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1. 发明申请

WO2002062961A2 PEPTIDE SCAFFOLD ENCAPSULATION OF TISSUE CELLS AND USES THEREOF 审中-公开
标题翻译：组织细胞的组织切片包封及其用途
公开(公告)号：WO2002062961A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/003482
申请日：2002-02-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KISIDAY, John , GRODZINSKY, Alan, J. , THANG, Shuguang , SHERLEY, James , SEMINO, Carlos
发明人： KISIDAY, John , GRODZINSKY, Alan, J. , THANG, Shuguang , SHERLEY, James , SEMINO, Carlos
IPC分类号： C12N
CPC分类号： C12N5/0655 , A61K35/12 , C12N5/0012 , C12N5/0618 , C12N5/0672 , C12N2500/25 , C12N2501/11 , C12N2501/13 , C12N2502/1317 , C12N2533/30 , C12N2533/50
摘要： The invention features peptide scaffolds that are useful in the repair and replacement of diverse tissues. The invention also provides methods for making these scaffolds and methods for using them.
摘要翻译：本发明的特征在于可用于修复和替换不同组织的肽支架。本发明还提供了制备这些支架的方法和使用它们的方法。

2. 发明申请

WO2002062969A2 CELLULAR REPROGRAMMING IN PEPTIDE HYDROGEL AND USES THEREOF 审中-公开
标题翻译：肽水解中的细胞重编码及其用途
公开(公告)号：WO2002062969A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/003607
申请日：2002-02-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SEMINO, Carlos, E. , SHERLEY, James , ZHANG, Shuguang
发明人： SEMINO, Carlos, E. , SHERLEY, James , ZHANG, Shuguang
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N5/0012 , C12N5/0618 , C12N5/0672 , C12N2500/25 , C12N2501/11 , C12N2501/13 , C12N2502/1317 , C12N2533/30 , C12N2533/50
摘要： The present invention provides compositions featuring cells, e.g., progenitor cells, stem cells, and their progeny encapsulated within self-assembling three-dimensional peptide hydrogel structures (scaffolds). The scaffolds provide a nanoscale environment. Thus the invention provides a nanoscale environment scaffold encapsulating cells. According to certain embodiments of the invention the progenitor cells and/or their progeny are able to differentiate or transdifferentiate within the structures. According to certain embodiments of the invention the cells are liver lineage cells or neural lineage cells. The peptide hydrogel environment renders the cells permissive for instruction by differentiation-enhancing agents such as growth factors. The invention provides an in vitro culture system for growing stem and progenitor cells, for inducing their differentiation and transdifferentiation, and for studying their properties; an in vitro culture system for growing hepatocyte-like cells and/or mature hepatocytes, which may be used, for example, to propagate hepatotropic viruses; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, from which cells can be extracted and then either maintained in vitro or administered to a subject, e.g., for treating a tissue defect or other condition; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro within a structure that is to be implanted within a subject, e.g., for treating a tissue defect or other condition, and assay systems for testing compounds.
摘要翻译：本发明提供了组合物，其特征在于，细胞，例如祖细胞，干细胞及其后代，其包封在自组装的三维肽水凝胶结构（支架）内。支架提供了纳米尺度的环境。因此，本发明提供了一种封装细胞的纳米级环境支架。根据本发明的某些实施方案，祖细胞和/或其后代能够在结构内分化或转分化。根据本发明的某些实施方案，细胞是肝谱系细胞或神经谱系细胞。肽水凝胶环境使细胞允许通过分化增强剂如生长因子的指导。本发明提供了用于培养干细胞和祖细胞，用于诱导其分化和转分化并用于研究其性质的体外培养系统。用于生长肝细胞样细胞和/或成熟肝细胞的体外培养系统，其可以用于例如增殖嗜肝病毒; 用于控制和操纵体外细胞分化和转分化的系统，从中可以提取细胞，然后在体外保持或施用于受试者，例如用于治疗组织缺陷或其他病症; 用于在待植入受试者的结构内（例如用于治疗组织缺陷或其他病症）和用于测试化合物的测定系统的体外控制和操纵细胞分化和转分化的系统。

3. 发明申请

WO2004007683A2 CELLULAR REPROGRAMMING IN PEPTIDE HYDROGEL AND USES THEREOF 审中-公开
标题翻译：肽水解中的细胞重编码及其用途
公开(公告)号：WO2004007683A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021981
申请日：2003-07-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SEMINO, Carlos , SHEN, Collette , SHERLEY, James , ZHANG, Shuguang
发明人： SEMINO, Carlos , SHEN, Collette , SHERLEY, James , ZHANG, Shuguang
IPC分类号： C12N
CPC分类号： C12N5/0671 , A61K2035/126 , C12N5/0677 , C12N2501/01 , C12N2501/06 , C12N2501/11 , C12N2501/115 , C12N2501/998 , C12N2506/14 , C12N2533/50
摘要： The present invention provides compositions featuring cells, e.g., progenitor cells, stem cells, and their progeny encapsulated within self-assembling threedimensional peptide hydrogel structures (scaffolds). The scaffolds provide a nanoscale environment. Thus the invention provides a nanoscale environment scaffold encapsulating cells. According to certain embodiments of the invention the progenitor cells and/or their progeny are able to differentiate or transdifferentiate within the structures. According to certain embodiments of the invention the cells are or differentiate into liver lineage cells, neural lineage cells, or pancreatic lineage cells. The peptide hydrogel environment renders the cells permissive for instruction by differentiation-enhancing agents such as growth factors or extracellular matrix components. The invention provides an in vitro culture system for growing stem and progenitor cells, for inducing their differentiation and transdifferentiation, and for studying their properties; an in vitro culture system for growing hepatocyte-like cells and/or mature hepatocytes, which may be used, for example, to propagate hepatotropic viruses; a system for generating insulin secreting cells; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, from which cells can be extracted and then either maintained in vitro or administered to a subject; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, and assay systems for testing compounds. The invention provides methods of treating disease by implanting peptide hydrogel structures containing cells or cells extracted following culture in peptide hydrogels into the body.
摘要翻译：本发明提供了组合物，其特征在于细胞，例如祖细胞，干细胞及其后代，其封装在自组装三维肽水凝胶结构（支架）内。支架提供了纳米尺度的环境。因此，本发明提供了一种封装细胞的纳米级环境支架。根据本发明的某些实施方案，祖细胞和/或其后代能够在结构内分化或转分化。根据本发明的某些实施方案，细胞是或分化成肝谱系细胞，神经谱系细胞或胰腺谱系细胞。肽水凝胶环境使细胞允许通过分化增强剂如生长因子或细胞外基质组分的指导。本发明提供了用于培养干细胞和祖细胞，用于诱导其分化和转分化并用于研究其性质的体外培养系统。用于生长肝细胞样细胞和/或成熟肝细胞的体外培养系统，其可以用于例如增殖嗜肝病毒; 用于产生胰岛素分泌细胞的系统; 用于控制和操纵体外细胞分化和转分化的系统，从中可以提取细胞，然后在体外维持或施用于受试者; 用于在体外控制和操纵细胞分化和转分化的系统以及用于测试化合物的测定系统。本发明提供了通过在肽水凝胶中将含有细胞或细胞提取的细胞或细胞的肽水凝胶结构植入体内来治疗疾病的方法。

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