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1. 发明申请

WO2015112312A1 MONOSACCHARIDE-LIKE GLYCYLATED SUGAR ALCOHOL COMPOSITIONS FOR USE AS ANTI-DIABETIC DRUGS 审中-公开
标题翻译：用作抗糖尿病药物的单糖类糖甘油醇组合物
公开(公告)号：WO2015112312A1
公开(公告)日：2015-07-30
申请号：PCT/US2014/072693
申请日：2014-12-30
申请人： LIN, Shi-Lung , CHANG-LIN, Samantha , LIN, Yi-Wen , CHANG, Donald
发明人： LIN, Shi-Lung , CHANG-LIN, Samantha , LIN, Yi-Wen , CHANG, Donald
IPC分类号： A61K31/223 , A61K31/7032 , A61K8/41 , A61K8/60 , A61P3/04 , A61P3/10 , A61Q19/06
CPC分类号： A61K31/7032
摘要： This invention is related to a sugar-like chemical composition for use in diabetes therapy. Particularly, the present invention teaches the use of monosaccharide-like glycylated sugar alcohol compounds to block or reduce sugar absorption in diabetes patients, so as to prevent the risk of hyperglycemia symptoms. The novelty of the present invention is that glycylated sugar alcohols were found to be useful for treating Diabetes mellitus. In addition, the present application discloses a method for producing these glycylated sugar alcohols. In sum, the present invention includes not only a kind of sugar-like chemical composition for use in treating diabetes but also discloses a state-of-the-art protocol and methodology for producing such a composition via glycylation of sugars and sugar alcohols.
摘要翻译：本发明涉及用于糖尿病治疗的糖类化学组合物。特别地，本发明教导了使用单糖样的糖化糖醇化合物来阻止或减少糖尿病患者的糖吸收，以防止高血糖症状的风险。本发明的新颖性是发现糖基化糖醇可用于治疗糖尿病。此外，本申请公开了一种生产这些糖基化糖醇的方法。总之，本发明不仅包括一种用于治疗糖尿病的糖类化学组合物，而且还公开了通过糖和糖醇的糖基化制备这种组合物的最新方案和方法。

2. 发明申请

WO2015099839A1 NOVEL SUGAR ALCOHOL-BASED COMPOSITIONS FOR DELIVERING NUCLEIC ACID-BASED DRUGS IN VIVO AND IN VITRO 审中-公开
标题翻译：用于在体内和体内递送基于核酸的药物的新型基于酒石酸的组合物
公开(公告)号：WO2015099839A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/050114
申请日：2014-08-07
申请人： LIN, Shi-Lung , WU, David TS
发明人： LIN, Shi-Lung , LIN, Yi-Wen
IPC分类号： A61K47/18 , A61K47/26 , A61K9/08 , C12N15/113
CPC分类号： A61K9/08 , A61K47/183 , A61K47/26 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/3517 , C12N2320/32
摘要： This invention relates to a composition and its use for formulating nucleic acid-based drugs/vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as miRNA, microRNA precursors, shRNAs, siRNAs, ribozymes, antisense RNAs/DNAs, RNA-DNA hybrids and DNA vectors/vaccines, with glycylated sugar alcohols/sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis. Also, the present invention discloses that chemical compounds containing sugar alcohol- and/or sugar-like structures can protect nucleic acids, in particular miRNAs, shRNAs, siRNAs and ribozymes, from degradation in vivo as well as in vitro. Therefore, the present invention is also a formula and method for preserving the structural integrity and functional efficacy of these nucleic acid-based drugs and/or vaccines in vivo and in vitro.
摘要翻译：本发明涉及一种组合物及其用于将糖醇组合物配制成用于体外和体内递送的复合物的核酸基药物/疫苗的用途。特别地，本发明包括配制具有糖基化的治疗和药物核酸组合物如miRNA，微RNA前体，shRNA，siRNA，核酶，反义RNA / DNA，RNA-DNA杂交体和DNA载体/疫苗所必需的成分和过程糖醇/糖进入递送复合物，其然后可以通过活性内吞作用在体内和体外被细胞吸收。此外，本发明公开了含有糖醇和/或糖类结构的化合物可以保护核酸，特别是miRNA，shRNA，siRNA和核酶免受体内和体外降解。因此，本发明也是用于在体内和体外保存这些基于核酸的药物和/或疫苗的结构完整性和功能功效的配方和方法。

3. 发明申请

WO2010102007A3 MODULAR DIGITAL SIGNAL PROCESSING CIRCUITRY WITH OPTIONALLY USABLE, DEDICATED CONNECTIONS BETWEEN MODULES OF THE CIRCUITRY 审中-公开
公开(公告)号：WO2010102007A3
公开(公告)日：2010-09-10
申请号：PCT/US2010/026056
申请日：2010-03-03
申请人： ALTERA CORPORATION , STREICHER, Keone , LANGHAMMER, Martin , LIN, Yi-Wen , LEUNG, Wai-Bor , LEWIS, David , MAUER, Volker , LUI, Henry, Y. , DEMIRSOY, Suleyman, Sirri , YI, Hyun
发明人： STREICHER, Keone , LANGHAMMER, Martin , LIN, Yi-Wen , LEUNG, Wai-Bor , LEWIS, David , MAUER, Volker , LUI, Henry, Y. , DEMIRSOY, Suleyman, Sirri , YI, Hyun
IPC分类号： G06F7/53
摘要： Digital signal processing ("DSP") circuit blocks are provided that can more easily work together to perform larger (e.g., more complex and/or more arithmetically precise) DSP operations if desired. These DSP blocks may also include redundancy circuitry that facilitates stitching together multiple such blocks despite an inability to use some block (e.g., because of a circuit defect). Systolic registers may be included at various points in the DSP blocks to facilitate use of the blocks to implement systolic form, finite-impulse-response ("FIR"), digital filters.

4. 发明申请

WO2010101985A1 DIGITAL SIGNAL PROCESSING CIRCUITRY WITH REDUNDANCY AND BIDIRECTIONAL DATA PATHS 审中-公开
标题翻译：数字信号处理电路与冗余和双向数据处理
公开(公告)号：WO2010101985A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026023
申请日：2010-03-03
申请人： ALTERA CORPORATION , LANGHAMMER, Martin , LIN, Yi-Wen , STREICHER, Keone
发明人： LANGHAMMER, Martin , LIN, Yi-Wen , STREICHER, Keone
IPC分类号： G06F7/53
CPC分类号： H03K5/1252 , G06F7/5324 , G06F2207/382 , H03K19/17732
摘要： Digital signal processing ("DSP") circuit blocks are provided that can more easily work together to perform larger (e.g., more complex and/or more arithmetically precise) DSP operations if desired. These DSP blocks may also include redundancy circuitry that facilitates stitching together multiple such blocks despite an inability to use some block (e.g., because of a circuit defect).
摘要翻译：提供数字信号处理（“DSP”）电路块，如果需要，可以更容易地一起工作来执行更大（例如更复杂和/或更具有算术精度）的DSP操作。尽管不能使用某些块（例如，由于电路缺陷），这些DSP块还可以包括有助于将多个这样的块拼接在一起的冗余电路。

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