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1. 发明申请

WO2005117843A2 SUSTAINED RELEASE PREPARATIONS 审中-公开
标题翻译：持续发布准备
公开(公告)号：WO2005117843A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/016528
申请日：2005-05-11
申请人： MALLINCKRODT INC. , RAMAN, Siva, N. , CUNNINGHAM, John, P. , LANG, John, F.
发明人： RAMAN, Siva, N. , CUNNINGHAM, John, P. , LANG, John, F.
IPC分类号： A61K9/50
CPC分类号： A61K31/785 , A61K9/0095 , A61K9/5036 , A61K47/585
摘要： Disclosed are sustained release drug particles suitable for forming sustained release oral pharmaceutical compositions. The sustained release drug particles comprise a drug-ion exchange resin complex and a water-permeable, diffusion barrier surrounding at least a portion of the drug-ion exchange resin complex. The diffusion barrier comprises a film-forming polymer and is free or contains no substantial traces of organic solvent. Also disclosed are oral pharmaceutical compositions, for example, oral suspensions, comprising the sustained release drug particles, a method for the controlled administration of a drug to a patient, and a method for manufacturing the sustained release drug particles. The method of manufacturing involves the use of an aqueous coating composition comprising a water-permeable film-forming polymer such as ethylcellulose.
摘要翻译：公开了适于形成缓释口服药物组合物的缓释药物颗粒。缓释药物颗粒包含药物 - 离子交换树脂复合物和围绕药物 - 离子交换树脂复合物的至少一部分的透水的扩散阻挡层。扩散阻挡层包含成膜聚合物，并且不含或不含有实质痕量的有机溶剂。还公开了口服药物组合物，例如包含缓释药物颗粒的口服悬浮液，用于向患者控制施用药物的方法和制备缓释药物颗粒的方法。制造方法涉及使用包含透水性成膜聚合物如乙基纤维素的水性涂料组合物。

2. 发明申请

WO2005023217A2 GRANULAR SUSTAINED RELEASE PREPARATION AND PRODUCTION THEREOF 审中-公开
标题翻译：颗粒保持释放的准备和生产
公开(公告)号：WO2005023217A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/028545
申请日：2004-09-02
申请人： MALLINCKRODT INC. , RAMAN, Siva, N. , CUNNINGHAM, John, P.
发明人： RAMAN, Siva, N. , CUNNINGHAM, John, P.
IPC分类号： A61K9/00
CPC分类号： A61K9/2054 , A61K9/1652 , A61K31/787 , A61K47/585
摘要： There is disclosed a novel sustained release granular resin-pharmaceutical composition comprising an ion exchange resin complexed with a pharmaceutical material wherein said complex is embedded into and on the surface of a diffusion barrier material. There is also disclosed a novel process for preparing the granulated complex wherein an aqueous granulating vehicle is employed to form the complex and the granulated product, thereby avoiding the use of coatings and large amounts of organic solvents in the process.
摘要翻译：公开了一种新型的持续释放颗粒状树脂 - 药物组合物，其包含与药物材料复合的离子交换树脂，其中所述复合物嵌入扩散阻挡材料的表面和表面。还公开了一种制备造粒复合物的新方法，其中使用水性造粒载体形成复合物和造粒产物，从而避免了该方法中使用的涂料和大量的有机溶剂。

3. 发明申请

WO2010107802A1 CO-POLYMER BASED POLYIMIDE ARTICLES AND THEIR USES IN AN AIRCRAFT 审中-公开
标题翻译：基于聚合物的聚合物文章及其在飞机上的使用
公开(公告)号：WO2010107802A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027495
申请日：2010-03-16
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , CUNNINGHAM, John, P. , LOUDIN, Jeffrey, L.
发明人： CUNNINGHAM, John, P. , LOUDIN, Jeffrey, L.
IPC分类号： C08G73/10 , C08J9/00 , C08L79/08 , C08K3/00 , C08K3/04 , B29C43/00 , B29C43/02 , C09J9/00 , B64D33/00 , F02C7/00
CPC分类号： C08G73/1042 , B29C43/003 , B29K2079/08 , B29K2105/04 , B29K2503/04 , C08G73/1067 , C08L79/08 , F05B2220/40 , F05C2225/00
摘要： Disclosed herein is a method for making polyimide articles that are suitable for use in an aircraft. The articles disclosed herein are rigid, oxidatively stable, wear-resistant, and permeable to heated moisture and gases, and comprise co-polymer based polyimide, and at least one additive or filler, and are made using 20,000 to 50,000 psi of compression pressure.
摘要翻译：本文公开了一种用于制造适用于飞机的聚酰亚胺制品的方法。本文公开的制品是刚性的，氧化稳定的，耐磨的和对加热的水分和气体是可渗透的，并且包括基于共聚物的聚酰亚胺和至少一种添加剂或填料，并且使用20,000至50,000psi的压缩压力制成。

4. 发明申请

WO2010107797A1 CO-POLYMER BASED POLYIMIDE ARTICLES AND THEIR USES IN HIGH TEMPERATURE APPLICATIONS 审中-公开
标题翻译：基于聚合物的聚合物制品及其在高温应用中的应用
公开(公告)号：WO2010107797A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027487
申请日：2010-03-16
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , CUNNINGHAM, John, P. , LOUDIN, Jeffrey, L
发明人： CUNNINGHAM, John, P. , LOUDIN, Jeffrey, L
IPC分类号： C08G73/10 , C08J9/00 , C08L79/08 , C08K3/00 , C08K3/04 , B29C43/00 , B29C43/02 , F24C15/00 , F02B37/00 , C09J9/00 , F02M25/00
CPC分类号： C08G73/1042 , B29C43/003 , B29K2079/08 , B29K2105/04 , B29K2503/04 , C08G73/1067 , C08K3/013 , C08K3/04 , C08L79/08 , F01N13/16 , F02B39/00 , F02M26/11
摘要： Disclosed herein is a method for making polyimide articles that are suitable for high temperature applications. The articles disclosed herein are rigid, oxidatively stable, wear-resistant, and permeable to heated moisture and gases, and comprise co-polymer based polyimide, and at least one additive or filler, and are made using 20,000 to 50,000 psi of compression pressure.
摘要翻译：本文公开了一种制备适用于高温应用的聚酰亚胺制品的方法。本文公开的制品是刚性的，氧化稳定的，耐磨的和对加热的水分和气体是可渗透的，并且包括基于共聚物的聚酰亚胺和至少一种添加剂或填料，并且使用20,000至50,000psi的压缩压力制成。

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