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1. 发明申请

WO2016154010A1 IMMUNOGENIC COMPOSITIONS FOR USE IN VACCINATION AGAINST BORDETELLA 审中-公开
标题翻译：免疫组织用于对BORDETELLA进行疫苗接种
公开(公告)号：WO2016154010A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023160
申请日：2016-03-18
申请人： MAKIDON, Paul , BITKO, Vira , SMITH, Douglas , FATTOM, Ali
发明人： MAKIDON, Paul , BITKO, Vira , SMITH, Douglas , FATTOM, Ali
IPC分类号： A61K9/107 , A61K39/02 , A61K39/10 , A61P11/02
CPC分类号： A61K39/099 , A61K9/0043 , A61K9/1075 , A61K39/39 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/44 , A61K2039/543 , A61K2039/55566 , A61K2039/57
摘要： The present application relates to immunogenic compositions comprising a mixture of Bordetella (e.g., B. pertussis ) antigens and an oil in water nanoemulsion. In particular, the invention provides immunogenic compositions comprising nanoemulsion and a combination of Bordetella (e.g., B. pertussis ) antigens that have different functions, for example, combinations including B. pertussis adherence factors (adhesins), B. pertussis toxins or B. pertussis virulence factors. Vaccines, methods of treatment, uses of and processes to make a pertussis or whooping cough vaccine are also described. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
摘要翻译：本申请涉及包含博德特氏菌（例如百日咳百日香酵母）抗原和水中纳米乳液的混合物的免疫原性组合物。特别地，本发明提供包含纳米乳剂和具有不同功能的博德特氏菌（例如百日咳杆菌）抗原的组合的免疫原性组合物，例如包括百日咳杆菌粘附因子（粘附素），百日咳杆菌毒素或百日咳百日虫毒力因素。还描述疫苗，治疗方法，使用和制备百日咳疫苗或百日咳疫苗的方法。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如，疫苗接种））和研究应用。

2. 发明申请

WO2013036907A1 NANOEMULSION RESPIRATORY SYNCYTIAL VIRUS (RSV) SUBUNIT VACCINE 审中-公开
标题翻译： NANOMPULSION呼吸道同源病毒（RSV）亚型疫苗
公开(公告)号：WO2013036907A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054395
申请日：2012-09-10
申请人： NANOBIO CORPORATION , FATTOM, Ali, I. , BITKO, Vira , HAMOUDA, Tarek , BAKER, James, R.
发明人： FATTOM, Ali, I. , BITKO, Vira , HAMOUDA, Tarek , BAKER, James, R.
IPC分类号： A61K39/155
CPC分类号： A61K39/155 , A61K9/1075 , A61K39/12 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/44 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , A61K2039/55566 , C12N2760/18034
摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.
摘要翻译：本申请涉及免疫学领域，特别是呼吸道合胞病毒（RSV）表面蛋白，融合（F）和糖蛋白（G）蛋白亚基疫苗的疫苗组合物优先与免疫细胞靶向和增强子混合，纳米乳剂诱导保护性免疫应答，并避免疫苗诱导疾病增强。

3. 发明申请

WO2013006797A1 HUMAN RESPIRATORY SYNCYTIAL VIRUS VACCINE 审中-公开
标题翻译：人类呼吸道同种病毒疫苗
公开(公告)号：WO2013006797A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045769
申请日：2012-07-06
申请人： NANOBIO CORPORATION , FATTOM, Ali, I. , LUKACS, Nicolas , BAKER, James, R. , HAMOUDA, Tarek , BITKO, Vira
发明人： FATTOM, Ali, I. , LUKACS, Nicolas , BAKER, James, R. , HAMOUDA, Tarek , BITKO, Vira
IPC分类号： A61K39/155 , B82Y99/00
CPC分类号： A61K39/12 , A61K9/0019 , A61K9/06 , A61K9/1075 , A61K9/1271 , A61K9/5115 , A61K31/716 , A61K31/722 , A61K47/26 , A61K47/38 , A61K47/44 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , A61K2039/55566 , A61K2039/55583 , C07K16/1027 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18534 , A61K2300/00
摘要： The present invention relates to RSV vaccines and methods for inducing an immune response to RSV in a subject comprising administering an RSV vaccine.
摘要翻译：本发明涉及用于在受试者中诱导对RSV的免疫应答的RSV疫苗和方法，包括施用RSV疫苗。

4. 发明申请

WO2017079625A1 NOVEL PLATFORM DNA VACCINE 审中-公开
标题翻译：新的平台DNA疫苗
公开(公告)号：WO2017079625A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060631
申请日：2016-11-04
申请人： UNIVERSITY OF SOUTH ALABAMA , SOLODUSHKO, Victor, G. , FOUTY, Brian , BITKO, Vira
发明人： SOLODUSHKO, Victor, G. , FOUTY, Brian , BITKO, Vira
IPC分类号： A61K39/12 , A61K39/145 , C12N7/01
CPC分类号： A61K39/12 , A61K39/015 , A61K2039/53 , A61K2039/6075 , C12N2760/18534
摘要： The present invention relates to novel DNA vaccines, configured to induce a robust and sustained immune response, and methods of use thereof. DNA vaccines proposed herein are configured to achieve this immune response by fusing the extracellular domain of a viral fusion protein to selected antigens or antigen-binding polypeptides. After the expression and secretion of the viral fusion-antigen protein from the initially transfected cells, the natural ability of the viral fusion protein to fuse to cell membranes and actively enter cells will allow for passive delivery of the fused target epitopes into neighboring cells, thus inducing a more robust immune response. The presented method described herein allows for the use of this DNA vaccine against known antigens present in proteins produced by infectious agents or cancer cells within a subject, against unknown antigens produced by infectious agents or cancer cells within a subject, or against naturally-occurring or synthetically-derived antigens delivered by other routes, such as injection.
摘要翻译：本发明涉及新型DNA疫苗，其被配置为诱导稳健和持续的免疫应答，以及其使用方法。通过将病毒融合蛋白的胞外结构域与选择的抗原或抗原结合多肽融合来配置本文提出的DNA疫苗以实现该免疫应答。在从最初转染的细胞表达和分泌病毒融合抗原蛋白后，病毒融合蛋白融合到细胞膜并主动进入细胞的天然能力将允许被融合的靶表位被动递送到相邻细胞中，因此诱导更强大的免疫应答。本文所述的方法允许使用这种DNA疫苗针对存在于受试者体内的感染因子或癌细胞产生的蛋白质中的已知抗原，针对受试者体内的感染因子或癌细胞产生的未知抗原，或针对天然存在的或通过其他途径（如注射）递送的合成衍生抗原。

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