专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007046083A3 COMPOSITIONS FOR TREATMENT OF EYE DISEASES 审中-公开
标题翻译：用于治疗眼病的组合物
公开(公告)号：WO2007046083A3
公开(公告)日：2011-05-19
申请号：PCT/IL2006001168
申请日：2006-10-05
申请人： LYCORED LTD , SHARONI YOAV , LEVY JOSEPH , SELA YORAM , NIR ZOHAR
发明人： SHARONI YOAV , LEVY JOSEPH , SELA YORAM , NIR ZOHAR
IPC分类号： A61K31/07
CPC分类号： A61K31/01 , A61K31/07 , A61K31/192 , A61K31/355 , A61K31/375 , A61K33/34 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a mixture of carotenoids and adjuvants, which provides synergistic therapeutic potential. The compositions of the present invention, which can be administered orally or topically to the eye, are useful in preventing, attenuating or treating eye diseases such as age-related macular degeneration (AMD), glaucoma, diabetic retinopathy and cataracts.
摘要翻译：本发明涉及包含类胡萝卜素和佐剂的混合物的药物组合物，其提供协同的治疗潜力。可以口服或局部施用于眼睛的本发明组合物可用于预防，减弱或治疗诸如年龄相关性黄斑变性（AMD），青光眼，糖尿病性视网膜病变和白内障的眼部疾病。

2. 发明申请

WO2007043046A3 CAROTENOID OXIDATION PRODUCTS AS CHEMOPREVENTIVE AND CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：类胡萝卜素氧化产物作为化学疗法和化学治疗剂
公开(公告)号：WO2007043046A3
公开(公告)日：2007-07-05
申请号：PCT/IL2006001169
申请日：2006-10-05
申请人： LYCORED LTD , SHARONI YOAV , LEVY JOSEPH , SELA YORAM , NIR ZOHAR
发明人： SHARONI YOAV , LEVY JOSEPH , SELA YORAM , NIR ZOHAR
IPC分类号： A61K36/00
CPC分类号： A61K31/203 , A61K31/366
摘要： The present invention relates to a method for the chemoprevention and treatment of cancer, by administering a pharmaceutical composition comprising a carotenoid derivative, e.g., a derivative of lycopene, a- and b-carotene, phytoene, phytofluene, lutein, zeaxanthin, a- and b-cryptoxanthin, canthaxanthin, astaxanthin, or other carotenoid. The carotenoid derivative is a carotenoid oxidation product, and is preferably an aldehyde derivative, a dialdehyde derivative or a ketone derivative. The carotenoid derivative can be a derivative of any naturally occurring carotenoid, e.g., carotenoids found in tomatoes and other fruits and vegetables.
摘要翻译：本发明涉及化学预防和治疗癌症的方法，其通过施用药物组合物，所述药物组合物包含类胡萝卜素衍生物，例如番茄红素，α-和β-胡萝卜素，八氢番茄红素，植物萤烯，叶黄素，玉米黄质，α-和β-胡萝卜素 b-隐黄质，角黄素，虾青素或其他类胡萝卜素。类胡萝卜素衍生物是类胡萝卜素氧化产物，优选醛衍生物，二醛衍生物或酮衍生物。类胡萝卜素衍生物可以是任何天然存在的类胡萝卜素的衍生物，例如在番茄和其他水果和蔬菜中发现的类胡萝卜素。

3. 发明申请

WO2007096886A3 COMPOSITION AND METHODS FOR TREATING AND PREVENTING AGE-RELATED MACULAR DEGENERATION 审中-公开
标题翻译：用于治疗和预防老年相关性变性的组合物和方法
公开(公告)号：WO2007096886A3
公开(公告)日：2009-04-16
申请号：PCT/IL2007000247
申请日：2007-02-25
申请人： LYCORED LTD , SELA YORAM
发明人： SELA YORAM
IPC分类号： A61K31/497
CPC分类号： A61K31/404
摘要： The present invention relates to methods and compositions effective in preventing, attenuating, inhibiting the progression of, and treating eye diseases, e.g., age-related macular degeneration (AMD). The compositions comprise, as an active ingredient, an effective amount of 3,3'-diindolylmethane (DIM) and/or its precursor indole-3-carbinol (I3C). The compositions can further comprise additional agents such as carotenoids and other phytochemicals, which produce a synergistic effect in preventing, attenuating, inhibiting the progression of, and treating AMD and other eye diseases such as glaucoma, cataracts and diabetic retinopathy (DR). The compositions are particularly effective in treating and preventing wet AMD, and in preventing or inhibiting the progression of dry AMD (non-neovascular) to wet AMD (neovascular).
摘要翻译：本发明涉及有效预防，减弱，抑制进展和治疗眼部疾病例如年龄相关性黄斑变性（AMD）的方法和组合物。组合物包含有效量的3,3'-二吲哚基甲烷（DIM）和/或其前体吲哚-3-甲醇（I3C）作为活性成分。组合物可以进一步包含另外的试剂，例如类胡萝卜素和其它植物化学物质，其在预防，减弱，抑制AMD和其它眼睛疾病如青光眼，白内障和糖尿病性视网膜病变（DR）方面产生协同作用。该组合物在治疗和预防湿性AMD中以及在预防或抑制干性AMD（非新生血管）到湿性AMD（新生血管））的进展中特别有效。

4. 发明申请

WO2004069076A3 ORAL DEVICES AND METHODS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物递送的口服装置和方法
公开(公告)号：WO2004069076A3
公开(公告)日：2006-11-30
申请号：PCT/IL2004000123
申请日：2004-02-08
申请人： WOLFF ANDY , BEISKI BEN Z , SELA YORAM
发明人： WOLFF ANDY , BEISKI BEN Z , SELA YORAM
IPC分类号： A61M31/00 , A61C19/06 , A61J7/00 , A61K9/22
CPC分类号： A61J7/0092 , A61C19/063
摘要： Controlled-drug-delivery oral devices are implanted or inserted into an oral cavity, built onto a prosthetic tooth crown, a denture plate, braces, a dental implant, or the like. The devices are refilled or replaced as needed. The controlled drug delivery may be passive, based on a dosage form, or electro-mechanically controlled, for a high-precision, intelligent, drug delivery. Additionally, the controlled delivery method may vary and depend on a variety of factors. Drug absorption in the oral cavity may be assisted or induced by a transport mechanism. The oral devices require refilling or replacement at relatively long intervals of weeks or months, maintain a desired dosage level in the oral cavity, hence in the gastrointestinal tract, for extended periods, address situations of narrow drug therapeutic indices, and by being automatic, ensure adherence to a prescribed medication regimen. The oral devices and methods for controlled drug delivery apply to humans and animals.
摘要翻译：将控制药物输送口服装置植入或插入口腔中，内置于假牙齿冠，假牙板，支架，牙植入物等上。根据需要重新填充或更换设备。受控药物递送可以是基于剂型或电机械控制的被动的，用于高精度，智能的药物递送。此外，受控递送方法可以变化并且取决于多种因素。口腔中的药物吸收可以由运输机制辅助或诱导。口服装置需要以相对较长的间隔周或数月进行再填充或替换，在口腔中保持期望的剂量水平，因此在胃肠道中延长期限，解决窄药物治疗指数的情况，并通过自动确保遵守规定的用药方案。用于受控药物递送的口服装置和方法适用于人和动物。

5. 发明申请

WO2005105053A3 ACTIVE DRUG DELIVERY IN THE GASTROINTESTINAL TRACT 审中-公开
标题翻译：活性药物在胃肠道手术中的输送
公开(公告)号：WO2005105053A3
公开(公告)日：2006-05-18
申请号：PCT/IL2005000301
申请日：2005-03-16
申请人： PILL PHARMA LTD E , GROSS YOSSI , SELA YORAM , BELSKY ZIV , LEV RINA , GOLDSTEIN DANIEL
发明人： GROSS YOSSI , SELA YORAM , BELSKY ZIV , LEV RINA , GOLDSTEIN DANIEL
IPC分类号： A61K9/22 , A61B1/05 , A61B5/00 , A61B5/03 , A61B5/07 , A61B17/32 , A61B18/02 , A61B18/14 , A61B18/20 , A61B19/00 , A61J3/07 , A61K9/00 , A61K9/48 , A61M31/00 , A61N1/05 , A61N1/30 , A61N1/32 , A61N1/36 , A61N1/372 , A61N1/375 , G01K13/00
CPC分类号： A61B1/041 , A61B1/00016 , A61B1/00156 , A61B5/0008 , A61B5/01 , A61B5/036 , A61B5/073 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/4839 , A61B17/3203 , A61B18/02 , A61B18/14 , A61B18/20 , A61B34/70 , A61B34/72 , A61J3/07 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K9/4808 , A61M31/002 , A61N1/05 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/3756 , G01K13/002
摘要： Apparatus (30) for drug administration is provided, including an ingestible capsule (32), which includes a drug (36), stored by the capsule (32), and an environmentally-sensitive mechanism (18), adapted to change a state thereof responsively to a disposition of the capsule (32) within a gastrointestinal (GI) tract (50) of a subject. The capsule (32) further includes first and second electrodes (16), and a control component (14), adapted to facilitate passage of the drug (36), in response to a change of state of the environmentally-sensitive mechanism (18), through an epithelial layer of the GI tract (50) by driving the first and second electrodes (16) to apply a series of pulses at a current of less than about 10 mA, at a frequency of between about 12 Hz and about 24 Hz, and with a pulse duration of between about 0.5 milliseconds and about 3 milliseconds. Other embodiments are also described.
摘要翻译：提供了用于药物给药的装置（30），包括可吸收胶囊（32），其包括由胶囊（32）储存的药物（36）和适于改变其状态的环境敏感性机构（18）响应于胶囊（32）在受试者的胃肠（GI）道（50）内的布置。胶囊（32）还包括响应于环境敏感机构（18）的状态改变而适于促进药物（36）通过的第一和第二电极（16）和控制部件（14）通过驱动第一和第二电极（16）通过GI道（50）的上皮层以约12Hz至约24Hz的频率施加小于约10mA的电流的一系列脉冲并且脉冲持续时间在约0.5毫秒至约3毫秒之间。还描述了其它实施例。

6. 发明申请

WO2005007074A2 GELLAN GUM BASED ORAL CONTROLLED RELEASE DOSAGE FORMS- A NOVEL PLATFORM TECHNOLOGY FOR GASTRIC RETENTION 审中-公开
标题翻译：基于GELLAN GUM的口腔控制释放剂量形式 - 一种新型平台保存技术
公开(公告)号：WO2005007074A2
公开(公告)日：2005-01-27
申请号：PCT/IL2004000654
申请日：2004-07-19
申请人： BIO DAR LTD , HOIKHMAN DAVID , SELA YORAM
发明人： HOIKHMAN DAVID , SELA YORAM
IPC分类号： A61K20060101 , A61K9/00 , A61K9/14 , A61K9/22 , A61K
CPC分类号： A61K9/0065 , A61K9/205 , A61K9/2054 , A61K9/2077
摘要： A controlled-release dosage form is described, which comprises a matrix formed of ingredients (a) and (b): (a) gellan gum, and (b) one or more hydrophilic polymers; and further comprising a drug incorporated within said matrix. The invention also describes a method for the preparation of said controlled-release dosage forms.
摘要翻译：描述了一种控释剂型，其包含由成分（a）和（b）形成的基质：（a）结冷胶，和（b）一种或多种亲水性聚合物; 并且还包含并入所述基质内的药物。本发明还描述了制备所述控释剂型的方法。

7. 发明申请

WO2006072940A3 CONTROLLED LONG ACTING RELEASE PHARMACEUTICAL PREPARATION FOR USE IN THE ORAL CAVITY 审中-公开
标题翻译：用于口腔的控制长效释放药物制剂
公开(公告)号：WO2006072940A3
公开(公告)日：2006-12-14
申请号：PCT/IL2005001385
申请日：2005-12-28
申请人： CALCIDENT ACTIVE LTD , SELA YORAM
发明人： SELA YORAM
IPC分类号： A61K9/20 , A61K8/19 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/19 , A61K9/0004 , A61K9/0056 , A61K9/0065 , A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/00 , A61K31/7048 , A61K33/06 , A61K33/30
摘要： The present invention relates to a controlled long acting release pharmaceutical preparation for use in the oral cavity either for the treatment of diseases of the oral cavity or; for releasing said pharmaceutical preparation into said oral cavity. Said pharmaceutical preparation comprises at least a therapeutic agent, a binder and a lubricant (hereinafter "the preparation" or "the pharmaceutical preparation"). Preferred active agents are a calcium salt for the treatment of dental caries; an antifugal agent such as nystatin or clotrimazole; an antiseptic agent; a breath refresher agent; a therapeutic agent for the treatment of mouth ulcerations; an anesthetic; an antiviral or an antibiotic. The preparation can be in the form of a conventional tablet or an osmotic tablet, or any pharmaceutical dosage form.
摘要翻译：本发明涉及用于口腔治疗口腔疾病的受控长效释放药物制剂;或用于将所述药物制剂释放到所述口腔中。所述药物制剂至少包含治疗剂，粘合剂和润滑剂（以下称为“制剂”或“药物制剂”）。优选的活性剂是用于治疗龋齿的钙盐; 防霉剂如制霉菌素或克霉唑; 防腐剂; 呼吸清新剂; 治疗口腔溃疡的治疗剂; 麻醉剂抗病毒药物或抗生素。制剂可以是常规片剂或渗透片剂或任何药物剂型的形式。

8. 发明申请

WO2005072709A2 FORMULATIONS FOR POORLY SOLUBLE DRUGS 审中-公开
标题翻译：不良溶剂药物的配方
公开(公告)号：WO2005072709A2
公开(公告)日：2005-08-11
申请号：PCT/IL2005000093
申请日：2005-01-26
申请人： BIO DAR LTD , YISSUM RES DEV CO , MAGDASSI SHLOMO , SELA YORAM , COHEN KEREN
发明人： MAGDASSI SHLOMO , SELA YORAM , COHEN KEREN
IPC分类号： A61K9/16
CPC分类号： A61K9/1682 , A61K9/1635 , A61K9/1652 , A61K9/1658
摘要： The present invention provides a drug delivery system comprising nanoparticles or microparticles of a water poorly soluble drug dispersed in a polymeric bead containing essentially only of hydrophilic polymers (i.e. without hydrophobic polymers). The present invention further provides a method of producing the drug delivery system of the invention.
摘要翻译：本发明提供一种药物递送系统，其包含分散在基本上仅含有亲水性聚合物（即不含疏水性聚合物）的聚合物珠粒中的难溶于水的药物的纳米颗粒或微粒。本发明还提供一种制备本发明的药物递送系统的方法。

9. 发明申请

WO2004066903B1 ACTIVE DRUG DELIVERY IN THE GASTROINTESTINAL TRACT 审中-公开
标题翻译：活性药物在胃肠道手术中的输送
公开(公告)号：WO2004066903B1
公开(公告)日：2005-07-21
申请号：PCT/IL2004000093
申请日：2004-01-29
申请人： PILL PHARMA LTD E , GROSS YOSSI , SELA YORAM
发明人： GROSS YOSSI , SELA YORAM
IPC分类号： A61B5/00 , A61B5/07 , A61J3/07 , A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61B1/041 , A61B5/0008 , A61B5/01 , A61B5/073 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4839 , A61J3/07 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61M31/002 , A61N1/30 , A61N1/306 , A61N1/325
摘要： Apparatus (100) for drug (36, 106) administration is provided, including an ingestible capsule (30, 102). The capsule (30, 102) includes a drug (36, 106), stored by the capsule (30, 102). An environmentally-sensitive mechanism (e.g., coating 104) is adapted to change a state thereof responsive to a disposition of the capsule (30, 102) within a gastrointestinal tract of a subject. A driving mechanism (e.g., driving mechanism 108), in response to a change of state of the environmentally-sensitive mechanism, is adapted to drive the drug (36, 106) directly through an endothelial layer of the gastrointestinal tract.
摘要翻译：提供用于药物（36,106）给药的装置（100），包括可摄入胶囊（30,102）。胶囊（30,102）包括由胶囊（30,102）储存的药物（36,106）。响应于在受试者的胃肠道内的胶囊（30,102）的布置，环境敏感的机构（例如，涂层104）适于改变其状态。驱动机构（例如，驱动机构108）响应于环境敏感机构的状态的改变而适于直接驱动药物（36,106）通过胃肠道的内皮层。

10. 发明申请

WO2004066903A3 ACTIVE DRUG DELIVERY IN THE GASTROINTESTINAL TRACT 审中-公开
标题翻译：胃肠道中的活性药物递送
公开(公告)号：WO2004066903A3
公开(公告)日：2005-05-12
申请号：PCT/IL2004000093
申请日：2004-01-29
申请人： PILL PHARMA LTD E , GROSS YOSSI , SELA YORAM
发明人： GROSS YOSSI , SELA YORAM
IPC分类号： A61B5/00 , A61B5/07 , A61J3/07 , A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61B1/041 , A61B5/0008 , A61B5/01 , A61B5/073 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4839 , A61J3/07 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61M31/002 , A61N1/30 , A61N1/306 , A61N1/325
摘要： Apparatus (100) for drug (36, 106) administration is provided, including an ingestible capsule (30, 102). The capsule (30, 102) includes a drug (36, 106), stored by the capsule (30, 102). An environmentally-sensitive mechanism (e.g., coating 104) is adapted to change a state thereof responsive to a disposition of the capsule (30, 102) within a gastrointestinal tract of a subject. A driving mechanism (e.g., driving mechanism 108), in response to a change of state of the environmentally-sensitive mechanism, is adapted to drive the drug (36, 106) directly through an endothelial layer of the gastrointestinal tract.
摘要翻译：提供了用于药物（36,106）给药的装置（100），包括可摄取胶囊（30,102）。胶囊（30,102）包括由胶囊（30,102）存储的药物（36,106）。响应于胶囊（30,102）在受试者的胃肠道内的布置，环境敏感机构（例如，涂层104）适于改变其状态。响应于环境敏感机构的状态改变，驱动机构（例如，驱动机构108）适于直接驱动药物（36,106）穿过胃肠道的内皮层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式