物。在本发明的某些方面，这种调节是通过调节干细胞微环境中的糖胺聚糖（即在细胞表面上和/或细胞外基质中）上的调节剂来完成的。因此，提供了在干细胞的微环境中调节糖胺聚糖部分，例如硫酸乙酰肝素糖胺聚糖（HSGAG）部分的方法和组合物。还提供了用于促进或抑制胚胎干细胞分化（例如分化成内皮细胞）的方法和组合物。因此，本发明还部分地涉及可以用所提供的方法和组合物产生的细胞群体（例如内皮细胞群体或贫瘠的内皮细胞群体）。此外，本发明部分地涉及通过所提供的方法和组合物形成的组织及其用途。此外，本发明还部分地涉及使用提供的方法和组合物的治疗方法。

10. 发明申请

WO2002023190A8 METHODS AND PRODUCTS RELATED TO LOW MOLECULAR WEIGHT HEPARIN 审中-公开
公开(公告)号：WO2002023190A8
公开(公告)日：2002-03-21
申请号：PCT/US2001/028457
申请日：2001-09-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SUNDARAM, Mallikarjun , VENKATARAMAN, Ganesh , SHRIVER, Zachary , LIU, Dongfang , QI, Yi, Wei , SASISEKHARAN, Ram
IPC分类号： A61K31/727 , G01N33/86
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.

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