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1. 发明申请

WO2007145991A2 ANTI-INFLAMMATORY AND ANALGESIC COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：抗炎和毒理组合物及相关方法
公开(公告)号：WO2007145991A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013313
申请日：2007-06-05
申请人： LIPOCINE, INC. , TYAVANAGIMATT, Shanthakumar , FIKSTAD, David , GILIYAR, Chandrashekar , PATEL, Mahesh , VENKATESHWARAN, Srinivasan
发明人： TYAVANAGIMATT, Shanthakumar , FIKSTAD, David , GILIYAR, Chandrashekar , PATEL, Mahesh , VENKATESHWARAN, Srinivasan
IPC分类号： A61K31/5415
CPC分类号： A61K31/5415 , A61K9/2054 , A61K9/4858 , A61K9/5084
摘要： Methods and compositions for delivering a meloxicam compound are disclosed and described. In one aspect, a method may include perorally administering to a subject a therapeutically effective amount of a meloxicam compound that provides a meloxicam plasma concentration within 1 hour which is at least about 40% of the maximum plasma concentration attained by the formulation. In another aspect, a composition may include a therapeutically effective amount of a meloxicam compound in a pharmaceutically acceptable carrier including at least one of an alkalizer or a solubilizer, with the meloxicam compound having a solubility in the carrier that is greater than about 1.0 mg/gm.
摘要翻译：公开和描述了递送美洛昔康化合物的方法和组合物。在一个方面，一种方法可以包括向受试者口服施用治疗有效量的美洛昔康化合物，所述美洛昔康化合物在1小时内提供美洛昔康血浆浓度，其为制剂达到的最大血浆浓度的至少约40％。在另一方面，组合物可以包括药学上可接受的载体中的治疗有效量的美洛昔康化合物，其包括碱化剂或增溶剂中的至少一种，其中美洛昔康化合物在载体中的溶解度大于约1.0mg / 克。

2. 发明申请

WO2006119498A2 PHARMACEUTICAL COMPOSITIONS WITH SYNCHRONIZED SOLUBILIZER RELEASE 审中-公开
标题翻译：具有同步溶解氧化物释放的药物组合物
公开(公告)号：WO2006119498A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/017445
申请日：2006-05-04
申请人： LIPOCINE, INC. , FIKSTAD, David , VENKATESHWARAN, Srinivasan , GILIYAR, Chandrashekar , PATEL, Mahesh
发明人： FIKSTAD, David , VENKATESHWARAN, Srinivasan , GILIYAR, Chandrashekar , PATEL, Mahesh
IPC分类号： A61K31/724 , A61K31/401 , A61K31/366 , A61K9/22 , A61K31/355 , A61K31/225
CPC分类号： A61K47/44 , A61K9/0004 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/4808 , A61K9/4833 , A61K9/4858 , A61K9/4866 , A61K31/17 , A61K31/225 , A61K31/265 , A61K31/28 , A61K31/34 , A61K31/35 , A61K31/355 , A61K31/366 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4709 , A61K31/568 , A61K31/66 , A61K31/724 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/40
摘要： Pharmaceutical compositions with synchronized solubilizer release as well as various methods associated therewith, are disclosed and described. More specifically, the aqueous solubility of a drug is enhanced by synchronized release of a solubilizer.
摘要翻译：公开和描述了具有同步增溶剂释放的药物组合物以及与其相关的各种方法。更具体地，通过增溶剂的同步释放来提高药物的水溶性。

3. 发明申请

WO2007018943A2 SOLID CARRIERS FOR IMPROVED DELIVERY OF ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：用于改善药物组合物中活性成分的固体载体
公开(公告)号：WO2007018943A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/027159
申请日：2006-07-12
申请人： LIPOCINE, INC. , PATEL, Mahesh
发明人： PATEL, Mahesh
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K9/1676 , A61K9/5078
摘要： The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, liydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.
摘要翻译：本发明提供用于改善递送其中所含的各种药物活性成分或分开施用的固体药物组合物。在一个实施方案中，固体药物组合物包括固体载体，固体载体包括底物和基材上的包封涂层。包封涂层可以包括药物活性成分，亲水性表面活性剂，亲脂性表面活性剂和甘油三酸酯的不同组合。在另一个实施方案中，固体药物组合物包括固体载体，固体载体由药物活性成分，亲水性表面活性剂，亲脂性表面活性剂和甘油三酯的不同组合形成。本发明的组合物可用于改进递送亲水或疏水性药物活性成分，例如药物，营养剂，药妆和诊断剂。

4. 发明申请

WO2012071290A1 TWISTED PAIR COMMUNICATIONS CABLE WITH SELECTIVE SEPARATION OF PAIRS 审中-公开
标题翻译：双绞线通信线与选择性分离对线
公开(公告)号：WO2012071290A1
公开(公告)日：2012-05-31
申请号：PCT/US2011/061574
申请日：2011-11-21
申请人： COMMSCOPE INC. OF NORTH CAROLINA , PATEL, Mahesh
发明人： PATEL, Mahesh
IPC分类号： H01B11/06
CPC分类号： H01B11/06
摘要： A communications cable includes: a cable jacket; first, second, third and fourth twisted pairs of insulated conductors positioned within the jacket, the first, second, third and fourth twisted pairs having, respectively, first, second, third and fourth twist lengths, wherein a first difference between the first and third twist lengths and a second difference between the second and fourth twist lengths are greater than the difference between the twist lengths of any other combination of twisted pairs, and wherein a third difference between the third twist length and the fourth twist length is greater than the difference between the twist lengths of any other combination of twisted pairs except for the first and second differences; and a separator positioned between the third and fourth pairs. There is no separator present between the first and second pairs, the second and third pairs, and the first and fourth pairs. A cable of this configuration can provide adequate crosstalk performance while utilizing less material and experiencing improved burn performance over cables with more robust separators.
摘要翻译：通信电缆包括：电缆护套; 第一，第二，第三和第四绞合线对定位在护套内，第一，第二，第三和第四双绞线分别具有第一，第二，第三和第四扭曲长度，其中第一和第三扭转长度和第二和第四扭曲长度之间的第二差异大于双绞线的任何其他组合的扭转长度之间的差异，并且其中第三扭转长度和第四扭曲长度之间的第三差异大于差异在除了第一和第二差异之外的任何其他组合的双绞线的扭转长度之间; 以及位于第三和第四对之间的分离器。在第一对和第二对之间没有分隔符，第二和第三对以及第一和第四对。这种配置的电缆可以提供足够的串扰性能，同时利用更少的材料，并在具有更强大的分离器的电缆上经历改进的烧录性能。

5. 发明申请

WO2010023454A1 STACKED PATCH ANTENNA ARRAY 审中-公开
标题翻译：堆叠天线阵列
公开(公告)号：WO2010023454A1
公开(公告)日：2010-03-04
申请号：PCT/GB2009/002087
申请日：2009-08-28
申请人： ERA TECHNOLOGY LIMITED , PHILIPPAKIS, Michael , MOORE, David , KEMP, Dean , PATEL, Mahesh
发明人： PHILIPPAKIS, Michael , MOORE, David , KEMP, Dean , PATEL, Mahesh
IPC分类号： H01Q9/04 , H01Q21/06 , H01Q5/00
CPC分类号： H01Q9/0421 , H01Q5/40 , H01Q9/0414 , H01Q9/0457 , H01Q21/065
摘要： A radiating element board for use in a passive antenna, the radiating element board comprising a plurality of multi-layer radiating elements, each of which comprises a first patch (11) provided on a first layer for receiving signals within a first frequency band and a second patch (12) provided on a second layer for receiving signals within a second frequency band, wherein the plurality of radiating elements are arranged on the radiating element board such that each radiating element is sequentially rotated a predetermined angle from its neighbouring element, all elements being rotated in the same direction and in the same plane.
摘要翻译：一种用于无源天线的辐射元件板，所述辐射元件板包括多个多层辐射元件，每个辐射元件板包括设置在第一层上的用于接收第一频带内的信号的第一贴片（11）第二贴片（12），设置在第二层上用于接收第二频带内的信号，其中所述多个辐射元件布置在所述辐射元件板上，使得每个辐射元件从其相邻元件顺序旋转预定角度，所有元件沿同一方向旋转并在同一平面内。

6. 发明申请

WO2012076989A1 KETOLIDE COMPOUNDS 审中-公开
标题翻译：胶体化合物
公开(公告)号：WO2012076989A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/050464
申请日：2011-02-03
申请人： WOCKHARDT LIMITED , TRIVEDI, Bharat , DESHPANDE, Prasad , TADIPARTHI, Ravikumar , GUPTA, Sunil , DIWAKAR, Santosh , PAWAR, Shivaji , PATIL, Vijay , DEKHANE, Deepak , PATEL, Mahesh , BHAVSAR, Satish , MISHRA, Amit , SOLANKI, Manish , JAFRI, Mohammad , BHAGWAT, Sachin
发明人： TRIVEDI, Bharat , DESHPANDE, Prasad , TADIPARTHI, Ravikumar , GUPTA, Sunil , DIWAKAR, Santosh , PAWAR, Shivaji , PATIL, Vijay , DEKHANE, Deepak , PATEL, Mahesh , BHAVSAR, Satish , MISHRA, Amit , SOLANKI, Manish , JAFRI, Mohammad , BHAGWAT, Sachin
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , C07D417/04 , C07H23/00
摘要： The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is -C*H(R 1 )-P-Q; R 1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R 3 is hydrogen or fluorine, With the provision that when R 1 is hydrogen, R 3 is fluorine.
摘要翻译：本发明涉及具有抗微生物活性的式（I）的酮内酯化合物及其药学上可接受的盐，溶剂合物，水合物，多晶型物和立体异构体。本发明还提供含有本发明化合物的药物组合物和本发明化合物治疗或预防微生物感染的方法，其中T为-C * H（R 1）-P-Q; R1是氢; 未取代或取代的低级烷基，环烷基或芳基; P是杂芳基环; Q是未取代或取代的芳基或杂芳基环; P通过碳 - 碳键连接到Q上; 并且R 3是氢或氟，条件是当R 1是氢时，R 3是氟。

7. 发明申请

WO2014055954A1 PROGESTERONE CONTAINING ORAL DOSAGE FORMS AND KITS 审中-公开
标题翻译：含有口服剂型的孕激素
公开(公告)号：WO2014055954A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/063584
申请日：2013-10-04
申请人： LIPOCINE INC.
发明人： NACHAEGARI, Satish Kumar , GILIYAR, Chandrashekar , NACHIAPPAN, Chidambaram , PATEL, Mahesh , VENKATESHWARAN, Srinivasan
IPC分类号： A61K31/57 , A61K9/20 , A61K9/48 , A61K47/30
CPC分类号： A61K31/57 , A61K9/0053 , A61K9/2018 , A61K9/2077 , A61K9/209 , A61K9/2846 , A61K9/4808 , A61K9/4858 , A61K31/565
摘要： The present invention provides for progesterone containing pharmaceutical oral dosage forms, pharmaceutical kits, and related methods. In one embodiment, an oral dosage form formulated for on-going administration is provided. The oral dosage form includes an amount of progesterone and a pharmaceutically acceptable carrier. The oral dosage form is formulated such that upon single dose administration to a non-pregnant woman in follicular phase, the oral dosage form provides a serum progesterone C 24h of at least 0.20 ng/mL.
摘要翻译：本发明提供了含有孕酮的药物口服剂型，药物盒和相关方法。在一个实施方案中，提供了配制用于持续给药的口服剂型。口服剂型包括一定量的孕酮和药学上可接受的载体。配制口服剂型，使得在对卵泡期的非孕妇进行单剂量给药时，口服剂型提供至少0.20ng / mL的血清孕酮C24h。

8. 发明申请

WO2016049382A1 COMPOSITIONS AND THEIR USE IN ORAL DOSING REGIMENS 审中-公开
标题翻译：组合物及其在口服给药方案中的使用
公开(公告)号：WO2016049382A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/052064
申请日：2015-09-24
申请人： LIPOCINE INC.
发明人： PATEL, Mahesh , CHIDAMBARAM, Nachiappan , NACHAEGARI, Satish Kumar , VENKATESHWARAN, Srinivasan
IPC分类号： A61K31/568
CPC分类号： A61K31/568 , A61K9/0053 , A61K9/4858
摘要： Described herein are oral pharmaceutical compositions and their use in testosterone replacement therapy applications. Disclosed herein is an oral testosterone replacement therapy ("TRT"). The TRT described herein provides for three different daily doses of testosterone undecanoate formulated for oral administration that are typically divided into two administrations e.g., a morning dose and an evening dose. Typically, the doses of testosterone undecanoate are administered with a meal.
摘要翻译：本文描述的是口服药物组合物及其在睾酮替代治疗应用中的用途。本文公开了口服睾酮替代疗法（“TRT”）。本文所述的TRT提供了配制用于口服给药的三种不同日剂量的十一酸睾酮，其通常分为两种给药，例如早晨剂量和晚剂量。通常情况下，用一顿饭服用十一酸睾酮的剂量。

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