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1. 发明申请

WO2004078776A2 NY-ESO-1 PEPTIDES WHICH BIND TO CLASS II MOLECULES AND USES THEREOF 审中-公开
标题翻译：包含II类分子的NY-ESO-1肽类及其用途
公开(公告)号：WO2004078776A2
公开(公告)日：2004-09-16
申请号：PCT/US2004006341
申请日：2004-03-01
申请人： LUDWIG INST CANCER RES , PFREUNDSCHUH MICHAEL , NEUMANN FRANK , RAMMENSEE HANS-GEORGE , STEVANOVIC STEFAN
发明人： PFREUNDSCHUH MICHAEL , NEUMANN FRANK , RAMMENSEE HANS-GEORGE , STEVANOVIC STEFAN
IPC分类号： A61K38/00 , A61K39/00 , C07K20060101 , C07K14/47 , C07K16/00 , C12N1/20 , C12N5/00 , C12N15/00 , C07K
CPC分类号： C07K14/4748 , A61K38/00 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/1764
摘要： The invention relates to peptides which consist of amino acid sequences found in the NY-ESO-1 molecule, which bind to MHC-Class II molecules. These can be used alone, or in combination with other peptides.
摘要翻译：本发明涉及由NY-ESO-1分子中发现的结合MHC-II类分子的氨基酸序列组成的肽。这些可以单独使用，也可以与其他肽组合使用。

2. 发明申请

WO9904265A3 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：癌症相关核酸和多糖
公开(公告)号：WO9904265A3
公开(公告)日：1999-08-26
申请号：PCT/US9814679
申请日：1998-07-15
申请人： LUDWIG INST CANCER RES , SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO TSENG , GOUT IVAN , HARE MICHAEL O , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
发明人： SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO-TSENG , GOUT IVAN , O'HARE MICHAEL , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/569 , G01N33/574 , C12N15/12 , A61K31/70 , A61K35/12 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , G01N33/53
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Tumor cell-specific antigens from melanoma cells have previously been identified using autologous cytolytic T cells clones from the patient, but the same approach did not work well with other tumour types. Here, screening of such antigens was successfully performed using antisera from the patient. Provided are several tumor cell-specific antigens, nucleic acids encoding them, antibodies and CTL's directed against these antigens, antigenic fragments diagnostic kits, etc.
摘要翻译：以前已经使用来自患者的自体细胞溶质T细胞克隆来鉴定来自黑素瘤细胞的肿瘤细胞特异性抗原，但是与其他肿瘤类型相同的方法不能很好地发现。在这里，使用来自患者的抗血清成功地进行了这些抗原的筛选。提供了几种肿瘤细胞特异性抗原，编码它们的核酸，针对这些抗原的抗体和CTL，抗原片段诊断试剂盒等。

3. 发明申请

WO9904265A9 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：癌相关的核酸和多肽
公开(公告)号：WO9904265A9
公开(公告)日：1999-07-08
申请号：PCT/US9814679
申请日：1998-07-15
申请人： LUDWIG INST CANCER RES , SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO TSENG , GOUT IVAN , HARE MICHAEL O , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
发明人： SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO-TSENG , GOUT IVAN , O'HARE MICHAEL , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/569 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

4. 发明申请

WO9904265A8 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：癌症相关核酸和多糖
公开(公告)号：WO9904265A8
公开(公告)日：1999-05-14
申请号：PCT/US9814679
申请日：1998-07-15
申请人： LUDWIG INST CANCER RES , SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO TSENG , GOUT IVAN , HARE MICHAEL O , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
发明人： SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO-TSENG , GOUT IVAN , O'HARE MICHAEL , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/569 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

5. 发明申请

WO0023625A2 ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE SCP PROTEINS, AND USES THEREOF 审中-公开
标题翻译：编码SCP蛋白的分离的核酸分子及其用途
公开(公告)号：WO0023625A2
公开(公告)日：2000-04-27
申请号：PCT/US9925069
申请日：1999-10-22
申请人： LUDWIG INST CANCER RES
发明人： TURECI OZLEM , SAHIN UGUR , PFREUNDSCHUH MICHAEL
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/68 , A61K38/17 , A61K39/00 , A61K48/00 , G01N33/50
CPC分类号： C07K14/4748 , A61K38/00 , C07K16/18 , C12Q1/6886 , C12Q2600/136 , G01N33/6872 , Y10S436/813
摘要： The invention involves the recognition of a previously unidentified protein family which belongs to the human SCP family. The members of the family, such as SCP-2 and rat SCP-3 homolog, are markers for cell transformation. Also disclosed is the analysis of SCP proteins association with nuclear bodies. Diagnostic and therapeutic uses of these proteins and related molecules are taught.
摘要翻译：本发明涉及识别属于人类SCP家族的先前未鉴定的蛋白质家族。家族成员，如SCP-2和大鼠SCP-3同系物，是细胞转化的标记。还披露了SCP蛋白与核体的关联分析。教导了这些蛋白质和相关分子的诊断和治疗用途。

6. 发明申请

WO02068667A3 REGULATORY ELEMENTS FROM RP1 GENE AND USES THEREOF 审中-公开
标题翻译： RP1基因的调节元件及其用途
公开(公告)号：WO02068667A3
公开(公告)日：2002-11-14
申请号：PCT/US0203539
申请日：2002-02-08
申请人： LUDWIG INST CANCER RES
发明人： WADLE ANDREAS , RENNER CHRISTOPH , PFREUNDSCHUH MICHAEL
IPC分类号： C07K14/47 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47
摘要： The invention describes a promoter, isolated from the RP1 gene. The promoter is 10 times more active than known CMV promoters. Also described are nucleic acid molecules which are more extensive that the most active promoter described.
摘要翻译：本发明描述了从RP1基因分离的启动子。启动子比已知的CMV启动子活性高10倍。还描述了更广泛的是所描述的最活性启动子的核酸分子。

7. 发明申请

WO0123560A3 ISOLATED PEPTIDES WHICH BIND TO MHC CLASS II MOLECULES, AND USES THEREOF 审中-公开
标题翻译：包含MHC II类分子的分离的肽，及其用途
公开(公告)号：WO0123560A3
公开(公告)日：2001-11-29
申请号：PCT/US0026411
申请日：2000-09-26
申请人： LUDWIG INST CANCER RES
发明人： TURECI OZLEM , SAHIN UGUR , PFREUNDSCHUH MICHAEL
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C12N15/12 , A61K31/70 , A61K35/14 , A61K38/17 , A61K39/395 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： Peptides which have an amino acid sequence identical to sequences found in tumor rejection antigen precursors, such as NY-ESO-1, and SSX-2, are disclosed. These peptides bind to MHC-Class II molecules, such as HLA-DR molecules, and provoke proliferation of CD4+ cells.
摘要翻译：公开了具有与在肿瘤排斥抗原前体中发现的序列相同的氨基酸序列的肽，例如NY-ESO-1和SSX-2。这些肽结合MHC-II类分子，如HLA-DR分子，并引发CD4 +细胞的增殖。

8. 发明申请

WO0100874A3 CANCER ASSOCIATED ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：癌症相关抗原及其用途
公开(公告)号：WO0100874A3
公开(公告)日：2002-05-02
申请号：PCT/US0017207
申请日：2000-06-23
申请人： LUDWIG INST CANCER RES
发明人： SAHIN UGUR , TURECI OZLEM , PFREUNDSCHUH MICHAEL
IPC分类号： G01N33/53 , A61K35/12 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/574 , A61K35/14 , C07K7/04 , C12N15/63
CPC分类号： G01N33/57484 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , C07K14/4748
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in testis cells using antisera from seminoma patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with a variety of cancers. The invention provides, inter alia , isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自精原细胞瘤患者的抗血清的睾丸细胞中表达的核酸文库的自体抗体筛选来鉴定癌症相关抗原。本发明涉及在患有多种癌症的患者中表达的癌症相关抗原的核酸和编码多肽。本发明提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

9. 发明申请

WO0020587A2 CANCER ASSOCIATED ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：癌症相关抗原及其用途
公开(公告)号：WO0020587A2
公开(公告)日：2000-04-13
申请号：PCT/US9922873
申请日：1999-10-04
申请人： LUDWIG INST CANCER RES
发明人： OBATA YUICHI , GOUT IVAN , TURECI OZLEM , SAHIN UGAR , PFREUNDSCHUH MICHAEL , SCANLAN MATTHEW J , STOCKERT ELISABETH , CHEN YAO-TSENG , OLD LLOYD J , JAGER ELKE , KNUTH ALEX
IPC分类号： A61K31/711 , A61K35/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/574 , G01N33/577 , A61K31/70 , A61K35/12 , A61K38/13
CPC分类号： G01N33/57492 , A61K35/00 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/11 , C07K14/47 , C12Q1/6886 , C12Q2600/158 , G01N33/57488
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in renal cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with renal cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的肾癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有肾癌的患者中表达的癌相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有那些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，对那些识别蛋白质和肽的那些蛋白质和肽和细胞毒性T淋巴细胞的抗体。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可以用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

10. 发明申请

WO9107437A2 IMPROVED CD-30 ANTIBODIES AND FRAGMENTS THEREOF 审中-公开
标题翻译：改进的CD-30抗体及其片段
公开(公告)号：WO9107437A2
公开(公告)日：1991-05-30
申请号：PCT/US9006802
申请日：1990-11-20
申请人： PARKER DAVID L , PFREUNDSCHUH MICHAEL
发明人： PFREUNDSCHUH MICHAEL
IPC分类号： A61K38/00 , A61K47/48 , C07K14/415 , C07K14/705 , C07K16/28 , C07K16/30 , C07K19/00 , C12P21/08
CPC分类号： C07K14/415 , A61K38/00 , A61K47/6827 , A61K47/6849 , A61K47/6851 , A61K47/6867 , C07K14/70578 , C07K16/2878 , C07K16/30 , C07K16/3061 , C07K19/00
摘要： Disclosed are methods and compositions for the treatment of Hodgkin's disease and processes involving Hodgkin's disease cells or Reed-Sternberg cells, through specific elimination of Hodgkin's disease cells through the application of immunotoxin technology. The compositions of the invention include toxin conjugates composed of a Hodgkin's disease cell binding ligand conjugated to a toxin A chain moiety such as ricin A chain or deglycosylated ricin A chain, by means of a cross-linker or other conjugation which includes a disulfide bond. In preferred aspects of the invention, therapeutic amounts of conjugates composed of a CD-30 or IRac antibody or fragment thereof conjugated to deglycosylated A chain by means of an SMPT linker is administered to a Hodgkin's disease patient so as to specifically eliminate Hodgkin's disease cells without exerting significant toxicity against non-tumor cells. Also disclosed are particular hybridomas and monoclonal antibodies, and associated methodology, which may be employed, e.g., in the preparation of these immunotoxins as well as other uses such as diagnostic applications.
摘要翻译：公开了通过应用免疫毒素技术特异性消除霍奇金病细胞来治疗霍奇金病和涉及霍奇金病细胞或里德 - 斯特伯格细胞的方法和组合物。本发明的组合物包括由与包含二硫键的交联剂或其它缀合物缀合至毒素A链部分如蓖麻毒素A链或去糖基化的蓖麻毒蛋白A链的霍奇金病细胞结合配体组成的毒素缀合物。在本发明的优选方面，向霍奇金氏病患者施用治疗量由CD-30或IRac抗体或其通过SMPT接头与去糖基化A链结合的片段组成的缀合物，以便特异性地消除霍奇金氏病细胞而没有对非肿瘤细胞发挥显着毒性。还公开了特定的杂交瘤和单克隆抗体以及相关方法，其可用于例如制备这些免疫毒素以及其它用途如诊断应用。

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