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1. 发明申请

WO2005099878A1 PROCESS FOR PRODUCING HOLLOW CAPILLARY POLYMERIC MEMBRANES FOR THE TREATMENT OF BLOOD AND ITS DERIVATIVES 审中-公开
标题翻译：生产用于治疗血液及其衍生物的中毛细胞聚乙烯膜的方法
公开(公告)号：WO2005099878A1
公开(公告)日：2005-10-27
申请号：PCT/IT2005/000220
申请日：2005-04-15
申请人： LYSITECH SRL , REVERCHON, Ernesto
发明人： REVERCHON, Ernesto
IPC分类号： B01D69/08
CPC分类号： B01D69/02 , B01D67/0016 , B01D69/08 , B01D71/40 , B01D71/68 , B01D2323/08 , B01D2323/10 , B01D2323/225 , Y10T428/1376
摘要： A process to produce semi-permeable polymer membranes that allows to obtain hollow capillary membranes to be preferably (but not, exclusively) used in the field of the treatment of blood and its derivatives, particularly for hemodialysis, hemodiafiltration, and hemofiltration. The process is based on a phase separation mechanism to produce the semi permeable membrane, and uses dense or supercritical fluids instead of the liquid solvents as non-solvents in the phase separation. Supercritical or dense fluids act as non-solvents, for polymers and as solvents for liquid solvents used to form the membrane. The temperature, pressure, residence time and composition ranges have been designed so as to allow the modulation of the porosity of the produced capillary membranes.
摘要翻译：制备半透性聚合物膜的方法，其允许获得空心毛细管膜，以优选（但不是，专门）用于治疗血液及其衍生物，特别是用于血液透析，血液透析滤过和血液滤过的领域。该方法基于相分离机制以产生半透膜，并且在相分离中使用致密或超临界流体代替液体溶剂作为非溶剂。超临界或致密流体作为非溶剂，用作聚合物和用作形成膜的液体溶剂的溶剂。已经设计了温度，压力，停留时间和组成范围，以便调制所产生的毛细管膜的孔隙率。

2. 发明申请

WO2005012402A1 NANOPOROUS AND MICROPOROUS MANUFACTS BASED ON SYNDIOTACTIC POLYSTYRENE AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：基于合成聚苯乙烯的纳米和微波制备及其制备方法
公开(公告)号：WO2005012402A1
公开(公告)日：2005-02-10
申请号：PCT/EP2004/051556
申请日：2004-07-20
申请人： UNIVERSITA' DEGLI STUDI DI SALERNO , GUERRA, Gaetano , MENSITIERI, Giuseppe , VENDITTO, Vincenzo , REVERCHON, Ernesto , DANIEL, Christophe
发明人： GUERRA, Gaetano , MENSITIERI, Giuseppe , VENDITTO, Vincenzo , REVERCHON, Ernesto , DANIEL, Christophe
IPC分类号： C08J5/18
CPC分类号： C08J9/28 , C08J2201/0502 , C08J2205/026 , C08J2325/06
摘要： The present invention relates to microporous manufacts (i.e, manufact presenting high porosity, often referred as aerogels) based on syndiotactic polystyrene and characterized by the presence of cavities with nanometric dimensions characteristic of the δ crystalline form and to processes for their preparation. These manufacts are capable to absorb with a fast kinetics volatile organic compounds from liquid or gaseous phases, also when such components are present at very low concentrations.
摘要翻译：本发明涉及基于间同立构聚苯乙烯的微孔制品（即具有高孔隙率，通常称为气凝胶的制造商），其特征在于存在具有三角形晶形特征的纳米尺寸的空腔及其制备方法。这些制造商能够用液体或气相的快速动力学挥发性有机化合物吸收，而且当这些组分以非常低的浓度存在时也是如此。

3. 发明申请

WO2006095372A1 PROCESS FOR PRODUCING POLYMERIC MEMBRANES LOADED WITH ACTIVE INGREDIENTS 审中-公开
标题翻译：生产含有活性成分的聚合物膜的方法
公开(公告)号：WO2006095372A1
公开(公告)日：2006-09-14
申请号：PCT/IT2005/000642
申请日：2005-11-04
申请人： UNIVERSITA' DEGLI STUDI DI SALERNO , REVERCHON, Ernesto , CARDÉA, Stefano
发明人： REVERCHON, Ernesto , CARDÉA, Stefano
IPC分类号： C08J5/22 , B01D69/14
CPC分类号： B01D67/0011 , A61K9/70 , B01D67/0009 , B01D67/0016 , B01D69/08 , B01D69/141 , B01D71/22 , B01D71/40 , B01D2323/08 , B01D2323/10 , B01D2323/225 , B01J35/065 , D01D5/24 , D01D5/247
摘要： A process for obtaining membranes loaded with one or more active ingredients, consisting of contacting a solution, or suspension, formed by one or more solvents, one or more polymers and one or more active ingredients with supercritical carbon dioxide (SC-CO 2 ). SC-CO 2 , at suitable process conditions, has a high affinity for organic solvents; therefore, a supercritical fluid solution is formed and a continuous solid structure precipitates. The latter is characterized by interconnected cells (membrane) loaded with the active ingredient initially present in the solution (or suspension). The described process is extremely versatile and allows to obtain membranes with different morphologies, as well as to control the mean cell diameter and porosity.
摘要翻译：一种用于获得负载有一种或多种活性成分的膜，该方法包括将由一种或多种溶剂形成的溶液或悬浮液与一种或多种聚合物和一种或多种活性成分与超临界二氧化碳（SC-CO） 2 ）。 SC-CO 2在合适的工艺条件下对有机溶剂具有高亲和力; 因此，形成超临界流体溶液并且连续的固体结构沉淀。后者的特征在于负载初始存在于溶液（或悬浮液）中的活性成分的相互连接的细胞（膜）。所描述的方法是非常通用的，并且允许获得具有不同形态的膜，以及控制平均细胞直径和孔隙率。

4. 发明申请

WO2010064272A8 STERILIZATION OF MEDICAL DEVICES USING EXPANDED ORGANIC ACIDS 审中-公开
公开(公告)号：WO2010064272A8
公开(公告)日：2010-06-10
申请号：PCT/IT2009/000545
申请日：2009-12-03
申请人： UNIVERSITA' DEGLI STUDI DI SALERNO , REVERCHON, Ernesto , DELLA PORTA, Giovanna , ADAMI, Renata
发明人： REVERCHON, Ernesto , DELLA PORTA, Giovanna , ADAMI, Renata
IPC分类号： A61L2/18 , A61L2/20 , A61L2/22 , A01N37/00
摘要： The present invention concerns a process for sterilizing biomedical devices using organic acids expanded by compressed gases to form an "expanded liquid". The term "expanded liquid" means, in the technical literature, an organic solvent that is liquid at room temperature and pressure, modified by dissolution therein of a compressed gas to modify the diffusivity and the surface tension of the liquid compound, while maintaining part of its original In the proposed process the diffusivity and the surface tension of the liquid component is modified while maintaining part of its characteristics, such as the solvent power and the oxidizing ability. The invention proposes the use of expanded organic acids as sterilizing agents for complex biomedical devices, due to their particular effectiveness, both as a result of their favourable transfer properties (similar to the properties of a gas) and for the oxidizing properties, that can vary in accordance with the composition of the gas-liquid mixture.

5. 发明申请

WO2006095371A1 PROCESS FOR CLEANING ENGRAVED CYLINDERS USED IN PRINTING AND PACKAGING INDUSTRY FROM ADHESIVE AND/OR INK RESIDUES 审中-公开
标题翻译：用于清洁粘合剂和/或墨水残留物印刷和包装工业中使用的加压气瓶的方法
公开(公告)号：WO2006095371A1
公开(公告)日：2006-09-14
申请号：PCT/IT2005/000603
申请日：2005-10-14
申请人： UNIVERSITA'DEGLI STUDI DI SALERNO , REVERCHON, Ernesto , DELLA PORTA, Giovanna
发明人： REVERCHON, Ernesto , DELLA PORTA, Giovanna
IPC分类号： B08B7/00 , B41F35/00
CPC分类号： B44D3/16 , B01D11/0203 , B01D11/028 , B08B7/0021 , B41F35/02
摘要： A process for the removal of dry adhesives and/or inks from the surface and from the interior of the cells of the engraved cylinders used in printing and coupling processes, using a supercritical mixture formed by one or more organic solvents and a supercritical fluid, preferably consisting of supercritical carbon dioxide. The microscopic cells of the engraved cylinders used in printing industry or of the cylinders used for film coupling in packaging industry are thoroughly and easily cleaned by a process comprising the steps of forming the said supercritical mixture, delivering it in a high pressure autoclave previously filled with the engraved cylinders to be cleaned, cleaning for a given residence time, eliminating the organic solvent residue in the autoclave by washing it with supercritical fluid and precipitating the extracted inks and/or adhesives in one or more separators located downstream the autoclave.
摘要翻译：一种用于使用由一种或多种有机溶剂和超临界流体形成的超临界混合物从印刷和偶联过程中使用的雕刻圆柱体的细胞表面和内部去除干燥粘合剂和/或油墨的方法，优选地由超临界二氧化碳组成。用于印刷工业中的雕刻圆柱体或用于包装工业中的薄膜耦合的圆柱体的显微细胞通过包括以下步骤的方法被彻底地和容易地清洁，所述方法包括形成所述超临界混合物，将其输送到先前填充有待清洗的雕刻圆柱体，给定的停留时间进行清洗，通过用超临界流体洗涤除去高压釜中的有机溶剂残留物，并将提取的油墨和/或粘合剂沉淀在位于高压釜下游的一个或多个分离器中。

6. 发明申请

WO2003004142A1 PROCESS FOR THE PRODUCTION OF MICRO AND/OR NANO PARTICLES 审中-公开
标题翻译：生产微量和/或纳米颗粒的方法
公开(公告)号：WO2003004142A1
公开(公告)日：2003-01-16
申请号：PCT/IB2001/001780
申请日：2001-09-27
申请人： MICRO & NANO MATERIALS SAGL , REVERCHON, Ernesto
发明人： REVERCHON, Ernesto
IPC分类号： B01J2/04
CPC分类号： A61K9/5192 , A61K9/1688 , B01J2/04
摘要： A process and an apparatus are proposed to perform the supercritical assisted atomization of nano and/or micro metric powders. It is possible to use liquid solvent at process conditions in which they show a low solubility in carbon dioxide. Atomization is obtained by solubilizing pressurized carbon dioxide (compressed, liquid, supercritical) in a solution formed by the solid to be micronized and the liquid solvent, solubilizing carbon dioxide up to near equilibrium conditions and then atomizing the solution down to near atmospheric conditions through a thin wall injector, to produce very small droplet of micronic and sub-micronic dimensions. The subsequent evaporation of the droplets produces particles with diameters ranging between 0.02 and 10 micron.
摘要翻译：提出了一种方法和装置，用于执行纳米和/或微米粉末的超临界辅助雾化。在其在二氧化碳中显示低溶解度的工艺条件下可以使用液体溶剂。通过将加压二氧化碳（压缩，液体，超临界）溶解在由待微粉碎的固体和液体溶剂形成的溶液中，将二氧化碳溶解至接近平衡条件，然后通过以下步骤将溶液雾化至接近大气条件薄壁注射器，产生非常小的微米和亚微米尺寸的液滴。随后的液滴蒸发产生直径范围在0.02和10微米之间的颗粒。

7. 发明申请

WO2015079419A1 ANTIMICROBICALLY ACTIVE PACKAGING, ANTIMICROBICALLY ACTIVE MEMBRANE FOR PACKAGING AND RELATED USES 审中-公开
标题翻译：抗微生物活性包装，用于包装和相关用途的抗微生物活性膜
公开(公告)号：WO2015079419A1
公开(公告)日：2015-06-04
申请号：PCT/IB2014/066424
申请日：2014-11-28
申请人： REVERCHON, Ernesto , BALDINO, Lucia , CARDEA, Stefano
发明人： REVERCHON, Ernesto , BALDINO, Lucia , CARDEA, Stefano
IPC分类号： C08J9/28 , C08J9/00
CPC分类号： C08J9/28 , C08J9/0004 , C08J2201/054 , C08J2205/026 , C08J2205/044 , C08J2205/05 , C08J2207/00
摘要： An antimicrobically active packaging comprising thereinside at least one antimicrobically active membrane having an open-cell structure in a polymeric material loaded with an active antimicrobial agent and in the absence of solvents of the polymeric material of said structure. An antimicrobically active membrane suitable for the production of an antimicrobically active packaging and having an open-cell structure of a polymeric material having pores loaded with an active antimicrobial agent and in the absence of solvents of the polymeric material of said structure. Use of the packaging and of the membrane for the preservation of a food or perishable product of natural origin.
摘要翻译：一种抗微生物活性包装，其包含至少一种在负载有活性抗微生物剂的聚合物材料中和在不存在所述结构的聚合物材料的溶剂的情况下具有开孔结构的抗微生物活性膜。一种适用于生产抗微生物活性包装的抗微生物活性膜，其具有开孔结构的聚合材料，该聚合物材料具有负载有活性抗微生物剂的孔，并且在不存在所述结构的聚合物材料的溶剂的情况下。使用包装和隔膜来保存天然来源的食物或易腐产品。

8. 发明申请

WO2009016677A2 CONTINUOUS PROCESS FOR MICROSPHERES PRODUCTION BY USING EXPANDED FLUIDS 审中-公开
标题翻译：用膨胀流体生产微球的连续方法
公开(公告)号：WO2009016677A2
公开(公告)日：2009-02-05
申请号：PCT/IT2008/000504
申请日：2008-07-25
申请人： UNIVERSITA DEGLI STUDI DI SALERNO , REVERCHON, Ernesto , DELLA PORTA, Giovanna
发明人： REVERCHON, Ernesto , DELLA PORTA, Giovanna
CPC分类号： A61K9/16 , A61K9/1635 , A61K9/1647 , A61K9/1694 , B01F3/0092 , B01F2003/0064 , B01J3/008 , B01J2203/00
摘要： The invention concerns a process for the continuous treatment of an emulsion and/or a micro-emulsion assisted by an "expanded liquid' for the production of micro- and/or nano-particles or micro- and/or nano- spheres containing one or more active ingredients. In particular, a liquid solvent expanded by compressed or supercritical CO 2 is contacted with an O/W emulsion, or alternatively a W/O emulsion or multiple emulsions, formed by an external phase that is itself a liquid expanded by compressed CO 2 . The expanded liquid forms a solution with the dispersed phase of the emulsion and extracts it inducing the formation of the desired particles of the dissolved compounds. The process is carried out in a counter-current packed column wherein the expanded emulsion is fed from the top, while the expanded liquid is fed from the bottom. Thanks to the presence of the expanded liquid, any deposition of the solid particles produced on the packing elements is avoided, thus preventing any column blockage. A suspension of micro-structured particles of the desired product can be collected continuously at the bottom of the column.
摘要翻译：本发明涉及连续处理由“膨胀液体”辅助的用于生产微米和/或纳米颗粒或微米颗粒的乳液和/或微乳液的方法，和/或含有一种或多种活性成分的纳米球。特别地，通过压缩或超临界CO 2膨胀的液体溶剂与O / W乳液或者W / O乳液或多重乳液接触，所述乳液或外部相本身是液体通过压缩的CO _{2 进行扩展。膨胀的液体与乳液的分散相形成溶液并将其萃取出来，诱导形成所需的溶解化合物颗粒。该方法在逆流填充塔中进行，其中膨胀的乳液从顶部进料，而膨胀的液体从底部进料。由于膨胀液体的存在，避免了在填充元件上产生的固体颗粒的任何沉积，因此避免了任何柱堵塞。可以在色谱柱底部连续收集所需产物的微结构颗粒悬浮液。}

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