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1. 发明申请

WO1996010762A1 WAVELENGTH SELECTIVE FILTER 审中-公开
标题翻译：波长选择滤波器
公开(公告)号：WO1996010762A1
公开(公告)日：1996-04-11
申请号：PCT/GB1995002326
申请日：1995-09-29
申请人： LYNXVALE LIMITED , MEARS, Robert, Joseph , WARR, Stephen, Thomas , PARKER, Michael, Charles
发明人： LYNXVALE LIMITED
IPC分类号： G02B05/20
CPC分类号： G02F1/31 , G02B5/203 , G02F1/139 , G02F1/141 , G02F1/292 , G02F2203/055 , G02F2203/06 , G02F2203/12 , G02F2203/22 , G02F2203/50 , G03H1/0005 , G03H1/2294
摘要： A tunable optical wavelength selective filter comprises a dynamic holographic diffraction element (3) in combination with a fixed diffraction grating or hologram (2). The dynamic diffraction element (3) is preferably implemented as an electronically controlled image displayed on a pixelated spatial light modulator and in particular a spatial light modulating using opto-electronic integrated circuits fabricated using silicon VLSI technology and integrated with ferro-electric liquid crystals. Amongst other uses, the filter can be implemented to form a digitally tunable laser.
摘要翻译：可调谐光学波长选择滤光器包括与固定衍射光栅或全息图（2）组合的动态全息衍射元件（3）。动态衍射元件（3）优选地实现为在像素化空间光调制器上显示的电子控制图像，特别是使用利用硅VLSI技术制造并与铁电液晶结合的光电集成电路的空间光调制。在其他用途中，可以实现滤波器以形成数字可调激光器。

2. 发明申请

WO1996010776A1 OPTICAL SWITCH 审中-公开
标题翻译：光开关
公开(公告)号：WO1996010776A1
公开(公告)日：1996-04-11
申请号：PCT/GB1995002327
申请日：1995-09-29
申请人： LYNXVALE LIMITED , MEARS, Robert, Joseph , WARR, Stephen, Thomas
发明人： LYNXVALE LIMITED
IPC分类号： G02F01/29
CPC分类号： G02B5/203 , G02F1/139 , G02F1/141 , G02F1/292 , G02F1/31 , G02F2203/055 , G02F2203/06 , G02F2203/12 , G02F2203/22 , G02F2203/50 , G03H1/0005 , G03H1/2294
摘要： A polarisation independent optical switch comprises a light input (6), a diffractive and re-configurable liquid crystal device (8), a collimating lens (7) for distributing the input light over the liquid crystal device (8), a transform lens (9) receiving light from the liquid crystal device (8) and a light output (6), wherein no polarisers are present between the light input and output. The diffractive and re-configurable liquid crystal device (8) may be formed as a liquid crystal spatial light modulator configured as a binary phase computer generated hologram with the holograms required to form broadcast, individual or multicast switching being re-generated using an iterative algorithm and then being recalled on demand. In one embodiment the switch has a folded configuration and includes a reflector (10) so that the light input and output are both on the same side of the liquid crystal device (8).
摘要翻译：偏振无关光开关包括光输入（6），衍射和可重新配置的液晶装置（8），用于将输入光分布在液晶装置（8）上的准直透镜（7），变换透镜 9）接收来自液晶装置（8）的光和光输出（6），其中在光输入和输出之间不存在偏振器。衍射和可重新配置的液晶装置（8）可以形成为配置为二进制相位计算机产生的全息图的液晶空间光调制器，其中使用迭代算法重新生成广播，个人或多播切换所需的全息图然后按要求召回。在一个实施例中，开关具有折叠构造，并且包括反射器（10），使得光输入和输出都在液晶装置（8）的同一侧。

3. 发明申请

WO1996009727A1 OPTICAL CROSSBAR SWITCH 审中-公开
标题翻译：光学交叉开关
公开(公告)号：WO1996009727A1
公开(公告)日：1996-03-28
申请号：PCT/GB1995002245
申请日：1995-09-21
申请人： LYNXVALE LIMITED , CROSSLAND, William, Alden , MEARS, Robert, Joseph , WARR, Stephen, Thomas
发明人： LYNXVALE LIMITED
IPC分类号： H04Q03/52
CPC分类号： H04Q11/0005 , H04Q2011/0026 , H04Q2011/0056
摘要： There is provided a switch for connecting one or more data inputs to one or more outputs, in which the interconnections are made optically, through the use of light beams directed between the inputs and outputs. An input device is illuminated by a source array such that the selected output depends upon the angle of incidence of the illuminating beam.
摘要翻译：提供了一种用于通过使用在输入和输出之间定向的光束将一个或多个数据输入连接到一个或多个输出的开关，其中互连是光学的。输入装置由源阵列照亮，使得所选择的输出取决于照明光束的入射角。

4. 发明申请

WO1995020044A1 NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN AND USES THEREOF 审中-公开
标题翻译：自然抗性相关蛋白及其用途
公开(公告)号：WO1995020044A1
公开(公告)日：1995-07-27
申请号：PCT/GB1995000095
申请日：1995-01-19
申请人： LYNXVALE LIMITED , BARTON, Charles, Howard , WHITE, Jacqueline, Katie , BLACKWELL, Jenefer, Mary
发明人： LYNXVALE LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , A61K38/00
摘要： Macrophages, the main phagocytic cells of animals, can bind and ingest microorganisms. A natural resistance-associated macrophage protein is provided having an N-terminal region comprising an Src homology 3 binding domain. When present in the macrophage, the protein is capable of controlling resistance to the microorganisms.
摘要翻译：巨噬细胞是动物的主要吞噬细胞，可以结合并摄取微生物。提供了具有包含Src同源性3结合结构域的N末端区域的天然抗性相关巨噬细胞蛋白质。当存在于巨噬细胞中时，蛋白质能够控制对微生物的抗性。

5. 发明申请

WO1996004395A1 RECOMBINANT VIRUS VECTORS 审中-公开
标题翻译：重组病毒载体
公开(公告)号：WO1996004395A1
公开(公告)日：1996-02-15
申请号：PCT/GB1995001790
申请日：1995-07-28
申请人： LYNXVALE LIMITED , SPECK, Peter, Gerald
发明人： LYNXVALE LIMITED
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2710/16643
摘要： A mutant herpesvirus that can be used as a recombinant virus vector comprises (a) a mutation such that the mutant virus has a reduced ability in comparison with a parent type to cause lysis of an infected cell, and (b) an inactivating mutation in a gene essential for the production of infectious virus. An example is a HSV1 mutant lacking the essential glycoprotein gH gene and having a mutation impairing the function of gene product VP16. A heterologous gene can be carried at the site of the inactivated essential gene, e.g. a gene suitable for administering gene therapy. The vector has an increased margin of safety over known herpesvirus vectors in respect of incidence of cytopathic effects and/or risk of reversion.
摘要翻译：可用作重组病毒载体的突变疱疹病毒包含（a）突变病毒与母体类型相比具有降低的能力以引起感染细胞裂解的突变，和（b）在对感染性病毒生产至关重要的基因。一个例子是缺乏必需糖蛋白gH基因并具有损害基因产物VP16功能的突变的HSV1突变体。异源基因可以在灭活的必需基因的位点携带，例如一种适合基因治疗的基因。载体与已知疱疹病毒载体相比，在致病性病变发生率和/或逆转风险方面具有更高的安全性。

6. 发明申请

WO1992016562A1 HUMANISED ANTIBODIES HAVING MODIFIED ALLOTYPIC DETERMINANTS 审中-公开
标题翻译：具有改性的全能决定因子的人类抗体
公开(公告)号：WO1992016562A1
公开(公告)日：1992-10-01
申请号：PCT/GB1992000445
申请日：1992-03-12
申请人： LYNXVALE LIMITED , CLARK, Michael, Ronald
发明人： LYNXVALE LIMITED
IPC分类号： C07K15/28
CPC分类号： C07K16/00
摘要： The invention relates to molecules which have an amino acid sequence derivable from part or all of the constant region of an immunoglobulin heavy chain. The constant regions are of a particular isotype and have one or more allotypic determinants. The amino acid sequence is substantially homologous to the amino acid sequence of the constant region. However, it has been altered so that it is without at least one of said allotypic determinants by making its sequence the site for an allotypic determinant identical to the amino acid sequence from the corresponding position in another equivalent immunoglobulin constant region of a different isotype. The invention provides synthetic immunoglobulins with reduced allotypic differences as compared to a given wild-type immunoglobulin.
摘要翻译：本发明涉及具有可衍生自免疫球蛋白重链的恒定区的部分或全部的氨基酸序列的分子。恒定区具有特定的同种型，并具有一个或多个同种异型决定簇。氨基酸序列与恒定区的氨基酸序列基本上同源。然而，通过使其序列与来自不同同种型的另一等效免疫球蛋白恒定区中的相应位置的氨基酸序列相同的同种异型决定簇的位点，其已被改变，使得其不具有所述同种异型决定簇中的至少一种。与给定的野生型免疫球蛋白相比，本发明提供具有降低的同种异型差异的合成免疫球蛋白。

7. 发明申请

WO1992007944A1 VACCINIA VECTORS, VACCINIA GENES AND EXPRESSION PRODUCTS THEREOF 审中-公开
标题翻译：疫苗疫苗，疫苗基因及其表达产物
公开(公告)号：WO1992007944A1
公开(公告)日：1992-05-14
申请号：PCT/GB1991001882
申请日：1991-10-28
申请人： LYNXVALE LIMITED , SMITH, Geoffrey, Lilley
发明人： LYNXVALE LIMITED
IPC分类号： C12N15/86
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K14/705 , C12N15/86 , C12N2710/24122 , C12N2710/24143 , C12N2710/24161
摘要： This application concerns vaccinia vectors and it is based upon the discovery of three unobvious gene sequences in the viral genome. One or more of the gene sequences may be inactivated, or part of all of one or more of these gene sequences may be deleted from the viral genome to allow (i) greater attenuation of the virus and/or (ii) enhancement of immunogenicity of recombinant vaccinia virus; and/or (iii) further gene sequence insertion sites, so that more foreign DNA may be incorporated in the virus. Where however, the gene sequences are essential for viral replication, viral attenuation can still be effected by altering the gene product (e.g. by manipulation at gene level ), such that a protein function effecting pathogenicity is adversely affected, whilst keeping the protein functional for virus replication.
摘要翻译：该应用涉及痘苗载体，其基于在病毒基因组中发现三个不显着的基因序列。一个或多个基因序列可以被失活，或者可以从病毒基因组中删除一个或多个这些基因序列的一部分，以允许（i）病毒的更大的减弱和/或（ii）增强免疫原性的增强重组痘苗病毒; 和/或（iii）进一步的基因序列插入位点，使得可以在病毒中掺入更多的外源DNA。然而，然而，基因序列对于病毒复制是必需的，病毒衰减仍然可以通过改变基因产物（例如通过在基因水平进行操作）来实现，使得影响致病性的蛋白质功能受到不利影响，同时保持蛋白质对病毒的功能复制。

8. 发明申请

WO1992003490A1 SEMICONDUCTIVE COPOLYMERS FOR USE IN LUMINESCENT DEVICES 审中-公开
标题翻译：用于发光器件的半导体共聚物
公开(公告)号：WO1992003490A1
公开(公告)日：1992-03-05
申请号：PCT/GB1991001420
申请日：1991-08-22
申请人： CAMBRIDGE RESEARCH AND INNOVATION LIMITED , CAMBRIDGE CAPITAL MANAGEMENT LIMITED , LYNXVALE LIMITED
发明人： CAMBRIDGE RESEARCH AND INNOVATION LIMITED , CAMBRIDGE CAPITAL MANAGEMENT LIMITED , LYNXVALE LIMITED , HOLMES, Andrew , BRADLEY, Donal, Donat, Conor , KRAFT, Arno , BURN, Paul , BROWN, Adam , FRIEND, Richard
IPC分类号： C08G61/02
CPC分类号： H05B33/14 , C07C43/2055 , C07C43/225 , C08G61/00 , C09K11/06 , H01B1/127 , H01B1/128 , H01L51/0036 , H01L51/0038 , H01L51/0043 , H01L51/5012 , H01L51/5036 , H01L51/56 , Y10T428/3158 , Y10T428/31587 , Y10T428/31645
摘要： A semiconductive conjugated copolymer comprises at least two chemically different monomer units which, when existing in their individual homopolymer forms, have different semiconductor bandgaps. The proportion of said at least two chemically different monomer units in the copolymer is selected to control the semiconductor bandgap of the copolymer so as to control the optical properties of the copolymer. The copolymer is formed in a manner enabling it to be laid down as a film without substantially affecting the luminescent characteristics of the copolymer and is stable at operational temperature. The semiconductor bandgap may be spatially modulated so as to increase the quantum efficiency of the copolymer when excited to luminescence, to select the wavelength of radiation emitted during luminescence or to select the refractive index of the copolymer.
摘要翻译：半导体共轭共聚物包含至少两种化学上不同的单体单元，当其各自的均聚物形式存在时，其具有不同的半导体带隙。选择共聚物中所述至少两种化学上不同的单体单元的比例以控制共聚物的半导体带隙，从而控制共聚物的光学性能。共聚物的形成方式使得其能够以膜形式放置而基本上不影响共聚物的发光特性，并且在操作温度下是稳定的。半导体带隙可以被空间调制，以便当被激发成发光时增加共聚物的量子效率，以选择在发光期间发射的辐射的波长或选择共聚物的折射率。

9. 发明申请

WO1995032708A1 USE OF ANTI-VEGF AGENTS IN THE TREATMENT OF ENDOMETRIOSIS 审中-公开
标题翻译：抗VEGF细胞在治疗子宫内膜异位症中的应用
公开(公告)号：WO1995032708A1
公开(公告)日：1995-12-07
申请号：PCT/GB1995001212
申请日：1995-05-26
申请人： LYNXVALE LIMITED , CHARNOCK-JONES, David, Stephen , McLAREN, John , PRENTICE, Andrew , SMITH, Stephen, Kevin
发明人： LYNXVALE LIMITED
IPC分类号： A61K31/00
CPC分类号： A61K31/569 , A61K31/00 , A61K31/138 , A61K31/57 , A61K31/575 , A61K31/7105 , A61K38/179 , C07K16/24 , C07K2317/73
摘要： Disclosed are: a composition for use in the treatment of endometriosis, comprising an agent capable of interfering with the production and/or activity of VEGF, and a physiologically acceptable carrier substance; a composition for the treatment of endometriosis comprising an agent which inhibits the activation and/or recruitment of peritoneal macrophages, and a physiologically acceptable carrier; and methods of making the compositions and their use in the treatment of endometriosis.
摘要翻译：公开的是：用于治疗子宫内膜异位症的组合物，其包含能够干扰VEGF的产生和/或活性的药剂和生理上可接受的载体物质; 用于治疗子宫内膜异位症的组合物，其包含抑制腹膜巨噬细胞活化和/或募集的药剂和生理上可接受的载体; 以及制备组合物及其在治疗子宫内膜异位症中的用途的方法。

10. 发明申请

WO1994028432A1 NAVIGATION AND TRACKING SYSTEM FOR SHIELDED SPACES 审中-公开
标题翻译：用于屏蔽空间的导航和跟踪系统
公开(公告)号：WO1994028432A1
公开(公告)日：1994-12-08
申请号：PCT/GB1994001145
申请日：1994-05-26
申请人： LYNXVALE LIMITED , CAMBRIDGE RESEARCH AND INNOVATION LIMITED , CAMBRIDGE CAPITAL MANAGEMENT LIMITED , DUFFETT-SMITH, Peter, James , WOAN, Graham
发明人： LYNXVALE LIMITED , CAMBRIDGE RESEARCH AND INNOVATION LIMITED , CAMBRIDGE CAPITAL MANAGEMENT LIMITED
IPC分类号： G01S05/00
CPC分类号： G01S5/10 , G01S5/0009
摘要： A navigation and/or tracking system has a base station (B) and a roving receiver (R) both of which are capable of receiving signals from a plurality of transmission sources (Tx1, Tx2). A link signal (W, W') is passed between the base station and the roving receiver to enable the relative location of the roving receiver to be determined. The apparatus enables the determination of the position of the roving receiver within a space (such as a tunnel T) shielded from receipt of signals from the transmission sources and has equipment (P, Q) for producing substitute signals, each being locked in phase with a signal from a respective one of the transmission sources. A curvilinear transmission element or elements (F, F', F''), extend within the shielded space (T) for generating fields in the shielded space. The equipment (P, Q) propagates at least two of the substitute signals in opposite directions along the curvilinear transmission element or elements for receipt by the roving receiver (R). Additional equipment (S) passes the link signal (W') between the roving receiver and the base station (B) within the shielded space.
摘要翻译：导航和/或跟踪系统具有能够从多个发送源（Tx1，Tx2）接收信号的基站（B）和流动接收器（R）。链路信号（W，W'）在基站和粗纱接收机之间通过，以确定粗纱接收机的相对位置。该设备能够确定在接收来自传输源的信号的空间（例如隧道T）内的粗纱接收器的位置，并且具有用于产生替代信号的设备（P，Q），每个被替换信号与来自相应的一个传输源的信号。曲线传输元件（F，F'，F“）在屏蔽空间（T）内延伸，用于在屏蔽空间中产生场。设备（P，Q）沿着曲线传输元件或元件沿相反方向传播至少两个替代信号，以便由粗纱接收器（R）接收。附加设备（S）在屏蔽空间内通过流动接收器和基站（B）之间的链路信号（W'）。

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